Peripheral mononuclear cellsPBMCsPhagocyte systemBone marrowCytokinesProliferationFicollMonocytesInfiltrationGranulocytesInflammatory cellLymphocytesImmunityPatientsApoptoticInterleukinOral squamous cell carcInflammationMalignantMarkedlyEndothelialMyeloidEpithelialAlveolarSerumMacrophagesConclusionsBlood cellsRatsMultiple myelomaSubsetIsolationSubsetsTherapyProteinsSeparationPerivascularVitroEnzyme-linked immunosorbent assaysCytotoxicityConcentrationACE2ResponsesAntibodyHistiocyticTumorMeasurableImmune cellsConcentrations of totalAntigenProteinAberrantLymphomaCytotoxicHistiocytesInhibitorsSurrogate
Peripheral mononuclear cells2
- Here, we report that plasma exosomes of COVID-19 patients contain SARS-CoV-2 double stranded RNA (dsRNA) and stimulate robust production of interleukin-6 (IL-6), IL-8, tumor necrosis factor-α (TNF-α), and other inflammatory cytokines and chemokines by human peripheral mononuclear cells. (wphobby.com)
- Phenotypic transcriptional and functional examination of the peripheral mononuclear cells revealed age-, time, and disease severity-specific adaptations. (medrxiv.org)
PBMCs4
- Start immuno-oncology experiments confidently with a reliable supply of ethically sourced, cryopreserved peripheral blood products from donors diagnosed with multiple myeloma (MM). Options include cancer-sourced frozen peripheral blood mononuclear cells (MNCs or PBMCs) and custom-isolated frozen products such as plasma and serum. (stemcell.com)
- The presence of XMRV in PBMCs and plasma suggests a blood-borne route of transmission of the virus: transfusions, health care associated needle sticks, and intravenous drug use. (virology.ws)
- The study on PBMC cells is mandatory to understand the biology and pathology related pathways as well as in clinical research, research on life threatening diseases, immunology, vaccine development, etc.PBMCs provide information on effects of prospective novel medication molecules on people, particularly on their immune systems. (yahoo.com)
- To enable the first repertoire-scale comparison of these two compartments (homologous vs. heterologous), we optimized culture conditions for PBMCs (peripheral blood mononuclear cells) with the the goal of using optimized conditions as sample input into PePSeq, a highly multiplexed serological assay. (tgen.org)
Phagocyte system7
- In immunology, the mononuclear phagocyte system or mononuclear phagocytic system (MPS) also known as the reticuloendothelial system or macrophage system is a part of the immune system that consists of the phagocytic cells located in reticular connective tissue. (wikipedia.org)
- The mononuclear phagocyte system and the monocyte macrophage system refer to two different entities, often mistakenly understood as one. (wikipedia.org)
- citation needed] "Reticuloendothelial system" is an older term for the mononuclear phagocyte system, but it is used less commonly now, as it is understood that most endothelial cells are not macrophages. (wikipedia.org)
- The mononuclear phagocyte system is also a somewhat dated concept trying to combine a broad range of cells, and should be used with caution. (wikipedia.org)
- The spleen is the second largest unit of the mononuclear phagocyte system. (wikipedia.org)
- The mononuclear phagocyte system is part of both humoral and cell-mediated immunity. (wikipedia.org)
- Clearance of heparin via heparinases The various cell types of the mononuclear phagocyte system are all part of the myeloid lineage from the CFU-GEMM (precursor of granulocytes, erythrocytes, monocytes and megakaryocytes) Mononuclear+Phagocyte+System at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Inderbir Singh (2006). (wikipedia.org)
Bone marrow6
- Mononuclear cells from bone marrow have been used in various treatments of diseases in an attempt to regenerate tissues . (bvsalud.org)
- Mononuclear bone marrow cells , TGF-β and PRP were added to the lesion on the treated side and saline on the contralateral side. (bvsalud.org)
- Background Multiple myeloma is an incurable malignancy of bone marrow plasma cells. (haematologica.org)
- Multiple myeloma (MM) is an incurable hematologic malignancy characterized by the clonal proliferation of malignant plasma cells in the bone marrow. (haematologica.org)
