In free-living postmenopausal women with (n = 47) and without (n = 62) CAD, serum noncholesterol sterols including plant sterols were analyzed with gas-liquid chromatography, cholesterolabsorption with peroral isotopes, absolute cholesterol synthesis with sterol balance technique, and bile acid synthesis with quantitating fecal bile acids. (nih.gov)
Efficacy of plant2
However, the comparative efficacy of plant stanols versus plant sterols in reducing low-density lipoprotein cholesterol (LDL-CH) levels may still be unknown, they explained. (nutraingredients.com)
The short-term cholesterol-lowering efficacy of plant stanol esters has been open to debate, and the data from different clinical studies with hypercholesterolemic subjects are variable, partly due to lack of systematic studies. (biomedcentral.com)
Benecol7
Raisio Group licenses the Benecol brand and sells the ingredient stanol ester to food companies around the world. (wikipedia.org)
The European Commission approved the following statement regarding Benecol products: "Plant stanol esters have been shown to lower/reduce blood cholesterol. (wikipedia.org)
Benecol contains plant-based cholesterols such as plant stanols or sterols. (wikipedia.org)
A serving of Benecol buttery spread supplies 1 g of plant stanols. (wikipedia.org)
Consuming more than 3g of plant stanol per day is not recommended and Benecol foods may not be appropriate for pregnant or breast feeding women, and children under 5 years old. (wikipedia.org)
There are lots of Benecol products to choose from, including yogurts, yogurt drinks and spreads, to help you achieve the recommended intake of plant stanol esters to lower cholesterol. (benecol.co.uk)
Serum cholesterol2
[ 25-27 ] Thus, the consumption of foods enriched with plant sterols decreases serum cholesterol and markedly increases campesterol and sitosterol in serum and also proportionately in endothelial cells, while respective enrichment with plant stanols reduces serum and tissue plant sterol levels in humans. (medscape.com)
After ending the stanol ester use serum cholesterol concentrations began to return rapidly and after 7 days serum LDL cholesterol was 5.3% less than the initial value (P = ns). (biomedcentral.com)
Cholesterol levels4
The National Institute for Health and Clinical Excellence of England and Wales similarly found that while "[t]here is evidence that foods containing plant sterols and stanols reduce cholesterol levels", the government body concludes that "there is not enough evidence at the moment that these products prevent cardiovascular disease. (wikipedia.org)
The European Commission has authorised that an LDL-cholesterol lowering effect of 7-10% can be achieved in 2-3 weeks by a daily intake of plant stanol esters equivalent to 1.5-2.4 g of plant stanols in an appropriate food. (wikipedia.org)
The following is the FDA model health claim, to which certain designated optional modifications may be made: "Foods containing at least 0.5g per serving of plant stanols eaten with meals or snacks for a daily total intake of 2g as part of a diet low in saturated fat and cholesterol, may reduce the risk of heart disease. (wikipedia.org)
They said that as such, it is unclear whether greater reductions in LDL-cholesterol can be achieved with higher daily intakes of plant stanols or plant sterols, or whether plant stanols and plant sterols have similar LDL-cholesterol lowering efficacies at higher intake levels. (nutraingredients.com)
Significantly2
Even though the arterial wall lathosterol concentrations did not differ between the treatment groups, the lathosterol:campesterol ratio was significantly lower in the plant sterol ester group, suggesting that plant stanol ester consumption reduced carotid artery plant sterols in the statin-treated patients. (medscape.com)
They explained that the maximal LDL-cholesterol reductions for plant stanols and plant stanol ester (16.4 and 17.1 percent, respectively) were found to be significantly greater than the maximal LDL-cholesterol reductions for plant sterols and plant sterol ester (8.3 and 8.4 percent). (nutraingredients.com)
Consumption5
Plant Stanol Consumption for Cardiovascular Health: What Do We Know About Efficacy and Safety? (medscape.com)
Arterial sitostanol values were similar between the treatment groups, suggesting that sitostanol was not taken up into the arterial wall during plant stanol ester consumption. (medscape.com)
Cite this: Plant Stanol Consumption for Cardiovascular Health: What Do We Know About Efficacy and Safety? (medscape.com)
"Several scientific and authoritative bodies recommend the daily consumption of 2g plant stanols or plant sterols, expressed as free plant stanol or plant sterol equivalents, for improving blood lipid levels," said the authors. (nutraingredients.com)
