AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesTechnology, Industry, AgricultureInformation ScienceHealth Care
CholesterolCholesterol, DietaryCholesterol, HDLCholesterol, LDLCholesterol EstersLipoproteinsTriglyceridesHypercholesterolemiaLipidsCholesterol, VLDLCholesterol 7-alpha-HydroxylaseAnticholesteremic AgentsCholesterol OxidasePlasmaLiverApolipoproteins EReceptors, LDLHydroxymethylglutaryl CoA ReductasesLipoproteins, HDLDietary FatsArteriosclerosisBile Acids and SaltsDiet, AtherogenicLipoproteins, LDLApolipoprotein A-IHyperlipidemiasSterolsApolipoproteinsApolipoproteins BSterol O-AcyltransferaseSitosterolsLipoproteins, VLDLPhosphatidylcholine-Sterol O-AcyltransferaseLipid MetabolismBileCholestyramine ResinFats, UnsaturatedPhytosterolsPhospholipidsIntestinal AbsorptionHyperlipoproteinemia Type IIBody WeightDietATP Binding Cassette Transporter 1LovastatinCholesterol Ester Transfer ProteinsEsterificationFatty AcidsAtherosclerosisApolipoprotein E3XanthomatosisAortaVegetable ProteinsApolipoproteins ADehydrocholesterolsRabbitsFecesHydroxymethylglutaryl-CoA Reductase InhibitorsCell MembraneCholestanolBiological TransportHydroxycholesterolsATP-Binding Cassette TransportersAzetidinesFatty Acids, MonounsaturatedTime FactorsDesmosterolbeta-CyclodextrinsDietary FiberMesocricetusMice, KnockoutHypolipidemic AgentsMevalonic AcidMice, Inbred C57BLPhosphatidylcholinesSmith-Lemli-Opitz SyndromePlant OilsPlasma CellsEggsDietary Fats, UnsaturatedSimvastatinBlood GlucoseSoybean ProteinsPlant GumsCorn OilCyclodextrinsScavenger Receptors, Class BAortic DiseasesFoam CellsSteroidsCricetinaeApolipoprotein A-IIProbucolChenopodiaceaeSterol EsteraseLecithin Acyltransferase DeficiencyRisk FactorsFatty Acids, UnsaturatedJejunoileal BypassRats, Inbred Strains
LipidsTriglyceridesPhospholipidConcentrationsLipoproteinsAtherosclerosisEffluxEstersMetabolismReduced low density lipLevelsLipoprotein cholesterolCoronaryTriglycerideLecithinReverse cholesterol transportEsterificationMembrane cholesterolPeripheralProteinsGlucoseSerum cholesterolMeasurementImpairsProtein2021NCEPRatioTotal1980sFattyCardiovascularEnzymeAdult Treatment Panel IIIAdultsMacrophagesDensityBiosyntheticRole of cholesterolIncidenceMetabolicLiverPatientsFree cholesterolMiceEffectInsulinDietEnhancesBaselineTransportMembranes
Lipids11
Triglycerides5
Phospholipid9
  • We prospectively investigated the relation of plasma cholesterol ester (CE) and phospholipid (PL) fatty acid composition with the incidence of diabetes mellitus. (nih.gov)
  • Phospholipids are the important elements by mass of HDL plus a number of research suggest that HDL phospholipid levels are a greater predictor of cholesterol efflux than other HDL parameters48, 49. (lipophilic-platinum.com)
  • The effect of agonist remedy on HDL-phospholipid levels, nonetheless, is lost in 0.two cholesterol diet plan challenged LivKO animals (Figure 4D). (lipophilic-platinum.com)
  • Phospholipid transfer protein mRNA levels have already been shown to be regulated by LXR52 nonetheless we didn't detect considerable variations in plasma phospholipid transfer protein activity between floxed and LivKO mice on either dietary condition (Supplemental Table I).NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptArterioscler Thromb Vasc Biol. (lipophilic-platinum.com)
  • Other names in common use include lecithin---cholesterol acyltransferase, phospholipid---cholesterol acyltransferase, LCAT (lecithin-cholesterol acyltransferase), lecithin:cholesterol acyltransferase, and lysolecithin acyltransferase. (wikipedia.org)
  • Conclusions In people with high HDL-C decreased HDL phospholipid articles and cholesterol efflux capability is from the paradoxical advancement of CAD. (ampkpathway.com)
  • We discovered that the HDL from high HDL-C topics with CAD acquired decreased phospholipid articles and decreased cholesterol efflux capability in comparison to the HDL from high HDL-C topics without CAD. (ampkpathway.com)
  • Plasma Phospholipid Transfer Protein Promotes Platelet Aggregation. (nih.gov)
