Plasmodium falciparum erythrocyte binding antigen. Medical search. Frequent questions

On the day of admission with acute P. falciparum malaria, the prevalence of antibodies to PfRH5-complex proteins was low compared to other merozoite antigens (EBA175, GLURP-R0 and GLURP-R2). (ox.ac.uk)
Levels of immunoglobulin G (IgG) subclasses and C1q fixation in response to Plasmodium falciparum merozoite antigens (erythrocyte-binding antigen [EBA] 175RIII-V, merozoite surface protein 2 [MSP-2], and MSP-142) and opsonic phagocytosis of merozoites were measured in a multinational trial assessing the efficacy of artesunate therapy across 11 Southeast Asian sites. (ox.ac.uk)
Ntoumi F, Flori L, Mayengue PI, Matondo Maya DW, Issifou S, Deloron P, Lell B, Kremsner PG, Rihet P. Influence of carriage of hemoglobin AS and the Fc gamma receptor IIa-R131 allelle on levels of immunoglobin G2 antibodies to Plasmodium falciparum merozoite antigens in Gabonese children. (cermel.org)

The cause for this is not known but it was suggested that these findings might be the result of infection by Plasmodium falciparum. (wikipedia.org)
Age-related differences in the detection of Plasmodium falciparum infection by PCR and microscopy, in an area of Kenya with holo-endemic malaria. (umassmed.edu)
Low prevalence of Plasmodium falciparum infection among asymptomatic individuals in a highland area of Kenya. (umassmed.edu)
Broadly reactive antibodies specific for Plasmodium falciparum MSP-1(19) are associated with the protection of naturally exposed children against infection. (umassmed.edu)
Humoral and cellular immunity to Plasmodium falciparum merozoite surface protein 1 and protection from infection with blood-stage parasites. (umassmed.edu)
Plasmodium falciparum transmission intensity and infection rates in children in Gabon. (cermel.org)
Malaria is a potentially life-threatening disease caused by infection with Plasmodium protozoa transmitted by an infective female Anopheles mosquito. (medscape.com)
Plasmodium falciparum infection carries a poor prognosis with a high mortality if untreated, but it has an excellent prognosis if diagnosed early and treated appropriately. (medscape.com)
The Plasmodium falciparum protein, apical membrane antigen 1 forms a complex with another parasite protein, rhoptry neck protein 2, to initiate junction formation with the erythrocyte and is essential for merozoite invasion during the blood stage of infection. (nature.com)
Here we show that vaccination with AMA1-RON2L complex in Freund's adjuvant protects Aotus monkeys against a virulent Plasmodium falciparum infection. (nature.com)
Efficacious malaria vaccines are of major importance for preventing Plasmodium infection. (biomedcentral.com)
While infection is established by a small number of sporozoites that are largely ignored by the immune system, the abundant blood stage parasites use multiple and polymorphic variant surface antigens to avoid clearance and subvert the immune response. (immunopaedia.org.za)
Most Africans resist infection by P. vivax because their red cells have lost the Duffy antigen (though it doesn't help them resist P. falciparum ). (cosmosmagazine.com)
Effectiveness of quinine monotherapy for the treatment of Plasmodium falciparum infection in pregnant women in Lambarene, Gabon. (cermel.org)
Fcgamma receptor IIa (CD32) polymorphism is associated with protection of infants against high-density Plasmodium falciparum infection. (ajtmh.org)
A nationwide vaccination programme in Italy against hepatitis B virus infection in infants of hepatitis B surface antigen-carrier mothers. (shengsci.com)
In order to prevent hepatitis B virus (HBV) infection of infants of hepatitis B surface antigen (HBsAg)-positive mothers, a nation-wide immunization programme was initiated in Italy in January 1984. (shengsci.com)

Inverse relationship of plasma prostaglandin E2 and blood mononuclear cell cyclooxygenase-2 with disease severity in children with Plasmodium falciparum malaria. (cermel.org)
Kinetics of antibody responses to PfRH5-complex antigens in Ghanaian children with Plasmodium falciparum malaria. (ox.ac.uk)
Differential regulation of beta-chemokines in children with Plasmodium falciparum malaria. (cermel.org)

