AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
Blood ProteinsSerum AlbuminPlasmaBlood Protein ElectrophoresisSerumSerum GlobulinsBeta-GlobulinsOrosomucoidHaptoglobinsImmunoelectrophoresisAlpha-GlobulinsProtein BindingSeminal Plasma ProteinsBiological Markersgamma-GlobulinsHypoproteinemiaTransferrinLiverSerum Albumin, BovinePregnancy-Associated Plasma Protein-ATime FactorsPrealbuminPlasma CellsFibrinogenAlbuminsImmunoglobulin Galpha-MacroglobulinsGlycoproteinsMacroglobulinsAcute-Phase ProteinsCeruloplasminChromatography, High Pressure LiquidProteomicsElectrophoresis, Cellulose AcetateImmunoelectrophoresis, Two-DimensionalHemopexinFructosamineCell MembraneRadioimmunoassayEnzyme-Linked Immunosorbent AssaySpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationPlasma VolumeDialysisElectrophoresis, Polyacrylamide GelUltrafiltrationReference ValuesCattleRabbitsProtein-Losing EnteropathiesBlood Chemical AnalysisImmunodiffusionalpha-FetoproteinsMetabolic Clearance RateParaproteinsalpha 1-AntitrypsinChromatography, LiquidImmunoassayalpha-2-HS-GlycoproteinCholesterolMolecular Sequence DataCapillary PermeabilityComplement C3Molecular WeightHematocritProtein Array AnalysisProtein CarbonylationLipidsProteinsPregnancyLipoproteinsImmune SeraAdsorptionAmino Acid SequenceParaproteinemiasPlasma GasesMass SpectrometrySerum Amyloid P-ComponentBiuret ReactionCase-Control StudiesChromatography, GelSensitivity and SpecificityMustard CompoundsTurpentineBloodHalf-LifeProtein SDogsBlood Protein DisordersTissue DistributionElectrophoresisKidneyImmunoglobulinsCells, CulturedDose-Response Relationship, DrugSerum Albumin, Radio-IodinatedChromatography, AffinityBromcresol GreenSwineNephelometry and TurbidimetryBlood Glucose
ConcentrationsGlobulinBiomarkersAntibodiesAlbumin levelsAbundant proteinRecombinantSolubleUrineLiverConcentration of serumAmyloidBloodInflammationBilirubinNHANES IIILipoproteinLevelsBoundEnzymesAnticoagulantHumanFractionationMinusAntibodyCarrierWidelyMetabolismReactive proteinSynthesisResiduesLipidTotalProteaseFluidAmountsMeasurementCoagulationMolecular weightStabilityClinical applicationsRatsPotassiumLevelImmuneChronicBindTumor
Concentrations13
  • Plasma concentrations of C reactive protein, serum amyloid A protein, and serum albumin and leucocyte count. (bmj.com)
  • No strong associations were observed of these factors with Helicobacter pylori seropositivity, Chlamydia pneumoniae IgG titres, or plasma total homocysteine concentrations. (bmj.com)
  • Circulating concentrations of C reactive protein, serum amyloid A protein, and serum albumin and the leucocyte count can fluctuate widely during acute responses to tissue damage or infection. (bmj.com)
  • 4 g daily unless serum concentrations of total sulfapyridine and the phenotype of the patient are known. (drugs.com)
  • To address this, concentrations of testosterone, sex hormone binding globulin, androstanediol glucuronide (a metabolite of dihydrotestosterone) and estradiol were measured in stored serum specimens from men examined in the morning sample of the first phase of NHANES III (1988-1991). (cdc.gov)
  • Plasma FABP3 concentrations were measured by an enzyme-linked immunosorbent assay. (medsci.org)
  • The treated groups had lower serum total protein and albumin concentrations compared to the control. (scialert.net)
  • Whole blood was taken via puncture of the cubical vein and serum protein, albumin, total and direct bilirubin concentrations were determined using Synchron CX 5 autoanalyzer. (scialert.net)
  • They also had increased concentrations of both C reactive protein (β 0.04, 0.01 to 0.08) and fibrinogen (0.08, −0.01 to 0.18). (bmj.com)
  • It is one of the most common chronic infections and is associated with a moderate systemic inflammatory response, 3 such as raised concentrations of C reactive protein and other inflammatory biomarkers. (bmj.com)
  • Thus, oral infections might add to the inflammatory burden of the individual and result in increased levels of cardiovascular risk based on serum C reactive protein and fibrinogen concentrations as a consequence of the systemic inflammatory response subsequent to low grade chronic infections. (bmj.com)
  • Selenomethionine was more effective in raising blood Se concentrations than selenate, but both were equally effective in raising GSHPx activities in whole blood, erythrocytes and plasma, indicating a similar bioavailability for the two forms. (cambridge.org)
