Plaques from patients. Medical search. Frequent questions

Given the importance of inflammation in atherosclerosis, we sought to determine if atherosclerotic plaque inflammation could be measured noninvasively in humans using positron emission tomography (PET). (nih.gov)
Cardiovascular diseases are closely linked to atherosclerotic plaque development and rupture. (techscience.com)
Atherosclerotic plaque progression is generally considered to be closely associated with morphological and mechanical factors. (techscience.com)
Background The aim of the study was to determine the influence of hypertension on atherosclerotic plaque morphology in patients with coronary heart disease. (viamedica.pl)
Through the combination of CARS microscopy and computational methods, a powerful classification tool was developed to identify the progression of atherosclerotic plaque in an automated manner. (springer.com)
It involves interactions between oxidized low-density lipoprotein (LDL) deposits, endothelial cells, leukocytes, monocytes, macrophages, T-lymphocytes and smooth muscle cells, all of which are involved in promoting cellular migration and proliferation to drive the formation of foam cell clusters abundant in atherosclerotic plaque [ 4 ]. (springer.com)

Researchers in Germany and San Francisco believe they have identified an antibody that binds to the brain's immune cells and causes them to live longer, divide more quickly and better detect unwelcome substances such as the plaques believed to contribute to Alzheimer's. (beingpatient.com)
Scientists believe that amyloid plaque buildup is one of the key causes of Alzheimer's disease. (beingpatient.com)
They believe that TREM2 can vary greatly from individual to individual and can increase the risk of developing Alzheimer's by putting the brain's cells-known as microglia-into a dormant state, which prevents them from recognizing, absorbing and breaking down plaques and dead cells. (beingpatient.com)
Conversely we suspect that activation of the microglia could help to eliminate plaques and thus combat Alzheimer's," Haass said. (beingpatient.com)
Frustrated by the lack of an editorially independent source of information on brain health and Alzheimer's disease, we decided to create Being Patient. (beingpatient.com)
We are a team of dedicated journalists covering the latest research on Alzheimer's, bringing you access to the experts and elevating the patient perspective on what it's like to live with dementia. (beingpatient.com)
Being Patient is the leading online community for Alzheimer's & dementia patients & caregivers. (beingpatient.com)
An antibody that clears up brain-destroying plaques may settle the cause of Alzheimer's once and for all. (technologyreview.com)
A plaque-busting antibody being tested by Biogen stands a chance to become the first real treatment for Alzheimer's and could settle a long-running debate over the true cause of the disease. (technologyreview.com)
If the Biogen drug works, it will also basically prove the "amyloid hypothesis," the dominant theory that Alzheimer's is caused by the buildup of a peptide called amyloid beta as plaques on brain tissue. (technologyreview.com)
By some estimates, caring for Alzheimer's patients in the U.S. will cost a staggering $1 trillion per year by 2050. (technologyreview.com)
British researchers have shown that drug vaccination can remove amyloid plaques from the brains of people with Alzheimer's disease, but unexpectedly found this did not slow down the disease. (southampton.ac.uk)
The five-year study, funded by the Alzheimer's Research Trust and published in the Lancet, examined 80 patients with mild to moderate dementia who had been immunised with AN1792, a drug which acts to clear amyloid plaques from the brain. (southampton.ac.uk)
The brains of all people with Alzheimer's disease accumulate amyloid, a protein which clumps together to form toxic plaques. (southampton.ac.uk)
The previous consensus among dementia scientists - that removing amyloid plaques is key to defeating Alzheimer's - may now need to be rethought. (southampton.ac.uk)
Lead researcher Prof Clive Holmes of the University of Southampton said: "Our results suggest that brain deterioration can occur in Alzheimer's despite the removal of plaques. (southampton.ac.uk)
plaques in Alzheimer's patients select the pathogenic target structures. (the-scientist.com)
Two papers in October 15 Nature Medicine , show that vaccines designed to clear amyloid-beta (Aβ) protein in Alzheimer's patients are selective for the pathogenic target structures and can be further refined to become more selective. (the-scientist.com)
Together, amyloid plaques and neurofibrillary tangles disrupt both internal and external neuron function, affecting how systems in the brain operate and contributing in large part to what physicians today understand as Alzheimer's disease. (smh.com)
The first abnormality to present itself, and the one most familiar to the general public, is the oft-referenced 'amyloid plaque' present in the brains of patients with Alzheimer's. (smh.com)
Many physicians, including Dr. Grindal, believe that the amyloid plaque precedes the tau tangles, and so many physicians maintain that removing this plaque buildup may be the key to intervention for those with Alzheimer's. (smh.com)
While doctors do not yet have an effective treatment for removing amyloid plaque or curing Alzheimer's disease, there are preventative measures that studies say can help prevent amyloid buildup from ever occurring. (smh.com)
The hallmark of Alzheimer's disease - amyloid plaques in the brain - can be detected in living mice using a new technique based on magnetic resonance imaging. (newscientist.com)
Amyloid plaques are insoluble protein clumps in the brain which form early on in Alzheimer's disease and can precede dementia by many years. (newscientist.com)
With Alzheimer's, these fragments form hard, insoluble plaques. (sciencedaily.com)
Extensive deposits of beta-amyloid are found throughout the brains of all patients with Alzheimer's disease," said Rowe. (sciencedaily.com)

