AntigensHumansProteinsSpeciesBabesiaInfectionVaccinesInfectionsProteinErythrocytesGenusMerozoiteMiceVivax malariaMalariaeHuman malaria parasiteAntigenImmunityCauses human malariaAntigenicMerozoitesStagesMonoclonal antibodiesParasitemiaMosquitoEpitopesToxoplasmaGametocytesImmunoglobulinIsolatesAotusProduce antibodiesExposureSerologyResponsesAnophelesSevere malariaErythrocyte MembraneBacteriaELISAPeptidesSchizogonyMalaria casesKenyanMolecularKenyaMalarialSerum samplesMorbidityIntracellularAssayImmune
Antigens15
- However, the protective effect of maternal antibodies has not been fully established, especially the role of antibodies to variant surface antigens (VSA) expressed on IE. (tropmedres.ac)
- We quantified antibodies against seven Plasmodium falciparum merozoite antigens in plasma obtained at six cross-sectional surveys spanning these five years. (ox.ac.uk)
- Antigenic diversity and size diversity of P. falciparum antigens in isolates from Gambian patients. (ox.ac.uk)
- Background: We investigated the poorly understood impact of declining malaria transmission on maintenance of antibodies to Plasmodium falciparum merozoite antigens and infected erythrocytes (IEs), including functional immunity. (ox.ac.uk)
- Methods: In a 3-year longitudinal cohort of 300 Kenyan children, antibodies to different AMA1 and MSP2 alleles of merozoites, IE surface antigens, and antibody functional activities were quantified. (ox.ac.uk)
- In contrast, complement-fixing antibodies to merozoites did not decline and antibodies to IE surface antigens expressing virulent phenotypes were much better maintained (half-life, 4-10 years). (ox.ac.uk)
- P= 0.029) after adjustment for responses to all other merozoite antigens tested, while those against MSP-2, MSP-3, Plasmodium falciparum Rh2 [PfRh2], MSP-119, and the infected red blood cell surface antigens were not. (ox.ac.uk)
- Screening of viral-vectored P. falciparum pre-erythrocytic candidate vaccine antigens using chimeric rodent parasites. (ox.ac.uk)
- To screen for additional vaccine candidate antigens of Plasmodium pre-erythrocytic stages, fourteen P. falciparum proteins were selected based on expression in sporozoites or their role in establishment of hepatocyte infection. (ox.ac.uk)
- Histidine-rich proteins-2 (HRP-2) and HRP-3 are the antigens commonly used in RDT's to detect Plasmodium falciparum . (thenativeantigencompany.com)
- BACKGROUND: IgG antibodies to pre-erythrocytic antigens are involved in prevention of infection and disease in animal models of malaria but have not been associated with protection against disease in human malaria. (umassmed.edu)
- CONCLUSIONS: Kenyan children with high levels of IgG antibodies to the pre-erythrocytic antigens CSP, LSA-1, and TRAP have a lower risk of developing clinical malaria than children without high levels of these antibodies. (umassmed.edu)
- The antibodies specifically bind to the antigens that induced the immune response. (cdc.gov)
- All pathogens leave behind immunologic footprints in the form of antibodies that last for months to years and can be detected by testing dried blood spots or serum samples against panels of well-defined antigens. (cdc.gov)
- Application of the antibody dependent cellular inhibition (ADCI) assay to the identification of protective antigens and the study of the establishment of protective immunity in Myanmar / by Soe Soe Daw. (who.int)
Humans2
- Malaria is a parasite, a protozoa with four species affecting humans - Plasmodium falciparum, P vivax, P ovale and P malariae. (theness.com)
- Plasmodium vivax primarily depends on Anopheles mosquitoes as its vector for transmission to humans. (thesciencenotes.com)
Proteins7
- Plasmodium invasion of red blood cells involves malaria proteins, such as reticulocyte-binding protein homolog 5 (RH5), RH5 interacting protein (RIPR), cysteine-rich protective antigen (CyRPA), apical membrane antigen 1 (AMA1) and rhoptry neck protein 2 (RON2), all of which are blood-stage malaria vaccine candidates. (ox.ac.uk)
- For preclinical evaluation of immunogenicity of these proteins in mice, chimeric P. berghei sporozoites were created that express the P. falciparum proteins in sporozoites as an additional copy gene under control of the uis4 gene promoter. (ox.ac.uk)
