Plasma homocysteine levels and risk of cardiovascular. Medical search. Frequent questions

Because homocysteine metabolism is related to thyroid and steroid hormones, we studied these relationships in severe hypothyroidism and in euthyroid state. (degruyter.com)
9 Both folate and vitamin B 12 are potent regulators of homocysteine metabolism through the modulation of the vitamin B 12 -dependent enzyme methionine synthase, which - in most tissues and cells - is the major (or only) pathway for the conversion of homocysteine to methionine, a critical component of the folate cycle. (dsm.com)
These practices for prevention of spontaneous abortion are supported by some studies suggesting a connection between impaired homocysteine metabolism and recurrent miscarriages. (healthyplace.com)
Further, some patients may have genetic enzyme deficiencies that may impair homocysteine metabolism. (patientoneformulas.com)
Because Quatrefolic is active when it enters the body, it is better able to influence pathways for homocysteine metabolism. (patientoneformulas.com)
Trimethylglycine, also known as betaine, is considered a key player in homocysteine metabolism and has long been administered as a methyl donor for remethylating homocysteine back into methionine. (patientoneformulas.com)
Trimethylglycine (TMG) betaine is a necessary cofactor in the secondary pathway of homocysteine metabolism. (patientoneformulas.com)
Homocysteine (Hcy) is a breakdown product of methionine metabolism. (bvsalud.org)
Homocysteine, generated in the metabolism of methionine, may have a role in the development of cardiovascular disease. (unboundmedicine.com)
Circulating levels of homocysteine are usually low due to its rapid metabolism via one of two pathways: a cobalamin (vitamin B12) and folate dependent re-methylation pathway that regenerates methionine, or a pyridoxal 5' phosphate (PLP, vitamin B6) dependent trans-sulphuration pathway that converts homocysteine into cysteine. (medicaltesting-europe.com)
T polymorphism is a genetic alteration in an enzyme involved in folate metabolism that causes elevated homocysteine concentrations, but its relevance to risk of CHD is uncertain. (ckbiobank.org)
These results support the hypothesis that impaired folate metabolism, resulting in high homocysteine levels, is causally related to increased risk of CHD. (ckbiobank.org)
Nutrition, metabolism, and cardiovascular diseases : NMCD 2012 Apr 22 (4): 362-8. (cdc.gov)

With respect to mechanisms concerning the B-vitamin complex, it has long been established that folate deficiency leads to increased plasma homocysteine (hyperhomocysteinemia), an independent risk factor for coronary artery disease, stroke, peripheral vascular atherosclerosis, and both arterial and venous thromboembolism. (dsm.com)
Folic acid is known to lower plasma homocysteine levels, and high levels of the amino acid, hyperhomocysteinemia, are a marker for heart disease and thought to be a risk factor for atherosclerotic disease, which contributes to heart attacks. (nutraingredients-usa.com)
Background: Hyperhomocysteinemia (HHcy) has been proposed as an important cardiovascular risk factor (cRF). (elsevierpure.com)
Experts in the field advocate treatment of elevated tHcy levels in high-risk people, such as those with a personal or family history of premature atherosclerosis or a predisposition to develop hyperhomocysteinemia. (unboundmedicine.com)
Hyperhomocysteinemia: an independent risk factor for vascular disease. (thieme-connect.de)
Hyperhomocysteinemia and Risk of First Venous Thrombosis: The Influence of (Unmeasured) Confounding Factors. (msdmanuals.com)
Polymorphism of MTHFR C677T, serum vitamin levels and cognition in subjects with hyperhomocysteinemia in China. (cdc.gov)

As it opens multiple pathways for catalyzing homocysteine remethylation to methionine, Homocysteine Cardioplex balances plasma homocysteine levels and promotes overall cardiovascular wellness. (patientoneformulas.com)
B-12 is an important donor for enabling homocysteine to be remethylated into methionine. (patientoneformulas.com)
B-12 also works in concert with the coenzyme methionine synthase, creating a primary pathway of remethylation of homocysteine. (patientoneformulas.com)
Featuring a biological advantage in assimilation, TRAACS requires no conversion: It is an active cofactor for promoting efficient homocysteine-to-methionine conversion. (patientoneformulas.com)
Homocysteine play an important role in many metabolic pathways, mainly the methionine cycle to the folate cycle (see image below). (medscape.com)
Homocysteine is not obtained from the diet, instead, it is biosynthesized from methionine via a multi-step process that probably occurs in every cell of the body. (medicaltesting-europe.com)
One of the most important folate-dependent reactions is the conversion of homocysteine to methionine in the synthesis of S-adenosyl-methionine, an important methyl donor. (nih.gov)
Plasma homocysteine concentration is a commonly used functional indicator of folate status because homocysteine levels rise when the body cannot convert homocysteine to methionine due to a 5-MTHF deficiency [ 9 ]. (nih.gov)
Homocysteine is a byproduct of the conversion of the amino acid cysteine into methionine. (yourfibrodoctor.com)
If homocysteine is not converted into methionine, it will become oxidized by free radicals. (yourfibrodoctor.com)
When you have the MTHFR gene mutation, your body is unable to properly break down homocysteine into methionine. (yourfibrodoctor.com)

A meta-analysis of 12 randomized trials that included 1,114 study subjects found that dietary folic acid appeared to reduce blood homocysteine levels by 25%, while vitamin B-12 was associated with another 7% reduction. (patientoneformulas.com)
Fortification of grain and cereal products with folate in the United States has led to a reduction in the number of NTD-affected births and to an increase in blood folate levels, as well as to a reduction in blood homocysteine levels, suggesting reduced risk for heart disease. (usda.gov)
Gender and four specific genes were found to be particularly important in determining blood homocysteine levels. (usda.gov)
Large-scale clinical trials of folic acid-based vitamin supplements are currently in progress to test whether lowering blood homocysteine levels can reduce the risks of CHD and stroke. (ox.ac.uk)