The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) has recently emerged as a leading candidate antigen against the blood-stage human malaria parasite. (nature.com)
This work identifies Drosophila S2 cells as a clinically-relevant platform suited for the production of 'difficult-to-make' proteins from Plasmodium parasites, and identifies a PfRH5 sequence variant that can be used for clinical production of a non-glycosylated, soluble full-length protein vaccine immunogen. (nature.com)
PAS-2') plays a functionally important role in maintaining erythrocyte shape and regulating membrane material properties, possibly through its interaction with protein 4.1. (wikipedia.org)
In the non erythroid cell lines, expression is lower than in the erythrocyte and the protein is differentially glycosylated. (wikipedia.org)
GPC appears to be synthesized in excess in the erythrocyte and that the membrane content is regulated by band 4.1 (protein 4.1). (wikipedia.org)
In total the glycophorins constitute ~2% of the total erythrocyte membrane protein mass. (wikipedia.org)
Red blood cells infected with the malaria parasite Plasmodium falciparum display a protein, VAR2CSA, which can recognize and bind CSA molecules present on placental cells and in placental blood spaces. (elifesciences.org)
Gamma interferon responses to Plasmodium falciparum liver-stage antigen 1 and thrombospondin-related adhesive protein and their relationship to age, transmission intensity, and protection against malaria. (umassmed.edu)
Stability of interferon-gamma and interleukin-10 responses to Plasmodium falciparum liver stage antigen-1 and thrombospondin-related adhesive protein in residents of a malaria holoendemic area. (umassmed.edu)
Allele specificity of gamma interferon responses to the carboxyl-terminal region of Plasmodium falciparum merozoite surface protein 1 by Kenyan adults with naturally acquired immunity to malaria. (umassmed.edu)
Age-related differences in naturally acquired T cell memory to Plasmodium falciparum merozoite surface protein 1. (umassmed.edu)
Variants of Plasmodium falciparum erythrocyte membrane protein 1 expressed by different placental parasites are closely related and adhere to chondroitin sulfate A. J Infect Dis. (cermel.org)
High prevalence of human antibodies to recombinant duffy binding-like alpha domains of the Plasmodium falciparum-infected erythrocyte membrane protein 1 in semi-immune adults compared to that in nonimmune children. (cermel.org)
Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) encoded by the var2CSA gene is believed to be the main parasite ligand for CSA-mediated placental binding. (biomedcentral.com)
The var2CSA gene, which is a member of the P. falciparum Erythrocyte Membrane Protein 1 (PfEMP1) family, may have an important role in PAM disease and immunity. (biomedcentral.com)
This gene encodes a large protein with an estimated molecular weight of 350 kDa, and can be divided into six Duffy-binding-like domains (DBL 1-6) based on several conserved cysteines. (biomedcentral.com)
Plasmodium falciparum PfRH5 protein binds Ripr, CyRPA and Pf113 to form a complex that is essential for merozoite invasion of erythrocytes. (ox.ac.uk)
The virulence of Plasmodium falciparum is linked to the ability of infected erythrocytes (IE) to adhere to the vascular endothelium, mediated by P. falciparum erythrocyte membrane protein 1 (PfEMP1). (ox.ac.uk)
Plasmodium vivax rhoptry-associated membrane antigen (RAMA) is a glycophosphatidylinositol-anchored membrane protein currently under consideration as a malaria vaccine candidate. (biomedcentral.com)
Plasmodium falciparum rhoptry-associated membrane antigen (PfRAMA) is a glycophosphatidylinositol (GPI)-anchored protein highly expressed in the early stage of the asexual erythrocyte cycle [ 7 ]. (biomedcentral.com)
Plasmodium falciparum rhoptry-associated protein 1 (PfRAP1) and P. falciparum high-molecular-weight rhoptry protein 3 (PfRhopH3) have been proved to be escorted to the rhoptry protein via an interaction with the PfRAMA [ 7 ]. (biomedcentral.com)
For many years now, researchers have tried to copy nature and interfere with the ability of P.vivax to latch to the Duffy protein by developing vaccines that target the parasite's grappling hook, known as Duffy Binding Protein or DBP. (cosmosmagazine.com)
For Tham, the take-home message is that "the best vaccine will be a combination of both one that targets PvRBP and one against the Duffy binding protein, as they potentially function in different molecular steps of parasite invasion. (cosmosmagazine.com)
Neonatal and maternal immunological responses to conserved epitopes within the DBL-(gamma)3 chondroitin sulfate A-binding domain of Plasmodium falciparum erythrocyte membrane protein 1. (cermel.org)
Here we utilise the split-protein conjugation system to generate stable isopeptide bound antigen-cVLP complexes by simply mixing of the antigen and VLP components. (adaptvac.com)
C-reactive protein binding to FcgammaRIIa on human monocytes and neutrophils is allele-specific. (ajtmh.org)
The protein encoded by this gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. (antibodypedia.com)
Southeast Asian ovalocytosis (SAO, Melanesian ovalocytosis) results from the heterozygous presence of a deletion in the encoded protein and is common in areas where Plasmodium falciparum malaria is endemic. (antibodypedia.com)
The differences in the characteristics between the murine model and humans are the host receptor and the absence of knob-like structures of the P. falciparum erythrocyte membrane protein 1 (PfEMP1) (Table 2 ) [ 11 ]. (biomedcentral.com)
Modified high activity binding peptides (mHABPs) were synthesised for complete full protection antimalarial vaccine development producing a large panel of individually fully protection-inducing protein structures (FPIPS) and very high long-lasting antibody-inducing (VHLLAI) mHABPs. (shengsci.com)
EBA-175 protein is used as ligand in Plasmodium falciparum binding to erythrocytes. (shengsci.com)
Evidence shows that conserved peptide 1815 from this protein having high red blood cell binding ability plays an important role in the invasion process. (shengsci.com)
The motility and invasion of Plasmodium parasites is believed to require a cytoplasmic actin-myosin motor associated with a cell surface ligand belonging to the TRAP (thrombospondin-related anonymous protein) family. (ox.ac.uk)
Here, we identify the GPI-linked protein Semaphorin-7A (CD108) as an erythrocyte receptor for the P. falciparum merozoite-specific TRAP homolog (MTRAP) by using a systematic screening approach designed to detect extracellular protein interactions. (ox.ac.uk)
Differential Protein Expression Profiles Between Plasmodium falciparum Parasites Isolated From Subjects Presenting With Pregnancy-Associated Malaria and Uncomplicated Malaria in Benin. (labex-grex.com)