The thinner the hard cap is, the more likely it is to rupture, which could allow the plaques to block the artery and cause another heart attack. (acc.org)
Overall plaque material and lipid deposits on their arterial walls regressed to a greater extent (twofold reduction), and the hard caps covering the plaques became thicker (twofold thickening), meaning they were less likely to rupture. (acc.org)
Atherosclerotic plaques eventually lead to the blockage of blood flow, causing in extreme cases, the eventual rupture of the arteries [ 2 ]. (springer.com)
Plaques may also rupture suddenly, causing a blood clot to form which may totally obstruct a coronary artery - the cause of a heart attack. (texasheart.org)
Some plaques remain quiescent and stable for years and others become unstable and vulnerable, ultimately leading to plaque rupture. (nature.com)
Background: Rupture of carotid plaques is an important cause of cerebrovascular events. (houstonmethodist.org)
Results: The plaque rupture was just distal to the site of maximum stenosis in a region of low WSS, where MRI and histology both demonstrated fibrous cap thinning, a large lipid pool and calcification in the shoulder region. (houstonmethodist.org)
Plaque vulnerability analysis indicated critically vulnerable plaque at the rupture site by a wide margin. (houstonmethodist.org)
Conclusions: Both low and high WSS have been associated with plaque vulnerability, and high mechanical stress in the cap has been linked to plaque rupture, but these parameters are not routinely assessed clinically. (houstonmethodist.org)
that this finding could be related to Lp(a) increasing inflammatory signaling in the plaque, "making it more prone to rupture, and we saw that on the CCTA scans," where high Lp(a) levels were associated with the presence of more high-risk plaques. (medscape.com)
Plaques that rupture can cause a stroke or myocardial infarction, and it is important to identify dangerous plaques as early as possible to prevent serious complications. (lu.se)
The most common cause of death and the most disabling illness worldwide is plaque in the blood vessels which, if they rupture, can lead to a heart attack or a stroke", says Isabel Gonçalves, Professor in cardiologist at the Clinical Research Centre in Malmö. (lu.se)
It is when the capsule around the plaque is weakened and rupture that it becomes dangerous. (lu.se)
Isabel Gonçalves and her colleagues are trying to find out why this happens and how to find harmful plaques before they rupture. (lu.se)

Following early initiation of alirocumab on top of high-intensity statin therapy in a high-risk population with acute myocardial infarction, we observed a twofold regression of coronary atherosclerosis and stabilization of high-risk plaques when compared with treatment with statins alone," said Lorenz Räber, MD, PhD, professor of cardiology and director of the catheterization laboratory at Bern University Hospital in Switzerland and the trial's principal investigator. (acc.org)
We suggest that near-infrared autofluorescence imaging is a novel technology that allows identification of atherosclerotic plaques with intraplaque hemorrhage and ultimately holds promise for detection of high-risk plaques in patients. (nature.com)

The home dental plaque identification test shows where plaque builds up. (medlineplus.gov)
however, its bacterial composition greatly differs from that of dental plaque microbiota, which is a dominant etiologic factor of oral diseases. (elsevierpure.com)
Stage 4: Early Maturation: Early colonizers make their debut, leading to more dental plaque complexity due to allogenic factors. (sfdentistry.com)
During this stage, a thick, three-dimensional layer of dental plaque biofilm develops. (sfdentistry.com)
So by coming to your dental appointments every 3 months, you get a chance to always prevent your dental plaque to mature. (sfdentistry.com)
Aim: This study aimed to determine the feasibility and first efficacy of indocyanine green (ICG)-assisted antimicrobial photodynamictherapy (aPDT) as activated using LED light to the dental plaque. (mdpi.com)
Motivating self care through an effective dental plaque control should be one of the main measures of oral health prevention in dental clinics. (bvsalud.org)
The findings indicated a 33% reduction in the amount of dental plaque. (bvsalud.org)

Nine factors (6 morphological factors and 3 mechanical factors) including average cap thickness, lipid area, calcification area, lumen area, plaque area, plaque burden, wall shear stress (WSS), plaque wall stress (PWS) and plaque wall strain (PWSn) were selected for each slice. (techscience.com)
Plaques were classified as: soft, mixed and hard - based on echointensity, with or without calcification, concentric and eccentric. (viamedica.pl)
No statistical differences were obtained for the occurrence of calcification and plaque distribution in hypertensive patients compared to normotensive patients. (viamedica.pl)
Some researchers believe the resulting increased duration plaques (with or without calcification), pleural effusions, of exposure to amphibole asbestos significantly increases pleural thickening, and rounded atelectasis. (cdc.gov)
Bilateral pleural plaques and/or calcification of the diaphragm are virtually pathognomonic of previous exposure to asbestos. (msdmanuals.com)
Plaque calcification is common. (msdmanuals.com)

A stress-based plaque vulnerability index (SPVI) was proposed to combine mechanical analysis, plaque morphology and composition for more complete carotid plaque vulnerability assessment. (techscience.com)
Plaque morphological information on intravascular ultrasound (IVUS) and optical coherence tomography (OCT) images could complement each other and provide for more accurate plaque morphology. (techscience.com)
Plaque morphology was evaluated by means of intracoronary ultrasound. (viamedica.pl)
Morphology and size of plaques were analyzed in cross-sections of coronary arteries. (viamedica.pl)
Our study was the first to use three intracoronary imaging tests in combination to provide a comprehensive picture of plaque size, composition and morphology [shape and structure]. (acc.org)
Several factors, including wall shear stress (WSS), plaque morphology and peak cap stress, have been associated with plaque vulnerability. (houstonmethodist.org)