Low folate status also increases plasma homocysteine levels, a potential risk factor for chronic diseases, such as cardiovascular disease or cognitive function. (cdc.gov)
Potential roles of folate and other B vitamins in modulating the risk for diseases (e.g., heart disease, cancer, and cognitive impairment) are under investigation. (cdc.gov)
Hypothyroidism is very often associated with cardiovascular diseases and neurological complications. (degruyter.com)
Cardiovascular and cerebrovascular diseases are the leading cause of morbidity and mortality worldwide ( 5 ). (spandidos-publications.com)
An elevated blood level of the amino acid homocysteine has been identified as a risk factor for some of these diseases. (encyclopedia.com)
Reduce consumption of saturated fat, cholesterol and risk of chronic diseases [2]. (slideshare.net)
3. Reduce the diseases related to gastrointestinal problem and lung cancer [5] and also the risk of cancer incidence predominantly for colon cancer [3-5] 4. (slideshare.net)
If you choose more fatty foods in your daily dietary consumption, the risk of suffering from various diseases will be more often than you will get for suffering if you reduce various fatty foods. (slideshare.net)
The Mediterranean diet is a healthy eating pattern, associated with reduced risk for metabolic, cardiovascular, and neoplastic diseases,that has consistently been shown to provide a degree of protection against chronic degenerative diseases. (ethicare.in)
In particular, the monounsaturated fatty acids intake, whose major source is represented by extra virgin olive oil (EVOO), was found to be associated with a reduced prevalence of risk factors for major chronic inflammatory diseases. (ethicare.in)
Recurrence referred to any recurrence is also risk factor in these diseases. (who.int)
Elevated homocysteine is associated with a variety of diseases, including Alzheimer's disease (AD) and depressive disorder. (nel.edu)
We found that ADMA levels were lower in CS than co-morbid diseases matched control group, which should be further investigated. (endocrine-abstracts.org)
In several studies, a high total plasma homocysteine level (Hcys) has been linked with age-associated cardiovascular and neurodegenerative diseases. (uni-giessen.de)
International Archives of Cardiovascular Diseases is a peer reviewed, open access journal focused on clinical areas of cardiovascular medicine. (clinmedjournals.org)
The journal publishes original communications of scientific excellence concerned with clinical approach to the diagnosis and treatment of cardiovascular diseases. (clinmedjournals.org)
The journal publishes the latest findings in cardiovascular medicine, cardiovascular diseases and observational studies. (clinmedjournals.org)
International Archives of Cardiovascular Diseases ensures the maintenance of international standards of open access publishing. (clinmedjournals.org)
Apart from the prevention of congenital malformations by supple- mentation of folic acid, the association of folate intake and cardiovascular diseases has been studied. (thieme-connect.de)
However, a large number of relative studies could prove the influence of folate on the homocysteine concentration of plasma which is considered a risk factor for cardiovascular diseases. (thieme-connect.de)
It was, for instance, not possible to find out whether an increased homocysteine concentration contributes to the pathogenesis of atherosclerosis or whether it denotes an indirect risk factor for cardiovascular diseases such as a folic-acid deficiency. (thieme-connect.de)
Cardiovascular diseases are 1.5-2-fold more frequent in RA patients than in the general population. (bmj.com)
Cardiovascular diseases have been shown to occur 1.5-2 times more often in RA patients than in the general population, leading to increased mortality in this group of patients. (bmj.com)
Cardiovascular diseases incl. (muni.cz)
The Canadian First Nations population has poorer overall health than does the general Canadian population ( 1 ), specifically in terms of chronic diseases, chronic disease risk factors ( 2 ), and injuries and accidents ( 3 ). (cdc.gov)

Folate is an essential vitamin that plays a role in prevention of cardiovascular disease, dementia, and hypertension, as well as reducing occurrence of neural tube defect. (usda.gov)
2. Reduce the heart disease and the risk of high blood pressure/hypertension incidence [3-7]. (slideshare.net)
Conventional stroke risk factors such as hypertension, atrial fibrillation, cigarette smoking, diabetes mellitus and obesity are well established. (bmj.com)
Objective: Cushing s syndrome (CS) is related to diabetes mellitus, dyslipidaemia, hypertension, and obesity, which lead to cardiovascular disease (CVD). (endocrine-abstracts.org)
Accumulating evidence suggests that nonoccupational exposures to lead may increase the risk for cardiovascular and neurologic outcomes such as hypertension and accelerated decline in cognition. (thestemcellfoundation.com)
It is believed that homocysteine causes damage to the lining of the arteries and thereby promotes atherosclerosis and hypertension. (yourhealthbase.com)
Age, smoking, hypertension, and high cholesterol levels were other significant risk factors for coronary artery disease found in the study. (yourhealthbase.com)
Is isolated home hypertension as opposed to isolated office hypertension a sign of greater cardiovascular risk? (hdcn.com)

It is clear now that raised plasma homocysteine concentrations both predict and precede the development of cardiovascular disease including stroke. (medicaltesting-europe.com)

Plasma cholesterol concentration, lipoprotein profile, and homocysteine levels are a few of the other markers currently incorporated into the toolbox for assessment of the risk of coronary artery disease. (ift.org)
A low-dose daily supplement of folic acid improved levels homocysteine in people with high levels of the amino acid and could reduce the risk of coronary artery disease, suggests a small study from Taiwan. (nutraingredients-usa.com)
Homocysteine and coronary heart disease. (ox.ac.uk)
Children with homocystinuria have markedly elevated plasma homocysteine concentrations and increased risks of stroke and coronary heart disease (CHD). (ox.ac.uk)
Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins: the Atherosclerosis Risk in Communities (ARIC) study. (thieme-connect.de)
Plasma homocysteine levels and mortality in patients with coronary artery disease. (thieme-connect.de)
T polymorphism and risk of coronary heart disease: a meta-analysis. (ckbiobank.org)
CONTEXT: In observational studies, individuals with elevated levels of plasma homocysteine tend to have moderately increased risk of coronary heart disease (CHD). (ckbiobank.org)
The normal range of homocysteine in adults is between 5 and 15 micromol/L. An excess of just 5 micromol/L has been found to correspond to an increased risk of coronary artery disease of 60 per cent in men and 80 per cent in women. (yourhealthbase.com)
The researchers found that homocysteine levels increased in a linear fashion from 9.2 micromol/L for patients with no coronary disease to an average of 12.4 in patients with three-vessel disease. (yourhealthbase.com)
The researchers recommend routine testing of homocysteine levels as an important factor in evaluation risk for coronary artery disease. (yourhealthbase.com)
Association of plasma homocysteine with the number of major coronary arteries severely narrowed. (yourhealthbase.com)
A study published in the August 2004 issue of The American Journal of Clinical Nutrition examined folate and homocysteine levels in a group of Finnish men and found that folate, but not homocysteine, had a significant inverse association with the risk of experiencing an acute coronary event (defined as a heart attack or prolonged episode of chest pain). (lifeextension.com)
Men who experienced acute coronary events were older, had higher systolic blood pressures and higher cholesterol levels, and had lower lycopene levels than those who remained event-free. (lifeextension.com)
Those whose serum levels were in the highest one-third of the group had a risk of undergoing an acute coronary event that was 65 percent lower than that experienced by men whose folate was in the lowest third. (lifeextension.com)
In contrast with other studies, homocysteine levels were not associated with acute coronary event risk in this study, although when smokers were separately analzyed, high homocysteine was associated with almost double the risk of an acute coronary event compared to the risk experienced by smokers with low homocysteine. (lifeextension.com)