- 6 , 7 CXCL12 is an important mediator of several aspects of MM biology including transendothelial migration, 8 , 9 MM plasma cell migration and retention within the bone marrow, 10 , 11 angiogenesis, 7 and osteoclastic bone resorption. (haematologica.org)
- 6 Recent animal studies involving systemic injection of labeled MM plasma cells have also demonstrated that blocking the CXCL12/CXCR4 axis leads to a 20% reduction in bone marrow tumor burden. (haematologica.org)
Cytokines7
- Examination of T cells showed profound lymphopenia, that worsened over time and correlated with lower levels of plasma cytokines important for T cell survival in aged patients with severe disease. (medrxiv.org)
- The cytokines released by PBMC from farmers indicated skewing toward Type-2 helper T-cell responses: interferon (IFN)-γ:interleukin (IL)-4 and IFNγ:IL-13 ratios were significantly lower than for control PBMC. (go.jp)
- Circulating plasma inflammatory and regulatory cytokines were assessed with enzyme-linked immunosorbent assays. (deepdyve.com)
- Immune status was assessed by measuring lytic activity of natural killer (NK) cells, secretion of cytokines (IL-2, IL-4, TNFalpha), and proliferation by activated peripheral blood mononuclear cells. (nih.gov)
- Compared with controls, the detectable proportion of HIV-1 particles derived from CD14 macrophages and CD26 lymphocytes was increased in persons with acute malaria coinfection and correlated with markedly increased plasma concentrations of both proinflammatory cytokines and soluble markers of macrophage and lymphocyte activation. (lww.com)
- Resveratrol was safe and well tolerated and was associated with significant increases in the numbers of circulating γδ T cells and regulatory T cells and resulted in small, yet significant, decreases in the plasma levels of the proinflammatory cytokines TNF- α and MCP-1 and a significant increase in the plasma antioxidant activity compared with the corresponding antioxidant baseline activity and with that in four control individuals. (hindawi.com)
- The aim of our research was to determine how immunotherapy changes the proportion of lymphocyte subsets in dog peripheral blood and the levels of cytokines secreted by these cells during therapy. (mdpi.com)
Proliferation3
- The objective of this study was to evaluate the accession and proliferation of mononuclear cells in a critical defect, with the addition of platelet-rich plasma (PRP) and / or TGF-β1 ( transforming growth factor beta 1), and then to evaluate bone repair at defective sites on the femurs of rats . (bvsalud.org)
- The Lymphocyte Proliferation Test (LymPro Test™) is a diagnostic blood test that determines the ability of peripheral blood lymphocytes (PBLs) and monocytes to withstand an exogenous mitogenic stimulation that induces them to enter the cell cycle. (yahoo.com)
- For IL-2, NK cell cytotoxicity, and lymphocyte proliferation, maximum responses were observed during depletion periods. (nih.gov)
Ficoll2
- Plasma and circulating peripheral blood mononuclear cells were isolated using Ficoll density centrifugation. (deepdyve.com)
- Peripheral Blood Mononuclear Cells (PBMC) were separated on a Ficoll layer (Eurobio, Les Ulis, France) and frozen in 10% DMSO diluted human plasma (Sigma-Aldrich, St Louis, MO). (nih.gov)
Monocytes7
- The cells are primarily monocytes and macrophages, and they accumulate in lymph nodes and the spleen. (wikipedia.org)
- COVID-19 plasma exosomes induced proinflammatory responses in CD4 + T cells, CD8 + T cells, and CD14 + monocytes but not significantly in regulatory T cells, Th17 T cells, or central memory T cells. (wphobby.com)
- These exosomes significantly increase expression of endosomal toll-like receptor 3 (TLR3), TLR7, TLR8, and TLR9 in peripheral T cells and monocytes. (wphobby.com)
- A pharmacological inhibitor of TLR3 considerably reduced cytokine and chemokine production by CD4 + and CD8 + T cells but not by CD14 + monocytes, highlighting divergent signaling pathways of immune cells in response to COVID-19 plasma exosomes. (wphobby.com)
- The interleukin-1 (IL-1) responses of U937 cells and peripheral blood monocytes to organic dusts were compared. (cdc.gov)
