AnatomyChemicals and DrugsPhenomena and ProcessesDisciplines and OccupationsInformation Science
OsteopontinSialoglycoproteinsPlasmaEncyclopedias as TopicMoonChemotaxisNeurobiologyMedlinePlus
Spp1GlycoproteinPrognosticBiomarkersProteinSeminal plasmaThrombospondinOsteoprotegerinSpliceGene promoterBiomarkerFibrosisVariantsCorrelationSurvivalCorrelateRegulationCreatinineInflammationPredictorProstate cancerSignificantlySevereBiologicalSystemicProgressionLevelsExpressionConcentrationsPatientsAssociationSerumGenesTissueFormHumanChemicalArticleRESULTSRelationships between plasmaTherapyTreatment
Spp12
  • Osteopontin (OPN), also known as bone /sialoprotein I (BSP-1 or BNSP), early T-lymphocyte activation (ETA-1), secreted phosphoprotein 1 (SPP1), 2ar and Rickettsia resistance (Ric), is a protein that in humans is encoded by the SPP1 gene (secreted phosphoprotein 1). (wikipedia.org)
  • Osteopontin (SPP1, OPN) is an extra cellular matrix glycoprotein and cytokine with a known role in granuloma formation and in autoimmune and inflammatory diseases. (iucc.ac.il)
Glycoprotein5
  • Osteopontin is a SIBLING (glycoprotein) that was first identified in 1986 in osteoblasts. (wikipedia.org)
  • Osteopontin (OPN) is a multifunctional glycoprotein expressed by a number of cell types. (biomedcentral.com)
  • Background: The Osteopontin (OPN) is a highly phosphorylated glycoprotein in numbers of bovine tissues and milk. (ijbiotech.com)
  • Osteopontin is a highly phosphorylated glycoprotein and is expressed in several tissues (13). (ijbiotech.com)
  • Complement factor H, a 155 kDaplasma glycoprotein, is an essential regulatory protein that plays a critical role in the homeostasis of the complement system in plasma and in the protection of bystander host cells and tissues from damage by complement activation. (biovendor.com)
Prognostic3
  • Identification of osteopontin as a prognostic plasma marker for head and neck squamous cell carcinomas. (ox.ac.uk)
  • AbstractBackground: A previously developed monoclonal/polyclonal ELISA (Mono/Poly) to detect plasma concentrations of osteopontin (OPN) was shown to provide prognostic information in breast, prostate, and other cancers. (openaire.eu)
  • Biomarkers are of interest for the simplicity of determination in plasma or serum and the possibility of their use for diagnostic, prognostic and therapeutic purposes. (atheroreview.eu)
Biomarkers5
  • Scientists at Yale University have identified a set of plasma biomarkers that could reasonably predict the risk of metastasis among patients with melanoma , according to findings published in Clinical Cancer Research, a journal of the American Association for Cancer Research. (analytica-world.com)
  • Inflammatory MCP-1 and fibrosis (collagen, fibronectin, plasminogen activator inhibitor-1, and osteopontin) renal biomarkers were significantly reduced in the CXA-10 (2.5 mpk) group. (aspetjournals.org)
  • METHODS: We analyzed relationships between plasma OPN and cardiac structure/function (assessed using cardiovascular magnetic resonance imaging) and immune activation (biomarkers and flow cytometry) among 20 WWH and 14 women without HIV (WWOH). (monocyte.eu)
  • Positive correlations with atherosclerosis and its complications have been demonstrated in biomarkers associated with bone meta-bolism such as fibroblast growth factor 23, osteocalcin, osteoglycin, osteopontin or osteoprotegerin. (atheroreview.eu)
  • The impact of heat exposures on biomarkers of AKI and plasma metabolome among agricultur al and non- agricultur al workers. (cdc.gov)
Protein9
  • Osteopontin is an extracellular structural protein and therefore an organic component of bone. (wikipedia.org)
  • Osteopontin (OPN) is an integrin-binding protein overexpressed in various experimental models of malignancy and appears to be involved in tumorigenesis and metastasis. (aacrjournals.org)
  • Osteopontin (OPN) is an integrin-binding protein, believed to be involved in a variety of physiological cellular functions (1) . (aacrjournals.org)
  • However, many doctors and scientists have discovered that an increase in the protein called osteopontin plasma indicates severe covid 19 complications in children. (infiressources.ca)