- All fourteen chimeric parasites produced sporozoites but sporozoites of eight lines failed to establish a liver infection, indicating a negative impact of these P. falciparum proteins on sporozoite infectivity. (ox.ac.uk)
- We discuss both the low protective immunogenicity of these proteins in the chimeric rodent malaria challenge model and the negative effect on P. berghei sporozoite infectivity of several P. falciparum proteins expressed in the chimeric sporozoites. (ox.ac.uk)
- With its history as an original manufacturer, Abcepta has a deep and practical understanding of the production process for antibodies, peptides, and recombinant proteins. (abcepta.com)
- Our findings support the identification of proteins important for sexual reproduction and further development of the mosquito midgut stages and provide insights into the genetic basis of the rapid adaption of Plasmodium to the insect vector. (biomedcentral.com)
- The human malaria parasite Plasmodium falciparum contains two nucleosome assembly proteins termed PfNapL and PfNapS. (biomedcentral.com)
Species16
- The induced IgG and IgM antibodies were able to stimulate various Fc-mediated effector mechanisms associated with protection against malaria, including phagocytosis, release of reactive oxygen species, production of IFN-γ as well as complement activation and fixation. (nature.com)
- The antibody does not cross react with other Plasmodium species. (thenativeantigencompany.com)
- The progression of the disease to severe malaria can depend on many factors including the species of the Plasmodium species involved, the age of the individual, immune status, correct diagnosis and availability of treatment ( WHO) . (thenativeantigencompany.com)
- Babesiosis is infection with Babesia species of protozoa. (msdmanuals.com)
- Malaria, caused by various species of the Plasmodium parasite, has plagued humankind for centuries. (thesciencenotes.com)
- One of the most prevalent and widely distributed species is Plasmodium vivax. (thesciencenotes.com)
- Plasmodium vivax exhibits distinctive features that set it apart from other Plasmodium species. (thesciencenotes.com)
- This species of Plasmodium exhibits several distinctive characteristics that set it apart from other malaria-causing parasites. (thesciencenotes.com)
- This preference differentiates it from Plasmodium falciparum, another malaria-causing species that shows a higher preference for mature red blood cells. (thesciencenotes.com)
- Like other Plasmodium species, P. vivax has shown some level of resistance to certain antimalarial drugs. (thesciencenotes.com)
- However, microhematocrit centrifugation does not allow the identification of the species of Plasmodium . (medscape.com)
- PCR assay testing is a very specific and sensitive means of determining if species of Plasmodium are present in the blood of an infected individual. (medscape.com)
- However, they are very effective at detecting the Plasmodium species in patients with parasitemias as low as 10 parasites/mL of blood. (medscape.com)
- The thick smear allows examination of a larger volume of blood and should be used for the detection of malaria parasites (typically able to detect 10-90 parasites/uL of blood depending on expertise - the thin film should be used for species identification and calculation of parasitemia, which influence treatment decisions in the case of P falciparum and P knowlesi infection. (medscape.com)
- Protozoal organisms that can be passed on through transfusion include species of the genus Plasmodium , which cause malaria. (medscape.com)
- There are four plasmodium species that causes human malaria. (iprojectmaterials.com)
Babesia2
- Babesia ovis is a tick-transmitted protozoan haemoparasite causing ovine babesiosis in sheep and goats leading to considerable economic loss in Turkey and neighbouring countries. (bvsalud.org)
- Babesia may be mistaken for malarial parasites, particularly the ring forms of P. falciparum . (medscape.com)
Infection9