Data will be used in research to further define nutrient requirements as well as optimal levels for disease prevention and health promotion. (cdc.gov)
They are widely used in primary and secondary prevention of thrombotic cerebrovascular or cardiovascular disease. (cdc.gov)
Cardiovascular disease represents the world's leading cause of death and disability, placing a significant burden on both family and community. (dsm.com)
Over 17 million patients die annually of cardiovascular disease (CVD), representing 31% of all deaths and making CVD the leading cause of global morbidity and mortality by a significant margin. (dsm.com)
Cardiovascular disease etiologies remain complex and multifactorial. (dsm.com)
The critical role of NO bioavailability in vascular biology is well documented, and endothelial dysfunction - the reduced ability of the endothelium to produce NO - is a hallmark of cardiovascular disease. (dsm.com)
Total cholesterol is an independent risk factor for cardiovascular disease. (ecopolitan.com)
A person with this level has twice the risk of heart disease compared with someone whose cholesterol is 200 mg/dL. (ecopolitan.com)
The higher the level of LDL, the greater your risk for heart disease. (ecopolitan.com)
Rheumatoid arthritis (RA) is a chronic inflammatory systemic disease predisposing to atherosclerosis and high cardiovascular risk ( 1 , 2 ). (spandidos-publications.com)
Their life expectancy is reduced by 5-10 years and 35-50% of deaths result from cardiovascular disease ( 6 ). (spandidos-publications.com)
People who are at high risk of strokes and heart disease may greatly benefit by taking folic acid supplements. (encyclopedia.com)
Taking vitamin B6 supplements by mouth or eating large amounts of vitamin B6 in the diet doesn't seem to reduce the risk for Alzheimer disease. (medlineplus.gov)
In 2003, the American Heart Association and the Centers for Disease Control and Prevention issued guidelines for measuring inflammatory markers such as CRP in assessing the risk of cardiovascular disease ( http://circ.ahajournals.org/cgi/content/full/107/3/499 ). (ift.org)
In many cases, however, cardiac disease risk factors are reduced with appropriate weight reduction and dietary management, as indicated in guidelines from the National Cholesterol Education Program ( http://hin.nhlbi.nih.gov/ncep.htm ). (ift.org)
Elevated levels of this substance appear to be linked to certain chronic conditions such as heart disease and, possibly, depression and Alzheimer's Disease . (healthyplace.com)
Data should soon be available on three to seven years of supplementation with B vitamins on cognitive function on about 20,000 of the 50,000 participants with previous cardiovascular or renal disease in the 12 large homocysteine-lowering trials for the prevention of cardiovascular events. (nutraingredients-usa.com)
Middle-aged obesity has been consistently recognized in epidemiological studies as a risk factor for dementia and Alzheimer's disease (AD) 6 . (nature.com)
BACKGROUND: Epidemiological studies suggest that mild to moderate elevation in plasma homocysteine concentration is associated with increased risk of atherothrombotic cardiovascular (CV) disease. (ox.ac.uk)
METHODS: A total of 5522 patients aged 55 years or older with pre-existing CV disease or with diabetes and additional risk factor(s) at 145 centres in 13 countries were randomly assigned to daily therapy with combined folic acid 2.5 mg, vitamin B6 50 mg and vitamin B12 1 mg, or to placebo. (ox.ac.uk)
The risk of cardiovascular disease (CVD) correlates with an increase in plasma Hcy levels. (bvsalud.org)
ABSTRACT Hyperhomocysteinaemia is considered as an important independent risk factor for atherosclerosis and thrombotic disease. (who.int)
Further epidemiological studies are needed to determine the precise role of Hcy in cardiovascular disease. (who.int)
The definition of normohomocyst- a risk factor for cardiovascular disease Data collection einaemia was Hcy 15 µmol/L and (CVD) [1,2]. (who.int)
The risk factor for heart disease that is especially closely related to folate intake is blood homocysteine. (usda.gov)
In 1995, a gene was discovered that is a risk factor for neural tube defect, a disease that is sensitive to folate supplementation. (usda.gov)
Therefore, we investigated the interactive effects of individual traits of gender, age, BMI, and 64 gene variations on heart disease risk factor blood homocysteine. (usda.gov)
Therefore, gender and genotype for several specific genes are important determinants in heart disease risk factor blood homocysteine. (usda.gov)
As discussed, understanding Hcy and genetic regulation is hugely important as Hcy may be related to inflammation, obesity, cardiovascular disease, and diabetes mellitus. (usda.gov)
Reduce the risk of diverticular disease [3,4] 5. (slideshare.net)
Elevated plasma levels of the cholesteryl-ester rich lipoprotein (a) [Lp(a)] increase the risk for development of cardiovascular disease through both proatherogenic and prothrombotic properties [ 4 ]. (biomedcentral.com)
Cardiovascular disease is the leading cause of death in Canada. (unboundmedicine.com)
If population-based studies are correct, tHcy may be responsible for up to 10% of CAD events and thus may represent an important and potentially modifiable risk factor for cardiovascular disease. (unboundmedicine.com)
Homocysteine - An elevated concentration of homocysteine is an independent risk factor for cardiovascular disease. (ammoliteprodukties.nl)
A study published this year in the British Medical Journal1 showed clearly that homocysteine levels in blood plasma predicts risk of death from cardiovascular disease in older people even better than any conventional measure of risk including cholesterol, blood pressure or smoking. (medicaltesting-europe.com)
Homocysteine has therefore been shown to play a crucial role as a key marker for disease development determining longevity and health throughout a person's life. (medicaltesting-europe.com)
ABSTRACT This study investigated the role of hyperhomocysteinaemia as a risk factor in Sudanese adults suffering from cardiovascular disease or malaria and children with protein-energy malnutrition. (who.int)
Plasma homocysteine in Alzheimer's disease with or without co-morbid depressive symptoms. (nel.edu)
The association of high homocysteine with degree of cognitive impairment or stage of dementia in AD indicate potential role of high plasma homocysteine as a biomarker of the disease and/or indicator of brain damage during the progression of AD dementia. (nel.edu)
Kitzlerová E, Fisar Z, Jirák R, Zvĕrová M, Hroudová J, Benaková H, Raboch J. Plasma homocysteine in Alzheimer's disease with or without co-morbid depressive symptoms. (nel.edu)
Interventions that aimed to reduce the risk of disease by reducing Hcys have been unsuccessful. (uni-giessen.de)
Elevated levels of plasma homocysteine (Hcy) are associated with cognitive decline and dementia, as well as cardiovascular disease. (thestemcellfoundation.com)
The relevance, if any, of moderately elevated homocysteine levels to cardiovascular disease in the general population is uncertain. (ox.ac.uk)
The results of retrospective studies of homocysteine and risk of cardiovascular disease (where blood is collected after the onset of disease) indicate that CHD or stroke patients invariably have higher homocysteine levels than age-matched controls. (ox.ac.uk)
In contrast, the results of prospective studies (where blood is collected before onset of disease) show much weaker associations of homocysteine with cardiovascular disease. (ox.ac.uk)
This article examines the background, epidemiological evidence relating homocysteine with vascular disease, and effects of vitamin supplements on homocysteine concentrations. (ox.ac.uk)
Plasma homocysteine as a risk factor for cardiovascular disease: The European Concerted Action Project. (thieme-connect.de)
Prospective studies of homocysteine and cardiovascular disease. (thieme-connect.de)
Homocyst(e)ine and cardiovascular disease: a systematic review of the evidence with special emphasis on case-control studies and nested case-control studies. (thieme-connect.de)
A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. (thieme-connect.de)
Homocysteine and risk of ischemic heart disease and stroke. (thieme-connect.de)
Relation of serum homocysteine and lipoprotein(a) concentrations to atherosclerotic disease in a prospective Finnish population based study. (thieme-connect.de)
Homocyst(e)ine and risk of cardiovascular disease in the Multiple Risk Factor Intervention Trial. (thieme-connect.de)
There is substantial evidence that high levels of homocysteine (a sulphur- containing amino acid) are directly associated with an increased risk of cardiovascular disease. (yourhealthbase.com)
A team of American and Swiss researchers now reports that the severity of cardiovascular disease, as indicated by the number of arteries affected, is directly proportional to the homocysteine level. (yourhealthbase.com)
The study analzyed subjects in the Kuopio Ischaemic Heart Disease Risk Factor Study, which enrolled 2,682 men aged 42 to 60 between 1984 and 1989. (lifeextension.com)
The authors recommend intervention studies to determine the effect of folic acid supplements on cardiovascular health, and to ascertain whether the vitamin's ability to reduce homocysteine prevents heart disease or if high homocysteine and low folate levels are markers of atherosclerosis or an unhealthy lifestyle. (lifeextension.com)
Disease activity (DAS28) and plasma lipoproteins concentrations (total, HDL and LDL-cholesterol, triglycerides, ApoA, ApoB) were assessed in 55 RA patients and 55 controls. (bmj.com)
During therapy, the changes in disease activity and inflammatory status were inversely correlated with changes in plasma total and HDL cholesterol levels and positively correlated with the variation of atherogenic index. (bmj.com)
The long-term effects of menopause can include: bone loss and eventual osteoporosis, changes in cholesterol levels and greater risk of heart disease. (santegra.eu)
Niacin lowers heart disease risk. (santegra.eu)
It has suggested that grape juice consumption has lipid- lowering effect and it is associated with a decreased risk of heart disease. (openbiochemistryjournal.com)
alterations in this nutrient are a risk factor for cardiovascular disease. (biomedcentral.com)
The abling many patients with end-stage kidney disease (ESKD) level of evidence was evaluated using the Grading of Rec- to maintain their lives. (bvsalud.org)
Learn how to accurately quantify your personal heart disease status and risk, and if necessary, take clear actions to reduce that risk by eliminating plaque in the arteries. (thequantifiedbody.net)
We focus on the key topic of quantifying your real heart disease risk. (thequantifiedbody.net)
One in three deaths in the United States are caused by cardiovascular disease. (thequantifiedbody.net)
While heart disease is a big risk which is worthwhile taking a look at, it is not a big risk for everyone. (thequantifiedbody.net)
Thus it is important to know if heart disease is something you personally need to act on - in a proactive way which reduces the risk for it. (thequantifiedbody.net)
The way to approach this issue is by quantifying our risk for cardiovascular disease. (thequantifiedbody.net)
In this show we go deeper into details, looking at metrics which give you a real accurate view of your heart disease status and risk. (thequantifiedbody.net)
To really nail down your personal risk of experiencing the number one killer in the Western world, heart disease. (thequantifiedbody.net)
Joel Kahn has focused his career on preempting cardiovascular and heart disease. (thequantifiedbody.net)
Infrared Sauna treatment is proven to have positive effects on cardiovascular disease treatment (23:27). (thequantifiedbody.net)
Using chelation in treating disease to lower toxins levels - including heavy metals (26:03). (thequantifiedbody.net)
The abnormality is established by measuring fasting plasma homocysteine levels in patients with cardiovascular disease or thromboembolism who are suspected of having the disorder. (msdmanuals.com)
Vitamin D may modulate cardiometabolic disease risk, although the relationship has not been investigated in the general Canadian population. (cdc.gov)
Vitamin D may modulate various metabolic processes and may influence cardiometabolic disease risk in Canadians. (cdc.gov)
Inadequate vitamin D status has been associated with elevated cardiometabolic disease risk, although results are inconsistent, as evidenced by recent meta-analyses pooling multiple study populations (6-8). (cdc.gov)
Understanding the association between vitamin D and cardiometabolic risk in Canadians may provide a clearer understanding of how this micronutrient modulates cardiometabolic disease and may inform public health strategies to curb the incidence of cardiometabolic disease in Canada and elsewhere. (cdc.gov)
We assessed chronic disease and chronic disease risk factors. (cdc.gov)