  • High-density lipoprotein cholesterol (HDL-C), which consists mostly of cholesterol, phospholipid, and protein, is produced and secreted by the liver and intestine. (medscape.com)
Concentrations7
  • Low levels of high-density lipoprotein cholesterol (HDL), or hypoalphalipoproteinemia (HA), includes a variety of conditions, ranging from mild to severe, in which concentrations of alpha lipoproteins or high-density lipoprotein (HDL) are reduced. (medscape.com)
  • We have assayed the total cholesterol (TC) and the DBI plasma concentrations in patients with liver cirrhosis complicated by hepatocellular carcinoma (HCC) in comparison with those of uncomplicated liver cirrhosis. (unimore.it)
  • Reduced plasma concentrations of high-density lipoprotein-cholesterol (HDL-C) are a significant risk factor for cardiovascular disease. (cims-ops.cz)
  • Short-term effects of anti-TNF on plasma lipid concentrations seemed beneficial and anti-atherogenic. (bmj.com)
  • However, these changes did not persist: plasma concentrations of total and LDL-cholesterol and the atherogenic index increased after 6 months and 1 year from the start of therapy. (bmj.com)
  • 1 Among the traditional cardiovascular risk factors, the lipid profile in RA has often been described as "pro-atherogenic", 2 based on decreased HDL-cholesterol (HDL-C) and increased LDL:HDL-C ratio and lipoprotein (a) plasma concentrations in both active and treated RA. (bmj.com)
  • UPF consumption was not associated with high LDL cholesterol plasma concentrations. (nih.gov)
Lipoproteins5
  • A reversed net transport of free cholesterol from plasma to cultured fibroblasts, as well as greatly reduced levels of plasma cholesterol esterification and cholesterol ester transfer rates to low and very low density lipoproteins (LDL and VLDL), was found in the hemodialysis group compared to the controls. (jci.org)
  • A low HDL cholesterol level is thought to accelerate the development of atherosclerosis because of impaired reverse cholesterol transport and possibly because of the absence of other protective effects of HDL, such as decreased oxidation of other lipoproteins. (medscape.com)
  • Brain cholesterol metabolism is segregated from the peripheral circulation by the blood-brain barrier (BBB) and cholesterol transport in the central nervous system (CNS) is operated by lipoproteins very similar to the circulating high-density lipoproteins (HDLs) and called "HDL-like particles" [ 1 ]. (biomedcentral.com)
  • LCAT, the major player in HDL maturation, is mainly synthesized by the liver but also in the brain, suggesting a crucial role of this enzyme in the maturation of brain lipoproteins, although LCAT concentration in the cerebrospinal fluid (CSF) is much lower than in plasma [ 12 ]. (biomedcentral.com)
  • 1,500 mg/dl, associated with a marked increase in VLDL, intermediate density lipoproteins (IDL), and LDL cholesterol, and a decrease in HDL cholesterol. (jci.org)
Atherosclerosis4
Efflux6
Esters3
  • The LDL triglyceride content was doubled in the hemodialysis group, whereas cholesterol esters were decreased. (jci.org)
  • CETP facilitates the transfer of cholesterol esters from HDL to apolipoprotein B containing particles thereby decreasing HDL cholesterol levels54. (lipophilic-platinum.com)
  • Glucose-induced activation of DAG/PKC signaling in microsomes was not associated with a change in the translocation of Glut-4 transporters from microsomes to the plasma membrane, a biological response that is known to be stimulated by agonists, e.g., phorbol esters, which increase DAG/PKC signaling in plasma membranes, as well as in microsomes. (jci.org)
Metabolism5
  • Plasma cholesterol metabolism in end-stage renal disease. (jci.org)
  • Plasma cholesterol metabolism was investigated in normotriglyceridemic patients with end-stage renal disease treated by hemo- or continuous ambulatory peritoneal dialysis (CAPD), and compared with that in a control group with normal renal function. (jci.org)
  • Decreased plasma HDL-Ch may affect AA metabolism and NO production in the platelet membranes of CAD patients without LDL-hypercholesterolemia. (rsu.lv)
