An understanding of how psychostimulants regulate the function of not only plasmalemmal, but also vesicular monoamine transporter function is important to appreciate the pharmacological and sometimes neurotoxic consequences of administering these drugs, as well as the physiological regulation of these carrier proteins. (cocaine.wiki)
Hence, this review will describe recent ex vivo studies investigating the rapid and differential affects of several stimulants on both plasmalemmal and vesicular monoamine transporter function. (cocaine.wiki)
At the current time (1 st September 2021), the effects, steroid injections are for other lifestyle choices plasmalemmal or vesicular dopamine uptake in castrated rats. (sanfordcoffee.com)
Reuptake1
RIs work by blocking the plasmalemmal transporter-mediated reuptake of a neurotransmitter from the synapse into the pre-synaptic neuron. (smartshopperdaily.com)
Transporters2
Glycine transporters (GlyTs) are plasmalemmal neurotransmitter transporters. (wikipedia.org)
The retinol BP complex is taken up by target the cells via plasmalemmal transporters, which later important function in recognizing retinol blood formation of chylomicron remnants, which areplay ataken up by the liver [93]. (caspaseinhibitor.com)
Exchangers2
Plasmalemmal Cl - -HCO3 - exchangers regulate intracellular pH and [Cl - ] and cell volume. (tcdb.org)
The plasmalemmal Na + /Ca 2+ exchangers also play a role, particularly in heart and skeletal muscle. (schoolbag.info)
Receptor1
Insulation of a G protein-coupled receptor on the plasmalemmal surface of the pancreatic acinar cell. (nih.gov)
Endothelial Cells1
We hypothesize that the presence of plasmalemmal vacuolar-type proton ATPases (pmV-ATPases) allows microvascular endothelial cells to better cope with this acidic environment and that pmV-ATPases are required for cell migration. (northwestern.edu)
Membranes1
The effect of phosphorylation by cyclic GMP-dependent protein kinase (G-kinase) on the activity of the plasmalemmal Ca2+-transport ATPase was studied on isolated plasma membranes and on the ATPase purified from pig erythrocytes and from the smooth muscle of pig stomach and pig aorta. (portlandpress.com)
Pump1
It is proposed that G-kinase stimulates the plasmalemmal Ca2+ pump of smooth-muscle cells indirectly via the phosphorylation of an associated PI kinase. (portlandpress.com)
Channels5
Excitation-contraction coupling in striated muscle requires proper communication of plasmalemmal voltage-activated Ca2+ channels and Ca2+ release channels on sarcoplasmic reticulum within junctional membrane complexes. (duke.edu)
Shmigol, A , Kostyuk, P & Verkhratsky, A 1995, ' Dual action of thapsigargin on calcium mobilization in sensory neurons: Inhibition of Ca 2+ uptake by caffeine-sensitive pools and blockade of plasmalemmal Ca 2+ channels ', Neuroscience , vol. 65, no. 4, pp. 1109-1118. (uaeu.ac.ae)
This project will exploit the technology of iPSCs to generate midbrain dopaminergic neurons from PD patients and healthy controls and investigate the molecular mechanisms underlying midbrain neuron susceptibility to PD degeneration, focusing on the function and dysfunction of plasmalemmal Ca 2+ channels. (ox.ac.uk)
SERCA2b and Ca(2+) permeable nicotinic plasmalemmal channels were expressed in oocytes, and hyperpolarizing pulses were delivered to induce Ca(2+) influx and thereby load ER stores. (ox.ac.uk)
Ryanodine-sensitive Ca2+ release ('Ca2+ sparks') through the sarcoplasmic reticulum (SR) can activate plasmalemmal Ca2+-turned on K+ channels (KCa) to cause membrane hyperpolarization and soft muscle relaxation. (biongenex.com)
Function1
M any psychostimulants alter plasmalemmal monoaminergic transporter function. (cocaine.wiki)
Neurotransmitter3
Glycine transporters (GlyTs) are plasmalemmal neurotransmitter transporters. (wikipedia.org)
These modifications of plasmalemmal (but not vesicular) lipids increase the evoked neurotransmitter release. (bvsalud.org)
RI's work by blocking the inhibiting the plasmalemmal transporter-mediated reuptake of a neurotransmitter from the synapse into the pre-synaptic neuron. (leadstories.com)
Reuptake1
This reuptake can be enhanced or inhibited by plasmalemmal cholesterol oxidation or sphingomyelin hydrolysis, respectively. (bvsalud.org)
Synthesis1
Synthesis of plasmalemmal glycoproteins in intestinal epithelial cells. (rupress.org)
Membrane1
Mitochondrial voltage-dependent anion channels (mt-VDACs) translocate a variety of metabolites, including ATP and ADP, across the mitochondrial outer membrane, and a plasmalemmal splice variant (pl-VDAC-1) has been proposed to mediate ATP translocation across the plasma membrane. (silverchair.com)
Depletion1
1. Localization of VE-cadherin in plasmalemmal cholesterol rich microdomains and the effects of cholesterol depletion on VE-cadherin mediated cell-cell adhesion. (nih.gov)
Endothelial2
11. Plasmalemmal concentration and affinity of mouse vascular endothelial cadherin, VE-cadherin. (nih.gov)
Plasmalemmal vesicle associated protein-1 (PV-1) is selectively expressed in human brain microvascular endothelial cells derived from clinical specimens of primary and secondary malignant brain tumors, cerebral ischemia, and other central nervous system (CNS) diseases associated with blood-brain barrier breakdown. (nih.gov)
Sphingomyelin1
Hydrolysis of plasmalemmal sphingomyelin profoundly enhanced the rate of FFN511 loss due to K+-depolarization, but completely prevented potentiating action of reserpine on FFN511 unloading. (bvsalud.org)
Cholesterol1
Plasmalemmal cholesterol oxidation increased FFN511 release upon K+-depolarization and more markedly potentiated FFN511 unloading in the presence of reserpine. (bvsalud.org)