"The significant result of this study was that a low dose of folic acid supplementation (400 microg/d) could significantly decrease plasma homocysteine concentration in hyperhomocysteinemic patients with CAD but not in normohomocysteinemia patients," wrote the researchers. (nutraingredients-usa.com)
Low-dose folic acid supplementation for eight weeks for the TT genotype people led to a significant 2.1 micromoles per litre reduction in homocysteine levels, and 1.4 micromoles per litre for people who carry the T-allele either hetero- or homozygously. (nutraingredients-usa.com)
A low-dose (400 microg/d) rather than a high-dose of folic acid supplementation may be sufficient to reduce plasma homocysteine concentration in hyperhomocysteinemic patients with CAD. (nutraingredients-usa.com)
It has been reported that vitamin B12 is a more important determinant of high homocysteine levels in people over 70 than folate, and some experts have called for future studies to focus on dietary supplementation of 1000 micrograms of B12 in elderly people. (nutraingredients-usa.com)
In this study we report on the effect of this intervention with and without fiber supplementation on plasma homocysteine, lipoprotein (a) [Lp(a)], C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-α). (biomedcentral.com)
This article reviews the available evidence on the association between plasma tHcy levels and CAD and the effect of lowering tHcy levels through vitamin supplementation or dietary intake. (unboundmedicine.com)
Supplementation with folic acid, vitamin B6, and vitamin B12 lower homocysteine levels and such therapy is remarkably effective in delaying the occurrence of vascular events in affected individuals. (ox.ac.uk)
Folic acid supplementation may protect athletes against alterations that can lead to cardiovascular events related to exertion during competition. (biomedcentral.com)

