• 2015 find the asymmetric dimethylarginine-to-arginine ratio is indicative of disease severity in mice with P. berghei ANKA. (wikipedia.org)
  • In the present study, infection of C57BL/6 mice with P . berghei ANKA ( Pb A) caused intestinal pathological changes, such as detachment of epithelia in the small intestines and increased intestinal permeability, which correlated with development with experimental cerebral malaria (ECM). (nature.com)
  • C57BL/6 mice received 10 5 red blood cells infected with Plasmodium berghei ANKA intraperitoneally. (hindawi.com)
  • We used the TRPV1 antagonist, capsazepine, to assess whether TRPV1 is able to modulate the innate immune response to malaria in animals infected with Plasmodium berghei ANKA. (hindawi.com)
  • CD mice were treated with phenylhydrazine two days prior to infection by intra peritoneal inoculation with P. berghei ANKA strain, obtained from a donor mouse between the second and sixth passage from cryopreserved stock [ 11 ]. (biomedcentral.com)
  • Antiplasmodial study was subjected ex vivo against P. berghei strain ANKA infected into Balb-C mice. (phcogj.com)
  • Therefore, the objective of this study is to find out whether A. paniculata has an effect on IL-12 producing capacity in mice inoculated with Plasmodium berghei (P. berghei) ANKA. (undip.ac.id)
  • Conclusion: A. paniculata does not significantly affect IL-12 producing capacity in BALB/c mice inoculated with P. berghei ANKA. (undip.ac.id)
  • Keywords: Interleukin-12, Plasmodium berghei ANKA, Andrographis paniculata. (undip.ac.id)
  • As a result, wild type Plasmodium berghei ANKA (WTPbA) has recently been transformed to express mouse interferon gamma (mIFN-γ). (biomedcentral.com)
  • Plasmodium berghei infection of laboratory mouse strains is frequently used in research as a model for human malaria. (wikipedia.org)
  • Methods: Female mosquitoes were inoculated with hemozoin and the Plasmodium infection rate and intensity were measured. (unl.pt)
  • Conclusions: We have for the first time shown the impact of hemozoin treatment in Plasmodium infection, reducing both rate and intensity of the infection. (unl.pt)
  • 14. Somsak V, Damkaew A, Onrak P. Antimalarial activity of kaempferol and its combination with chloroquine in Plasmodium berghei infection in mice. (jabonline.in)
  • Phyllanthus niruri before infection can increase the activ-ity of macrophages in mice were infected by Plasmodium berghei but there has been no research after infection. (knepublishing.com)
  • Protection from Plasmodium berghei infection by priming and boosting T cells to a single class I-restricted epitope with recombinant carriers suitable for human use. (ox.ac.uk)
  • Like all malaria parasites of mammals, including the four human malaria parasites, P. berghei is transmitted by Anopheles mosquitoes and it infects the liver after being injected into the bloodstream by a bite of an infected female mosquito. (wikipedia.org)
  • Malaria caused by protozoan parasites of the genus Plasmodium is the most prevalent infectious disease in tropical and subtropical regions. (nature.com)
  • Malaria (Plasmodium) parasites are well-known for their synchronised cycles of replication within host red blood cells. (ed.ac.uk)
  • Overall, host rhythms do not affect the performance of P. berghei and its asynchronous IDC is resistant to the scheduling forces that underpin synchronous replication in closely related parasites. (ed.ac.uk)
  • Background: Malaria is a worldwide infectious disease caused by Plasmodium parasites and transmitted by female Anopheles mosquitoes. (unl.pt)
  • Plasmodium malariae and Plasmodium ovale--the bashful malaria parasites. (jabonline.in)
  • The situation is further complicated by the spread of drug-resistant parasites in many parts where plasmodium falciparum is endemic. (phcog.com)
  • Novel interventions are needed to prevent the transmission of the Plasmodium parasites that cause malaria. (duq.edu)
  • The administration of increasing doses of minocycline to mice infected with 1 × 10 7 parasites for 86 successive passages over 600 days made it possible to obtain a resistant P. berghei strain with a median drug inhibitory concentration (IC 50 ) of 600 mg/kg/d, which is 6-fold higher than that of the susceptible starting strain (100 mg/kg/d) ( 6 ). (cdc.gov)