  • Among all the newborns, mean serum concentrations in the vancomycin valley were 40% adequate, 13.34% lower than expected, and 46.67% higher than the reference values. (bvsalud.org)
Globulin6
  • The serum globulin electrophoresis test measures the levels of proteins called globulins in the fluid part of a blood sample. (medlineplus.gov)
  • This test is done to look at globulin proteins in the blood. (medlineplus.gov)
  • In addition to albumin levels, your protein test may also detect blood levels of globulin. (healthline.com)
  • Nevertheless, because immune globulins manufactured before 1985 were derived from plasma of human donors who were not screened for antibody to human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV), CDC and the U.S. Food and Drug Administration (FDA) have received inquiries concerning the safety of immune globulin (IG), hepatitis B immune globulin (HBIG), and intravenous immune globulin (IVIG). (cdc.gov)
  • The globulin fraction contains myosin, the contractile protein, which also occurs in blood platelets , small bodies found in blood. (britannica.com)
  • Most of the circulating testosterone is bound to carrier proteins (SHBG = sex hormone-binding globulin). (cdc.gov)
Biomarkers5
  • In this prospective cohort, serum biomarkers of biochemical disease were effective in short-term prediction of preeclampsia, and the performance of GlyFn in particular as a POC test may meet the needs of rapid and accurate triage and intervention. (biomedcentral.com)
  • Hypocholesterolemia and decreased plasma protein C and antithrombin activities may function as exposure biomarkers. (avma.org)
  • no validated serum biomarkers currently exist. (lu.se)
  • The serum biomarkers proposed to date have not yet demon- pendent test cohort (prevalidation). (lu.se)
  • The results from this prevali- the field of cancer biomarkers (11-13), and that approach was dation study showed that patients could be classified into high- adopted here to define predictive serum biomarkers associated versus low-risk groups for developing metastatic breast cancer with tumor relapse in breast cancer patients. (lu.se)
Antibodies5
  • In addition, review of the manufacturer's records for RhoGAM lot RHG 636 confirmed that all plasma used for that lot had been screened for antibodies to HIV and found negative and that all steps in its manufacture were in accordance with good manufacturing practices. (cdc.gov)
  • Since late April 1985, all units of plasma for production of Rh-IG have been screened for antibodies to HIV, and all repeatedly reactive units have been discarded. (cdc.gov)
  • CoV-2 RNA by using rPCR and plasma specimens ticipant age was 32 years (interquartile range 24-43 for SARS-CoV-2 antibodies by using ELISA. (cdc.gov)
  • Antibodies are special proteins in the plasma that have the potential to be used to fight the infection. (bibalex.org)
  • 135 antibodies against 65 mainly immunoregulatory proteins, we of a multitude of different genes (8, 9). (lu.se)
Albumin levels1
Abundant protein3
  • Although PPL is present in the bloodstream, no information is found on the interaction between PPL and rat serum albumin (RSA), the most abundant protein with the function of transporting endo/exogenous molecules. (nature.com)
  • It is the single most abundant protein in plasma and constitutes about two-thirds of total protein content. (medscape.com)
  • We consider two systems: Ig and serum albumin (the two most abundant protein types in blood plasma), and Ig in cellular lysate, mimicking the cellular environment. (lu.se)
Recombinant8
  • Using Dyadic's proprietary filamentous fungal based microbial protein production platforms, the Company has been able to successfully develop stable cell lines to produce animal-free recombinant bovine serum albumin and recombinant human serum albumin at high levels. (itbusinessnet.com)
  • The requirement of high dosage of serum albumin in clinical applications is expected to continue to drive demand for economical large-scale production of animal-free recombinant serum albumin which provides us the opportunity to leverage our microbial expression platforms to potentially develop and commercialize multiple end-market serum albumin products in both pharmaceutical and non-pharmaceutical applications. (itbusinessnet.com)
  • Today, serum albumin can be manufactured without blood plasma through recombinant protein production technology. (itbusinessnet.com)