The trial is the first to examine the effect of the PCSK9 inhibitor alirocumab on "vulnerable plaques" (fatty deposits in arteries that are considered likely to cause future cardiac events) using three imaging tests that assess the probability of future cardiac events in patients recovering from a heart attack. (acc.org)
Its primary application is to detect vulnerable coronary plaque. (diagnosticimaging.com)
It is known that 70% of acute coronary syndromes are caused by vulnerable plaques, which are not angiographically significant and are currently undetectable by available imaging tools. (diagnosticimaging.com)
Using the intravascular MRI catheter in a cardiac catheterization procedure will allow the detection of lipid-rich vulnerable plaques, characterization of plaque composition and geometry, and therapy guidance,' said Eyal Kolka, senior vice president of business development for TopSpin. (diagnosticimaging.com)
Vulnerable plaque was associated with recurrent cardiovascular events. (bvsalud.org)
This study was designed to explore predictive biomarkers of vulnerable plaque in patients with coronary artery disease . (bvsalud.org)
To reveal the phenotype -associated cell type in the development of vulnerable plaque and to identify hub gene for pathological process, we combined single- cell RNA and bulk RNA sequencing datasets of human atherosclerotic plaques using Single- Cell Identification of Subpopulations with Bulk Sample Phenotype Correlation (Scissor) and Weighted gene co-expression network analysis (WGCNA). (bvsalud.org)
Adjusted multivariate regression analysis revealed that serum SPP1 was an independent determinant of the presence of vulnerable plaque. (bvsalud.org)
P serum SPP1 in predicting of vulnerable plaques. (bvsalud.org)

She received a diagnosis of tinea and began oral terbinafine spread, inflamed, pruritic plaques on the body (tinea corporis), therapy in January 2022 after the birth of her baby. (cdc.gov)

If subsequent natural history studies link increased FDG-PET activity in carotid arteries with clinical events, this noninvasive measure could be used to identify a subset of patients with carotid atherosclerosis in need of intensified medical therapy or carotid artery intervention to prevent stroke. (nih.gov)
Vulnerability of carotid atherosclerosis: relationship with plaque location, plaque eccentricity and vessel remodeling patterns. (escardio.org)
During atherosclerosis, the narrowing of the arterial lumen is observed through the accumulation of bio compounds and the formation of plaque within artery walls. (springer.com)
Atherosclerosis is a progressive disease, with a characteristic increase in lipid accumulation, inflammation, and plaque formation within the arterial walls [ 1 ]. (springer.com)
A study from Neuroradiology has shown for the first time the capability of CT texture analysis (CTTA) in determining the risk of stroke and transient ischemic attack (TIA) in patients with carotid atherosclerosis. (mdct.net)
This could explain the greater risk for major adverse cardiovascular events seen in patients with high lipoprotein(a) [Lp(a)] levels, suggests the research, presented at the 91st European Atherosclerosis Society (EAS) Congress on May 23. (medscape.com)
In atherosclerosis, fat accumulates in the arterial walls creating atherosclerotic plaques. (lu.se)
Type 2 diabetes increases the risk of atherosclerosis, and this patient group may be helped by the innovation in the future. (lu.se)

The the risk for mesothelioma and, to a lesser extent, presence of pleural plaques is considered to be a marker asbestosis and lung cancer compared with chrysotile. (cdc.gov)
On radiograph, pleural plaques are usually that stir up dust in soils containing asbestos fibers. (cdc.gov)
including pleural effusion, pleural plaques, and pleural thickening. (msdmanuals.com)
Discrete pleural plaques typically affect the parietal pleura bilaterally and areas adjacent to the diaphragm. (msdmanuals.com)
The latency from time of exposure to development of pleural plaques is generally ≥ 20 years. (msdmanuals.com)

The study met its primary endpoint-a reduction in percent atheroma volume (PAV), which is a measure of cholesterol plaque buildup in the coronary arteries. (acc.org)
As a chronic inflammatory condition, one of its hallmarks is the narrowing of the arterial lumen through plaque buildup within the inner lining of artery walls. (springer.com)
Amyloid plaque is a gradual buildup and accumulation of protein fragments, called beta-amyloid, that forms between neurons, eventually impacting brain function. (smh.com)
If amyloid buildup can be detected early, maybe it can be disrupted before they harden into a stubborn plaque. (smh.com)
However, widespread identification of potential research participants, patients who are high risk or have early buildup, is not currently possible because the discovery process is very expensive and it's not covered by Medicaid. (smh.com)

These moderate to severe plaque psoriasis patients previously had a suboptimal response to treatment with secukinumab or ixekizumab, both IL-17A inhibitor therapies, for at least six months before switching to risankizumab. (biospace.com)
This study showed that risankizumab was able to improve clinical signs and symptoms of patients who had a suboptimal response with the anti-IL-17 therapies secukinumab and ixekizumab, contributing to the whole of evidence supporting risankizumab use in moderate to severe plaque psoriasis. (biospace.com)
The findings presented today are part of a Phase 3b, multicenter, interventional, open-label, single-arm study of adults ages 18 years or older with moderate to severe plaque psoriasis. (biospace.com)
Evidence from five systematic reviews (four with network meta-analysis and one with traditional meta-analysis) and one randomized controlled trial suggested that adalimumab was less effective than infliximab, ixekizumab, risankizumab, and secukinumab in achieving skin clearance and improvements in health-related quality of life in patients diagnosed with moderate-to-severe plaque psoriasis. (cadth.ca)
Risankizumab efficacy for moderate-to-severe plaque psoriasis over 256 weeks in patients with prior biologic treatments. (dermatologytimes.com)