- Extracts of bulk cotton samples were tested with U937 cells and monocytes. (cdc.gov)
- These included (i) temporally ordered upward and downward changes in plasma proteins reestablishing homeostasis and (ii) post-transfusion disappearance of a subset of monocytes characterized by hyperactivated Interferon responses and decreased TNF-α signaling. (frontiersin.org)
Infiltration3
- An incisional biopsy revealed epithelial hyperplasia associated with intense and diffuse mononuclear inflammatory cell infiltration consisting mainly of plasma cells, in a perivascular and perineural distribution. (nih.gov)
- 2002). The most common manifestation is chronic interstitial pneumonitis with infiltration of lymphocytes, histiocytes, and plasma cells (Saltini and Amicosante 2001). (cdc.gov)
- infiltration of alveolar septa with plasma and mononuclear cells, and an increase in the number of bronchiolar mucous glands and goblet cells. (msdmanuals.com)
Granulocytes2
- During centrifugation, the gel forms a physical barrier between the mononuclear cells in plasma and the erythrocytes and granulocytes. (bdbiosciences.com)
- Others components of the infiltrated include lymphocytes, plasma cells, granulocytes and mast cells and occasionally it is misdiagnosed as lymphoma on microscopic examination 4,7,12 . (bvsalud.org)
Inflammatory cell1
- A dense inflammatory-cell infiltrate is present in both papillary and reticular dermis (Fig. 3). (cdlib.org)
Lymphocytes4
- HHV-6B-positive children had mild "viral" illnesses, as did rapidly dividing cells, including lymphocytes. (cdc.gov)
- LymPro is unique in the use of peripheral blood lymphocytes as a surrogate for neuronal cell function, suggesting a common relationship between PBLs and neurons in the brain. (yahoo.com)
- Plasma and/or sera of 221 COVID-19 patients from different cohorts, infected with successive SARS-CoV-2 variants including the Omicron, had detectable HERV-W ENV, which correlated with ENV expression in T lymphocytes and peaked with the disease severity. (unmc.edu)
- Histopathologic analysis revealed an ulcerated lesion with a dense mixed infiltrate of eosinophils, variably sized lymphocytes and epithelioid cells extending into submucosa. (bvsalud.org)
Immunity2
- [ 9 ] A lack of natural killer (NK) cell and B-cell activity in pityriasis rosea lesions has been noted, suggesting a predominantly T-cell mediated immunity in the development of the condition. (medscape.com)
- Progesterone is proven to decrease the response from the immune system by preventing a Th1-response and thereby the cell mediated immunity, and also causing a shift towards a Th2-response. (slu.se)
Patients12
- Gene expression signatures within memory B cells suggest qualitative differences in the antibody responses in aged patients with severe disease. (medrxiv.org)
- Several of these critical changes, such as the reduction of surface HLA-DR on myeloid cells, were reversed in young but not aged patients over time. (medrxiv.org)
- We conducted a cross-sectional study of -herpes- in the host, seldom causing disease unless the immune sys- viruses in febrile pediatric oncology patients (n = 30), with tem is weakened, as occurs after treatment for solid-organ a reference group of febrile pediatric solid-organ transplant and stem cell transplantation. (cdc.gov)
- Multiple immunological abnormalities have been reported in T1D patients including autoantibody production against the insulin molecule, the 65 kD isoform of glutamic acid decarboxylase (GAD65), various islet antigens, and the zinc transporter 8 (ZnT8) as well as decreased regulatory T cell (Treg) capacity to suppress T-cell mediated destruction of the islets of Langerhans 3 . (nature.com)
- As for GAD65 antigen (GAD-alum) treatment per se in new onset T1D, an initial 2008 report of 70 patients was auspicious insofar as residual beta-cell function over 30 months was somewhat preserved. (nature.com)
- Results Strong hypoxia-inducible factor-2 protein expression was detected in CD138 + multiple myeloma plasma cells in patients' biopsy specimens. (haematologica.org)