  • It plays a role in cholesterol and fatty acid metabolism. (nih.gov)
  • In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. (nih.gov)
Reduced low density lip1
  • The BN25, BN50 and BNBF50 diets also reduced low density lipoprotein (LDL) cholesterol. (usda.gov)
Levels27
  • Given the crucial role of cholesterol in regulating different neuronal processes, eukaryotes have developed sophisticated homeostatic mechanisms to preserve cholesterol levels in an optimal range in each brain region ( Segatto et al, 2013 ). (nature.com)
  • An arbitrary cutoff is the 10th percentile of HDL cholesterol levels. (medscape.com)
  • The common, mild forms of HA have no characteristic physical findings, but patients may have premature coronary heart or peripheral vascular disease, as well as a family history of low HDL cholesterol levels and premature CHD. (medscape.com)
  • This review addresses the pathogenesis and presenting features of, and the diagnostic tests, therapeutic interventions, and follow-up strategies for, low HDL cholesterol levels. (medscape.com)
  • High levels of plasma high-density lipoprotein (HDL)-cholesterol have been shown to have a protective effect. (pitt.edu)
  • Recent genome-wide association studies (GWAS) and candidate gene studies have identified genes thought to contribute to HDL-cholesterol levels. (pitt.edu)
  • Two genes, APOA1 and APOA4, have been associated with HDL-cholesterol levels in multiple studies with inconsistent results. (pitt.edu)
  • The aim of this study was to further investigate the role of common and rare variation in these two genes by sequencing individuals having extremely low and high HDL-cholesterol levels in two populations, U.S. Non-Hispanic Whites (NHWs), and African Blacks, and then screening the identified variants in the entire sample. (pitt.edu)
  • Route of administration: Oral anabolic steroids are known as being very fast to reach peak blood plasma levels in the body, and equally very fast to clearplasma levels in days to weeks, even in severe cases of liver failure. (onsidesportspodcast.com)
  • Persons with low high-density lipoprotein (HDL) cholesterol levels, except those patients with a deficiency syndrome, have no symptoms specific to the condition. (medscape.com)
  • High cholesterol levels are a risk factor for the development of Alzheimer's dis- ease. (unifi.it)
  • An inverse association between plasma HDL-cholesterol levels and the risk of dementia and AD has been reported, although with conflicting results [ 1 ], but an involvement of circulating HDLs in AD etiology and progression has never been proven. (biomedcentral.com)
  • out there in PMC 2015 August 01.Breevoort et al.PageCETP decreases macrophage-derived cholesterol in plasma To test the hypothesis that LXR-dependent regulation of HDL levels and activity plays a major function in driving the accumulation of macrophage-derived cholesterol in plasma, we took advantage from the observation that LXR agonist-dependent increases in HDL cholesterol are lost in CETP transgenic mice53. (lipophilic-platinum.com)
  • 1997. Effect of arsenic (V)-chromium (III) interaction on plasma glucose and cholesterol levels in growing rats. (cdc.gov)
  • During therapy, the changes in disease activity and inflammatory status were inversely correlated with changes in plasma total and HDL cholesterol levels and positively correlated with the variation of atherogenic index. (bmj.com)
  • Drinking beet juice may increase plasma nitrate levels and boost physical performance . (healthline.com)
  • New research has challenged the fundamental belief that raising levels of 'good' HDL-cholesterol will lower the risk of heart disease. (nutraingredients.com)
  • The study - published in The Lancet - challenges the assumption that raising levels of 'good high-density lipoprotein (HDL) cholesterol will necessarily lower the risk of heart disease. (nutraingredients.com)
  • The researchers said their findings raise significant questions over whether products that are aimed at raising levels of HDL-cholesterol will prove effective in lowering heart attack risk across the population. (nutraingredients.com)