  • Conclusions Osteopontin protein levels are elevated in sarcoidosis. (iucc.ac.il)
  • This report addresses the issue of optimizing extracellular matrix protein density required to support osteogenic lineage differentiation of mesenchymal stem cells (MSCs) by culturing MSCs on surface-bound density gradients of immobilized collagen type I (COL1) and osteopontin (OPN). (monash.edu)
  • The protein is found in urine (14), bile (13), milk (15), seminal plasma of Holstein bulls (16) and has been detected in bull accessory sex gland, seminal vesicle and ampullary fluids (16). (ijbiotech.com)
  • In addition, factor H has multiple physiological activities acts as an extracellularmatrix component, binds to cellular receptors of the integrintype, and interacts with a wide selection of ligands, such as the C-reactive protein, thrombospondin, bone sialoprotein, osteopontin, and heparin. (biovendor.com)
  • In recent experiments, we have also found that a four protein panel including ST2, CXCL9, MMP3 (matrix metaaloproteinase) and osteopontin is associated with the diagnosis of chronic GvHD. (cryostem.org)
Seminal plasma2
Thrombospondin2
  • Recent investigators have demonstrated other substrates for factor XIIIa, including proteins such as osteopontin, factor V, thrombospondin, vinculin, and endothelial cell receptors avb3 and VEGFR-2. (medscape.com)
  • Investigators have demonstrated other substrates for factor XIIIa, including proteins such as osteopontin, factor V, thrombospondin, vinculin, and endothelial cell receptors α v β 3 integrin and VEGFR-2. (medscape.com)
Osteoprotegerin1
  • Methods Osteopontin, osteoprotegerin, sTNF receptor 1, sTNF receptor 2 and the tumor necrosis factor-like weak inducer of apoptosis called TWEAK, were determined in plasma after 6 months and 42 months in 219 community-living elderly persons, of whom 119 received supplements of selenium (200 μg/day) and coenzyme Q10 (200 mg/day), and 101 received a placebo. (inn.no)
Splice2
Gene promoter1
  • They indicated that the Tn motif in OPN-3907, bears an osteopontin regulator element at further up to the gene promoter. (ijbiotech.com)
Biomarker1
  • Biomarker concentrations were determined in the plasma of an additional 49 cases with benign asbestos-related disease. (bmj.com)
Fibrosis4
  • Plasma osteopontin relates to myocardial fibrosis and steatosis and to immune activation among women with HIV. (monocyte.eu)
  • Among WWH, plasma OPN related directly to the markers of cardiac fibrosis, growth differentiation factor-15 (rho = 0.51, P = 0.02) and soluble interleukin 1 receptor-like 1 (rho = 0.45, P = 0.0459). (monocyte.eu)
  • Among WWH (but not among WWOH or the whole group), plasma OPN related directly to both myocardial fibrosis (rho = 0.49, P = 0.03) and myocardial steatosis (rho = 0.46, P = 0.0487). (monocyte.eu)
  • CONCLUSION: Among WWH, plasma OPN, a powerful predictor of heart failure outcomes, related to myocardial fibrosis and steatosis and the expression of CCR2 and CX3CR1 on select monocyte subpopulations. (monocyte.eu)
Variants1
  • Objective To determine whether plasma OPN levels are elevated in patients with sarcoidosis and compare the frequency of four single nucleotide polymorphism (SNPs) variants in the OPN gene in sarcoidosis patients compared to healthy controls. (iucc.ac.il)
Correlation1
  • We found no correlation between SNPs distribution and plasma OPN levels. (iucc.ac.il)
Survival4
  • The relationships between plasma OPN levels, tumor pO(2) as measured by the Eppendorf microelectrode, freedom from relapse (FFR), and survival in HNSCC patients were evaluated. (ox.ac.uk)
  • In 27 patients with NSCLC (non-small cell lung cancer), OPN levels at the completion of radiation, as well as the change in plasma concentration during therapy, was predictive of overall survival. (shu.edu)
  • Using the 6 ELISAs, we measured OPN in plasma from 66 patients with castration-resistant prostate cancer, and we assessed the ability of each assay to predict patient survival.Results: The assays varied in measured plasma OPN concentrations, with median values ranging from 112 to 1740 μg/L, and ability to predict patient survival. (openaire.eu)