  • Recombinant serum albumin is purified, bacteria-free, animal component-free, and virus-free and is structurally equivalent to plasma-derived serum albumin. (itbusinessnet.com)
  • Recombinant serum albumin provides high-quality consistency reducing time and offering high-grade performance for applications where protein contaminants are undesirable. (itbusinessnet.com)
  • In addition, recombinant serum albumin is more homogeneous than plasma-derived serum albumin and lacks immunogenicity and toxicity while offering a distinct and uniform medium. (itbusinessnet.com)
  • Increasingly, recombinant serum albumin is being used as an alternative to plasma-derived albumin in human therapeutics, cell culture media, diagnostic test kits, and research & development. (itbusinessnet.com)
  • The primary end users of recombinant serum albumin are biotech and pharmaceutical companies, especially those in vaccine development, hospitals and medical clinics, and research and development organizations. (itbusinessnet.com)
Soluble2
  • In contrast to the scleroproteins, the contractile proteins are soluble in salt solutions and susceptible to enzymatic digestion . (britannica.com)
  • GlyFn, pregnancy-associated plasma protein-A2 (PAPPA2), placental growth factor (PlGF), and soluble fms-like tyrosine kinase-1 (sFlt-1) were measured by immunoassay. (biomedcentral.com)
Urine8
  • Serum, plasma, and urine specimens are obtained from NHANES study participants aged six years and older who have given consent for their specimens to be used in future studies. (cdc.gov)
  • and serum, urine, and a limited number of plasma specimens are available from continuous NHANES (1999-present). (cdc.gov)
  • In total, there are over 1 million combined serum, plasma, and urine specimens available. (cdc.gov)
  • Therefore, all proposals seeking the use of NHANES serum, plasma, or urine for must not produce laboratory results that are clinically significant to the NHANES participant. (cdc.gov)
  • Is there a time limit on how long I can use the serum, plasma, and urine specimens? (cdc.gov)
  • The Atago MASTER-SUR/NM clinical refractometer is an ideal instrument used for clinical purposes to measure Serum Protein, Specific Gravity of Urine and refractive index scales. (thomassci.com)
  • Laxco Analog Clinical Refractometers uses three-scales to measure Total Serum Protein, Urine Specific Gravity, and Refractive Index. (thomassci.com)
  • CLINICAL REFRACTOMETER 300005 Measures protein concentration, urine specific gravity, or gives the refractive index in seconds using only a few drops of blood serum, plasma, urine or albumen. (thomassci.com)
Liver5
Concentration of serum1
  • To analyse the concentration of serum level in the voucher (one hour before the next administration of the drug dose) of vancomycin in newborns with Staphylococcus aureus infection or oxacillin-resistant coagulase-negative. (bvsalud.org)
Amyloid2
  • 2 3 Moreover, highly sensitive assays for C reactive protein and serum amyloid A protein are now available that can detect low grade inflammation that would previously have been unnoticed. (bmj.com)
  • Proteins enriched in HDL from patients with ESRD (ESRD-HDL) included surfactant protein B (SP-B), apolipoprotein C-II, serum amyloid A (SAA), and α-1-microglobulin/bikunin precursor. (lww.com)
Blood29
Inflammation4
  • Your doctor may also order plasma protein tests if they believe that you have certain underlying health conditions, such as inflammation or certain autoimmune conditions like rheumatoid arthritis and celiac disease. (healthline.com)
  • Several reports have suggested that plasma C reactive protein and other possible markers of low grade inflammation can predict increased risks of coronary heart disease, but it is not known whether the associations are causal. (bmj.com)
  • The in vivo antioxidant effects and the anti-inflammatory potential were tested on a rat turpentine oil-induced inflammation, by measuring serum nitric oxide (NOx) and TNF-alpha, total oxidative status (TOS), total antioxidant reactivity (TAR), oxidative stress index (OSI), 3-nitrothyrosine (3NT), malondialdehyde (MDA), and total thiols (SH). (hindawi.com)
  • Objective To examine if self reported toothbrushing behaviour is associated with cardiovascular disease and markers of inflammation (C reactive protein) and coagulation (fibrinogen). (bmj.com)