- 3 - 5 CXCL12 is highly expressed by MM plasma cells, 6 and circulating levels of CXCL12 are higher in the peripheral blood of MM patients than in age-matched normal donors and MGUS patients. (haematologica.org)
- Our report of COVID-19 resolution following convalescent plasma therapy in a patient unable to generate humoral responses to SARS-CoV-2 infection, together with a previous report of convalescent plasma-associated COVID-19 resolution in a patient with humoral immunodeficiency ( 15 ), strongly supports the use of well-characterized convalescent plasma for therapeutic use in COVID-19 patients who exhibit humoral immunocompromise due to underlying immunological defects or immunosuppressive therapies. (frontiersin.org)
- To date the virus has been detected in malignant prostate cells and in the peripheral blood mononuclear cells and plasma of patients with CFS. (virology.ws)
- Patients now have a better alternative to cell-based therapies with respect to traditional regenerative medicines, but their side effects can hinder their usage.Developed regions such as North America and Europe have a strong presence of cell therapies for human well-being. (yahoo.com)
- That study found XMRV in peripheral blood mononuclear cells from 67% of 101 patients with CFS compared with 3.7% of 218 healthy controls. (medscape.com)
- The authors reported that they could secondarily transmit the virus from the blood cells and plasma of infected patients with CFS, raising the possibility of blood-borne transmission. (medscape.com)
Apoptotic1
- However, the fatal diseases such as acute myocardial infarction, chronic heart failure, spinal cord injury, stroke, and wound healing have all been successfully treated in pre-clinical studies using the secretome of apoptotic peripheral blood mononuclear cells which drives the market growth, globally. (yahoo.com)
Interleukin1
- We utilized a combination of an interleukin, to proliferate B memory cells, and a TLR (toll like receptor) agonist, to stimulate antibody production. (tgen.org)
Oral squamous cell carc1
- Clinical diagnosis hypothesis was either traumatic ulcer or oral squamous cell carcinoma. (bvsalud.org)
Inflammation2
- Regarding Type 1 diabetes(T1D), animal/islet-cell studies found that GABA promotes insulin secretion, inhibits α-cell glucagon and dampens immune inflammation, while GAD immunization may also preserve β-cells. (nature.com)
- The immune responses associated with severe and fatal COVID-19 manifestations include defective antiviral mechanisms such as type I interferon (IFN) responses ( 3 , 4 ), imbalanced T cell responses ( 5 , 6 ), abnormal expansion of potentially dysfunctional B cells ( 7 ), exuberant inflammation driven by altered myeloid responses ( 8 , 9 ), and production of potentially pathogenic antibodies (autoantibodies and/or proinflammatory antibodies) ( 10 - 12 ). (frontiersin.org)
Malignant1
- 3] This is believed to constitute an important mechanism of resistance to topoisomerase I inhibitors in malignant cells. (cancernetwork.com)
Markedly1
- There were markedly focal mononuclear cell infiltrations and hemorrhage at some areas of the interstitium, especially at the corticomedullar junction. (fluoridealert.org)
Endothelial3
- Many mature plasma cells associated with marked endothelial swelling within the dermis (Fig. 4). (cdlib.org)
- Higher magnification reveals a pleomorphic perivascular infiltrate with many mature plasma cells in association with marked endothelial swelling (Fig. 4). (cdlib.org)
- Moreover, Smulders and Blom suggested that high dose of B vitamins might be harmful to vascular endothelial cells. (hindawi.com)
Myeloid2
- Although hallmarks of a cytokine storm were evident in both groups, older individuals exhibited elevated levels of chemokines that mobilize inflammatory myeloid cells, notably in those who succumbed to disease. (medrxiv.org)
- Monitoring specific dysfunctional myeloid cell subsets in peripheral blood may provide prognostic keys in COVID-19. (frontiersin.org)
Epithelial2
- Hydropic epithelial cell degenerations and moderate tubular dilatation were observed in some proximal and distal tubules. (fluoridealert.org)
