Total losses throughout early sporogony were greatest in P. vinckei (ca. 250,000-fold loss), followed by P. yoelii (ca. 70,000-fold loss), P. berghei (ca. 45,000-fold loss), and P. chabaudi (ca. 15,000-fold loss). (allenpress.com)
Significant correlations between ookinete and oocyst densities existed for P. berghei , P. chabaudi , and P. yoelii (but not for P. vinckei ), and were best described by nonlinear functions ( P. berghei = sigmoid, P. chabaudi = hyperbolic, P. yoelii = sigmoid), indicating that conversion of ookinetes to oocysts in these species is density dependent. (allenpress.com)
The upper theoretical limit for oocyst density on the mosquito midgut for P. chabaudi and P. yoelii (ca. 300 oocysts per midgut) was higher than for P. berghei (ca. 30 oocysts per midgut). (allenpress.com)
In the second vaccine trial, the TCTP from P. yoelii and P. berghei was expressed in Escherichia coli and used in several mouse malaria models. (johnshopkins.edu)
Draft RMP genomes have been published for Plasmodium yoelii , P. berghei ANKA ( Pb A) and P. chabaudi AS ( Pc AS). (biomedcentral.com)
Therefore, the present study aimed to investigate parasitological and immunopathological aspects of the lung during murine experimental concomitant coinfection by Plasmodium berghei and Ascaris suum during larvae ascariasis. (biomedcentral.com)
Malaria parasite5
Here we report the whole-genome shotgun sequence of one species, Plasmodium yoelii yoelii, and comparative studies with the genome of the human malaria parasite Plasmodium falciparum clone 3D7. (umd.edu)
Our laboratory develops and uses genetic and genomic approaches to study host-malaria parasite interaction and molecular mechanisms of the interaction using the rodent malaria parasite Plasmodium yoelii as a model. (nih.gov)
3. Transfection studies to explore essential folate metabolism and antifolate drug synergy in the human malaria parasite Plasmodium falciparum. (nih.gov)
The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) has recently emerged as a leading candidate antigen against the blood-stage human malaria parasite. (nature.com)
A study of PBLP in the rodent malaria parasite Plasmodium yoelii showed that it has an important role in invasion. (inrae.fr)
Infected with Plasmodium yoelii sporozoites1
The effect of a recombinant hybrid human interferon alpha (IFN-alpha) (which cross-reacts with murine cells) on C57BL/6 mice infected with Plasmodium yoeliisporozoites or parasitized erythrocytes was determined. (pasteur.fr)
Rodent2
Interestingly enough, mild infections with Schistosoma mansoni (100 cercariae per animal) was found to be beneficial to the rodent host in attenuating infections with Plasmodium yoelli nigeriensis within the early days of the Schistosoma infection. (edu.ng)
Plasmodium vinckei genomes provide insights into the pan-genome and evolution of rodent malaria parasites. (edu.sa)
Parasites7
We have characterized large numbers of microsatellites and single nucleotide polymorphisms (SNPs) from several P. yoelii parasites and performed various genetic crosses to identify parasite genes linked to parasite development, virulence, and drug resistance. (nih.gov)
This work identifies Drosophila S2 cells as a clinically-relevant platform suited for the production of 'difficult-to-make' proteins from Plasmodium parasites, and identifies a PfRH5 sequence variant that can be used for clinical production of a non-glycosylated, soluble full-length protein vaccine immunogen. (nature.com)
Plasmodium falciparum parasites are the causative agent of the most severe form of human malaria, and the development of an effective vaccine remains a key strategic goal to aid the control, local elimination and eventual eradication of this disease. (nature.com)
Malaria is caused by protozoan parasites of the genus Plasmodium that are transmitted through the bites of infected female Anopheles mosquitoes and that infect the red blood cells. (nih.gov)
Early sporogony of Plasmodium parasites involves 2 major developmental transitions within the insect vector, i.e., gametocyte-to-ookinete and ookinete-to-oocyst. (allenpress.com)
In prior studies, the memory capabilities of liver-resident NK cells can control viral pathogenesis but the responses to other pathogens including the responses to parasites like Plasmodium remain unknown. (nih.gov)
The overlapping distribution of these parasites results in the occurrence of Plasmodium spp. (biomedcentral.com)