  • Results showed that Rubia cordifolia and Sanchus schwein furthii had higher anti-plasmodial activity against P. berghei parasites with values of 82.4 % (p = 0.001) and 78.6% (p = 0.003). (journalcra.com)
  • Human microRNAs translocate from host erythrocytes to Plasmodium falciparum parasites. (jove.com)
  • The effect of the co-administration of artemether, lumefantrine and selenium was studied in mice infected with Plasmodium berghei parasite. (edu.ng)
  • this could be a potential explanation for Ang II protection from CM. Our unpublished results using mice infected with Plasmodium berghei seem to confirm that the elevation of Ang II levels results in modestly decreased parasitemias in this animal model. (frontiersin.org)
  • Plasmodium berghei is a single-celled parasite causing rodent malaria. (wikipedia.org)
  • Why the intraerythrocytic development cycle (IDC) of, for example P. chabaudi, is governed by host rhythms, yet seems completely independent of host rhythms in P. berghei, another rodent malaria species is mysterious. (ed.ac.uk)
  • Reversal of chloroquine resistance in rodent and human Plasmodium by antihistaminic agents. (jabonline.in)
  • To model cognitive function after malaria, we created a rodent model of cerebral malaria by infecting C57BL/6 mice with Plasmodium berghei strainANKA.After 7 days, an object-recognition test of working memory revealed a significant impairment in the visual memory of infected mice. (elsevierpure.com)
  • A rodent malaria parasite, Plasmodium berghei , which was maintained at the Ethiopian Health and Nutrition Research Institute (EHNRI) laboratory, was inoculated into Swiss albino mice. (ajol.info)
  • To identify the biochemical basis for this effect, we disrupted the plasmodium arginase gene in the rodent malaria model P. berghei. (nih.gov)
  • Gastrointestinal symptoms, such as abdominal pain and diarrhea, are frequently observed in patients with Plasmodium falciparum malaria. (nature.com)
  • Multicentric assessment of the efficacy and tolerability of dihydroartemisinin-piperaquine compared to artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Sub-Saharan Africa. (jabonline.in)
  • The World Health Organization also recommends doxycycline in combination with quinine or artesunate as the second-line treatment for uncomplicated Plasmodium falciparum malaria ( 3 ). (cdc.gov)
  • These symptoms are to a certain degree comparable to symptoms of cerebral malaria in patients infected with the human malaria parasite Plasmodium falciparum. (wikipedia.org)
  • Protective immune mechanisms to the asexual erythrocytic stages of the malaria parasite Plasmodium chabaudi AS strain include antibody-independent mechanisms. (ncl.ac.uk)
  • The malaria parasite Plasmodium falciparum relies on an exchange of metabolites with the host for proliferation. (nih.gov)
  • Disrupting Plasmodium UIS3-host LC3 interaction with a small molecule causes parasite elimination from host cells. (ncbs.res.in)
  • Although it is still not well-established that Ang II has beneficial effects on malaria and particularly on CM, different lines of evidence suggest a possible 'protective' effect that could be mediated by different, non-exclusive mechanisms that could affect parasite development and/or host susceptibility to Plasmodium-induced pathology. (frontiersin.org)
  • The results specifically indicated the inhibitory effects of the A.diffusa crude extracts and the fraction which contains sesquiterpene lactones including Tehranolide, on the developmental stages of P. berghei by decreasing parasitaemia. (phcog.com)
  • Extracts from the roots and aerial parts of A.africanus were observed to inhibit Plasmodium berghei parasitaemia in the Swiss albino mice by 46.1% and 40.7% respectively. (ajol.info)
  • An inoculum which consisted of 5 x 107 Plasmodium berghei infested erythrocytes per ml of blood from a donor mouse with 64% parasitaemia was injected into each mouse by intraperitoneal route. (bvsalud.org)