- Severe malaria (SM) is a life-threatening complication of infection with Plasmodium falciparum Epidemiological observations have long indicated that immunity against SM is acquired relatively rapidly, but prospective studies to investigate its immunological basis are logistically challenging and have rarely been undertaken. (ox.ac.uk)
- Antibodies to PfSEA-1 block parasite egress from RBCs and protect against malaria infection. (iu.edu)
- Thomas, Bolaji N. "Genetic Diversity of CD14 Promoter Gene Polymorphism (rs2569190) is Associated With Regulation of Malaria Parasitemia and Susceptibility to Plasmodium falciparum Infection. (rit.edu)
- Plasmodium falciparum, the protozoan parasite responsible for severe malaria infection, undergoes a complex life cycle. (ox.ac.uk)
- Infected individuals develop antibodies in response to P. vivax infection. (thesciencenotes.com)
- Malaria disease of human caused by infection with protozoan parasite belongs to the genus plasmodium and is characterised by chills, fever (sustained elevation of the body temperature) and in the most severe cases coma leading to death. (iprojectmaterials.com)
- Malaria infection can be either uncomplicated or severe it is said to be severe when plasmodium falciparum is the cause of the infection. (iprojectmaterials.com)
- Malaria is a potentially life-threatening disease caused by infection with Plasmodium protozoa transmitted by an infective female Anopheles mosquito. (medscape.com)
- Plasmodium falciparum infection carries a poor prognosis with a high mortality if untreated, but it has an excellent prognosis if diagnosed early and treated appropriately. (medscape.com)
Vaccines4
- However, liver stage vaccines offer no or very little protection against the subsequent asexual blood stages that cause most of the pathology associated with P. falciparum malaria, including anaemia, hypoglycaemia, vaso-occlusive events and the syndromes associated with maternal and cerebral malaria 10 . (nature.com)
- DETAILED DISEASE AND PREVENTION INFORMATION Simultaneous Administration of Vaccines Simultaneous administration of most inactivated vaccines has not resulted in impaired antibody responses or increased rates of adverse reactions. (cdc.gov)
- Data indicates that simultaneous administration of cholera and yellow fever vaccines produces a less-than-normal antibody response. (cdc.gov)
- Our data provide epidemiological evidence that multiple antibody-dependent mechanisms contribute to protective immunity via distinct targets whose identification could accelerate the development of vaccines to protect against SM. (ox.ac.uk)
Infections5
- Efforts to develop a blood stage vaccine have been sobering, in spite of encouraging immune-epidemiological studies showing that residents from malaria endemic areas are able to attain, with time and after repeated exposure to P. falciparum infections, a strain-transcending antigenic memory that protects against clinical disease 11 . (nature.com)
- In sub-Saharan Africa, children below 5 years bear the greatest burden of severe malaria because they lack naturally acquired immunity that develops following repeated exposure to infections by Plasmodium falciparum. (tropmedres.ac)
- We hypothesize that intensive exposure is a prerequisite for protective antibody concentrations, while little to modest exposure may manifest as multiple clinical infections with low levels of antibodies. (ox.ac.uk)
- These antibodies play a role in the immune response against the parasite and may offer some level of immunity against subsequent infections. (thesciencenotes.com)
- Antiparasitic drugs are a group of medications used in the management and treatment of infections by parasites, including protozoa, helminths, and. (outletonline--michaelkors.com)
Protein17
- In particular, we have never obtained antibody to determine if the GFP protein is even made. (bio.net)
- A panel of monoclonal antibodies has been shown previously to identify both serologically diverse and serologically conserved epitopes on a major polymorphic surface protein of P. falciparum schizonts from culture-adapted isolates. (ox.ac.uk)
- The virulence of Plasmodium falciparum is linked to the ability of infected erythrocytes (IE) to adhere to the vascular endothelium, mediated by P. falciparum erythrocyte membrane protein 1 (PfEMP1). (ox.ac.uk)