  • GPR146 showed a causal effect on plasma HDL-cholesterol levels (p = 2×10 -15 ), without evidence for reverse causality. (lu.se)
  • Mean LDL cholesterol levels in New York City and nationally were similar. (cdc.gov)
  • Population approaches - such as making the food environment more heart-healthy - and aggressive clinical management of cholesterol levels are needed. (cdc.gov)
  • Despite advances in lowering total blood cholesterol, particularly throughout the 1980s (6,7), and the recent broad-scale use of medications targeting LDL cholesterol, control of lipid levels remains poor in the United States. (cdc.gov)
  • However, no study has examined LDL cholesterol levels by using a representative sample in New York City or in any exclusively urban setting. (cdc.gov)
  • To define high LDL levels, we used the National Cholesterol Education Program Adult Treatment Panel III (ATP III) guidelines, which provide thresholds for diagnosing and targets for lowering high LDL cholesterol on the basis of individual CHD risk (5,14). (cdc.gov)
  • Criteria for the definition of familial HAs are (1) a low HDL cholesterol level in the presence of normal VLDL cholesterol and LDL cholesterol levels, (2) an absence of diseases or factors to which HA may be secondary, and (3) the presence of a similar lipoprotein pattern in a first-degree relative. (medscape.com)
  • Increases in HDL-C levels may also be attributable to decreasing plasma cholesteryl ester transfer protein (CETP) activity by statins. (medscape.com)
Lipoprotein cholesterol6
  • Is Isolated Low High-Density Lipoprotein Cholesterol a Cardiovascular Disease Risk Factor? (medscape.com)
  • Objective Plasma degrees of high-density lipoprotein cholesterol (HDL-C) are strongly inversely connected with coronary artery disease (CAD) and high HDL-C is normally associated with decreased threat of CAD. (ampkpathway.com)
  • Keywords: High-density lipoprotein cholesterol coronary artery disease ABC transporter Launch Plasma high-density lipoprotein cholesterol (HDL-C) amounts are highly inversely correlated with the occurrence of coronary artery disease (CAD)1. (ampkpathway.com)
  • It's been approximated Tetracosactide Acetate that for every mg/dL upsurge in HDL-C the chance of cardiovascular occasions is reduced by 2 Therefore degrees of HDL-C are factored into many cardiovascular risk assessments and HDL continues to be intensively pursued as a second objective for risk decrease after low-density lipoprotein cholesterol (LDL-C) reducing. (ampkpathway.com)
  • Diabetes mellitus was the most frequent component of metabolic syndrome in males, while low serum high-density lipoprotein cholesterol and high waist circumference ranked first and second in females. (who.int)
  • The reference range of high-density lipoprotein cholesterol (HDL-C) is 40-50 mg/dL in men and 50-60 mg/dL in women. (medscape.com)
Coronary7
  • The US National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III) redefined the HDL cholesterol level that constitutes a formal coronary heart disease (CHD) risk factor. (medscape.com)
  • A prospective analysis by Mora et al investigated the link between cholesterol and cardiovascular events in women and found baseline HDL-C level was consistently and inversely associated with incident coronary and CVD events across a range of LDL-C values. (medscape.com)
  • The aorta and coronary ostia exhibited gross atheromata, and the aortic valve leaflets were thickened by cholesterol-laden macrophages. (jci.org)
  • Low-density lipoprotein (LDL) cholesterol is a major contributor to coronary heart disease and the primary target of cholesterol-lowering therapy. (cdc.gov)
  • High LDL cholesterol and coronary heart disease risk were defined using National Cholesterol Education Program Adult Treatment Panel III (ATP III) guidelines. (cdc.gov)
  • the risk of a coronary event is thought to increase 2% for every 1% decrease in HDL cholesterol. (medscape.com)