It is assessing whether the positron emission tomography (PET) tracer 18F-sodium fluoride is as a marker of coronary plaque vulnerability and can detect culprit and non-culprit unstable coronary plaques in patients with recent myocardial infarction. (ed.ac.uk)
Assessment of plaque vulnerability is of fundamental significance to cardiovascular research and disease diagnosis, prevention, treatment and management. (techscience.com)
SPVI has the potential to improve the current image-based screening and plaque vulnerability assessment schemes. (techscience.com)
TUESDAY, May 19, 2015 (HealthDay News) -- For patients with coronary artery disease (CAD) pretreated with lipid-lowering therapy, daily glucose fluctuation may affect coronary plaque vulnerability, according to a study published in the May issue of JACC: Cardiovascular Interventions . (healthday.com)
Daily glucose fluctuation may have an effect on coronary plaque vulnerability in patients with CAD pretreated with lipid-lowering therapy,' the authors write. (healthday.com)
Compared with a placebo, the addition of the injectable cholesterol-lowering drug alirocumab to high-intensity statin treatment in patients who have had a heart attack resulted in twofold greater reductions in three key measures of plaque vulnerability that signal risk for future cardiac events, according to research presented at the American College of Cardiology's 71st Annual Scientific Session. (acc.org)
PAV, cholesterol content of the plaque and cap thickness are key characteristics of vulnerability to future cardiac events," Räber said. (acc.org)
Plaque vulnerability was assessed using a biomechanical method based on modified Glagov criteria. (houstonmethodist.org)
Serum secreted phosphoprotein 1 level is associated with plaque vulnerability in patients with coronary artery disease. (bvsalud.org)
Macrophages were found to be strongly correlated with plaque vulnerability while vascular smooth muscle cell (VSMC), fibrochondrocyte (FC) and intermediate cell state (ICS) clusters were negatively associated with unstable plaque. (bvsalud.org)
Elevated serum SPP1 levels confer an increased risk for plaque vulnerability in patients with coronary artery disease . (bvsalud.org)

We established that FDG-PET imaging can be used to assess the severity of inflammation in carotid plaques in patients. (nih.gov)
Comparing plaque structure in 3 groups of the cross-sections with different severity of lumen reduction, only in group I ( (viamedica.pl)
However, coronary artery disease risk is also driven by biological processes, such as inflammation, that are not fully reflected by severity of stenosis, myocardial ischaemia or by coronary plaque features. (bmj.com)
This study evaluated the relative abundance of subgingival plaque-specific bacteria in the salivary microbiota and examined a relationship between the abundance and severity of periodontal condition in patients with periodontitis. (elsevierpure.com)
Four samples (subgingival and supragingival plaques, saliva, and tongue coating) per each subject were collected from 14 patients with a broad range of severity of periodontitis before periodontal therapy. (elsevierpure.com)
The formation of plaque build-up within the intima provides some indicators into the severity of the disease. (springer.com)
According to the consensus study "From the Medical Board of the National Psoriasis Foundation: Treatment Targets for Plaque Psoriasis," the use of BSA to assess disease severity should be complemented by assessments of patient-reported measures of quality of life and symptoms, such as pruritus and pain, which have been shown to affect patients' perception of disease severity. (medscape.com)

In 2017, Being Patient spoke with Dr. Roxana Carare, a professor of clinical neuroanatomy and experimental neuropathology at the University of Southampton, about how the body clears protein plaques from the brain. (beingpatient.com)
The issue is that it is not properly broken down," explains Dr. Grindal, and the patient is left with protein fragments that cannot be properly disposed of, so they accumulate in the brain instead. (smh.com)
At baseline, per cent plaque volumes were 1.8 times greater in high Lp(a) patients vs those with low levels of the protein. (medscape.com)
One of the hallmarks of the always-fatal disease is the accumulation of protein amyloid plaques between nerve cells in the brain. (sciencedaily.com)

Clinical review of all patients will continue until study completion (given 2 years of recruitment this is likely to last 4 years) and following this the investigators will continue to monitor for further cardiovascular events via review of patient electronic health records for a further 5 years. (ed.ac.uk)
Very low or zero CACS is reassuring and clinically valuable, but age and other prevalent risk factors are major drivers of CACS, 1 such that most middle-aged or older patients in higher cardiovascular risk groups have elevated CACS. (bmj.com)
The development of a method to reliably identify high-risk atherosclerotic plaques is seen as one of the major quests of contemporary cardiovascular medicine. (nature.com)
In contrast, our study demonstrates that autofluorescence in the NIR range uniquely characterizes atherosclerotic plaques with intraplaque hemorrhage and may allow classification of atherosclerotic plaques into lesions of low or high risk for future cardiovascular events. (nature.com)
Besides establishing fluorescence emission tomography (FLECT) as a preclinical tool for the detection of plaques with intraplaque hemorrhage and its potential use in testing and monitoring of plaque-stabilizing drugs, our report has the potential to support technical developments for imaging technologies that will ultimately allow to risk stratify atherosclerotic plaques in patients and, in particular, to identify plaques that are prone to cause cardiovascular events. (nature.com)
These are expected to substantially reduce Lp(a) levels and achieve a reduction in cardiovascular risk of around 20%-40%, "which would be interesting," especially as "we have patients who have Lp(a) levels four times above the upper normal value. (medscape.com)
Crucially, they may already have normal LDL cholesterol levels, meaning that, for some patients, "there is clearly a need for such treatment, as long as it is proven that it will decrease cardiovascular risk. (medscape.com)
Despite the effectiveness of statin therapy in reducing the incidence and progression of atherosclerotic cardiovascular disease (ASCVD), considerable residual risk remains for patients with hypertriglyceridemia. (acc.org)
The Reduction of Cardiovascular Events with EPA-Intervention Trial ( REDUCE-IT ) showed a 31% reduction in total ischemic events compared to placebo in at-risk patients with triglycerides (TG) above 100 mg/dL despite statin therapy. (acc.org)
The first trial investigating the effect of a pure EPA medication on cardiovascular outcomes was the JELIS trial, which randomized patients with hypercholesteremia (total cholesterol ≥250 mg/dL) to receive 1.8 g of EPA daily plus statin therapy versus statin alone without. (acc.org)
REDUCE-IT demonstrated an impressive 25% (P=0.00000001) relative risk reduction in first and 31% (P=0.0000000004) reduction in total major cardiovascular events in patients receiving IPE. (acc.org)
The clinical value of carotid plaque score in patients with metabolic syndrome and cardiovascular diseases. (bvsalud.org)
To investigate the relationship between carotid plaque load score (CPS) and metabolic syndrome (MS) and cardiovascular diseases (CVD), in order to provide theoretical basis for the precaution and control of MS and CVD. (bvsalud.org)