Plasmodium falciparum parasites are the causative agent of the most severe form of human malaria, and the development of an effective vaccine remains a key strategic goal to aid the control, local elimination and eventual eradication of this disease. (nature.com)
The surface of erythrocytes containing mature parasites bound antibody, but the surface of uninfected cells or cells containing early parasite stages did not react. (ox.ac.uk)
Antibodies against CSA-binding parasites that develop in multigravidae in endemic areas also block CSA-binding of placental isolates from different parts of the world, demonstrating the development of strain transcending antibodies to the Plasmodium falciparum ligands that mediate adhesion to CSA [ 5 ]. (biomedcentral.com)
At this point the immune system is essentially unaware that P. falciparum parasites are growing within the body. (fieldofscience.com)
Malaria is caused by protozoal parasites belonging to genus Plasmodium , among which infections caused by Plasmodium vivax are the most prevalent type in malaria-endemic areas outside of the African continent. (biomedcentral.com)
Although the notion that malaria has helped shape the human genome is well- accepted, the lack of a nucleus in human erythrocytes has hindered our ability to study genetic interactions between these unusual host cells and P. falciparum parasites. (stanford.edu)
The genome of P. falciparum contains hundreds of genes that show CVGE, such that individual parasites within an isogenic population express these genes at very different levels, often fully active or completely silenced [15] . (plos.org)
This disease is caused by different species of apicomplexan parasites belonging to the genus Plasmodium . (biomedcentral.com)
Over the past few decades, healthcare professionals and general public were educated that malaria was caused by four species of human malaria parasites, namely Plasmodium falciparum , Plasmodium vivax , Plasmodium malariae , and Plasmodium ovale [ 3 ]. (biomedcentral.com)
Antigens are often foreign substances such as parts of invading bacteria, viruses or parasites. (cdc.gov)