Bilirubin3
  • The effects of gender and alcohol consumption on serum enzymes, protein and bilirubin in heavy, moderate and non-drinkers were investigated. (scialert.net)
  • Serum protein, albumin and bilirubin levels were significantly different in both male and female heavy and moderate drinkers. (scialert.net)
  • Serum protein, albumin and bilirubin levels were impaired by alcohol consumption in both males and females and may provide additional information in the diagnosis and management of alcoholism. (scialert.net)
NHANES III1
  • This data file contains results of the testing of 1637 males age 12 or more years who participated in the morning examination of phase 1 of NHANES III and for whom serum was still available in the repository. (cdc.gov)
Lipoprotein4
  • IV: A system for the separation into fractions of the protein and lipoprotein components of biological tissues and fluids. (cdc.gov)
  • It circulates as a component of lipoprotein particles and as a lipid-free serum protein (6). (rndsystems.com)
  • The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). (nih.gov)
  • Phospholipid transfer protein: its impact on lipoprotein homeostasis and atherosclerosis. (nih.gov)
Levels22
  • A plasma protein test can detect an underlying condition by measuring these protein levels. (healthline.com)
  • Symptoms may vary depending on the condition causing your abnormal plasma protein levels. (healthline.com)
  • With a tourniquet, your total protein levels may be measured as higher than they really are. (healthline.com)
  • It's important to have normal levels of plasma proteins during your pregnancy. (healthline.com)
  • Studies suggest that low levels of pregnancy-associated plasma protein A (PAPP-A) in early pregnancy are related to certain complications. (healthline.com)
  • However, if doses greater than those recommended are given, it is likely that higher plasma levels will be achieved, the safety of which has not been established (see DOSAGE AND ADMINISTRATION ). (nih.gov)
  • The aim of the present study is to replicate the effects of the plasma levels of MHC class I polypeptide-related sequence B (MICB) and cluster of differentiation 209 (CD209) proteins reported in a previous hypothesis-free MR study. (plos.org)
  • For MICB and CD209, we used data from a large-scale genome-wide association study (GWAS) for plasma protein levels (N = 3,301). (plos.org)
  • The aim of this study was therefore to evaluate the plasma levels of FABP3 at different stages of estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes mellitus (T2DM). (medsci.org)
  • Thus, we conducted this systemic review and meta-analysis to explore the alteration of serum BDNF levels in PSD. (frontiersin.org)
  • More large-sample clinical trials exploring the alteration of serum BDNF levels in PSD among stroke patients need to be conducted to verify this result. (frontiersin.org)
  • plasma protein levels. (thomassci.com)
  • protein levels. (thomassci.com)
  • Generally men have higher levels of serum iron than women. (irondisorders.org)
  • 10 , 11 Dyslipidemia in ESRD patients is characterized by a dysregulation of the synthesis and activity of HDL, leading to decreased plasma levels of HDL cholesterol (HDL-C). 10 Many epidemiologic studies have documented an inverse relationship between HDL-C levels and the progression of atherosclerosis and increased risk of cardiovascular disease in the general population. (lww.com)
  • This study in Egypt investigated the association between serum adiponectin levels and pre-eclampsia and between adiponectin levels and some clinical and hormonal parameters. (who.int)
  • Serum adiponectin levels in pre-eclamptic women were significantly higher than in normal pregnant women and the increase was more marked in cases of severe pre-eclampsia. (who.int)
  • However, there was no correlation between serum adiponectin and proteinuria or estradiol and progesterone levels. (who.int)
  • We collected and recorded their serum levels. (bvsalud.org)
  • the remaining 11 stayed at high levels, which raised great concern due to the fact that if the infection is not being treated, the elevated serum level leads to nephrotoxic and ototoxic problems. (bvsalud.org)
  • The monitoring of serum levels in the vancomycin valley is of great importance as it minimises nephrotoxic effects, thus increasing the efficacy of the drug. (bvsalud.org)