- Mouse anti Plasmodium falciparum histidine-rich protein 2 (HRP-2) (IgG1, clone M482). (thenativeantigencompany.com)
- Mouse anti Plasmodium falciparum HRP-2 antibody (clone M482) recognises histidine-rich protein 2 (HRP-2) from Plasmodium falciparum . (thenativeantigencompany.com)
- Recognises Plasmodium falciparum histidine-rich protein 2. (thenativeantigencompany.com)
- METHODS: Levels of IgG antibodies to circumsporozoite protein (CSP), liver-stage antigen type 1 (LSA-1), and thrombospondin-related adhesive protein (TRAP) were measured in 86 children in a malaria-holoendemic area of Kenya. (umassmed.edu)
- Chapter One investigated an alternative activity of the plant ribosome-inactivating protein (RIP) gelonin, which was proposed to be responsible for the cytotoxicity seen in RIP treated P. falciparum. (jefferson.edu)
- It is unlikely that the DNase activity of both the native and recombinant protein were due to a contaminant because nuclease activity gel analysis in conjunction with Western blotting using an anti-gelonin antibody indicated that the polypeptide responsible for DNase activity was gelonin. (jefferson.edu)
- His study looks at the relationship between Plasmodium falciparum and fields such as Transport protein, as well as how they intersect with chemical problems. (research.com)
- In Plasmodium falciparum, he works on issues like Transport protein, which are connected to Protein structure. (research.com)
- His Vacuole study incorporates themes from Transport protein, Prenylation, Protein prenylation and Plasmodium, Apicoplast. (research.com)
- The concepts of his Plasmodium falciparum study are interwoven with issues in Transport protein, Vacuole and Protein prenylation. (research.com)
- Calcium-Dependent Protein Kinase 5 Is Required for Release of Egress-Specific Organelles in Plasmodium falciparum . (iu.edu)
- Genetic Diversity and Allelic Frequency of Glutamate-Rich Protein (GLURP) in Plasmodium Falciparum Isolates from Sub-Saharan Africa. (rit.edu)
- Genetic Polymorphism of Plasmodium Falciparum Merozoite Surface Protein-1 and 2 and Diversity of Drug Resistance Genes in Blood Donors from Bamako, Mali. (rit.edu)
- Thus, it is important to understand the fundamental biological processes of P. falciparum , which may provide avenues for the identification of new protein targets for development of new anti-malarials. (biomedcentral.com)
Erythrocytes1
- Antibodies to the surface of P. falciparum infected erythrocytes (IE) play an important role in this immunity. (tropmedres.ac)
Genus2
- Malaria is a globally widespread infectious disease caused by obligate intracellular protozoan parasites of the genus Plasmodium. (thenativeantigencompany.com)
- Malaria is caused by protozoan parasites of the genus Plasmodium , and the most serious form of the disease is caused by Plasmodium falciparum [ 4 ]. (biomedcentral.com)
Merozoite3
- In contrast, the five-year temporal dynamics of anti-merozoite antibodies were similar in the three groups. (ox.ac.uk)
- CONCLUSIONS: We conclude that in the context of a low malaria transmission setting, susceptibility to clinical malaria is not accounted for by anti-merozoite antibodies but appears to be a consequence of increased parasite exposure. (ox.ac.uk)
- We investigated the merozoite targets and antibody-mediated mechanisms associated with protection against SM in Kenyan children aged 0 to 2 years. (ox.ac.uk)
Mice2
- We investigated the role of IL-6 on the ability of nine adjuvant formulations to induce antibody responses to the Plasmodium falciparum MSP1-19 malaria vaccine, using IL-6-/- (KO) mice. (nih.gov)
- Thomas, Bolaji N. "Ethanol Extract of Blighia Sapida Stem Bark Show Remarkable Prophylactic Activity in Experimental Plasmodium berghei-Infected Mice. (rit.edu)
Vivax malaria3
- Plasmodium vivax, a protozoan parasite responsible for causing vivax malaria, is a significant public health concern worldwide. (thesciencenotes.com)
- Compared to Plasmodium falciparum, vivax malaria typically causes less severe symptoms and shorter febrile episodes. (thesciencenotes.com)