Additionally high levels appear to be independently associated with strokes and dementia as well as other things. (ecopolitan.com)
The findings may also have an impact on cognitive function with epidemiological studies reporting that high levels of homocysteine associated with suspected or confirmed dementia. (nutraingredients-usa.com)
Indeed, the Framingham study reported that people with homocysteine levels above 14 micromoles per litre of serum had twice the risk of dementia. (nutraingredients-usa.com)
This has led to the hypothesis that by lowering circulating levels of homocysteine by B vitamin supplements, the risk and occurrence of dementia could be reduced. (nutraingredients-usa.com)
Recent research shows that obesity in middle age is not only associated with an increased risk of dementia in old age but also with a decrease in the rate of cognitive function in middle age itself. (nature.com)
Raised levels of homocysteine are also linked to Alzheimer's, dementia, declining memory, poor concentration and judgment and lowered mood2. (medicaltesting-europe.com)
Silent brain infarcts and white matter lesions are frequently seen on magnetic resonance imaging in healthy elderly people and both are associated with an increased risk of stroke and dementia. (ox.ac.uk)
Plasma total homocysteine may be a potentially modifiable risk factor for stroke and dementia. (ox.ac.uk)

However, little is known about the association between plasma homocysteine levels and peripheral microvascular endothelial dysfunction (PMED), which is an integrated index of vascular health. (elsevierpure.com)
This study was designed to detect an association between plasma homocysteine and AD with or without co-morbid depressive symptoms. (nel.edu)

In most cases, vitamin B-12 deficiency is associated with an elevation in plasma homocysteine and methylmalonic acid levels, whereas folate deficiency is associated with elevated homocysteine levels only. (medscape.com)

Using linear regression models, we studied the main and two-way interaction effects of the predictor variables gender, age, BMI, and 64 folate/vitamin B-12/homocysteine/lipid/cholesterol-related single nucleotide polymorphisms (SNP) on log-transformed plasma homocysteine normalized by red blood cell folate measurements (nHcy) in 373 healthy Caucasian adults, 50% women. (usda.gov)
Serum levels of neuro- and immunomodulatory adrenal steroids together with selected hormonal, lipid and other relevant biochemical parameters were investigated to examine the differences between first-episode schizophrenia patients and age-matched healthy subjects, and the effect of treatment with atypical antipsychotics. (nel.edu)
The aim of our study was to investigate CVD risk markers, such as asymmetric dimethylarginine (ADMA), lipoprotein-associated phospholipase A2 (Lp-PLA2), highly sensitive C-reactive protein (hsCRP), homocysteine, lipid levels, ankle-brachial index (ABI), and carotid intima media thickness (CIMT) in CS. (endocrine-abstracts.org)
Short-term effects of anti-TNF on plasma lipid concentrations seemed beneficial and anti-atherogenic. (bmj.com)
1 Among the traditional cardiovascular risk factors, the lipid profile in RA has often been described as "pro-atherogenic", 2 based on decreased HDL-cholesterol (HDL-C) and increased LDL:HDL-C ratio and lipoprotein (a) plasma concentrations in both active and treated RA. (bmj.com)

Vitamin B9 works closely with vitamins B6 and B12 as well as the nutrients betaine and S-adenosylmethionine (SAMe) to control blood levels of the amino acid homocysteine. (healthyplace.com)
A deficiency of Vitamin B6, B12 and folic acid have been linked to elevated levels of the amino acid homocysteine. (tissuerecovery.com)

Recently, homocysteine has been studied as an independent risk factor for atherosclerosis which negatively affects vascular endothelial cells. (degruyter.com)
RA is characterized by a significant biological inflammatory syndrome that leads to a significant risk of atherosclerosis that can be assessed by carotid intima-media thickness (IMT). (spandidos-publications.com)

Reduce osteoporosis and rheumatoid arthritis risk incidence [3,4] 6. (slideshare.net)
However, these factors do not entirely account for the occurrence of stroke in unexposed populations and also fail to explain the incidence of stroke in select individuals within a population that is uniformly exposed to environmental risk factors. (bmj.com)
However, the true incidence, prevalence and risk factors associated with SBI remain controversial. (biomedcentral.com)
However, the true incidence and prevalence of SBI remain controversial, and our understanding of risk factors limited. (biomedcentral.com)
6 However, the increased incidence of cardiovascular events in RA patients cannot be entirely explained by these traditional risk factors. (bmj.com)
Higher levels of homocysteine increased the incidence of deep vein thrombosis. (yourfibrodoctor.com)

These data will be used to estimate deficiencies and other health effects of specific nutrients in the population and subgroup, to provide population reference data, and to estimate the contribution of diet, supplements, and other factors to the levels of nutrients. (cdc.gov)
Globally, clinical outcomes vary considerably according to dietary standards, vitamin and mineral fortification and a variety of patient-specific risk factors and comorbidities. (dsm.com)
Factors associated with cardiovascular risk, such as smoking, aging, and body mass index are also associated with elevated CRP. (ift.org)
These guidelines stem from the vital need to identify better biomarkers that assess clinical risk that are based on many factors, including epidemiological studies and utilization of other markers to predict health outcomes. (ift.org)
This study determined the distribution of homocysteine (Hcy) levels in healthy Tunisian subjects and evaluated the relationship between Hcy levels and some cardiovascular risk factors. (who.int)
Body eters showed a normal distribution only in Tunisia and their impact on CVD mass index (BMI) was calculated as for BMI, HDL cholesterol and apolipo- risk factors. (who.int)
less is known regarding emerging CVD risk factors. (biomedcentral.com)
Though traditional markers of cardiovascular risk are still an integral part of initial cardiovascular risk assessment, several additional risk factors have emerged that provide a more complete picture of total risk status. (biomedcentral.com)
The cross-sectional relation of total homocysteine with silent infarcts and white matter lesions was analyzed with adjustment for cardiovascular risk factors. (ox.ac.uk)
We concluded that total homocysteine levels are associated with silent brain infarcts and white matter lesions independent of each other and of other cardiovascular risk factors. (ox.ac.uk)
Homocysteine levels, however, are not a highly specific indicator of folate status because they can be influenced by other factors, including kidney dysfunction and deficiencies of vitamin B12 and other micronutrients [ 1 , 3 , 9 , 10 ]. (nih.gov)
Hyperhomocysteinaemia in stroke: prevalence, cause, and relationships to type of stroke and stroke risk factors. (thieme-connect.de)
T genotype, case-control status, and plasma levels of homocysteine, folate, and other cardiovascular risk factors. (ckbiobank.org)
This systematic review supports the association of a number of traditional vascular risk factors, but also highlights disparities between clinically apparent and silent strokes, potentially suggesting important differences in pathophysiology and warranting further investigation. (biomedcentral.com)
۴-Is Reducing Ovarian Volume in Polycystic Ovarian Syndrome Patients after Administration of Metformin Associated with Improving Cardiovascular Risk Factors? (drneghab.com)
Population-based and multicenter case-control studies have identified acquired risk factors that may contribute to the development of VTE. (medscape.com)
In the perioperative period, there are several characteristic risk factors that contribute to an increase in VTE. (medscape.com)