  • Several situations require the monitoring of serum levels and adjustment of vancomycin doses. (bvsalud.org)
Bound4
Enzymes2
  • The thyroid hormone regulates energy and fat metabolism and protein synthesis by regulating different enzymes that are involved in those processes. (cdc.gov)
  • We are excited with the progress we are making in applying our proprietary filamentous fungal based microbial protein production platforms in our core business units to produce proteins and enzymes for pharmaceutical and non-pharmaceutical products for ourselves and our collaborators. (itbusinessnet.com)
Anticoagulant1
Human10
  • Inactivation and partition of human T-cell lymphotrophic virus, type III, during ethanol fractionation of plasma. (cdc.gov)
  • The covalent binding of acrolein to human serum albumin showed four new ninhydrin positive peaks. (cdc.gov)
  • About 40 percent of the body weight of a healthy human adult weighing about 70 kilograms (150 pounds) is muscle, which is composed of about 20 percent muscle protein. (britannica.com)
  • Thus, the human body contains about 5 to 6 kilograms (11 to 13 pounds) of muscle protein. (britannica.com)
  • Immunoassay for the in vitro quantitative determination of Sample testosterone in human serum and plasma. (cdc.gov)
  • We are developing bovine and human animal-free serum albumin, both of which were successfully expressed efficiently with high purity. (itbusinessnet.com)
  • The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. (nih.gov)
  • Find Prekallikrein Proteins for a variety of species such as anti-Human Prekallikrein. (antibodies-online.com)
  • An image depicting human serum albumin can be seen below. (medscape.com)
  • The structure of human serum albumin. (medscape.com)
Fractionation1
  • Immune globulins produced by plasma fractionation methods approved for use in the United States have not been implicated in the transmission of infectious agents. (cdc.gov)
Minus1
Antibody2
  • One of the 183 HBIG recipients is now positive for HTLV-III/LAV antibody, but no preexposure serum was available for this individual, and seropositivity may have predated the needlestick exposure and IG prophylaxis. (cdc.gov)
  • Here, we present a neutron backscattering study on the nanosecond self-diffusion of the antibody proteins immunoglobulins (Ig) in aqueous solution. (lu.se)
Carrier1
Widely1
  • Approximately 10-40% of the intra- and extracellular fluids of living organisms is occupied by macromolecules such as proteins, the internal dynamics of which is widely recognized as a crucial aspect for their function. (lu.se)
Metabolism1
  • In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. (nih.gov)
Reactive protein3
  • Compared with men in the bottom third of baseline measurements of C reactive protein, men in the top third had an odds ratio for coronary heart disease of 2.13 (95% confidence interval 1.38 to 3.28) after age, town, smoking, vascular risk factors, and indicators of socioeconomic status were adjusted for. (bmj.com)
  • 2 6 A variety of mechanisms by which C reactive protein might directly promote vascular disease have been proposed, 7 but none is proved. (bmj.com)
  • 8 C reactive protein and fibrinogen are sensitive markers used to evaluate the inflammatory status of an individual, and the results of prospective longitudinal studies indicate that these markers might be useful predictors for future cardiovascular events in various populations. (bmj.com)
Synthesis3
  • It binds on the DNA, exerting an effect on DNA to regulate the synthesis of proteins regulated by DNA. (cdc.gov)
  • The action of hormones are transduced by regulating the synthesis of proteins (5% of proteins in the body are regulated by thyroid hormone). (cdc.gov)
  • 1991) are consistent with the incorporation of Se from selenomethionine into a general tissue protein pool while selenate is directly available for GSHPx synthesis, and explain the poorer correlation between Se and GSHPx in individuals with higher Se status. (cambridge.org)
Residues1
  • The authors suggest that more tyrosine and/or tryptophan residues were exposed as a result of the unfolding of the protein through covalent modification of the lysyl and histidyl residues. (cdc.gov)
Lipid2
  • Association between the PLTP rs4810479 SNP and Serum Lipid Traits in the Chinese Maonan and Han Populations. (nih.gov)
