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FalciparumMosquitoMalaria parasitesProteinMale

Falciparum8

• The colony of Anopheles stephensi mosquitoes at the GSK R&D, Tres Cantos insectary in Spain began to lose its ability to become infected with the human malaria parasite Plasmodium falciparum . (beds.ac.uk)
• This was followed by a bloodmeal infected with Plasmodium falciparum or the rodent malaria, P. berghei . (beds.ac.uk)
• Here the lipid profiles of red blood cells infected with the five different sexual stages of Plasmodium falciparum were analysed by mass spectrometry and compared to those from uninfected and asexual trophozoite infected erythrocytes. (biomedcentral.com)
• Intraerythrocytic sexual stages of human malaria parasites are essential for the transmission of Plasmodium falciparum from human host to mosquito. (biomedcentral.com)
• The prolonged duration of gametocyte maturation is a unique feature of only a few Plasmodium species infecting higher primates ( P. falciparum and P. reichenowi ) [ 1 , 2 ]. (biomedcentral.com)
• Infection with P. falciparum causes by far the highest morbidity of all human Plasmodium species. (biomedcentral.com)
• The transmission of the malaria parasite Plasmodium falciparum from the human to the mosquito is mediated by dormant sexual precursor cells, the gametocytes, which become activated in the mosquito midgut. (biomedcentral.com)
• Comparison of mRNA levels of P. falciparum gametocytes before and 30 min following activation using suppression subtractive hybridization (SSH) identified 126 genes, which changed in expression during gametogenesis. (biomedcentral.com)

Mosquito5

• In contrast, Plasmodium has a reduced set of RSPs including a single RSP9 orthologue, deletion of which in Plasmodium berghei leads to failure of axoneme formation, failed male gamete release, greatly reduced fertilisation and inefficient life cycle progression in the mosquito. (bvsalud.org)
• The analysis has revealed that the most likely processes lie within the population dynamic events of malaria within the mosquito, namely gametogenesis, fertilization and mortality. (lshtm.ac.uk)
• The distribution is similar in all Plasmodium - mosquito combinations examined so far, whether they are of laboratory (P. gallinaceum in Aedes aegypti) or field (P. vivax in An. (lshtm.ac.uk)
• The human-to-mosquito transmission triggers important molecular changes in the gametocytes, which initiate gametogenesis and prepare the parasite for life-cycle progression in the insect vector. (biomedcentral.com)
• Our findings support the identification of proteins important for sexual reproduction and further development of the mosquito midgut stages and provide insights into the genetic basis of the rapid adaption of Plasmodium to the insect vector. (biomedcentral.com)

Malaria parasites1

• Malaria parasites (Plasmodium spp. (pberghei.eu)

Protein1

• For selected genes, a regulated expression during gametogenesis was confirmed on the protein level, using quantitative confocal microscopy. (biomedcentral.com)

Male2

• The structure and function of actin II are not as well understood, but mutational analyses have revealed two essential functions in male gametogenesis and in the zygote. (pberghei.eu)
• Male gametogenesis (exflagellation) was not affected, but ookinete formation was. (beds.ac.uk)