  • High-density lipoprotein (HDL) cholesterol is used in the assessment of coronary or other vascular pathology risk. (medscape.com)
Triglyceride2
  • Genetic association study of APOA1/C3/A4/A5 gene cluster and haplotypes on triglyceride and HDL cholesterol in a community-based population. (medscape.com)
  • Effects of dietary cadmium on circulatory function plasma cholesterol and triglyceride. (cdc.gov)
Lecithin4
  • Tangier disease, familial hypoalphalipoproteinemia and familial deficiency of lecithin cholesterol acyltransferase deficiency]. (medscape.com)
  • Lecithin:cholesterol acyltransferase (LCAT) activity and cholesterol esterification rate (CER), two measures of the efficiency of the esterification process, were reduced by 29% and 16%, respectively, in the plasma of AD patients. (biomedcentral.com)
  • Among these factors, lecithin:cholesterol acyltransferase (LCAT), the enzyme responsible of cholesterol esterification in plasma, plays a major role in HDL maturation [ 3 ]. (biomedcentral.com)
  • However, extreme HDL deficiencies caused by rare autosomal recessive disorders, including familial hypoalphalipoproteinemia (HA), familial lecithin-cholesterol acetyltransferase (LCAT) deficiency, and Tangier disease, do not always correlate with more frequent CHD. (medscape.com)
Reverse cholesterol transport4
Esterification2
Membrane cholesterol1
  • By using a fluores- cence bioassay coupled with flow cytometry we found a direct correlation between the increase in membrane cholesterol amount and the degree of APP shedding in living human neuroblastoma cells. (unifi.it)
Peripheral2
  • Peripheral plasma vitamin D and non-HDL cholesterol reflect the severity of cerebral cavernous malformation disease. (uchicago.edu)
  • A polypeptide, diazepam binding inhibitor (DBI), which is an endogenous ligand for peripheral benzodiazepine receptors enhances steroidigenesis by promoting cholesterol delivery to the inner mitochondrial membrane which represents the rate-limiting step of steroid biosynthesis. (unimore.it)
Proteins2
  • Transport of the 'accessible' pool of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) by ER-localized GRAMD1 proteins (GRAMD1a/1b/1c) contributes to cholesterol homeostasis. (ntu.edu.sg)
  • The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. (nih.gov)
Glucose1
  • Glucose rapidly increased DAG content and PKC enzyme activity in microsomes, but not in plasma membranes or other membranes, during a 30-min treatment of rat adipocytes. (jci.org)
Serum cholesterol3
  • 5. Commonly recognized influences seemed not to account for the findings and the possibility is raised of a dependence of renin secretion upon serum cholesterol. (portlandpress.com)
  • The effect occurs at the level of serum cholesterol found in man. (portlandpress.com)
  • Consuming oats or oat-containing food products reduces serum cholesterol in lean, overweight, or obese male and female adults without diabetes. (greenmedinfo.com)
Measurement2
  • Measurement of the amount of cholesterol, a eukaryotic sterol that in higher animals is the precursor of bile acids and steroid hormones and a key constituent of cell membranes, carried in low-density lipoprotein (LDL) molecules in a specified volume of plasma, the fibrinogen-containing fluid portion of the blood in which the particulate components are suspended. (mcw.edu)
  • You could go to your doctor in the early 80s, get a cholesterol measurement, and go down the hall to another doctor and get another measurement done. (nist.gov)
Impairs1
  • We find that a mutation within the GRAM domain of GRAMD1b that is associated with intellectual disability in humans specifically impairs cholesterol sensing. (ntu.edu.sg)
Protein1
  • Experiments investigating the influence of cholesterol on the proteolytic processing of the amyloid precursor protein (APP) by the b-secretase Bace1 and on their proximity in cells have led to conflicting results. (unifi.it)
20211
  • Une recherche documentaire a été effectuée dans PubMed de 1980 à 2021 en utilisant diverses combinaisons de termes MeSH comme tabac, diabète, hypertension, dyslipidémie, trouble dépressif majeur, trouble bipolaire, schizophrénie. (who.int)