17XNL3
Three subspecies are recognised: Plasmodium yoelii killicki Plasmodium yoelii nigeriensis Plasmodium yoelii yoelli P. yoelii 17XNL This species occurs in Africa. (wikipedia.org)
2012 find mice tolerating P. yoelii 17XNL do not clear coinfections with other pathogens as easily as they normally would. (wikipedia.org)
From our data, mouse liver-resident NK cells respond to traditional NK cell stimuli and in a primary Plasmodium yoelii 17XNL infection. (nih.gov)
Sporozoites2
Among them, compound 11 appeared to be the most effective by evaluation in mice infected with sporozoites of Plamodium yoelii. (nih.gov)
According to a literature report dealing with Plasmodium yoeliisporozoites, breaching the membrane of certain host cells may be a common phenomenon for coccidian sporozoites, but may not be for merozoites. (uni-giessen.de)
Exoantigens of Plasmodium vivax-parasitized erythrocytes stimulated macrophages to secrete tumor necrosis factor, and antisera raised against the exoantigens inhibited this secretion. (ox.ac.uk)
The antisera also inhibited the activity of Plasmodium falciparum and Plasmodium yoelii exoantigens, and conversely, antisera against the latter cross-reacted with the exoantigens of P. vivax. (ox.ac.uk)
Species7
As in all Plasmodium species, P. yoelii has both vertebrate and insect hosts. (wikipedia.org)
As human malaria species also display different tropism for reticulocytes, these findings could be relevant for people coinfected with multiple Plasmodium species or strains or coinfected with Plasmodium and virus. (pasteur.fr)
Malaria is a tropical disease caused by protozoan parasite, Plasmodium , which is transmitted to humans by various species of female anopheline mosquitoes. (biomedcentral.com)
Late apoptosis of cells of the defence system could be beneficial to the host, clearing excess cells and thereby avoiding the detrimental effects of excessive inflammatory response in the tissue that they would cause (e.g. the deleterious effect of reactive oxygen species or pro-inflammatory cytokines triggered by Plasmodium in the liver) [ 1 ]. (biomedcentral.com)
We have greatly improved the genome assemblies of Pb A and Pc AS, newly sequenced the virulent parasite P. yoelii YM genome, sequenced additional RMP isolates/lines and have characterized genotypic diversity within RMP species. (biomedcentral.com)
Additionally, we sequenced seven isolates of the RMP species Plasmodium chabaudi and Plasmodium yoelii, thus extending genotypic information for four additional subspecies enabling a re-evaluation of the genotypic diversity and evolutionary history of RMPs. (edu.sa)
Putative1
A 94 kDa region named Nucleotide-Binding Domain 94 (NBD94) of Plasmodium yoelii YM, representative of the putative nucleotide binding region of RH, has been demonstrated to bind ATP and ADP selectively. (core.ac.uk)
Murine1
5. Effect of dietary p-aminobenzoic acid on murine Plasmodium yoelii infection. (nih.gov)
Vinckei3
This was supported by the finding that IFN-alpha inhibited a different strain of P yoelii (17X clone A), which also displays a tropism for reticulocytes, but not a line of Plasmodium vinckei petteri, which infects only mature red blood cells. (pasteur.fr)
His Biochemistry study integrates concerns from other disciplines, such as Plasmodium vinckei, Molecular biology and Chloroquine. (research.com)
Among the four RMPs originally collected from wild thicket rats in sub-Saharan Central Africa and adapted to laboratory mice, Plasmodium vinckei is the most geographically widespread with isolates collected from five separate locations. (edu.sa)
The Biology of Plasmodium yoelli nigeriensis in rodents and the reaction of rats and mice to the infection were studied. (edu.ng)
In investigations into the course of infection of Plasmodium yoelli nigeriensis in rats and mice, it was found that adult mice and baby rats were susceptible to the infection, while adult rats were totally resistant. (edu.ng)
In investigations correlating the quantity of food to the course of infection of Plasmodium yoelli nigeriensis in adult mice, it was found that animals which had adequate food were in better condition to withstand infections with Plasmodium yoelli nigeriensis. (edu.ng)
Schistosomiasis, on the course of infection of Plasmodium yoelli nigeriensis was also investigated. (edu.ng)
