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  • homocysteine
  • Mild hyperhomocysteinemia, ie, an elevation of the plasma levels of homocysteine, homocystine, or homocysteine-mixed disulfides, has been shown to be a risk factor for atherosclerotic vascular disease and its thrombotic complications. (ahajournals.org)
  • Humans with either acutely elevated total plasma homocysteine levels after a methionine challenge 16-19 or chronic, mild hyperhomocysteinemia 20,21 also show impaired endothelium-dependent vasodilator function but preserved endothelium-independent vasodilator responses. (ahajournals.org)
  • One of the mechanisms suggested for the adverse effects of homocysteine on endothelial function involves oxidant stress, with a resulting depletion of bioavailable NO. 24 When added to plasma, homocysteine, like other thiol-containing amino acids, undergoes auto-oxidation, which is accompanied by the generation of reactive oxygen species such as hydrogen peroxide (H 2 O 2 ) or superoxide anion. (ahajournals.org)
  • In healthy blood donors and in patients with CAD complicated by myocardial infarction (MI) four apolipoprotein gene polymorphisms [APO (a) PNR, APO E, APO CI and APO CII] were determined and plasma levels of total homocysteine, total cholesterol (TC), triglycerides (TG), HDL-cholesterol (HLD-C) and apolipoproteins (apo A-I, Apo B, Apo E) were measured. (beds.ac.uk)