Folic acid, together with vitamins B 6 and B 12 , helps break down homocysteine, and may help reverse the problems associated with elevated levels. (encyclopedia.com)

It could be anything smoldering, but there has been a lot of work done in the past 10 years that suggests that many people with no overt inflammatory condition and who have elevated levels (not as high as RA mind you) are at increased risk for CVD. (ecopolitan.com)
Hence this is an independent risk factor for CVD and the general acceptance that CVD is in part an inflammatory mediated condition. (ecopolitan.com)
These medications can inhibit or reduce the inflammatory process and thus reduce blood levels of CRP. (ift.org)
However, the overall impact of these changes on the cardiovascular risk is more complex, considering the strong anti-inflammatory effects of anti-TNF drugs. (bmj.com)
7 Increased levels of inflammatory markers, including CRP and IL-6, have been shown to be associated with the risk of developing acute cardiovascular events in the general population. (bmj.com)

In a retrospective study, Shrum et al found no association between ocular pseudoexfoliation and cardiovascular or cerebrovascular mortality. (medscape.com)
The association between HHcy and PMED, and its impact on MACE (all-cause mortality and atherosclerotic cardiovascular events) was investigated. (elsevierpure.com)

People with the so-called TT homozygote genotype with low folate status are reported to have higher homocysteine concentrations than the other genotypes, putting this subset at increased risk of CAD and cognitive decline. (nutraingredients-usa.com)

The link is being further examined by the B-Vitamin Treatment Trialists' Collaboration which should soon be better able to address the link between B-vitamins, homocysteine levels, cardiovascular health, and cognitive function. (nutraingredients-usa.com)
Rationale, design and baseline characteristics of a large, simple, randomized trial of combined folic acid and vitamins B6 and B12 in high-risk patients: the Heart Outcomes Prevention Evaluation (HOPE)-2 trial. (ox.ac.uk)
Simple, inexpensive and nontoxic therapy with folic acid and vitamins B6 and B12 reduces plasma homocysteine levels by approximately 25% to 30% and may reduce CV events. (ox.ac.uk)
OBJECTIVES: To evaluate whether long-term therapy with folic acid and vitamins B6 and B12 reduces the risk of major CV events in a high-risk population. (ox.ac.uk)
HOPE-2 is one of the largest trials of folate and vitamins B6 and B12 and is expected to significantly contribute to the evaluation of the role of homocysteine lowering in CV prevention. (ox.ac.uk)
Homocysteine Cardioplex overcomes these challenges by supplying highly absorbable and bioavailable forms of key B vitamins along with diverse methyl donor nutrients. (patientoneformulas.com)
Supplying vitamins B-6 (as pyridoxal-5-phosphate) and B-12 (as methylcobalamin), Homocysteine Cardioplex provides two extensively researched clinical standards for nutritional homocysteine management. (patientoneformulas.com)
Insufficient vitamin B 12 and folate correlate with plasma homocysteine levels, and supplemental B vitamins and folate can be part of an effective dietary treatment [ 4 ]. (biomedcentral.com)
B-vitamins are important for many reasons and especially the nervous systems but also for the cardiovascular system. (tissuerecovery.com)
Homocysteine levels are properly maintained through the presence of certain vitamins including vitamin B12, folate and vitamin B6. (yourfibrodoctor.com)
Homocysteine lowering by B vitamins and the secondary prevention of deep vein thrombosis and pulmonary embolism: A randomized, placebo-controlled, double-blind trial. (msdmanuals.com)

Specimen preparation: Plasma (preferred) or serum should be separated within one hour of collection and then transferred to a transport tube. (medscape.com)
MTHFR polymorphisms and serum cobalamin affect plasma homocysteine concentrations differentially in females and males. (medscape.com)
Labcorp test details for Copper, Serum or Plasma. (ammoliteprodukties.nl)
Serum folate and risk for ischemic stroke. (thieme-connect.de)
Blood samples drawn at the beginning of the study provided serum folate and total homocysteine levels. (lifeextension.com)
Folate concentrations in serum and cerebrospinal fluid fall and plasma homocysteine rises with age, perhaps contributing to the ageing process. (santegra.eu)
Serum HDL-C, apoAI, apoB and plasma Hcy levels were measured before and after one month RGj consumption. (openbiochemistryjournal.com)
The present study demonstrates that RGj consumption can significantly increase serum HDL-C levels and decrease Hcy levels. (openbiochemistryjournal.com)

High homocysteine has also been linked to migraines, and those with conditions such as diabetes and osteoporosis are at increased risk of raised homocysteine levels. (medicaltesting-europe.com)

according to neurological investigations, hippocampal atrophy due to obesity in middle age has been associated with an increased risk of cognitive deterioration in the elderly 13 , 14 . (nature.com)

The researchers report that, while the low-dose folic acid supplements had no significant effect on homocysteine concentrations in the general study population, levels did significantly decrease in hyperhomocysteinemic subjects by 1.8 micromoles per litre. (nutraingredients-usa.com)
Subjects with hyperhomocysteinaemia had significantly elevated total cholesterol, LDL cholesterol, apolipoprotein A and apolipoprotein B and lower vitamin B levels compared with subjects with 12 normohomocysteinaemia. (who.int)
Trans fatty acid intake was significantly reduced (-38.6%) while dietary folate was unchanged, as was plasma homocysteine. (biomedcentral.com)
Significantly higher mean plasma homocysteine was found in AD patients, but not in depressive patients, when compared with controls. (nel.edu)
Significantly lower dehydroepiandrosterone sulfate and of 7α-hydroxy- dehydroepiandrosterone levels than in controls were found in male patients. (nel.edu)
Results: Plasma ADMA levels were significantly lower in CS compared to the control group ( P =0.013). (endocrine-abstracts.org)
The severity of periventricular white matter lesions and extent of subcortical white matter lesions were also significantly associated with total homocysteine levels, even after excluding those with silent brain infarcts. (ox.ac.uk)
Higher levels of lead independently predicted significantly higher levels of plasma Hcy. (thestemcellfoundation.com)
CONCLUSIONS: Individuals with the MTHFR 677 TT genotype had a significantly higher risk of CHD, particularly in the setting of low folate status. (ckbiobank.org)

Yet, these markers cannot and should not be accepted as stand-alone indicators of risk. (ift.org)