- These are plasmodium vivax that causes vivax malaria, falciparum malaria is caused by plasmodium falciparum malaria malariae caused by plasmodium malariae and the fourth type oval malaria, caused by plasmodium ovale. (iprojectmaterials.com)
Malariae1
- Plasmodium- P. vivax, P. malariae, P-falciparum (malignant malaria). (physicscatalyst.com)
Human malaria parasite1
- Radical control of malaria likely requires a vaccine that targets both the asymptomatic liver stages and the disease-causing blood stages of the human malaria parasite Plasmodium falciparum . (nature.com)
Antigen8
- Seroprevalence of antibody to TgGRA7 antigen of Toxoplasma gondii in livestock animals from Western Java, Indonesia. (obihiro.ac.jp)
- The molecular nature of the antigen recognized by eight of these monoclonal antibodies was studied with three isolates analyzed directly from patients in The Gambia. (ox.ac.uk)
- Those monoclonal antibodies which reacted positively with an isolate by indirect immunofluorescence also immunoprecipitated a single 3H-leucine or 3H-glucosamine labelled antigen of mol. (ox.ac.uk)
- Monoclonal antibodies which did not react by indirect immunofluorescence failed to immunoprecipitate this antigen. (ox.ac.uk)
- Each antibody is crafted with care according to rigorous protocols for immunogen design and preparation, presentation to host animal, and high-affinity purification against the antigen. (abcepta.com)
- The life cycle of the parasite (pathogenesis) is so complicated because of the tendency of the merozite (daughter cell of the parasite) to produce different antigen that are sensitive to different antibody. (iprojectmaterials.com)
- This parasitized blood sample was prepared, using the Plasmodium falciparum malarial antigen, and stained using the indirect fluorescent antibody (IFA) staining technique. (cdc.gov)
- The fluorescence indicates that the patient serum being tested contains antibodies that are reacting with the P. falciparum antigen preparation. (cdc.gov)
Immunity6
- Multiple clinical episodes of Plasmodium falciparum malaria in a low transmission intensity setting: exposure versus immunity. (ox.ac.uk)
- Here, we investigated the determinants of increased susceptibility to clinical malaria by comparing the intensity of exposure to Plasmodium falciparum and the acquisition of immunity in children at the extreme ends of the over-dispersed distribution of the incidence of clinical malaria. (ox.ac.uk)
- Importantly in all groups, antibody levels were below the threshold concentrations previously observed to be correlated with protective immunity. (ox.ac.uk)
- Declining Malaria Transmission Differentially Impacts the Maintenance of Humoral Immunity to Plasmodium falciparum in Children. (ox.ac.uk)
- Antibodies are unique among biomarkers in their ability to identify persons with protective immunity to vaccine-preventable diseases and to measure past exposure to diverse pathogens. (cdc.gov)
- Antibody response provides an objective and sensitive way to uncover immunization coverage gaps or waning immunity to vaccine-preventable diseases ( 5 - 7 ) and monitor a population's exposure to malaria ( 8 ), enteric pathogens ( 9 - 12 ), and many NTDs ( 13 - 17 ). (cdc.gov)
Causes human malaria1
- The investigations described in this thesis report two novel findings: (1) the identification of a new class of adenine specific single-stranded DNA glycosylases and (2) the first description of DNA repair activities in Plasmodium falciparum, the protozoan parasite that causes human malaria. (jefferson.edu)
Antigenic1
- Infected animals produce antibodies to successive antigenic baths () to treat arthritis in the. (outletonline--michaelkors.com)
Merozoites1
- Antibodies promoting opsonic phagocytosis of merozoites declined rapidly (half-life, 0.15 years). (ox.ac.uk)
Stages1
- Plasmodium vivax exists in various stages during its lifecycle, each with distinct morphological characteristics. (thesciencenotes.com)
Monoclonal antibodies3
- The introduced genes are for monoclonal antibodies which will attack the Plasmodium. (theness.com)
- Although each of the three isolates studied in detail was very similar serologically with the panel of monoclonal antibodies specific for this mol. (ox.ac.uk)