Sequestration of malaria parasite in the human placenta is mediated by interactions between chondroitin sulphate A (CSA) on the syncytiotrophoblasts and proteins expressed on the surface of infected human erythrocytes. (biomedcentral.com)
No correlation between IgG levels and protection against P. falciparum malaria was observed for any of the PfRH5 complex proteins. (ox.ac.uk)
From this we conclude that specific IgG was induced against proteins from the PfRH5-complex during acute P. falciparum malaria, but the prevalence was low and the IgG levels decayed rapidly after treatment. (ox.ac.uk)
He then described an interesting immunological mechanism whereby antibodies, such as LAIR1 antibodies, that are self-reactive and have high binding affinity for self-proteins undergo somatic hypermutation that leads to the abolishment of self-reactivity a process called clonal redemption. (immunopaedia.org.za)
Parasite secretes an array of proteins within the host erythrocyte and beyond to facilitate its own survival within the host cell and for immunomodulation. (biomedcentral.com)
The identification of secretory proteins of Plasmodium falciparum has got limited success, since experimental identification of these proteins is rather difficult due to complex nature of parasite. (biomedcentral.com)
Thus it is not possible to use subcellular localization methods developed either for eukaryotes [ 4 ] or prokaryote [ 5 ] for localization of P. falciparum proteins. (biomedcentral.com)
However, a number of well known and experimentally documented secretory/erythrocyte membrane associated proteins lack these motifs, thus emphasizing the existence of multiple pathways that operate in parallel [ 9 ]. (biomedcentral.com)
With the completion of Plasmodium genome sequence, the challenge is to combine experimental and bioinformatics tools in order to develop algorithm with high predictive value for secretory proteins of malaria parasite. (biomedcentral.com)
Attempts to block the interaction during in vitro erythrocyte invasion assays using recombinant proteins and antibodies showed no significant inhibitory effect, suggesting the inaccessibility of the complex to proteinaceous blocking agents. (ox.ac.uk)

The virulence of Plasmodium falciparum relative to the other species of malarial parasite which infect humans is thought to be due to this parasite's ability to adhere to endothelial cells lining small blood vessels and, in some cases, to its ability to form rosettes with uninfected erythrocytes. (ox.ac.uk)

All variants bound the PfRH5 receptor basigin and were recognized by a panel of monoclonal antibodies. (nature.com)
One such receptor is well known - the so called Duffy antigen. (cosmosmagazine.com)
Perkmann T, Winkler H, Graninger W, Kremsner PG, Winkler S. Circulating levels of the interleukin (IL)-4 receptor and IL-18 in patients with Plasmodium falciparum malaria. (cermel.org)
A single amino acid in the second Ig-like domain of the human Fc gamma receptor II is critical for human IgG2 binding. (ajtmh.org)
The results of laboratory, field, post-mortem and direct receptor-binding studies indicate that, of the receptors currently identified, ICAM-1 binding is more likely to be associated with the development of cerebral malaria. (ox.ac.uk)
The evidence for this conclusion and progress in defining the regions of var-gene products responsible to receptor-specific binding are discussed. (ox.ac.uk)
Semaphorin-7A is an erythrocyte receptor for P. falciparum merozoite-specific TRAP homolog, MTRAP. (ox.ac.uk)
Known naturally-occurring polymorphisms in Semaphorin-7A did not quantitatively affect MTRAP binding nor did the presence of glycans on the receptor. (ox.ac.uk)

Two methods are described for detecting the binding of serum antibodies from adults in an endemic malarious area (The Gambia) to surface antigens on Plasmodium falciparum-infected erythrocytes. (ox.ac.uk)

But while Africa is afflicted with the deadly Plasmodium falciparum , the rest of the world is plagued by the less-lethal but still debilitating Plasmodium vivax . (cosmosmagazine.com)
That's because older red blood cells, known as erythrocytes, also have the Duffy antigen but are not targeted by P. vivax . (cosmosmagazine.com)
Determinants of relapse periodicity in Plasmodium vivax malaria. (medscape.com)

Mechanisms underlying the monocyte-mediated antibody-dependent killing of Plasmodium falciparum asexual blood stages. (ajtmh.org)
According to the updated definition of severe falciparum malaria by the WHO (2015), severe falciparum malaria is defined as the presence of P. falciparum asexual parasitemia, with one or more clinical features or laboratory findings (Table 1 ) and without any identified alternative causes. (biomedcentral.com)