14 Moreover, the PACIFIC study - a double-blind, placebo-controlled, factorial randomized trial assessing the effects of two doses of folic acid versus placebo on plasma homocysteine levels - clearly demonstrated the beneficial effects of high-dose folic acid therapy in high-risk patients. (dsm.com)
Generally above 130 is considered high, but some high risk individuals should have that even lower. (ecopolitan.com)
High triglyceride levels also are associated with increased CVD risk. (ecopolitan.com)
That is, someone with rheumatoid arthritis would have a very high level. (ecopolitan.com)
Thus high levels are independently associated with CVD. (ecopolitan.com)
IMT ≥1 mm indicates a high risk of myocardial infarction and cerebrovascular accidents ( 9 ). (spandidos-publications.com)
Taking vitamin B6 by mouth, usually with folic acid, is effective for treating high homocysteine levels in the blood. (medlineplus.gov)
Some researchers have even speculated that there is a connection between high levels of this amino acid and cervical cancer, but the results of studies regarding this have been inconclusive. (healthyplace.com)
Therefore, a large, randomized clinical trial--the Heart Outcomes Prevention Evaluation (HOPE)-2 study--is being conducted to evaluate this therapy in patients at high risk for CV events. (ox.ac.uk)
RESULTS: The patients' baseline characteristics confirmed their high-risk status. (ox.ac.uk)
In the other mutations associated with homocystinuria, plasma levels can vary from high to intermediate. (medscape.com)
Patients aged 21-24: Patients will receive Image-guided Pap and, when the result is ASC-US, a high-risk HPV mRNA test. (ammoliteprodukties.nl)
It is clear that women with high homocysteine levels find it harder to conceive and are at risk from repeated early miscarriage3. (medicaltesting-europe.com)
Even where diagnosed by history, medical examina- hyper homocysteinaemia is a well estab- tion, electrocardiogram, echocardiogram lished risk factor, we do not know the exact and blood tests, including enzymes (tro- mechanism whereby high homocysteine ponin T and creatine phosphokinase). (who.int)
High levels of autoantibodies against thyroid peroxidase in the patients support the autoimmunity hypothesis of schizophrenia. (nel.edu)
In part two of this blog series I want to share more about the dangers of poor MTHFR conversion and high homocysteine levels. (yourfibrodoctor.com)
Through these mechanisms, high homocysteine levels contribute to widespread blood vessel injury. (yourfibrodoctor.com)
We aimed to evaluate the effects of red grape juice (RGj) consumption on high density lipoprotein-cholesterol (HDL-C), apolipoprotein AI (apoAI), apolipoprotein B (apoB) and homocysteine (Hcy) levels in healthy human volunteers. (openbiochemistryjournal.com)
Objectives: The aim of the work was to find biomarkers identifying patients at high risk of adverse clinical outcomes after TAVI and SAVR in addition to currently used predictive model (EuroSCORE). (muni.cz)
Conclusion: We identified malondialdehyde, a marker of oxidative stress, as the most promising predictor of adverse outcomes during the 30-day and 1-year follow-up in high-risk patients with symptomatic, severe aortic stenosis treated with TAVI. (muni.cz)
60%, indicating that aerobic exercise avoided abrupt changes in Hcy and may thus reduce the risk of cardiovascular accidents in high-performance athletes. (biomedcentral.com)

The mean plasma total homocysteine level was 11.5 micromol/l (standard deviation 4.1). (ox.ac.uk)
The most commonly used cutoff value for elevated homocysteine levels is 16 micromol/L, although slightly lower values of 12 to 14 micromol/L have also been used [ 2 ]. (nih.gov)
A homocysteine cutoff of 10 micromol/L has been proposed for assessing folate status in populations [ 3 ]. (nih.gov)
Homocysteine levels should be kept below 7 micromol/L of blood plasma. (yourfibrodoctor.com)

Lead Exposure and Plasma Homocysteine in Older Men: A Mechanism of Neurotoxicity and Vascular Toxicity? (thestemcellfoundation.com)

We previously demonstrated that intake of three eggs/d for 4 weeks increased plasma choline and decreased inflammation in subjects with metabolic syndrome (MetS). (mdpi.com)
Homocysteine is actually a by product of certain normal metabolic amino acid breakdown and processing. (ecopolitan.com)
The researchers looked at potential genetic defects in the metabolic pathway of homocysteine involving the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene mutation. (nutraingredients-usa.com)
simplified picture, showing Homocysteine involvement in different metabolic pathways as well as the role of vitamin B6, B12 and Folate as a co-factor in this pathways. (medscape.com)
Caption: Homocysteine involvement in different metabolic pathways, as well as the role of vitamin B-6, vitamin B-12, and folate as cofactors in these pathways. (medscape.com)
In particular, CRD have been repeatedly shown to promote weight loss and improve fasting and postprandial triglycerides, and plasma HDL-cholesterol (HDL-C), which indicates that such an approach may be an important treatment option for the dyslipidemia associated with the metabolic syndrome [ 2 ]. (biomedcentral.com)
Genetic polymorphisms in the vitamin D receptor and vitamin D metabolic pathway may impact levels of circulating vitamin D3. (ethicare.in)

Any cholesterol level of 200 mg/dL or more increases your risk. (ecopolitan.com)
The problem here is that homocysteine, akin to LDL cholesterol, appears to be athrogenic, i.e. it damages the vessel wall. (ecopolitan.com)
Hcy levels correlated with total cholesterol ( r = 0.09), apolipoprotein A ( r = 0.012), and B ( r = 0.013) levels and total/HDL cholesterol ratio ( r = -0.085). (who.int)
This group showed reduction in plasma LDL-cholesterol and triglycerides and elevations in HDL-cholesterol as well as reductions in large and medium VLDL particles and increases in LDL particle size. (biomedcentral.com)
However, these changes did not persist: plasma concentrations of total and LDL-cholesterol and the atherogenic index increased after 6 months and 1 year from the start of therapy. (bmj.com)
Homocysteine speeds up the oxidation (causing toxic damage) of cholesterol, which then becomes bound to small LDL particles. (yourfibrodoctor.com)
Estrogen is essential for maintaining healthy cardiovascular system, cholesterol level and strong bones. (santegra.eu)
Naturally, understanding of risk goes beyond the typical cholesterol numbers. (thequantifiedbody.net)
His goal is to reduce risks as well as to avoid surgery and cholesterol - lowering drugs. (thequantifiedbody.net)

Recent advances in genomics and statistical computation have allowed us to begin addressing the genetic basis of stroke at a molecular level. (bmj.com)

7,8 In fact, epidemiologic studies and clinical trials have consistently demonstrated that a 20% to 25% relative reduction in homocysteine levels is associated with a significant reduction in cardiovascular events. (dsm.com)
For example, although the general population of North America - where fortification of foods is mandated - on average achieves the RDA (recommended dietary allowance) of 400 mg/d for folate, clinical studies of folate in the restoration of endothelial function suggest that higher doses of folic acid are required to confer benefits on cardiovascular endpoints. (dsm.com)
Zhang F, Li X, Dong Q, Wang Y, Zhang H. Risk of Acute Cerebral Infarction and Plasma Asymmetrical Dimethylarginine and Homocysteine Levels: A Clinical Correlation Analysis of Chinese Population. (medscape.com)
1. Undas A, Brozek J, Szczeklik A . Homocysteine and thrombosis: from basic science to clinical evidence. (msdmanuals.com)