- wt Mr approximately 200 000 which exhibits size diversity and expresses antigenically conserved as well as diverse epitopes as defined by the panel of monoclonal antibodies. (ox.ac.uk)
Parasitemia2
- This was accompanied by a decline in infected erythrocyte surface antibodies and an increase in parasitemia during this period. (tropmedres.ac)
- Levels and prevalence of antimerozoite antibodies were consistently associated with increasing age and concurrent parasitemia. (ox.ac.uk)
Mosquito1
- The transmission of the malaria parasite Plasmodium falciparum from the human to the mosquito is mediated by dormant sexual precursor cells, the gametocytes, which become activated in the mosquito midgut. (biomedcentral.com)
Epitopes2
- Conserved epitopes, such as those targeted by 24E9, are promising candidates for the inclusion in a vaccine interfering with ICAM-1-specific adhesion of group A PfEMP1 expressed by P. falciparum IE during severe malaria. (ox.ac.uk)
- For established targets we seek to add antibodies that recognize new epitopes, including post-translational modifications such as phosphorylation and methylation. (abcepta.com)
Toxoplasma3
- We have had similar lack of success with attempts at expression in the related protozoan parasite Toxoplasma gondii. (bio.net)
- It is my understanding that at least 6 other groups have also failed in to express GFP in Plasmodium or in Toxoplasma. (bio.net)
- Toxoplasma gondii is a wide spread protozoan parasite belonging to the phylum Apicomplexa. (pdfmedarticles.com)
Gametocytes2
- An immunofluorescent antibody test using whole, acetone-fixed gametocytes as substrate revealed correlation between antibody titer and protection from gametocytemia among the semi-immune natives of Arso PIR, but not among the Javanese. (ox.ac.uk)
- Comparison of mRNA levels of P. falciparum gametocytes before and 30 min following activation using suppression subtractive hybridization (SSH) identified 126 genes, which changed in expression during gametogenesis. (biomedcentral.com)
Immunoglobulin2
- Immunoglobulin E (IgE) is a type of antibody (or immunoglobulin (Ig) "isotype") that has been found only in mammals. (wikipedia.org)
- This study assessed the total immunoglobulin G (IgG) levels to Plasmodium falciparum schizont among infants (5-17 months), estimated malaria incidence using routine health facility-based surveillance data and predicted trend relation between anti-schizont antibodies and malaria incidence in Bagamoyo.Methods252 serum samples were used for assessment of total IgG by enzyme-linked immunosorbent assay and results were expressed in arbitrary units (AU). (jenner.ac.uk)
Isolates2
Aotus1
- However, immunization with AMA1 bound with RON2L (AMA1-RON2L) induces better protection against P. falciparum malaria in Aotus monkeys. (ox.ac.uk)
Produce antibodies2
- Any substance that stimulates the immune system to produce antibodies. (cdc.gov)
- B cells develop into plasma cells, which produce antibodies. (cdc.gov)
Exposure5
- The observed increase in group A var gene expression with age in the first year of life, when the maternal antibodies are waning and before acquisition of naturally acquired antibodies with repeated exposure, is consistent with the idea that maternally acquired antibodies impose a selection pressure on parasites that infect infants and may play a role in protecting these infants against severe malaria. (tropmedres.ac)
- Introductionnaturally acquired blood-stage malaria antibodies and malaria clinical data have been reported to be useful in monitoring malaria change over time and as a marker of malaria exposure. (jenner.ac.uk)
- However, we did not observe differences when comparing total anti-schizont antibodies by gender and study year.Conclusiontotal anti-schizont antibody levels appear to be an important serological marker of exposure for assessing the dynamic of malaria transmission in infants living in malaria-endemic regions. (jenner.ac.uk)
- Antibody levels reflect past exposure over a period of months to years, so cross-sectional surveys contain an immense amount of information about past vaccination and pathogen exposure ( 8 , 20 ). (cdc.gov)