  • In this study, Songsungthong et al use whole genome sequencing to examine the P. berghei RC (PbRC) strain that in earlier work by Peters was selected to be chloroquine resistant. (peerj.com)
  • Overall the study by Songsungthong et al demonstrate the high level of divergence of the RC strain from other sequenced strains of P. berghei, and provide a foundation from which further genetic validation of drug resistance candidates could be based. (peerj.com)
  • Methods: Plasmodium berghei-infected pregnant mouse model was used to assess the combination drug efficacy and the outcome of abnormalities of the disease after drug treatment. (eurekaselect.com)
  • Clinical profile of Plasmodium falciparum and Plasmodium vivax infections in low and unstable malaria transmission settings of Colombia. (eurekaselect.com)
  • 2020. Plasmodium vivax liver stage assay platforms using Indian clinical isolates. . (ncbs.res.in)
  • Plasmodium falciparum , P. vivax , P. ma- province,bothmalariousprovinces, under×1000magnificationfor100and lariae and P. ovale arecausativeagents locatedinthesouthandsouth-eastern 200oilimmersionfields.Inlinewiththe formalariainhumans.Drugselection partoftheIslamicRepublicofIran aimofthisstudy,aplussystemofcount- foraneffectiveandsuitabletreatmentof respectively. (who.int)
  • Although sexuality is necessary in vivo in P. berghei as normal for most sexual organisms, it is a stark competitive disadvantage in vitro. (wikipedia.org)
  • The main aim of this research was to study the activity of methanolic extracts of the leaf from mangrove plants on Plasmodium berghei by using ex vivo model. (phcogj.com)
  • In this study, the antimalarial activity of Artemisia diffusa extracts and the fraction which contains sesquiterpene lactones including Tehranolide, on Plasmodium berghei in vivo on the mice model of malaria was investigated. (phcog.com)
  • It demonstrates that crude extracts of Artemisia diffusa inhibit the growth of Plasmodium berghei in vivo in NMRI mice. (phcog.com)
  • After review of the available clinical pharmacokinetic and safety data, selected compounds with low μM activity and a suitable clinical profile were tested in vivo either in a Plasmodium berghei four-day test or in the P. falciparum Pf3D7(0087/N9) huSCID 'humanized' mouse model. (nih.gov)
  • Of the six actives from the AZ library, two compounds (AZ-1 and AZ-3) were marginally efficacious in vivo in a P. berghei model. (nih.gov)
  • in vivo antimalarial activity of bark extracts of lannea acida (anacardiaceae) and chloroquine against plasmodium berghei in mice. (academicjournals.org)
  • Malaria is an infectious disease caused by intracellular protozoans of the genus Plasmodium and transmitted from person to person through bites of infected mosquitoes. (hindawi.com)
  • Inhibition of Plasmodium berghei development in mosquitoes by effector proteins secreted from Asaia sp. (duq.edu)
  • Asaia SF2.1 secreting these fusion proteins were fed to mosquitoes and challenged with Plasmodium berghei-infected blood. (duq.edu)
  • Suppressive activity of the extract was examined for five consecutive days with the extracts doses and chloroquine as the control drug, curative was infected for five days prior treatment, while the prophylactic groups were pretreated daily for five days before inoculation of 1Ã-107 chloroquine-sensitive Plasmodium berghei infected erythrocyte intraperitoneally. (academicjournals.org)
  • Screening of antiplasmodial activity from methanolic leaf extracts of Sonneratia alba , Acanthus ilicifolius and Sonneratia caseolaris against Plasmodium berghei was carried out in this study. (phcogj.com)
  • Plasmodium berghei is found in the forests of Central Africa, where its natural cyclic hosts are the thicket rat (Grammomys surdaster) and the mosquito (Anopheles dureni). (wikipedia.org)
  • The natural insect host of P. berghei is likely Anopheles dureni, however in laboratory conditions it has also been shown to infect An. (wikipedia.org)
  • In this study, we aim to investigate the role of this parasite's by-product as stimulator of Anopheles gambiae immunity to Plasmodium berghei. (unl.pt)