- In vivo, NTSR1 mRNA expression was undetectable in superficial differentiated epithelial cells in histological specimens of normal human colonic epithelium, but there was moderate and strong expression in adenomas and adenocarcinomas respectively. (springer.com)
Alveolar1
- Macrophages are diffusely scattered in the connective tissue and in liver (Kupffer cells), spleen and lymph nodes (sinus histiocytes), lungs (alveolar macrophages), and central nervous system (microglia). (wikipedia.org)
Serum3
- The analysis of IL-1beta in blood was accomplished by spiking blood samples, plasma, or serum with a known quantity of IL-1beta, allowing the blood or plasma to clot, and then analyzing the IL-1 content of the samples. (cdc.gov)
- The results of the study indicate that while IL-1 can be measured in serum and plasma, the values may be artificially elevated. (cdc.gov)
- Processing blood for serum, plasma, and peripheral blood mononuclear cells (PBMC). (usc.edu)
Macrophages2
- These exosomes can interact with immune cells, such as T cells, macrophages, and dendritic cells, to modulate proinflammatory immune responses. (wphobby.com)
- that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)
Conclusions1
- Conclusions Hypoxia-inducible factor-2 is a newly identified regulator of CXCL12 expression in multiple myeloma plasma cells and a major contributor to multiple myeloma plasma cell-induced angiogenesis. (haematologica.org)
Blood cells6
- Formation of new red blood cells (RBCs) and white blood cells (WBCs). (wikipedia.org)
- In the liver, Kupffer cells store excess iron from catabolism of heme from the breakdown of red blood cells. (wikipedia.org)
- It is intended for the collection of whole blood and the subsequent separation of mononuclear blood cells for the purposes of in vitro diagnostic examination. (bdbiosciences.com)
- Longitudinal unbiased proteomic analysis of plasma and single-cell transcriptomics of peripheral blood cells conducted prior to and at multiple times after convalescent plasma transfusion identified the key biological processes associated with the transition from severe disease to disease-free state. (frontiersin.org)
- Objectives Seeking to elucidate the origin of these vascular and BBB abnormalities, we studied platelets that are known to play a role in maintaining the integrity of the vasculature and thrombotic pathways linked to this, given they surprisingly contain the highest concentration of mHtt of all blood cells. (bmj.com)
- Progesterone has also been shown to lower the ability of peripheral mononuclear blood cells to respond to bacteria. (slu.se)
Rats1
- It was found that the plasma fluoride and kidney TBARS levels of fluoride-supplemented F1 and F2 rats were higher than controls. (fluoridealert.org)
Multiple myeloma4
- The hypoxic regulation of CXCL12 was examined in multiple myeloma plasma cell lines using polymerase chain reaction and western blotting. (haematologica.org)
- Prolonged exposure to hypoxia strongly up-regulated CXCL12 expression in multiple myeloma plasma cells and hypoxia-inducible factor-2 was found to play a key role in this response. (haematologica.org)
- Over-expression of hypoxia-inducible factor in multiple myeloma plasma cells strongly induced in vivo angiogenesis, and administration of a CXCL12 antagonist decreased hypoxia-inducible factor-induced angiogenesis. (haematologica.org)
- Genome sequencing identifies factors that cause resistance to multiple myeloma T cell. (tgen.org)
Subset2
- Parasite clearance following treatment with antimalarial drugs resulted in decreased detection of HIV-1 particles derived from the CD14 macrophage cell subset and correlated with a marked diminution in systemic immune activation. (lww.com)
- We show here that in vitro exposure to SARS-CoV-2 activates the expression of the human endogenous retrovirus (HERV) HERV-W proinflammatory envelope protein (ENV) in peripheral blood mononuclear cells from a subset of healthy donors, in ACE2 receptor and infection-independent manner. (unmc.edu)
Isolation2
- The Global Peripheral Blood Mononuclear Cells Market is segmented based on product, application, technique, source, region, and competitive landscape.Based on Product, the market can be split into Cryopreserved or Frozen PBMC, Cultured or Fresh PBMC and peripehral blood mononuclear cell isolation & viability kits. (yahoo.com)