  • After adjustment for risk factors independently associated with survival in our samples, OPN remained associated with survival only for the Mono/Poly and Dual Mono systems.Conclusions: OPN plasma values varied significantly depending on the assay used. (openaire.eu)
Correlate1
  • CONCLUSIONS: Plasma OPN levels appeared to correlate with tumor hypoxia in HNSCC patients and may serve as noninvasive tests to identify patients at high risk for tumor recurrence. (ox.ac.uk)
Regulation1
Creatinine1
  • Results: Median values of pre-shift creatinine and osteopontin (p agricultur al workers than non- agricultur al workers. (cdc.gov)
Inflammation1
  • To determine the effect of vitamin D supplementation in obese adults with low plasma levels of 25OH-D on liver fat content and obesity-related conditions including hypertension , dyslipidemia, inflammation and insulin resistance. (andeal.org)
Predictor1
  • Plasma OPN (osteopontin) is a powerful predictor of heart failure outcomes in the general population. (monocyte.eu)
Prostate cancer1
  • Our recent studies have shown an increase in the surface expression of CD44 isoforms (sCD44 and v4-v10 variant CD44) in prostate cancer cells over-expressing osteopontin (PC3/OPN) [ 15 ]. (biomedcentral.com)
Significantly2
  • Patients with VHL syndrome had significantly higher plasma OPN levels than healthy volunteers. (ox.ac.uk)
  • After 4 weeks of treatment, CXA-10 [2.5 millligrams per kilogram (mpk), p.o.] significantly attenuated increases in plasma cholesterol, heart weight, and kidney weight observed in the model without impacting systemic arterial blood pressure. (aspetjournals.org)
Severe1
  • With the absence of the carrier B subunits, the plasma half-life of the A subunits is shorter (ie, 3 d), resulting in decreased plasma levels of both A and B. However, because of the presence of A subunits in platelets and monocytes, the phenotype is less severe. (medscape.com)
Biological2
  • Osteopontin mediates biological function through signal transduction by binding to the cell surface receptors such as integrin αvβ3 and CD44 [ 5 ]. (biomedcentral.com)
  • This CLIA kit applies to the in vitro quantitative determination of Human OPN concentrations in serum, plasma and other biological fluids. (elabscience.com)
Systemic1
  • For years, the treatment of choice has been plasma-derived factor XIII concentrate that is pasteurized to provide virologic safety and is less likely than plasma to cause systemic reactions. (medscape.com)
Progression1
  • Osteopontin (OPN) has been shown to play many roles in the progression of cancer. (biomedcentral.com)
Levels9
  • Plasma OPN levels in 15 volunteers, 31 VHL patients, and 54 HNSCC patients were quantitatively measured by ELISA. (ox.ac.uk)
  • Accordingly, the CD44v7 ligand osteopontin, whose levels were elevated in Crohn's disease, specifically induced IL-6 in human monocytes, a cytokine also increased in these patients. (nature.com)
  • While fibulin-3 levels are elevated in the plasma of mesothelioma patients compared with controls, soluble mesothelin has a much greater diagnostic accuracy and fibulin-3 levels in pleural effusions are not specific for mesothelioma. (bmj.com)
  • Blood samples were analyzed for SNPs of the OPN gene and for plasma OPN and CRP levels. (iucc.ac.il)
  • We found no evidence for an association between SNPs on the osteopontin gene and plasma OPN levels or the presence of sarcoidosis, however, an association between genotype and several phenotypic clinical parameters of disease was observed. (iucc.ac.il)
  • No differences between groups at baseline for the following: fasting blood glucose, plasma PTH , smoking history and physical activity levels. (andeal.org)
  • High Levels of the Cleaved Form of Galectin-9 and Osteopontin in the Plasma Are Associated with Inflammatory Markers That Reflect the Severity of COVID-19 Pneumonia. (unige.ch)
  • Circulating fibroblast growth factor-23 plasma levels predict adverse cardiovascular outcomes in patients with diabetes mellitus with coronary artery disease. (atheroreview.eu)
  • Low Levels of Plasma Osteoglycin in Patients with Complex Coronary Lesions. (atheroreview.eu)
Expression1
  • Osteopontin (OPN) expression is modulated by Schistosoma mansoni egg antigen. (wikipedia.org)
Concentrations1