What they showed very nicely was a reduction in plaques as they increased the dose. (technologyreview.com)
The ART study showed immunisation caused a long-term reduction in amyloid in the brain and a variable degree of plaque removal compared with non-immunised control patients. (southampton.ac.uk)
4 Results of the EVAPORATE trial were recently presented at the European Society of Cardiology (ESC) Scientific Sessions and simultaneously published in the European Heart Journal and showed a small but statistically significant reduction in low-attenuation plaque at 18 months in patients treated with IPE compared those treated with placebo. (acc.org)
PCR) Assay Emergency Use Authorization, examined the use of non-CDC developed assays, and reviewed recommendations for plaque reduction neutralization testing in Puerto Rico. (cdc.gov)
The philosophy used in the classes related to the reduction in the quantity of plaque on the part of the patients proved to be promising. (bvsalud.org)

Intravascular imaging, using ultrasound (IVUS) or optical coherence tomography, reveals that angiographic assessment of the coronary lumen grossly underestimates the presence, nature and extent of coronary artery plaque. (bmj.com)
and the thickness of the hard outer layer, or cap, covering the plaques by optical coherence tomography (a light-based imaging technique that provides microscopic images of the artery). (acc.org)

In the initial phase of plaque burden development, minimal build-up of plaque is observed in the intima of the artery, allowing the arterial lumen to remain unaffected. (springer.com)
As the plaque expands, remodelling is observed to push the vessel wall outwards to maintain the volume of the arterial lumen. (springer.com)
Arterial plaque is hard to measure non-invasively. (texasheart.org)
These complications are caused by thrombotic arterial occlusion localized at the site of high-risk atherosclerotic plaques, of which early detection and therapeutic stabilization are urgently needed. (nature.com)

Patients will then have clinical follow-up before undergoing a repeat CTCA at 2 years to assess progression of coronary disease. (ed.ac.uk)
Accuracy and completeness of imaging and advanced modeling lead to accurate plaque progression predictions. (techscience.com)
Baseline and follow-up 3D FSI models with cyclic bending based on merged IVUS and OCT data were constructed to obtain plaque stress/strain and flow shear stress data for plaque progression prediction. (techscience.com)
Plaque area increase (PAI) and plaque burden increase (PBI) were chosen to measure plaque progression and serve as the target variables for prediction. (techscience.com)
PWSn is better than WSS for plaque progression using single factor. (techscience.com)
In combination with supervised machine learning, CARS imaged morphological features can be used to characterize the progression of atherosclerotic plaques. (springer.com)
MANNHEIM - Patients with high lipoprotein(a) levels not only have an almost twofold higher coronary plaque burden than those with low levels but also a faster rate of plaque progression, an observational imaging study shows. (medscape.com)
Similarly, registry data have suggested that Lp(a) is associated with worsening plaque progression over time. (medscape.com)
There were some red infiltrative nodules at the margin of the lesion which had appeared 3 years before referring to the SDLRC (Figure 3).The patient complained of recurrence and progression of his disease. (who.int)

Methods A retrospective review of 106 Ru plaque brachytherapy for patients with choroidal melanoma treated at St Bartholomew's Hospital, London. (bmj.com)
Methods: A 74-year-old male presenting with a transient ischemic attack underwent carotid magnetic resonance imaging (MRI), which indicated a ruptured plaque, followed by carotid endarterectomy, from which plaque histology was assessed. (houstonmethodist.org)
METHODS: In 26 centers, 450 patients admitted with a diagnosis of TTC underwent coronary angiography within 48 h of hospital admission and were included prospectively in the Tako-tsubo Italian Network Registry. (who.int)
Diabetes researcher and cardiologist Isabel Goncalves at LUDC is collaborating with ultrasound researchers Tobias Erlöv and Magnus Cinthio at the Faculty of Engineering at Lund University to develop methods that can help identify people who are at risk of developing a stroke because of dangerous plaques. (lu.se)
And working together allows us to deliver new diagnostic methods more quickly to patients. (lu.se)

We also validated our results in an independent cohort of patients by using intravascular ultrasound during coronary angiography . (bvsalud.org)

Approached for comment, Philippe Moulin, MD, PhD, head of endocrinology and professor of human nutrition at Faculté Lyon Est, Claude Bernard Lyon 1 University, Lyon, France, said that the association between Lp(a) and plaque burden has been seen previously in the literature in a very similar study, but with only 1-year follow-up. (medscape.com)
What is less clear is the exact underlying mechanism, he said, noting that there have been several imaging studies in high and low Lp(a) patients that have yielded conflicting results in terms of the relationship with plaque burden. (medscape.com)
Patients in MS group and CVD group have higher carotid plaque burden than those in non-MS group and non-CVD group. (bvsalud.org)

We have previously developed a mouse model that exhibits unstable plaques as seen in humans 16 . (nature.com)

Findings from this phase 3b, open-label single-arm study showed that 56.3% of patients who received risankizumab, without a washout period following a suboptimal response to secukinumab or ixekizumab achieved the week 16 primary endpoint of reduced signs and symptoms of psoriasis (sPGA 0/1). (biospace.com)
See Histologic Findings for more details on plaque histology. (medscape.com)
These impressive findings provided the rationale for the REDUCE-IT trial, wherein patients with fasting TG levels of 135 to 499 mg/dL and LDL-c levels of 41 to 100 mg/dL were randomized to receive 4g daily of IPE (Vascepa®) in addition to maximally tolerated statin therapy versus a mineral oil placebo. (acc.org)

