Loading...
  • lipid
  • These cationic dyes accumulate on hyperpolarized membranes and are translocated into the lipid bilayer. (thermofisher.com)
  • The lipid bilayer hypothesis, proposed in 1925 by Gorter and Grendel, created speculation to the description of the cell membrane bilayer structure based on crystallographic studies and soap bubble observations. (wikipedia.org)
  • In 1925 it was determined by Fricke that the thickness of erythrocyte and yeast cell membranes ranged between 3.3 and 4 nm, a thickness compatible with a lipid monolayer. (wikipedia.org)
  • Thus, membrane lipid therapy encompasses the use of novel compounds designed to modify membrane lipid structures and microdomains as pharmaceutical disease-modifying agents by reversing the malfunction or altering the expression of disease-specific protein or lipid signal cascades. (dsm.com)
  • Through preferentially modifying "lipid rafts" within tumor plasma membranes, EPA and DHA have the potential to modulate the physicochemical properties of various receptors and cytokines essential to tumor signal transduction, growth and proliferation. (dsm.com)
  • This proof-of-concept trial demonstrated the potential for DHA to convert malignant mammary tumors from resistant to chemo- or radiation therapy-sensitive in specific cohorts, namely those with high levels of DHA plasma lipid incorporation. (dsm.com)
  • MRs have been described in two forms, either flat portions of plasma membrane, named lipid rafts, or flask-like of about 70 nm in diameter, named caveolae. (hindawi.com)
  • By 1974, studies on the effects of temperature on membrane behaviour led investigators to propose the presence of "clusters of lipids" [ 5 ], and by the following year data were obtained that suggested that these clusters might be "quasicrystalline" regions, namely, a liquid-order phase, surrounded by more freely dispersed and disordered lipid bilayer [ 6 ]. (hindawi.com)
  • The key difference between MRs and the rest of the membrane bilayer is the lipid composition. (hindawi.com)
  • efflux
  • The NADPH oxidase of neutrophils produces large amounts of superoxide at the plasma and phagosomal membranes, resulting in an electrogenic efflux of electrons from the cytoplasm ( 6 ). (pnas.org)
  • Protein
  • This interaction triggers the refolding of the transmembrane protein (TM) and is thought to activate its fusogenic potential by unmasking its fusion peptide. (uniprot.org)
  • LC-MS/MS analysis of differentially expressed glioblastoma membrane proteome reveals altered calcium signaling and other protein groups of regulato. (nih.gov)
  • B , Western blot of calreticulin showing ascertain membrane protein enrichment. (nih.gov)
  • physicochemical properties
  • Currently, it is generally accepted that MRs exist within the plane of the membrane, where the pattern of molecules and the physicochemical properties are distinct from the environment [ 10 , 11 ]. (hindawi.com)
  • pore
  • Direct plasma membrane stretch triggered cation current activity that was blocked by tranilast and specific TRPV2 pore-blocking antibodies and mimicked by the TRPV2 activator, Δ9-tetrahydrocannabinol. (arvojournals.org)
  • dynamics
  • Connolly NMC, D'Orsi B, Monsefi N, Huber HJ, Prehn JHM (2016) Computational Analysis of AMPK-Mediated Neuroprotection Suggests Acute Excitotoxic Bioenergetics and Glucose Dynamics Are Regulated by a Minimal Set of Critical Reactions. (plos.org)
  • immune
  • Additionally, this work sheds light on the potential mode of interaction between galectin, an immune lectin and HIV-1. (utexas.edu)
  • hypothesis
  • In an attempt to accept or reject the hypothesis, researchers measured membrane thickness. (wikipedia.org)
  • This paper reports observations concerning the role of MRs in the control of lung extravascular water that ought to be kept at minimum to assure gas diffusion, supporting the hypothesis that MRs expression is a potential mechanism of sensing minor changes in the volume of extravascular water. (hindawi.com)
  • interactions
  • Information on the extent to which plants depend on such interactions will help to make more realistic predictions of the potential impacts of disturbances on plant-pollinator networks. (jove.com)
  • Plant functional dependence on pollinators (all interactions pooled) can be estimated by comparing seed set with and without pollinators (i.e. bagging flowers to exclude them). (jove.com)
  • known
  • Independently, the leptoscope was invented in order to measure very thin membranes by comparing the intensity of light reflected from a sample to the intensity of a membrane standard of known thickness. (wikipedia.org)
  • structure
  • Later in the 1930s, the membrane structure model developed in general agreement to be the paucimolecular model of Davson and Danielli (1935). (wikipedia.org)
  • complex
  • Killing involves both oxidative and nonoxidative processes, the oxidative pathway requiring electrogenic production of superoxide by the membrane-bound NADPH oxidase complex. (pnas.org)