C-reactive protein, an indicator of acute inflammation, is the subject of considerable controversy as an important biomarker of cardiovascular health. (ift.org)
It is believed to hinder formation of homocysteine at plasma protein binding sites while encouraging efficient elimination of homocysteine via urinary excretion. (patientoneformulas.com)
Homocysteine is a naturally occurring amino acid with the formula HSCH2CH2CH(NH2)CO2H, a derivative of protein that is found in blood plasma when body chemistry is out of balance. (medicaltesting-europe.com)

Plasma homocysteine can be a serious cardiovascular, endothelial and renal risk factor. (patientoneformulas.com)
As it works to promote healthy endothelial function, NAC offers further support for overall cardiovascular wellness. (patientoneformulas.com)
Thus, the link between homocysteine and MACE could be mediated by endothelial dysfunction, and will require further clarification with future studies. (elsevierpure.com)

Behavioral Risk Factor Surveillance System. (cdc.gov)
In this case, CRP is not a golden marker for inflammation, even though the Multiple Risk Factor Intervention Trial (Kuller et al. (ift.org)
Whether elevated plasma and urine homocysteine levels represent a cardiovascular risk factor is debatable. (medscape.com)
The importance of homocysteine as a risk factor is becoming much more familiar to us. (medicaltesting-europe.com)
Increased homocysteine is recognized as a risk factor for several serious conditions. (tissuerecovery.com)

Homocysteine, testosterone and allopregnanolone concentrations were measured in the fasting plasma from 16 women who underwent total thyroidectomy, and who were either hypothyroid or euthyroid. (degruyter.com)
Plasma homocysteine concentrations were measured in 85 AD patients (36 of them with depressive symptoms), 33 non-AD patients with a depression diagnosis and 44 healthy controls, all aged above 50 years. (nel.edu)

Assessments were performed on 115 patients diagnosed with RA on biological treatment to determine the evolution of IMT and Hcy levels. (spandidos-publications.com)
Carotid ultrasonography was used to assess the IMT, as a fast and easy tool for the prediction of cardiovascular events in patients with RA. (spandidos-publications.com)
However, folic acid supplements do not seem to lower plasma homocysteine in patients with CAD with normal plasma homocysteine level. (nutraingredients-usa.com)
Pirouzpanah S, Taleban FA, Mehdipour P, Atri M, Foroutan-Ghaznavi M. Plasma Total Homocysteine Level in Association With Folate, Pyridoxine, and Cobalamin Status Among Iranian Primary Breast Cancer Patients. (medscape.com)
We confirmed significant correlation between homocysteine concentration and the degree of cognitive impairment in AD patients. (nel.edu)
There was no incremental effect of concurrent depressive symptoms on homocysteine concentration in AD patients. (nel.edu)
Lower levels of 7α-hydroxydehydroepiandrosterone, abundant especially in brain, determined for the first time in schizophrenia patients, are in agreement with recent opinion of their neuroprotective and immunoprotective role. (nel.edu)
The patients had their homocysteine levels measured and an angiogram taken. (yourhealthbase.com)
Therefore, routine measurement of homocysteine levels in patients with venous and arterial thromboembolism is discouraged. (msdmanuals.com)
Recurrence is a risk in patients who have had VTE episodes. (medscape.com)

Emerging research has highlighted the role of B-vitamin therapy in cardiovascular risk reduction. (dsm.com)

Using large amounts of folic acid (e.g., over 5,000 mcg per day) can mask a vitamin B 12 deficiency and thereby risk of irreversible nerve damage. (encyclopedia.com)
Pregnancy can put a woman at risk for folic acid deficiency as the fetus easily depletes a mother's nutrient reserves. (healthyplace.com)
Folic acid deficiency during pregnancy increases the risk for neural tube defects including cleft palate, spina bifida, and brain damage. (healthyplace.com)
Recent studies in test tubes brings into question whether there is a connection between elevated homocysteine (and, therefore, folate deficiency) in the mother and Down's syndrome in the child. (healthyplace.com)
Plasma homocysteine levels are elevated in vitamin B-12 deficiency, vitamin B-6 deficiency and in folic acid deficiency. (medscape.com)
Plasma homocysteine levels are usually severely elevated in homozygous cystathionine-β synthase deficiency and moderately elevated in heterozygous cystathionine-β synthase deficiency. (medscape.com)
If elevated tHcy levels are discovered, vitamin deficiency should be ruled out to allow specific treatment and prevention of complications, such as neurological sequelae due to vitamin B12 deficiency. (unboundmedicine.com)
Handball players are a population at risk for nutrient deficiency because of poor dietary habits. (biomedcentral.com)
Plasma homocysteine levels are elevated ≥ 10-fold in homozygous cystathionine beta-synthase deficiency. (msdmanuals.com)
Furthermore, describing how vitamin D levels fluctuate month-to-month may provide a basis for implementing public health strategies to increase 25(OH)D levels when deficiency is most acute. (cdc.gov)
Vegetarians, particularly strict vegetarians, need to be aware of the risk of vitamin B-12 deficiency and other vitamin deficiencies. (medscape.com)

Strong consideration should be given to supplementing vitamin intake and checking levels. (medscape.com)

Gender and single nucleotide polymorphisms in MTHFR, BHMT, SPTLC1, CRBP2R, and SCARB1 are significant predictors of plasma homocysteine normalized by RBC folate in healthy adults. (usda.gov)

A prospective study of folate and vitamin B6 and risk of myocardial infarction in US physicians. (thieme-connect.de)

Anatomy7

Organisms1

Diseases19

Chemicals and Drugs53

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Psychiatry and Psychology2

Phenomena and Processes16

Technology, Industry, Agriculture4

Named Groups2

Health Care19

Geographicals1

Metabolism13

Hyperhomocysteinemia7

Methionine11

Blood homocysteine levels4

Diseases25

Hypertension8

Raised plasma homocysteine concentrations1

Coronary16

Disease81

Supplementation8

Dementia8

Association between plasma homocysteine2

Elevation in plasma homocysteine1

Lipid5

Amino acid homocysteine2

Atherosclerosis2

Incidence6

Factors17

Break down homocysteine1

Inflammatory5

Mortality2

Higher homocysteine1

Vitamins11

Serum8

Diabetes1

Obesity1

Significantly9

Markers1

High21

Micromol4

Vascular1

Metabolic7

Cholesterol9

Stroke1

Clinical4

Protein3

Endothelial3

Factor5

Concentrations were measured2

Patients10

Reduction1

Deficiency11

Intake1

MTHFR1

Folate and vitamin1