The investigators intend to recruit 700 patients hospitalised with myocardial infarction and proven multivessel coronary artery disease. (ed.ac.uk)
In vivo IVUS and OCT coronary plaque data at baseline and follow-up were acquired from left circumflex coronary and right coronary artery of one patient with patient's consent obtained. (techscience.com)
Cardiac imaging is central to the diagnosis and risk stratification of coronary artery disease, beyond symptoms and clinical risk factors, by providing objective evidence of myocardial ischaemia and characterisation of coronary artery plaque. (bmj.com)
New cardiac CT techniques can assess coronary artery inflammation by imaging perivascular fat, and this may represent an important step forward in identifying the 'residual risk' that is not detected by plaque or ischaemia imaging. (bmj.com)
Coronary artery disease risk assessment that incorporates clinical factors, plaque characteristics and perivascular inflammation offers a more comprehensive individualised approach to quantify and stratify coronary artery disease risk, with potential healthcare benefits for prevention, diagnosis and treatment recommendations. (bmj.com)
The current trial, known as PACMAN-AMI, enrolled 300 patients who had a heart attack and were treated with a stent (a tiny mesh tube) to open the blocked artery. (acc.org)
Carotid Artery Plaque Classification: Does Contrast Enhancement Play a Significant Role? (ajnr.org)
Previous articles have demonstrated that carotid artery plaques may have enhancement after administration of contrast material. (ajnr.org)
The results of this study indicate that the carotid artery plaques (fatty and mixed) significantly change according to whether analysis is performed before or after administration of contrast material. (ajnr.org)
The calcium score test shows the amount of coronary artery calcium that resides in the coronary artery plaque , which cannot be directly imaged non-invasively. (texasheart.org)
The amount of coronary artery calcium is a measure of coronary artery plaque. (texasheart.org)
Coronary artery plaques can sit and grow slowly over time to produce an artery obstruction. (texasheart.org)
The greater the coronary calcium score, the larger the amount of plaque is in the artery wall, and the greater the risk of a heart attack. (texasheart.org)

CT coronary angiography can detect coronary plaque with high resolution, estimate the degree of functional stenosis and characterise plaque features. (bmj.com)

NORTH CHICAGO, Ill., March 18, 2023 /PRNewswire/ -- AbbVie (NYSE: ABBV) today announced new 52-week data from an open-label, single-arm study demonstrating improved plaque psoriasis signs and symptoms among a difficult-to-treat patient population who received SKYRIZI ® (risankizumab), an IL-23 inhibitor. (biospace.com)

Masaru Kuroda, M.D., from the Kobe University Graduate School of Medicine in Japan, and colleagues examined the effect of daily glucose fluctuation on coronary plaque properties in patients with CAD pretreated with lipid-lowering therapy. (healthday.com)
A non-linear optical imaging modality (NLOM), coherent anti-stokes Raman scattering (CARS) microscopy, can be used to image lipid-rich structures commonly found in atherosclerotic plaques. (springer.com)
He added that in the absence of drugs that target Lp(a) levels directly, the results underline the need to focus on other means of lipid-lowering, as well as "creating awareness that Lp(a) is associated with plaque formation. (medscape.com)

Plaques of encephalomalacia in brains of patients dying late in disease. (cdc.gov)

They observed that antibodies from sera of patients who received a primary injection of pre-aggregated Aβ 42 recognized β-amyloid plaques, diffuse Aβ deposits and vascular β- amyloid in brain blood vessels. (the-scientist.com)
With the help of the technique, it is possible to carry out detailed examinations of atherosclerotic plaques in the blood vessels of the neck. (lu.se)
Plaque occurs when fat accumulates on the walls of blood vessels. (lu.se)
I was complaining about the fact that I wasn't able to give answers to my patients who were desperately wondering how long they had been walking around with plaques in their blood vessels without knowing it", she says. (lu.se)

In the office, dentists are often able to detect plaque by doing a thorough exam with dental tools. (medlineplus.gov)

Advanced therapies represent an important option in the treatment of plaque psoriasis, but as a physician, it's critically important to continually assess if patients are having an optimal response to treatment, as residual psoriasis can still have a significant impact on a patient's life," said Professor Richard Warren from the University of Manchester and Norten Care Alliance, UK. (biospace.com)
Lakshi, in your experience do patients have to fail certain therapies before you utilize a step-up therapy practice in treatment approach? (dermatologytimes.com)
Nurmohamed said that "For the moment, we have to treat patients with high Lp(a) with other risk-lowering therapies, such as low-density lipoprotein [LDL] cholesterol-lowering drugs, and the management of other risk factors. (medscape.com)
As noted in the Joint American Academy of Dermatology-National Psoriasis Foundation guidelines of care for the management of psoriasis with systemic nonbiologic therapies, speed of onset is a significant consideration when choosing systemic therapies for many patients with plaque psoriasis, particularly for those with inflammatory or erythrodermic psoriasis. (medscape.com)
Systemic therapies should be considered for patients with extensive psoriasis , or greater than 3% BSA involvement . (medscape.com)
Additionally, systemic therapies may be appropriate for patients with mild psoriasis (ie, ≤ 3% BSA involvement) who have an inadequate response to topical therapy or phototherapy, in cases where phototherapy is unfeasible , or when quality of life is negatively affected to the degree that the benefits of systemic therapy outweigh its potential risks. (medscape.com)