NCEP1
  • Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). (medscape.com)
Ratio2
  • The CSF unesterified to total cholesterol ratio was increased in AD patients, and CSF CER and CEC from astrocytes were significantly reduced in AD patients. (biomedcentral.com)
  • In the AD group, a significant positive correlation was observed between plasma unesterified cholesterol and unesterified/total cholesterol ratio with Aβ 1-42 CSF content. (biomedcentral.com)
Total5
  • In 2909 adults aged 45-64 y, plasma fatty acid composition was quantified by using gas-liquid chromatography and was expressed as a percentage of total fatty acids. (nih.gov)
  • The BN diets reduced total plasma cholesterol (TC). (usda.gov)
  • This suggests that increased fat excretion might offset the higher total fat and saturated fat of the BF diets to reduce adverse effects on body weight, adipose weight, and cholesterol. (usda.gov)
  • In wild type littermates fed the same diet, the total plasma cholesterol remained (jci.org)
  • Prevalence of high total cholesterol and high LDL cholesterol remained virtually unchanged between 1988-1994 and 1999-2004 (8,9), and only one-fourth of US adults with elevated LDL cholesterol have their condition appropriately controlled (8). (cdc.gov)
1980s1
Fatty2
  • Vaccenic acid and trans fatty acid isomers from partially hydrogenated oil both adversely affect LDL cholesterol: a double-blind, randomized controlled trial. (medscape.com)
  • The proportional saturated fatty acid composition of plasma is positively associated with the development of diabetes. (nih.gov)
Cardiovascular1
Enzyme1
  • The aim of the present work was to shed light on the role played by the isoprenoid/cholesterol biosynthetic pathway in the modulation of emotional reactivity and memory consolidation in rodents through the inhibition of the key and rate-limiting enzyme 3-hydroxy 3-methylglutaryl Coenzyme A reductase (HMGR) both in vivo and in vitro with simvastatin. (nature.com)
Adult Treatment Panel III1
  • Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. (medscape.com)
Adults2
  • In New York City, 28% of adults had high LDL cholesterol, 71% of whom were aware of their condition. (cdc.gov)
  • In this study, we examine prevalence, awareness, treatment, and control of high LDL cholesterol in New York City adults by using the first community Health and Nutrition Examination Survey (NYC HANES). (cdc.gov)
Macrophages1
Density1
  • An established body of evidence points to reducing low-density lipoprotein (LDL) cholesterol as one of the most effective ways to prevent and treat CHD, regardless of a person's risk (2-4). (cdc.gov)
Biosynthetic3
  • Taken together, the present findings indicate that the isoprenoid/cholesterol biosynthetic pathway is critically involved in the physiological modulation of both emotional and cognitive processes in rodents. (nature.com)
  • The isoprenoid/cholesterol biosynthetic pathway, also known as the mevalonate (MVA) pathway, is one of the most notorious metabolic processes as it leads to the production of cholesterol and other non-sterol isoprenoids, which are essential in the induction and the maintenance of several cellular processes. (nature.com)
  • Cholesterol is used by cells for biosynthetic processes and for steroid synthesis. (unimore.it)
Role of cholesterol1
  • Although the role of cholesterol in tumorigenesis is not clear it is known that steroids are important factors in human carcinogenesis. (unimore.it)
Incidence1
  • A meta-analysis showed that in healthy young men, the daily dose of testosterone (10-20 mg/day) was associated with an 8% increase in the incidence of incident high cholesterol, and in older age subjects this was approximately double, anabolic steroids and muscle growth. (onsidesportspodcast.com)
Metabolic2
  • Patients treated by CAPD, in marked contrast, had cholesterol metabolic rates that were within the normal range, as well as normal lipoprotein composition. (jci.org)