- Then total B cells were purified from PBMC by negative selection on magnetic columns according to the manufacturer's instructions (B cell isolation Kit II, Miltenyi Biotech, Gladbach, Germany). (nih.gov)
Subsets1
- However, our recent findings showed that mucosal-associated invariant T (MAIT) cells and effector memory (EM) T cells are enriched in the IVB of term placentas ( 4 ), indicating that certain immune cell subsets are recruited to or retained in the intervillous space. (frontiersin.org)
Therapy2
- Here we report the first, in-depth, longitudinal analysis of viral and host biologic correlates of the clinical resolution of COVID-19 in a patient who received convalescent plasma therapy during the first pandemic wave in the United States. (frontiersin.org)
- Population is gaining awareness regarding the use of peripheral blood mononuclear cells in cell and gene therapy.Hence, the extraction and usage of peripheral blood mononuclear cells prove to be the key driving force for the market growth. (yahoo.com)
Proteins3
- Formation of plasma proteins. (wikipedia.org)
- We find that disease resolution was associated with temporally ordered upward and downward changes in plasma proteins reestablishing homeostasis. (frontiersin.org)
- 99% bound to plasma proteins [ 734 ]. (nanomedicine.com)
Separation3
- Cancer-sourced primary human MNCs are isolated from peripheral blood, leukapheresis, or whole blood samples using density gradient separation or red blood cell lysis and cryopreserved in animal component-free CryoStor® CS10 medium. (stemcell.com)
- BD Vacutainer® CPT™ is a fully-closed system for separation of mononuclear cells from whole blood, where cell separation is carried out in the primary blood collection tube. (bdbiosciences.com)
- This decreases the complexity of steps for mononuclear cell separation, thereby minimizing variability from sample processing. (bdbiosciences.com)
Perivascular3
- Mononuclear cell infiltrations were also evident in some peritubular and perivascular areas. (fluoridealert.org)
- A biopsy specimen from the erosive lesion of the abdominal fold shows hyperplasia of the epidermis with a pleomorphic mononuclear perivascular infiltrate of the dermis (Figs. 3, 4). (cdlib.org)
- Hyperplasia of the epidermis with a pleomorphic mononuclear perivascular infiltrate of the dermis (Fig. 3). (cdlib.org)
Vitro4
- Further, GABA-deficient islets did not show appropriate glucagon inhibition in response to increasing glucose concentrations in vitro 22 , suggesting that GABA is directly involved in the suppression of glucagon secretion in pancreatic alpha cells. (nature.com)
- In in vitro studies, resveratrol significantly improved the growth of γδ T cells and regulatory T cells. (hindawi.com)
- In in vitro studies, the addition of NT to human colon cancer cell lines resulted in significantly increased cancer cell growth and the growth of xenografted human colon cancer cells in mice [ 9 ]. (springer.com)
- In vitro cytotoxicity against the HeLa S3 cell line has been evaluated by studying the inhibited growth rate [ 922 ], and some C 60 derivatives have shown promise as anti-cancer agents [ 1090 - 1092 ]. (nanomedicine.com)
Enzyme-linked immunosorbent assays1
Cytotoxicity1
- Single cell RNA sequencing revealed augmented signatures of activation, exhaustion, cytotoxicity, and type-I interferon signaling in memory T cells and NK cells. (medrxiv.org)
Concentration2
- Plasma vitamin C concentration increased similarly following BOJ or C-drink intake and was not affected by the S-drink. (cambridge.org)
- Our group compared supernatant collection methods (with and without pipette-mixing), varying concentrations of cell inputs, and how these factors influenced total IgG concentration over time. (tgen.org)
ACE21
- Viral infection primarily reflects binding between its membrane glycoprotein spike and the angiotensin-converting enzyme 2 (ACE2) receptor on select host human cell surfaces 15 . (wphobby.com)
Responses2
- Virus-infected cells release virus-associated exosomes, extracellular vesicles of endocytic origin, into the blood to deliver viral cargoes able to regulate immune responses. (wphobby.com)