What is the clinical effectiveness of adalimumab versus other biologic drugs in adult patients with plaque psoriasis? (cadth.ca)
Advantages of the technique include its low cost ($1000 and no expensive external setup), elimination of motion artifacts, accessibility to the patient during the procedure, compatibility with existing interventional tools, and resolution and diffusion contrast capabilities that are unattainable by conventional clinical MR imaging, according to Kolka. (diagnosticimaging.com)
Contrary to popular belief, based on clinical research and microbiological evidence of the periodontal disease process, Dr. Amin Samadian advises patients to come every three months for their dental hygiene appointment . (sfdentistry.com)
OBJECTIVE: This study aimed to evaluate the prevalence, clinical characteristics, and outcome of patients with TTC and relevant CAD in a large multicenter database. (who.int)
They hope that their method can improve the clinical assessment of patients at high risk of developing a stroke. (lu.se)

Pruritic urticarial papules and plaques of pregnancy (PUPPP), known in United Kingdom as polymorphic eruption of pregnancy (PEP), is a chronic hives-like rash that strikes some women during pregnancy. (wikipedia.org)
Pruritic urticarial papules and plaques of pregnancy (PUPPP) is one of many skin conditions that is specific to pregnancy and occurs in about 1 in every 160 (0.625%) of pregnancies. (wikipedia.org)
As a result of these papules and plaques from PUPPP, it causes the skin to be very itchy (pruritic) and immensely affects the patient's sleep quality throughout the night. (wikipedia.org)
Most skin infections are localized and pruritic plaques affecting the thighs and buttocks (Figure). (cdc.gov)

Researchers conducted a 256-week study in order to assess risankizumab's efficacy in patients with psoriasis who have previously used biologic treatments. (dermatologytimes.com)
Survival analysis was used to assess associations between evaluated age, sex, location, foveal proximity, tumour base and height, presence of lipofuscin and subretinal fluid, apex dose, radiation rate and type of plaque with time to local recurrence. (bmj.com)
Fluorescence emission computed tomography detecting near-infrared autofluorescence allows in vivo monitoring of intraplaque hemorrhage, establishing a preclinical technology to assess and monitor plaque instability and thereby test potential plaque-stabilizing drugs. (nature.com)

Seventeen patients with severe carotid stenoses underwent FDG-PET imaging 3 h after FDG administration (13 to 25 mCi), after which carotid plaque FDG uptake was determined as the ratio of plaque to blood activity (target to background ratio, TBR). (nih.gov)
This article shows some examples of what plaque psoriasis can look like and explains how to tell if you have a mild, moderate, or severe case. (healthline.com)
Is your plaque psoriasis mild, moderate, or severe? (healthline.com)
Plaques on the scalp, for example, can sometimes be more severe than plaques on the rest of the body. (healthline.com)
Plaques on the face are often associated with a more severe condition overall. (healthline.com)
In severe cases, patients may have mild hyperuricemia and low folate levels, presumably because of enhanced epidermopoiesis. (medscape.com)
Although the amounts of influenza A detected in cough aerosol particles during our experiments were relatively low, larger quantities could be expelled by influenza patients during a pandemic when illnesses would be more severe. (cdc.gov)

Plaque biofilm control for the periodontal patient. (medlineplus.gov)

Using a PET scan, doctors and researchers have long been able to locate, identify and study the amount of amyloid plaque in a patient's brain. (smh.com)
Researchers in Israel have gone one step further: They've developed an MR scanner that enters the patient, rather than vice versa. (diagnosticimaging.com)
In a multicenter study examining four commercially available artificial intelligence (AI) software products for chest X-rays in over 2,000 patients, researchers found sensitivity rates ranging between 33 to 61 percent for vague airspace disease and 9 to 94 percent for small pneumothorax and pleural effusion. (diagnosticimaging.com)
The researchers scanned five normal mice and eight mice genetically modified to have Alzheimer-like plaques, after injecting them with the tracer. (newscientist.com)
Even low doses were enough to identify the amyloid plaques in the GM mice's brains, the researchers found. (newscientist.com)
Diabetes researcher and cardiologist Isabel Goncalves at Lund University Diabetes Centre (LUDC) has teamed up with ultrasound researchers at the Faculty of Engineering at Lund University (LTH) to identify dangerous atherosclerotic plaques at an early stage. (lu.se)
Because the researchers also have access to patient blood samples, they are able to investigate whether some of these components can be found in the blood and, if so, be used as biomarkers - that is a molecule that, if found, can tell us how the patient feels. (lu.se)
The researchers used the Carbon-14 method - usually applied by archaeologists for dating ancient remains and fossils - to determine how the plaques were. (lu.se)

Plaque psoriasis is an inflammatory skin condition. (healthline.com)
Approximately one-third of people with plaque psoriasis also develop psoriatic arthritis, an inflammatory joint condition that causes painful, swollen joints and can lead to irreversible joint destruction. (skinsight.com)
But in humans these treatments have been associated with complications such as meningo-encephalitic cellular inflammatory reactions in some patients. (the-scientist.com)
In other cases, individual patient circumstances and comorbidities , such as concomitant obesity, psoriatic arthritis, inflammatory bowel disease, and infections, including viral hepatitis, latent tuberculosis, and HIV, may be compelling reasons to avoid or select specific medications. (medscape.com)

Hadlima (adalimumab-bwwd) is a tumor necrosis factor (TNF) blocker indicated for treatment of rheumatoid Arthritis ( RA ), juvenile idiopathic arthritis (JIA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), adult Crohn's disease (CD), ulcerative colitis (UC), and plaque psoriasis (Ps). (rxlist.com)
The recommended dose of Hadlima for adult patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), or ankylosing spondylitis (AS) is 40 mg every other week. (rxlist.com)
It may also be an option for patients whose daily functioning is adversely affected by psoriasis, who have psoriatic arthritis , and/or whose quality of life is impaired due to the disease. (medscape.com)