Eleven mildly to moderately hypercholesterolemic subjects consumed stanol ester margarine (2.0 g/day of stanols) as a part of their habitual diet for 14 days and the changes in serum lipid values were measured three times at 4, 8 and 15 days after the initiation of test margarine consumption (0 day). (biomedcentral.com)
Reduction3
Since it is not known whether the latter changes in serum plant sterols could be reflected in corresponding reduction in arterial plant sterols and cholesterol, a study was performed in which patients with detected carotid artery atheroma were endarterectomized and studied before and during the operation. (medscape.com)
Meta-analyses have confirmed LDL-C reduction of 9-10% with a daily dose of 2-2.2 g/day of plant stanols. (medscape.com)
Dr Musa-Veloso and colleagues referred to previous meta-analysis', noting that although many shown no significant differences between plant stanols and plant sterols for LDL-cholesterol reduction, many also failed to accurately distinguish between the two. (nutraingredients.com)
Dose4
Intakes of stanols in excess of the recommended 2 grams per day dose are associated with additional and dose-dependent reductions in LDL-cholesterol, according to a new meta-analysis of over 110 trials. (nutraingredients.com)
"Our results suggest that across a continuous dose range, LDL-cholesterol reductions are dose-dependent for plant stanols but not for plant sterols," they added. (nutraingredients.com)
"Thus, larger LDL-cholesterol reductions, as dose-dependently achievable with intakes of plant stanols in excess of the currently recommended 2 g/day dose, may have clinically significant implications with respect to reducing the risk of CHD at the population level," said Musa-Veloso. (nutraingredients.com)
Therefore, in the present study our aim was to find out the time needed to obtain the full cholesterol-lowering effect of plant stanol esters with a daily dose of 2.0 g stanols in healthy, hypercholesterolemic subjects. (biomedcentral.com)
Sterols may be found either as free sterols, acylated ( sterol esters ), alkylated ( steryl alkyl ethers ), sulfated ( sterol sulfate ), or linked to a glycoside moiety ( steryl glycosides) which can be itself acylated ( acylated sterol glycosides ). (gerli.com)
Effects of plant1
However, as far as we know, short-term cholesterol-lowering effects of plant stanol esters have not been studied at several repeated time points within short period of time in a real target group for use of stanol ester-enriched products, i.e. hypercholesterolemic subjects. (biomedcentral.com)
Reduce1
finding that stanols may reduce levels of LDL-cholesterol by more than twice that of sterols in doses over that of 2 grams per day (g/day). (nutraingredients.com)
Group1
Unsaturated steroids with most of the skeleton of cholestane containing a 3 b -hydroxyl group and an aliphatic side chain of 8 or more carbon atoms attached to position 17 form the group of sterols. (gerli.com)
Blood1
The United States Food and Drug Administration (FDA) recognizes the role of plant stanols in lowering blood total and LDL cholesterol, and has authorized a "Health Claim Meeting Significant Scientific Agreement (SSA)" for use on certain foods to which plant stanols have been added. (wikipedia.org)
Products1
Get the recommended amount of plant stanols from our range of products. (benecol.co.uk)
Levels1
In addition to the preoperative statin treatment, the plant stanol enrichment reduced serum LDL-C levels by approximately 17%, serum plant sterols over 30% (from ~400 to 280 × 10 2 µg/mg of cholesterol) and doubled serum sitostanol level (from 9 × 10 2 to 19 × 10 2 µg/mg of cholesterol). (medscape.com)
Approximately2
[ 28 ] Two groups of patients had preoperatively consumed plant stanol or plant sterol esters on an alternating basis for approximately 4 weeks. (medscape.com)
Approximately 60 clinical studies have been published evaluating the efficacy and safety of plant stanol esters. (medscape.com)
Weeks1
The specific effect of plant stanol esters on serum LDL cholesterol can fully be obtained within 1-2 weeks of the use of plant stanol ester-enriched margarine. (biomedcentral.com)
Range1
The new meta-analysis determined whether there are differences between plant stanols and plant sterols in their LDL-CH lowering effects over a range of intakes. (nutraingredients.com)
Small1
Plant stanols are present in small amounts in plants and, accordingly, in the human diet. (medscape.com)
Therefore, we investigated the time in days needed to obtain the full cholesterol-lowering effect of stanol esters in hypercholesterolemic subjects. (biomedcentral.com)