  • We propose that hemozoin boosts the innate immunity in Anopheles, activating key effector genes involved in mosquito resistance to Plasmodium, and this activation is REL2-mediated. (unl.pt)
  • Influence of midgut microbiota in Anopheles stephensi on Plasmodium berghei infections. (ncbs.res.in)
  • These observations suggest that the active constituents in the extract may be cytotoxic for P. berghei, thereby inhibiting their development to the erythrocytic stage. (phcog.com)
  • Antiplasmodial activity can also be identified by the life cycle inhibition of plasmodium . (phcogj.com)
  • Innate response is the major immunity component of patients who have been infected with Plasmodium for the first time, being essential to the development of an effective acquired immune response [ 6 ]. (hindawi.com)
  • P. berghei infections may also affect the brain and can be the cause of cerebral complications in laboratory mice (cerebral murine malaria, CMM). (wikipedia.org)
  • gambiae's hemocytes transcribe a wide array of molecular responses to Plasmodium infections. (wikipedia.org)
  • Originally, isolated from thicket rats in Central Africa, P. berghei is one of four Plasmodium species that have been described in African murine rodents, the others being P. chabaudi, P. vinckei, and P. yoelii. (wikipedia.org)
  • has been documented as a consequence of selective drug pressure in a P. berghei murine malaria model ( 6 ). (cdc.gov)
  • Treated groups were received 16.608 mg A. paniculata herb extract diluted in 0.1 ml CMC Na administered orally per day, started from 7 days pre-inoculation of P. berghei until 8 days post-inoculation (p.i. (undip.ac.id)
  • Whole genome sequencing of PbRC revealed a high level of divergence from the reference PbANKA, as well as several other sequenced P. berghei genomes. (peerj.com)
  • 2022. Active APPL1 sequestration by Plasmodium favors liver-stage development. . (ncbs.res.in)
  • Plasmodium berghei EXP-1 interacts with host Apolipoprotein H during Plasmodium liver-stage development. (bvsalud.org)
  • Erythrocyte membrane phosphorylation in Plasmodium berghei infected mice / by Porntip Chaimanee. (who.int)
  • This study was conducted to evaluate the toxicity and activity of Rubia cordifolia, Harrizonia abyssinica, Leucas Calistochys Olive and Sanchus schwein furthii against Plasmodium berghei. (journalcra.com)
  • Due to its ability to infect rodents and relative ease of genetic engineering, P. berghei is a popular model organism for the study of human malaria. (wikipedia.org)
  • The compound libraries of GlaxoSmithKline (GSK), Pfizer and AstraZeneca (AZ) comprising drugs that have undergone clinical studies in other therapeutic areas, but not achieved approval, and a set of US Food and Drug Administration (FDA)-approved drugs and other bio-actives were tested against Plasmodium falciparum blood stages. (nih.gov)
  • 138 : 221 Some phytochemicals show efficacy against P. berghei. (wikipedia.org)
  • 4. Aneesa S. Evaluation of Antihistamines for in Vitro Antimalarial Activity Against Plasmodium falciparum. (jabonline.in)
  • We examined the effect of an NO producer, S-nitroso-acetyl-penicillamine (SNAP), on the growth and survival in vitro of P. chabaudi AS, P. berghei and P. falciparum. (ncl.ac.uk)
  • Whilst most species of Plasmodium appear sensitive to the timing of the daily rhythms of hosts, and even vectors, some species present no detectable rhythms in blood-stage replication. (ed.ac.uk)
  • Both constructs (Ty and MVA) contain the H-2Kd-restricted pb9 CTL epitope from the circumsporozoite protein of P. berghei among a string of 8-15 human P. falciparum-derived CTL epitopes restricted through 7 common HLA alleles as well as widely recognized CD4 T cell epitopes. (ox.ac.uk)
  • This study reports a series of five experiments probing the relationships between the asynchronous IDC schedule of P. berghei and the rhythms of hosts and vectors by manipulating host time-of-day, photoperiod and feeding rhythms. (ed.ac.uk)
  • This study examined the antiplasmodial effect of desloratadine-dihydroartemisinin-piperaquine (DL/D/P) on Plasmodium berghei infected mice. (jabonline.in)