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  • standardization
  • CONCLUSIONS: The secondary reference material identified in this study has the potential to substantially improve equivalence between hepcidin measurement procedures and contributes to the establishment of a traceability chain that will ultimately allow standardization of hepcidin measurement results. (ox.ac.uk)
  • mutations
  • Different mutations of HJV are responsible for juvenile hemochromatosis (or type 2 hemochromatosis), 1 a severe disease with an early onset, characterized by hepcidin insufficiency which leads to clinical complications of iron overload, in particular hypogonadism and cardiomyopathy. (haematologica.org)
  • Tissue
  • The objective of this study was to determine if abdominal subcutaneous adipose tissue (AbScAT) releases hepcidin in vivo and if release is modified by obesity. (hindawi.com)
  • measurement
  • Eleven plasma hepcidin measurement procedures (5 mass spectrometry based and 6 immunochemical based) quantified native individual plasma samples (n = 32) and native plasma pools (n = 8) to assess analytical performance and current and achievable equivalence. (ox.ac.uk)
  • RESULTS: Absolute hepcidin values and reproducibility (intrameasurement procedure CVs 2.9%-8.7%) differed substantially between measurement procedures, but all were linear and correlated well. (ox.ac.uk)
  • Linear regression analysis and standardized residuals showed that a candidate reference material consisting of native lyophilized plasma with cryolyoprotectant was commutable for all measurement procedures. (ox.ac.uk)
  • maternal
  • The potential for the use of hepcidin for a simple point-of-care (PoC) diagnostic for when it is most safe and effective to give iron may improve maternal health outcomes. (biomedcentral.com)
  • whereas
  • We have previously shown that several hemojuvelin variants do not efficiently reach the plasma membrane, whereas a few N-terminal mutants localize to the plasma membrane. (haematologica.org)
  • found
  • The increased clearance of 25-hepcidin by HDF could be of benefit for the dialysis patient, bringing the pathological iron homeostasis found in this population toward a more normal state. (skemman.is)
  • Results
  • Results S85P, G99V and ΔRGD were localized to plasma membrane 36 hours after transfection, but less efficiently exported than the wild-type protein at earlier (24-30 hours) times. (haematologica.org)
  • study
  • Findings from this vein drainage study suggest there is no net release of hepcidin from the AbScAT depot and thereby no ability to signal systemically, even in obesity. (hindawi.com)
  • In this study, we aimed to determine the changes in pro-inflammatory cytokines and newly discovered antimicrobial proteins like hepcidin, chemerin and defensin in elderly women with IDA. (org.pk)
  • determine
  • To determine whether hepcidin interacts with Fpn, we generated a stable cell line (HEK293-Fpn) expressing mouse Fpn with a C-terminal green fluorescent protein (GFP) under the control of the ecdysone-inducible promoter. (sciencemag.org)