  • PhosphoLipid transfer protein (PLTP) exerts a direct pro-inflammatory effect on rheumatoid arthritis (RA) fibroblasts-like-synoviocytes (FLS) independently of its lipid transfer activity. (nih.gov)
Total5
  • Plasma protein tests are also known as a total protein test. (healthline.com)
  • If this ratio is off, it can affect your total protein count. (healthline.com)
  • Once your doctor gives you an order for a total protein test, you should have it done immediately. (healthline.com)
  • The total amount of muscle proteins in mammals, including humans, exceeds that of any other protein. (britannica.com)
  • Total iron binding capacity (TIBC) is often measured at the same time as serum iron. (irondisorders.org)
Protease1
Fluid1
Amounts1
  • Conse- demonstrated that this protein signature provided an added value quently, using minute amounts of nonfractionated serum (14) and compared with conventional clinical parameters. (lu.se)
Measurement2
  • This measurement indicates the potential capacity of transferrin molecules to bind with serum iron. (irondisorders.org)
  • Measurement of parathyroid hormone related protein (PTHrp) to aid in the diagnosis of hypercalcemia due to malignancy. (tamu.edu)
Coagulation1
  • ApoH inhibits thrombosis by blocking the activation of Coagulation Factor XI but also shows procoagulant activity by inhibiting the activation of Protein C (10, 11). (rndsystems.com)
Molecular weight1
  • Apolipoprotein H (ApoH), also known as beta 2‑Glycoprotein I/ beta 2-GPI, is a variably glycosylated member of the complement control superfamily of proteins with a molecular weight of aproximately 50 kDa (1, 2). (rndsystems.com)
Stability2
  • Stability of serum obtained with tubes containing separating gel: 48 hours at 2-8°C (note the data provided by the tube manufacturer). (cdc.gov)
  • The rather high concentration of such macromolecules is known as "macromolecular crowding" and was shown to influence reaction rates [1] and protein thermal stability. (lu.se)
Clinical applications1
  • Wei-Jun Qian is a bioanalytical chemist whose research centers primarily on the development and applications of mass spectrometry-based approaches to better quantify the dynamic changes in protein abundances and protein post-translational modifications in biological and clinical applications. (pnnl.gov)
Rats1
  • Published pharmacokinetic studies report that oral, intravenous and intraperitoneal administration in rats results in different times of PPL permanence in plasma 2 . (nature.com)
Potassium3
  • The effects of in vitro carbamylation of plasma with potassium cyanate on drug-protein binding have been investigated. (nih.gov)
  • Potassium cyanate added to samples of normal plasma and incubated for 30 to 150 min induced time-related plasma protein carbamylation. (nih.gov)
  • Scatchard plots for sulfadiazine binding in plasma from patients with uremia and in normal plasma carbamylated in vitro with potassium cyanate showed changes in the 2 groups when compared with those in normal individuals. (nih.gov)
Level4
  • It regulates the serum cholesterol level by influencing the level of cholesterol uptake into cells. (cdc.gov)
  • Our previous study revealed that plasma FABP1 and FABP2 were independently associated with CKD, however, little is known about the relationship between plasma FABP3 level and CKD. (medsci.org)
  • The plasma glucose level was higher in treated groups compared to the control and it increased with the increase of bleeding level. (scialert.net)
  • Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. (antibodies-online.com)
Immune2
  • HBIG and other specific immune globulins (e.g., varicella-zoster IG) may be prepared from plasma pools from fewer donors. (cdc.gov)
  • The question of safety arises out of concern that some immune globulins currently available were prepared from plasma pools that included units from donors who may have had HTLV-III/LAV viremia. (cdc.gov)
Chronic1
  • Fatty acid-binding protein 3 (FABP3) located in renal mesangial and distal tubular cells, and had been shown to be a sensitive marker of renal injury, potentially be a mediator in pathogenesis of chronic kidney disease (CKD). (medsci.org)
Bind3
Tumor1
  • In this respect, in contrast to predictors based for each serum protein was determined by comparing the samples upon tumor characteristics at the time of surgery, serum is a par- collected at the primary operation and then 3-6 mo later. (lu.se)