Phenotypic variation by P. falciparum mediates the evasion of inhibitory Abs, contributing to the capacity of P. falciparum to cause repeat and chronic infections. (edu.au)
It binds to collagen, thrombospondin, anionic phospholipids, and oxidized LDL, and directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. (thermofisher.com)
Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and the internalization of particles independently of TLR signaling. (creative-biolabs.com)
The molecule expressed on the surface of the infected erythrocyte which mediates adherence to endothelium belongs to a large family of clonally variable antigens encoded by the var genes. (ox.ac.uk)
The bite of a P. falciparum -infected female anopheline mosquito mediates the development of various disease severities ranging from uncomplicated malaria to severe malaria and CM. Uncomplicated malaria or mild malaria is defined as a febrile illness without any clinical or laboratory signs of severity or vital organ dysfunction. (biomedcentral.com)

Consequently, apical membrane antigen 1 has been a target of vaccine development but vaccination with apical membrane antigen 1 alone in controlled human malaria infections failed to protect and showed limited efficacy in field trials. (nature.com)

The development of an effective vaccine against the merozoite has proved exceptionally challenging, hindered by substantial levels of polymorphism in the most widely studied candidate antigens 4 and redundant erythrocyte invasion pathways 5 . (nature.com)
Progress in this arena, however, is being made with a new generation of merozoite antigen targets identified in recent years that exhibit relatively low levels of polymorphism and against which functional neutralizing antibodies can be raised by vaccination. (nature.com)

Analysis following immunization of rabbits identified quantitative and qualitative differences in terms of the functional IgG antibody response against the P. falciparum parasite. (nature.com)
Blood-stage vaccines seek to induce antibodies against the merozoite form of the parasite that invades erythrocytes 2 , and could complement pre-erythrocytic immunity afforded by RTS,S/AS01, protect against disease severity and/or reduce transmission by accelerating the control and clearance of blood-stage parasitemia. (nature.com)
Moreover, the kinetic constraints imposed by such rapid erythrocyte invasion mean that extremely high concentrations of functional antibody are required to neutralize the parasite 6 . (nature.com)
These findings demonstrate that a single VAR2CSA ectodomain variant displays conserved epitopes that are targeted by neutralizing (or binding-inhibitory) antibodies shared by multiple parasite strains, including maternal isolates. (elifesciences.org)
Parasite-infected-cell-agglutination and indirect immunofluorescence assays for detection of human serum antibodies bound to antigens on Plasmodium falciparum-infected erythrocytes. (ox.ac.uk)
An antibody-mediated parasite-infected-cell-agglutination assay (without secondary antibody) and an indirect immunofluorescence assay employing an anti-Fc secondary reagent were used to detect bound antibody. (ox.ac.uk)
Plasmodium falciparum: A major role for IgG3 in antibody-dependent monocyte-mediated cellular inhibition of parasite growth in vitro.Exp Parasitol. (cermel.org)
The prevalence of IgG3, complement-fixing antibodies, and merozoite phagocytosis vary according to transmission intensity, are associated with faster parasite clearance, and may be sensitive surrogates of an augmented clearance capacity of infected erythrocytes. (ox.ac.uk)
LAIR1- (and LILRB1-) containing antibodies bind to different families of parasite RIFINs and opsonize infected erythrocytes. (immunopaedia.org.za)
Her research is focused on understanding how host factors from the human erythrocyte influence the biology and pathogenesis of the malaria parasite Plasmodium falciparum. (stanford.edu)
In the last few years, chromatin modifications have been extensively studied in the malaria parasite Plasmodium falciparum (for recent reviews, see [9] - [13] ). (plos.org)
Plasmodium knowlesi is a zoonotic malaria parasite that has gained increasing medical interest over the past two decades. (biomedcentral.com)
Brustoski K, Möller U, Kramer M, Petelski A, Brenner S, Palmer DR, Bongartz M, Kremsner PG, Luty AJF, Krzych U. IFN-gamma and IL-10 mediate parasite-specific immune responses of cord blood cells induced by pregnancy-associated Plasmodium falciparum malaria. (cermel.org)

Erythrocyte-binding antigens of Plasmodium falciparum are targets of human inhibitory antibodies and function to evade naturally acquired immunity. (edu.au)
Abs that inhibit Plasmodium falciparum invasion of erythrocytes form an important component of human immunity against malaria, but key target Ags are largely unknown. (edu.au)
Recurrent Plasmodium falciparum malaria infections in Kenyan children diminish T-cell immunity to Epstein Barr virus lytic but not latent antigens. (umassmed.edu)
Pre-erythrocytic immunity to Plasmodium falciparum: the case for an LSA-1 vaccine. (cermel.org)
Migot-Nabias F, Luty AJF, Minh TN, Fajardy I, Tamouza GR, Marzais F, Charron D, Danze PM, Renaut A, Deloron P. HLA alleles in relation to specific immunity to liver stage antigen-1 from Plasmodium falciparum in Gabon. (cermel.org)
Naturally acquired immunity to Plasmodium falciparum. (kemri-wellcome.org)