  • The availability of a clinically validated, dual monoclonal-based ELISA will provide consistent reagents for studies of OPN plasma concentrations in cancer and other pathologies. (openaire.eu)
Patients4
  • Here, we investigated the relationship between osteopontin (OPN), tumor pO(2), and prognosis in patients with head and neck squamous cell carcinomas (HNSCC). (ox.ac.uk)
  • Methods Fibulin-3 and soluble mesothelin were determined by ELISA in the plasma and pleural fluid of 153 patients presenting with a pleural effusion including 82 with MM, 36 with non-MM malignant effusions and 35 with benign effusions. (bmj.com)
  • Kluger and colleagues tested the plasma of 216 individuals, including 108 patients with metastatic melanoma and 108 patients with stage 1 or 2 disease. (analytica-world.com)
  • Using proteomics, it has been shown that plasma concentration of Suppression of Tumorigenicity 2 (ST2), accurately stratified patients according to risk of non-response to acute GvHD therapy in large retrospective sets. (cryostem.org)
Association1
  • A body of studies suggests the role of osteopontin (OPN) in onset and development of osteoarthritis (OA), however, the association between OPN polymorphisms and OA susceptibility as well as its clinical features has not been reported. (biomedcentral.com)
Serum2
  • They allow up to 50 user-defined target analytes to be simultaneously profiled using cell culture supernates, serum, or plasma samples. (bio-techne.com)
  • Luminex Assays are validated for use with cell culture supernatants, plasma and serum. (bio-techne.com)
Genes1
  • Osteopontin gene (OPN) and PPARGC1A are located in the middle of chromosome 6 about 6 Mb apart, which is approximately 12 cM (6) and encodes osteopontin, the prime candidate among the six genes in the 420 Kb region (9). (ijbiotech.com)
Tissue1
Form1
  • The A2 and B2 dimers assemble in the plasma to form a heterotetramer, which has a long plasma half-life of 7-12 days. (medscape.com)
Human4
  • Osteopontin-c has been suggested to facilitate the anchorage-independent phenotype of some human breast cancer cells due to its inability to associate with the extracellular matrix. (wikipedia.org)
  • To evaluate the proliferative capacity of mesenchymal cells derived from human periodontal ligament on polished and plasma-treated titanium surfaces. (bvsalud.org)
  • We concluded that plasma nitriding produced surfaces that permitted the proliferation of human periodontal ligament mesenchymal cells. (bvsalud.org)
  • In this respect, this study evaluated the proliferation of mesenchymal cells derived from the periodontal ligament of human third molars on polished and plasma-nitrided titanium surfaces. (bvsalud.org)
Chemical2
  • A chemical surface gradient is prepared by tailoring the surface chemical composition from high hydroxyl groups to aldehyde groups using a diffusion-controlled plasma polymerization technique. (monash.edu)
  • Associated to other physical and chemical properties, it is possible to assume the feasibility of plasma nitriding method and its positive effect on the early cellular events of osseointegration. (bvsalud.org)
Article1
RESULTS2
  • Results Mesothelin provides better diagnostic accuracy than fibulin-3 for MM whether measured in plasma or pleural effusion: area under the curve (AUC) for plasma was 0.822 (95% CI 0.76 to 0.87) compared with 0.671 (0.61 to 0.73), respectively, and for pleural fluid AUC was 0.815 (0.74 to 0.87) compared with 0.588 (0.51 to 0.67), respectively. (bmj.com)
  • RESULTS: Plasma OPN did not differ between groups. (monocyte.eu)
Relationships between plasma1
  • Limited data exist on relationships between plasma OPN and surrogates of HIV-associated heart failure risk. (monocyte.eu)
Therapy1
  • One of the treatment options the patient may have researched is platelet-rich plasma therapy or commonly referred to as PRP. (caringmedical.com)
Treatment2
  • Five Platelet Rich Plasma Prolotherapy meniscus treatment cases presented in the medical literature. (caringmedical.com)
  • Fresh frozen plasma (FFP), cryoprecipitate, and factor XIII (FXIII) concentrates have been used for replacement of factor XIII and the treatment of acute bleeding. (medscape.com)