Plaque psoriasis typically involves patches of gray or silvery-white scales. (healthline.com)
People with plaque psoriasis typically have thickened, white scaly patches on their skin. (skinsight.com)

Here we tested the ability of FDG-PET to measure carotid plaque inflammation in patients who subsequently underwent carotid endarterectomy (CEA). (nih.gov)
Signs of inflammation can be observed throughout the dermis in persons with plaque psoriasis. (medscape.com)

Fluorodeoxyglucose uptake did not correlate with plaque area, plaque thickness, or area of smooth muscle cell staining. (nih.gov)

The papules and plaques often first appear within stretch marks before changing appearance and spreading to other areas of the body. (wikipedia.org)
As mentioned above, the papules and plaques usually first appear on the abdomen (although not on the umbilicus/belly button) and often spread to the legs, chest, underarms, etc. (wikipedia.org)
There may be papules (small, raised bumps) or plaques (larger, raised skin lesions that are bigger than a thumbnail), or both. (skinsight.com)

Plaque psoriasis can develop at any age, but it is usually diagnosed in the teenage or early adult years. (skinsight.com)

After 256 weeks of continuous risankizumab treatment, a high proportion of patients with prior biologic treatment achieved clear or almost clear skin," the study said. (dermatologytimes.com)
8,9 Subsequently two primary-prevention trials, ASCEND and VITAL , included a far greater proportion of patients already receiving statin therapy (75%), yet showed no difference in the rates of major vascular events or all-cause mortality among patients receiving a combination EPA/DHA compound. (acc.org)
CONCLUSION: The presence of CAD is a rather common finding in a large proportion of patients with TTC. (who.int)
These results suggest that a significant proportion of patients with influenza A release small airborne particles containing viable virus into the environment. (cdc.gov)

Results Mixed and hard plaques were observed significantly more frequently in hypertensive patients (70%, including mixed plaques - 57%, hard plaques - 13%) than in normotensive patients (45%, including mixed plaques - 38%, hard plaques - 7%) (p = 0.002). (viamedica.pl)
On all three imaging measures, patients who received alirocumab did significantly better than those who received a placebo. (acc.org)
Patients who had received alirocumab also needed significantly fewer repeat stenting procedures. (acc.org)
When there are less plaque and calculus present in your mouth the chances of developing cavities and gum disease significantly decrease. (sfdentistry.com)

Currently, the standard way to confirm the presence of the plaques, and thus the disease, is by autopsy. (newscientist.com)
Prior to the development of PIB and use of PET imaging, the presence of plaque could be confirmed only during autopsy. (sciencedaily.com)

The MM group showed a decrease of perforin level in CD8 + lymphocytes after stimulation compared with patients with PL. These results indicate that MM patients have characteristics of impairment in stimulation-induced cytotoxicity of peripheral blood CD8 + lymphocytes and that PL and MM patients have a common character of functional alteration in those lymphocytes, namely, an increase in memory cells, possibly related to exposure to asbestos. (elsevierpure.com)

Our method uses image preprocessing to first improve the quality of the CARS-imaged plaque, followed by the segmentation of the plaque using Otsu thresholding, marker-controlled watershed, K-means segmentation and a novel independent foam cell thresholding segmentation. (springer.com)

The GISSI-Prevenzione trial and GISSI-HF trials showed significant reductions in death, nonfatal myocardial infarction (MI), nonfatal stroke, and heart failure hospitalization among patients treated with EPA/DHA, although these early studies enrolled relatively few (5 to 22%) patients on concurrent statin therapy. (acc.org)

Of the 66 species- level operational taxonomic units (OTUs) representing the mean relative abundance of 1% in any of the four niches, 12 OTUs corresponding to known periodontal pathogens, including Porphyromonas gingivalis, were characteristically predominant in the subgingival plaque and constituted 37.3 ± 22.9% of the microbiota. (elsevierpure.com)
Based on these results, salivary microbiota might be a promising target for the evaluation of subgingival plaque-derived bacteria representing the present condition of periodontal health. (elsevierpure.com)
When you receive professional periodontal therapy the maturation cycle of the periodontal plaque will be disrupted and the bacteria won't evolve into periodontal pathogenic bacteria for another 3 months since they have to restart their maturation cycle all over again. (sfdentistry.com)
Also considering the fact that 95% of the periodontal disease is undiagnosed, even for patients who go to a dentist regularly, they might not know that they have it. (sfdentistry.com)

Anatomy34

Organisms17

Diseases61

Chemicals and Drugs55

Analytical, Diagnostic and Therapeutic Techniques and Equipment71

Phenomena and Processes18

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture6

Information Science7

Health Care20

Atherosclerotic plaque6

Alzheimer's26

Rupture14

High-risk plaques2

Dental Plaque8

Calcification6

Morphology6

Vulnerable9

20221

Atherosclerosis8

Pleural plaques5

Buildup5

Moderate to severe plaque psoriasis5

Vulnerability11

Severity7

Protein4

Cardiovascular13

Reduction5

Optical coherence2

Arterial4

Progression9

Methods5

Intravascular ultrasound1

Burden3

Unstable1

Findings3

Artery13

Coronary angiography1

20231

Lipid3

Brains of patients1

Blood vessels4

Detect1

Therapies6

Clinical5

Pruritic4

Assess3

Severe7

Biofilm1

Researchers8

Inflammatory4

Psoriatic arthritis3

Psoriasis typically2

Inflammation2

Thickness1

Papules3

Adult1

Proportion of patients4

Significantly4

Autopsy2

Characteristics1

Marker1

Myocardial1

Periodontal4