How prevalent are the LAIR1 antibodies specific to P.falciparum antigens? (immunopaedia.org.za)

In two independent antibody purification/depletion experiments with permutated order of VAR2CSA variants, IgG purified on the first VAR2CSA antigen displayed broad cross-reactivity to both recombinant and native VAR2CSA variants, and inhibited binding of all isolates to CSA. (elifesciences.org)
In contrast to the results with freshly collected isolates, antibodies from sera of Gambian adults did not bind to the surface of infected cells from five different culture-adapted isolates of P. falciparum. (ox.ac.uk)
We evaluated antibodies among Kenyan, Papua New Guinean, and Malawian men and Kenyan children against two different CSA-binding P. falciparum isolates expressing var2csa variants. (ox.ac.uk)

Conserved epitopes, such as those targeted by 24E9, are promising candidates for the inclusion in a vaccine interfering with ICAM-1-specific adhesion of group A PfEMP1 expressed by P. falciparum IE during severe malaria. (ox.ac.uk)
The disposition of oral and intramuscular pyrimethamine/sulphadoxine in Kenyan children with high parasitaemia but clinically non-severe falciparum malaria. (kemri-wellcome.org)
Quinine treatment of severe falciparum malaria in African children: a randomized comparison of three regimens. (kemri-wellcome.org)
Severe malaria caused by Plasmodium falciparum is a leading cause of morbidity and mortality in the developing world, particularly among young children and pregnant women. (stanford.edu)

These assays are suitable for studies on the antigenic diversity of erythrocyte antigens in natural infections and specific antibody responses to these antigens in infected patients. (ox.ac.uk)

In this study, we used novel approaches to determine the importance of P. falciparum erythrocyte-binding Ags (EBAs), which are important invasion ligands, as targets of human invasion-inhibitory Abs and define their role in contributing to immune evasion through variation in function. (edu.au)
Our findings provide important new evidence that variation in the expression and function of the EBAs plays an important role in evasion of acquired Abs and that a substantial amount of phenotypic diversity results from variation in expression of different EBAs that contributes to immune evasion by P. falciparum. (edu.au)
This knowledge will help to advance malaria vaccine development and suggests that multiple invasion ligands need to be targeted to overcome the capacity of P. falciparum for immune evasion. (edu.au)
Serum from 'non-immune' Europeans did not agglutinate infected erythrocytes, however, in the immunofluorescence test with anti-Ig and anti-F(ab')2 secondary reagents we could detect the binding of IgG antibody from 'non-immune' European serum to a small proportion of infected cells. (ox.ac.uk)
HLA-DQB1*0501-restricted Th1 type immune responses to Plasmodium falciparum liver stage antigen 1 protect against malaria anemia and reinfections. (cermel.org)
The effects of Plasmodium falciparum malaria on immune control of B lymphocytes in Gambian children. (kemri-wellcome.org)
These antibodies are then used to design therapeutic drugs or reverse engineer vaccine antigens that can induce robust immune responses. (immunopaedia.org.za)
Plasmodium falciparum uses multiple strategies to evade the human immune response. (immunopaedia.org.za)
Further clones that dominate antibody immune responses to infected P.falciparum erythrocytes are LAIR1 antibodies. (immunopaedia.org.za)
The antibodies specifically bind to the antigens that induced the immune response. (cdc.gov)

Plasmodium falciparum liver stage antigen-1 peptide-specific interferon-gamma responses are not suppressed during uncomplicated malaria in African children. (cermel.org)
The sickle cell trait is associated with enhanced imunoglobulin G antibody responses to Plasmodium falciparum variant surface antigens. (cermel.org)

Their particulate nature and dense repetitive subunit organisation makes them ideal scaffolds for display of vaccine antigens. (adaptvac.com)