- 14 , 15 HIF-1 and HIF-2 mediate adaptive responses to hypoxia by inducing the transcription of genes associated with erythropoiesis, glycolytic metabolism, cell survival and angiogenesis. (haematologica.org)
Antibody1
- Microscopy was utilized to qualitatively measure cell culture health and antibody quantification was performed using a commercial human IgG ELISA kit. (tgen.org)
Histiocytic2
- The histiocytic cell line U937 was found to produce IL-1 in response to environmental samples and it may be useful in the evaluation of the inflammatory potential of such samples. (cdc.gov)
- Numerous eosinophils and large histiocytic cells with pale nuclei and frequent mitoses, in some instances showing a pseudolymphomatous aspect, are characteristic 8 . (bvsalud.org)
Tumor3
- Resveratrol is the most extensively studied stilbene, and preclinical studies have revealed that this compound has several biological effects including, antioxidant, anti-inflammatory, and cytotoxic effects against human cancer cell lines derived from various tumor types [ 1 , 3 , 4 ]. (hindawi.com)
- Preclinical studies have shown that resveratrol induces immunomodulatory effects, including the upregulation of NKG2D receptors on natural killer cells (NK) that it promotes the NKG2D-dependent killing of tumor cells [ 13 , 14 ] and the induction of regulatory T cells (Treg) in the colonic tissues of mice exposed to colonic inflammatory stress [ 15 ]. (hindawi.com)
- 12 It is well established that hypoxia is an important selective force in the evolution of tumor cells, 13 and elevated expression of the hypoxia-inducible transcription factors HIF-1 and HIF-2 has been documented in several human cancers. (haematologica.org)
Measurable1
- Our data revealed that resveratrol induced measurable changes in circulating immune cells in humans and showed considerable antioxidant activities and other biological effects in humans in vivo. (hindawi.com)
Immune cells6
- Little is known about the maternal immune cells at this site, which are in direct contact with fetal tissues. (frontiersin.org)
- The potential factors involved in the migration of maternal immune cells to the placenta is still unexplored. (frontiersin.org)
- however, little is known about the in vivo effects of this naturally occurring polyphenol on human immune cells. (hindawi.com)
- We assessed the effects of repeated doses of resveratrol (1000 mg/day for 28 days) on circulating immune cells in healthy Japanese individuals. (hindawi.com)
- These findings demonstrate that resveratrol has some clear biological effects on human circulating immune cells. (hindawi.com)
- Thus, the current study evaluated the effects of repeated oral doses of resveratrol on circulating immune cells in healthy individuals. (hindawi.com)
Concentrations of total2
Antigen2
- Increased amounts of CD4 T cells and Langerhans cells are present in the dermis, possibly reflecting viral antigen processing and presentation. (medscape.com)
- Indeed, antigen-presenting cells are important reservoirs of HIV-1 [ 16,17 ] and induction of HIV-1 replication within these cells may contribute significantly to the cofactor effect of confections on HIV-1 pathogenesis. (lww.com)
Protein1
- This protein is ubiquitously expressed and known to confer toxicity to multiple cell types. (bmj.com)
Aberrant2
- It is believed that certain diseases, most notably Alzheimer's disease, are the result of compromised cellular machinery that leads to aberrant cell cycle re-entry by neurons, which then leads to apoptosis. (yahoo.com)
- While the mechanisms responsible for aberrant plasma cell expression of CXCL12 remain to be determined, studies in other systems suggest a role for hypoxia and hypoxia-inducible transcription factors. (haematologica.org)
Lymphoma2
- Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)
- genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)
Cytotoxic1
- In cell lines, the cytotoxic effect of topoisomerase I and II is scheduledependent. (cancernetwork.com)
Histiocytes1
- The Kupffer cells of the liver and tissue histiocytes are also part of the MPS. (wikipedia.org)
Inhibitors1
Surrogate1
- One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)