- Sero-identification of the aetiologies of human malaria exposure (Plasmodium spp. (cdc.gov)
Serology1
- Re- immunization should occur after 3 months unless serology confirms antibody production. (cdc.gov)
Responses2
- We analyzed the antibody responses to identify temporal dynamics that associate with disease susceptibility. (ox.ac.uk)
- some key functional responses and antibodies to IEs were better maintained and these may continue to provide some protection. (ox.ac.uk)
Anopheles1
- Protection against P. falciparum malaria was also demonstrated in clinical trials using attenuated sporozoites (the stage transmitted by Anopheles mosquitoes during blood feeding) as the drug product (Sanaria´s PfSPZ) 7 , 8 . (nature.com)
Severe malaria1
- In children under the age of 6 months, relative protection from severe malaria is observed and this is thought to be partly due to trans-placental acquired protective maternal antibodies. (tropmedres.ac)
Erythrocyte Membrane1
- We conclude that P. falciparum iRBC can bind host VEGF-R on the erythrocyte membrane and accumulate host VEGF within the parasitophorous vacuole, which may have a trophic effect on parasite growth. (ox.ac.uk)
Bacteria1
ELISA1
- The antibody is suitable for ELISA and lateral flow applications. (thenativeantigencompany.com)
Peptides1
- These immuno-specific peptides can be used as blocking agents when using the complementary antibodies in a range of applications. (abcepta.com)
Schizogony1
- During the asexual stage of the life cycle, Plasmodium falciparum replicates via schizogony, a division mode that can be divided into a growth phase and a budding phase. (iu.edu)
Malaria cases1
- In African regions, P. falciparum causes the majority of malaria cases, whereas P. vivax is the predominant cause of malaria in regions of the Americas ( WHO ). (thenativeantigencompany.com)
Kenyan1
- Targets and Mechanisms Associated with Protection from Severe Plasmodium falciparum Malaria in Kenyan Children. (ox.ac.uk)
Molecular3
- Its molecular characterization, subcellular localization and antibody recognition by infected sheep. (obihiro.ac.jp)
- The various strains of the protozoan that causes it, Plasmodium falciparum , use a number of different molecular methods to gain access to the red blood cells they infect, with no single molecule in common, and a common molecule, of course, is a requirement for developing an effective vaccine. (discovermagazine.com)
- The molecular replicative machinery utilized by the Plasmodium parasite, as well as whether the parasite uses local and global checkpoints to control the timing of DNA replication and nuclear division, remain a major gap of knowledge in the biology of the parasite. (iu.edu)
Kenya1
- The multifunctional activity of the humoral immune response remained for at least 6 months after vaccination and was comparable to that of naturally acquired anti-MSP1 antibodies from semi-immune adults from Kenya. (nature.com)
Malarial1
- The presence of malarial antibodies in this sample caused it to glow a bright green, when viewed under fluorescent light, producing a 2+ fluorescent reaction. (cdc.gov)
Serum samples1
- Seroprevalence studies (which measure antibodies from a large population of blood serum samples) done in the 1990s showed that 3% of people in a Lyme-endemic community in Mendocino county had antibodies, and 16% of soldiers stationed at Fort Ord in Monterey county had antibodies to B. duncani. (lymedisease.org)
Morbidity1
- Protection against malaria morbidity was associated primarily with antibodies to CSP and LSA-1. (umassmed.edu)
Intracellular1
- Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking. (research.com)
Assay1
- Rabbit antibodies against AMA1-RON2L, RH5, RIPR or CyRPA were tested either alone or in combinations in P. falciparum growth inhibition assay to determine Bliss' and Loewe's additivities. (ox.ac.uk)
Immune2
- IgE is also utilized during immune defense against certain protozoan parasites such as Plasmodium falciparum. (wikipedia.org)
- they prime our immune systems ahead of time), and it also needs to be exposed enough on the protozoan's surface for antibodies to find it. (discovermagazine.com)