PM results from accumulation of Plasmodium falciparum -infected erythrocytes (IE) that express the surface antigen VAR2CSA and bind to chondroitin sulfate A (CSA) in the placenta. (elifesciences.org)
The basis for the amassing of parasitized erythrocytes (PEs) in the placenta was unknown until it was shown that PEs from placenta primarily bind to chondroitin sulfate A (CSA) [ 3 ]. (biomedcentral.com)
During pregnancy, specific variants of Plasmodium falciparum-infected erythrocytes (IEs) can accumulate in the placenta through adhesion to chondroitin sulfate A (CSA) mediated by expression of PfEMP1 encoded by var2csa-type genes. (ox.ac.uk)

The five VAR2CSA variants purified ~0.7% of total IgG and yielded both strain-transcending and strain-specific reactivity to VAR2CSA and IE-surface antigen. (elifesciences.org)
Extensive sequence and structure comparisons of the various CSA-binding and non-binding DBL domains from the var2CSA gene from A4 and 3D7 strains of P. falciparum were performed. (biomedcentral.com)
Structural comparisons of the three-dimensional structures of CSA-binding DBL domains indicates that the proposed CSA interaction site on A4 DBL 3X is unlikely to be conserved across the other CSA-binding DBL domains from var2CSA . (biomedcentral.com)
Therefore, the 4 CSA-binding DBL domains encoded by var2CSA are unlikely to have common architectures to their CSA recognition sites. (biomedcentral.com)
These structural insights have clear implications in using CSA-binding DBL domains for vaccines against placental malaria as it is proposed that the various CSA-binding DBL domains on var2CSA will recognize their CSA ligands differently. (biomedcentral.com)
Antibodies among men and children to placental-binding Plasmodium falciparum-infected erythrocytes that express var2csa. (ox.ac.uk)

We evaluated the invasion-inhibitory activity of acquired Abs from malaria-exposed children and adults from Kenya, using P. falciparum with disruption of genes encoding EBA140, EBA175, and EBA181, either individually or combined as EBA140/EBA175 or EBA175/EBA181 double knockouts. (edu.au)

Placental malaria is typified by selective clustering of Plasmodium falciparum in the intervillous blood spaces of the placenta. (biomedcentral.com)

Low prevalence of antibodies to preerythrocytic but not blood-stage Plasmodium falciparum antigens in an area of unstable malaria transmission compared to prevalence in an area of stable malaria transmission. (umassmed.edu)

It has also been shown that through stimulation of peripheral blood mononuclear cells with PvRAMA in vitro, the antigen can induce CD4 + T cells to produce interleukin-10. (biomedcentral.com)
Tumor necrosis factor production by human macrophages stimulated in vitro by Plasmodium falciparum. (kemri-wellcome.org)

Mapping the Binding Site of a Cross-Reactive Plasmodium falciparum PfEMP1 Monoclonal Antibody Inhibitory of ICAM-1 Binding. (ox.ac.uk)
Characterization of a new human monoclonal antibody directed against the Vel antigen. (labex-grex.com)

Fine specificity of neonatal lymphocytes to an abundant malaria blood-stage antigen: epitope mapping of Plasmodium falciparum MSP1(33). (umassmed.edu)

24E9 recognizes native PfEMP1 expressed on the IE surface and shows cross-reactivity with and cross-inhibition of the ICAM-1 binding capacity of domain cassette 4 PfEMP1s. (ox.ac.uk)
The convex surface of DBLβ3_D4 has previously been shown to contain the ICAM-1 binding site of DBLβ domains, suggesting that the mAb acts by occluding the ICAM-1 binding surface. (ox.ac.uk)
Plasmodium falciparum: the human agglutinating antibody response to the infected red cell surface is predominantly variant specific. (kemri-wellcome.org)
Characterization and localization of Plasmodium falciparum surface antigens on infected erythrocytes from west African patients. (kemri-wellcome.org)
Surface antigen expression on Plasmodium falciparum-infected erythrocytes is modified in alpha- and beta-thalassemia. (kemri-wellcome.org)
Protection by alpha-thalassaemia against Plasmodium falciparum malaria: modified surface antigen expression rather than impaired growth or cytoadherence. (kemri-wellcome.org)
The specificity of the interaction was demonstrated by showing that binding was saturable and by quantifying the equilibrium and kinetic biophysical binding parameters using surface plasmon resonance. (ox.ac.uk)