  • Given the well-established links between diabetes and elevated rates of pancreatic cancer, there are reasons to anticipate that other markers of metabolic abnormality (increased body mass index, plasma cholesterol, and blood pressure) and their correlates (physical activity and socioeconomic status) may also confer increased risk. (aacrjournals.org)
Liver3
Patients4
  • Plasma HDL subclass distribution in AD patients was comparable to that of controls but the content of small discoidal preβ-HDL particles was significantly reduced. (biomedcentral.com)
  • Material: 16 healthy controls (C), 14 CAD patients with plasma HDL-hypocholesterolemia (nCAD) and 14 without HDL-hypocholesterolemia (nCAD). (rsu.lv)
  • 0.001 by ANOVA), suggesting that improvement of both oxidative and inflammation status in CKD patients could be explained, at least partly, by the cholesterol lowering effects. (edu.au)
  • Les prestataires de soins de santé primaires devraient être attentifs à l'importance du dépistage du syndrome métabolique chez les patients souffrant d'hypertension afin de prévenir et de prendre en charge la concomitance de ces pathologies. (who.int)
Free cholesterol1
Mice3
  • Certainly, remedy of CETP transgenic mice with T0901317 decreases HDL cholesterol by about 25 and raises the quantity of cholesterol CCR3 Antagonist list connected with apolipoprotein B containing lipoprotein particles (Figure 5A and B and Table 1). (lipophilic-platinum.com)
  • Consistent using a vital role for HDL in advertising the accumulation of macrophagederived cholesterol in plasma, the volume of 3H-cholesterol in this compartment at 24 and 48 hours is drastically reduced in CETP transgenic mice and also the capability of T0901317 to raise plasma cholesterol accumulation is lost (Figure 5C). (lipophilic-platinum.com)
  • Mice that are homozygous for a targeted disruption of the LDL receptor gene (LDLR-/- mice) were fed a diet that contained 1.25% cholesterol, 7.5% cocoa butter, 7.5% casein, and 0.5% cholic acid. (jci.org)
Effect3
  • By contrast, the cholesterol content was not correlated with changes in membrane dynamics of APP and Bace1 analyzed with single molecule tracking, indicating that the effect of cholesterol enrichment on APP processing by Bace1 is uncoupled from changes in their lateral diffusion. (unifi.it)
  • 2 It was easy to show that the claimed cholesterol-lowering effect of monoenes was the predictable result of reducing dietary saturates. (elsevierpure.com)
  • A similar earlier claim also misled the public and was exploited commercially.2 It was easy to show that the claimed cholesterol-lowering effect of monoenes was the predictable result of reducing dietary saturates.3 That nondiscovery was accompanied by praise for olive oil when, in fact, olive oil was not tested. (elsevierpure.com)
Insulin2
  • Coconut oil consumption improves fat-free mass, plasma HDL-cholesterol and insulin sensitivity. (greenmedinfo.com)
  • Aims/hypothesis: The aim of this study was to identify differentially expressed long non-coding RNAs (lncRNAs) and mRNAs in whole blood of people with type 2 diabetes across five different clusters: severe insulin-deficient diabetes (SIDD), severe insulin-resistant diabetes (SIRD), mild obesity-related diabetes (MOD), mild diabetes (MD) and mild diabetes with high HDL-cholesterol (MDH). (lu.se)
Diet3
Enhances1
  • In addition, we identified another point mutation within this domain that enhances cholesterol sensitivity without altering its PS sensitivity. (ntu.edu.sg)
Baseline1
  • Fifteen metals were detected in almost all participants urine samples using inductively coupled plasma mass spectrometry at the baseline. (cdc.gov)
Transport1
  • Cell-free reconstitution and cell-based assays revealed that the ability of the GRAM domain to sense accessible cholesterol regulates membrane tethering and determines the rate of cholesterol transport by GRAMD1b. (ntu.edu.sg)
Membranes1
  • The majority of cholesterol is present in myelin sheaths and in neuronal membranes, where this lipid fulfills structural and functional tasks. (nature.com)