In challenges made to animals which had worms that would have reached sexual maturity, the course of Plasmodium yoelli nigeriensis was comparable to that of normal mice. (edu.ng)
Fagbenro-Beyioku, F.A (1988), Plasmodium Yoelii Nigeriensis Infection and Immune Response in Mice and Rats, University of Lagos School of Postgraduate Studies Phd Thesis and Dissertation Abstracts, 157pp. (edu.ng)
Colorized scanning electron micrograph of malaria (Plasmodium yoelii nigeriensis) oocysts ( thick-walled structure in which sporozoan zygotes develop) developing on the midgut wall of the mosquito Ano. (ucsd.edu)
Protein4
To examine 17D as a vector for microbial T cell epitopes, we inserted the H-2K d -restricted CTL epitope of the circumsporozoite protein (CS) of Plasmodium yoelii between 17D nonstructural proteins NS2B and NS3. (rupress.org)
Structural determination of functional units of the nucleotide binding domain (NBD94) of the reticulocyte binding protein Py235 of Plasmodium yoelii. (core.ac.uk)
blood-stage membrane protein Ag-1 [Plasmodium yoelii yoelii str. (godziklab.org)
This is the first genome sequence of a model eukaryotic parasite, and it provides insight into the use of such systems in the modelling of Plasmodium biology and disease. (umd.edu)
As reticulocytes are the preferred target cells for the strain of P yoelii used (P yoelii yoelii 265 BY), it was postulated that the inhibition of reticulocytosis in IFN-alpha-treated mice was causally related to the observed decreased blood parasite load. (pasteur.fr)
Genome3
Assessment and improvement of the Plasmodium yoelii yoelii genome annotation through comparative analysis. (dagstuhl.de)
The fragmented nature of the genomes has hampered genome wide analysis of Plasmodium gene regulation and function. (biomedcentral.com)
Genome-wide Analysis of Host-Plasmodium yoelii Interactions Reveals Regulators of the Type I Interferon Response. (nih.gov)
Biology2
Complete RMP genomes, RNA-seq and genotypic diversity data are excellent and important resources for gene-function and post-genomic analyses and to better interrogate Plasmodium biology. (biomedcentral.com)
Amenability to genetic crossing and transfection make them also suitable for classical and functional genetics to study Plasmodium biology. (edu.sa)
The scientist's investigation covers issues in Plasmodium falciparum, Stereochemistry, 4-Aminoquinoline, In vitro and Pharmacology. (research.com)
Immunity2
Ongoing research is currently evaluating whether NK cells can mount memory-specific responses to Plasmodium that lead to sterile immunity and its implications towards an effective malaria vaccine. (nih.gov)
This reduction may be related to the development of cellular immunity to specific antigens expressed in the different life-cycle stages of Plasmodium falciparum . (biomedcentral.com)
Genes2
Of about 5,300 P. falciparum genes, more than 3,300 P. y. yoelii orthologues of predominantly metabolic function were identified. (umd.edu)
Full-length chromosomal annotation permitted a comprehensive classification of all subtelomeric multigene families including the ` Plasmodium interspersed repeat genes' ( pir ). (biomedcentral.com)
Gene1
A synteny map of 2,212 P. y. yoelii contiguous DNA sequences (contigs) aligned to 14 P. falciparum chromosomes reveals marked conservation of gene synteny within the body of each chromosome. (umd.edu)
BALB1
In the initial vaccine trial, Plasmodium falciparum TCTP (PfTCTP) was expressed in Saccharomyces cerevisiae and used to immunize BALB/c mice. (johnshopkins.edu)
Coinfections1
Several studies have previously aimed to correlate the effects of Ascaris-Plasmodium coinfections but have obtained contradictory and inconclusive results. (biomedcentral.com)
Mosquito1
We obtained 7061 and 8306 ESTs from the sugar-fed and P. yoelii infected mosquito midgut tissue libraries, respectively. (biomedcentral.com)
Responses1
P. yoelii impairs immune responses including impairing responses to other pathogens. (wikipedia.org)
Immune2
Detection of host pathways universally inhibited after Plasmodium yoelii infection for immune intervention. (nih.gov)
This study demonstrates that the Ascaris-Plasmodium interaction is harmful to the host and suggests that this coinfection may potentiate Ascaris -associated pathology by dampening the Ascaris -specific immune response, resulting in the early death of affected animals. (biomedcentral.com)