Population genetic analysis of the Plasmodium falciparum erythrocyte binding antigen-175 (eba-175) gene. (cermel.org)
As a postdoc in Manoj Duraisingh's lab at Harvard School of Public Health she performed a genetic screen to identify critical host factors for Plasmodium falciparum malaria using red blood cells derived from hematopoietic stem cells. (stanford.edu)
Population genetic studies dating back to the mid-20th century first proposed that erythrocytes (red blood cells), the host cell for P. falciparum, have been under natural selection due to malaria. (stanford.edu)

Niesporek S, Meyer CG, Kremsner PG, May J. Polymorphisms of transporter associated with antigen processing type 1 (TAP1), proteasome subunit beta type 9 (PSMB9) and their common promoter in African children with different manifestations of malaria. (cermel.org)

IgG remaining after depletion on all variants showed significantly reduced binding-inhibition activity compared to initial total IgG. (elifesciences.org)

Plasmodium falciparum is the causative organism leading to human CM development. (biomedcentral.com)

Additional members of the phylum Apicomplexa, important to global human and animal health include the organisms in the genus Plasmodium as well as T . parva and T . annulata , and Babesia bovis causes of malaria, bovine theileriosis and babesiosis, respectively. (biomedcentral.com)

Change in Plasmodium falciparum genotype during successive malaria episodes in Gabonese children. (cermel.org)

Erythrocyte-binding antigens of Plasmodium falciparum are targets of human inhibitory antibodies and. (edu.au)
Using a systematic search for antibodies that bind broadly to infected erythrocytes, they discovered, in 10% of malaria-exposed individuals, a new class of antibodies generated by insertions of genomic DNA encoding human inhibitory receptors (LAIR1 or LILRB1) into antibody genes (at the V-DJ junction or in the switch region). (immunopaedia.org.za)
The human malaria caused by Plasmodium falciparum has been one of the major infectious diseases in the world causing illness in 300 to 600 million people leading to 2 to 3 million deaths annually [ 1 ]. (biomedcentral.com)
Parasitologic and clinical human response to immunoglobulin administration in falciparum malaria. (ajtmh.org)

Antibodies to pre-erythrocytic Plasmodium falciparum antigens and risk of clinical malaria in Kenyan children. (umassmed.edu)
Antibody-mediated growth inhibition of Plasmodium falciparum: relationship to age and protection from parasitemia in Kenyan children and adults. (umassmed.edu)

It is expressed early in development and before the Kell antigens, Rhesus-associated glycoprotein, glycophorin A, band 3, the Rhesus antigen and glycophorin B. In melanocytic cells Glycophorin C gene expression may be regulated by MITF. (wikipedia.org)

Declining chloroquine resistance of Plasmodium falciparum in Lambarene, Gabon from 1992 to 1998. (cermel.org)

Malaria caused by Plasmodium falciparum ( Pf ) remains one of the most deadly infectious diseases in the world. (nature.com)

As most people know, malaria is acquired from mosquito bites (Anopheles mosquitoes to be specific), because Plasmodium spp. (fieldofscience.com)

Two isoforms are known and the gene is expressed in a wide variety of tissues including kidney, thymus, stomach, breast, adult liver and erythrocyte. (wikipedia.org)
The gene is expressed early in the development of the erythrocyte, specifically in the erythroid burst-forming unit and erythroid colony-forming unit. (wikipedia.org)

Other mutations that do not give rise to disease result in novel blood group antigens, which form the Diego blood group system. (antibodypedia.com)

Anatomy10

Organisms26

Diseases7

Chemicals and Drugs49

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Phenomena and Processes27

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Information Science3

Health Care2

Geographicals15

Merozoite antigens3

Infection17

Children with Plasmodium falciparum malaria3

Protein35

Parasites10

Proteins10

Humans1

Receptor8

Endemic1

Vivax3

Asexual2

Mediates5

Apical membrane antigen1

Polymorphism2

Parasite13

Immunity6

Antibodies specific1

Isolates3

Severe4

Infections1

Immune10

Responses2

Vaccine antigens1

Chondroitin sulfate3

VAR2CSA6

EBA1751

Placenta1

Prevalence of antibodies1

Vitro2

Monoclonal2

Epitope1

Surface7

Genetic3

Kremsner PG1

Variants1

Causative1

Genus1

Gabonese1

Human4

Kenyan2

Glycoprotein1

Lambarene1

Infectious diseases in the world1

Mosquito1

Gene2

Mutations1