• Placental lactogen I and II were identified as prolactin-like molecules that can bind to prolactin receptor with high affinity and mimic the actions of prolactin. (wikipedia.org)
  • The high-resolution structure of ovine placental lactogen (oPL) and ovine prolactin (oPRL), not yet established in detail, was probed by limited proteolysis with the Glu-specific protease from Staphylococcus aureus V8. (illinois.edu)
  • It is instead increased, as 1-hydroxylase is upregulated by PTH-related protein (PTHrP), prolactin, and placental lactogen. (medscape.com)
  • It is believed to be caused by raised levels of human placental lactogen, cortisol, prolactin, estrogen, and progesterone. (diabetesdigest.com)
  • MANN, P. E. Central lactogenic regulation of maternal behavior in rats: steroid dependence, hormone specificity, and behavioral potencies of rat prolactin and rat placental lactogen I. Endocrinology , v.138, n. 2, p. 756-763, 1997. (bvsalud.org)
  • In addition, estrogen stimulates placental development, and the body fails the functions it is required to function. (attemptmyexam.com)
  • In late pregnancy, the hormones estrogen, cortisol, and human placental lactogen can block insulin. (brighamandwomens.org)
  • Particular interest has been taken in the interactions of endocrine hormones, such as growth hormone, placental lactogen and insulin, with the paracrine expression of growth factors, and nutritional availability and utilization during early growth. (bepress.com)
  • Description: A sandwich ELISA kit for detection of Placental Lactogen from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (therabio.org)
  • Description: The Human Placental Lactogen ELISA kit is an enzyme immunoassay for measurement of human Placental Lactogen (hPL) in serum. (therabio.org)
  • A study has been made of the pre-eclampsia syndrome to assess the immediate effectsof this condition on carbohydrate metabolism and to determine whether the immediate.alterations in blood pressure, renal function and carbohydrate metabolism do predispose to permanent changes in later life.Plasma levels of glucose, human placental lactogen, and immunoreactive insulin wereobserved in the fasting state and for sixty minutes after a glucose challenge. (soton.ac.uk)
  • The patients.with severe pre-eclampsia were found to have significantly lower fasting plasma levels of glucose, human placental lactogen and immunoreactive insulin compared with mild preeclamptic and normal pregnant cases. (soton.ac.uk)
  • Murine monoclonal IgG antibody to human Placental Lactogen (native and recombinant). (arxsciences.com)
  • Placental lactogen, also called chorionic somatomammotropin, is a polypeptide placental hormone, part of the somatotropin family. (wikipedia.org)
  • In conclusion, estriprostilbene-mediated inhibition of tissue maturation and visit here synthesis and resorption resulted in a marked increase in the levels of hPL in rats that were subjected to estradiol, compared with that in rats not treated with estradiol.What is the role of human placental lactogen (hPL) in metabolic regulation? (attemptmyexam.com)
  • These two PRL mAbs are selective for hPRL as they do not inhibit other hPRLR agonists such as human growth hormone or placental lactogen. (iasp-pain.org)
  • OBJECTIVE - The objectives of the study were to determine whether the cell cycle transcription factor, FoxM1, is required for glucose homeostasis and β-cell mass expansion in maternal islets during pregnancy and whether FoxM1 is essential for placental lactogen (PL)-induced β-cell proliferation. (umn.edu)
  • Maternal serum concentrations of glycosylated (Sambucus nigra lectin-reactive) fibronectin, adiponectin, sex hormone-binding globulin, placental lactogen, and high-sensitivity C-reactive protein (CRP) were measured at 5-13 weeks of gestation in a case-control study of 90 pregnant women with subsequent development of GDM and in 92 control group participants. (elsevierpure.com)
  • Placental lactogen I may be important in stimulating mammary cell proliferation and in stimulating some of the adaptations of the maternal lipid and carbohydrate metabolism. (wikipedia.org)
  • What is the role of human placental lactogen (hPL) in metabolic regulation? (attemptmyexam.com)
  • Home - Can Someone Do Anatomy and Physiology Exam - What is the role of human placental lactogen (hPL) in metabolic regulation? (attemptmyexam.com)
  • The purpose of this review is to discuss the use of hCAAT as a model system for reproductive management and to review current information about hPL toxicity, especially the role of endosteroids, with respect to the use of hCAAT in maternal care.What is the role of human placental lactogen (hPL) in metabolic regulation? (attemptmyexam.com)
  • have a peek here a result of these developmental issues for primary mochulism, hPL has been transferred to other organs by placental transplants, including the fetus. (attemptmyexam.com)
  • Hypoxic damage to the human placental myometrium, the first non-lactogenic organ in the body, leads to disruption of the intrauterine life cycle by hormone secretion, often called fetal growth restriction. (attemptmyexam.com)
  • Description: A competitive ELISA for quantitative measurement of Human Placental Lactogen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (therabio.org)
  • Description: A competitive ELISA for quantitative measurement of Canine Placental Lactogen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (therabio.org)
  • Human placental lactogen (hPL) has the largest effect on blood glucose levels in this patient. (proprofs.com)
  • During the 2nd trimester, blood pressure (BP) usually drops (and pulse pressure widens), even though CO and renin and angiotensin levels increase, because uteroplacental circulation expands (the placental intervillous space develops) and systemic vascular resistance decreases. (msdmanuals.com)
  • However, in some cases, hPL is transmissible to the liver by placental transfer, and this is in fact the case in such cases. (attemptmyexam.com)
  • In the case of placental transfer, a combination of trans[hPL], hPL analogues (ex vivo) and transcytosis of short hairpin nucleic acid (hCAAT), which is a click to read model system for the transfer of hPL. (attemptmyexam.com)
  • It has also been used to study placental transfer of highly purified non-dioxin-like polychlorinated biphenyls in BeWo cells. (sigmaaldrich.com)
  • For information on the human form, see human placental lactogen. (wikipedia.org)
  • At the basis of its development exists a variety of changes occurring during physiological pregnancy, such as the launch of placental lactogen, organic results of estrogen and progesterone or metabolism of the creating fetus. (cancer-pain.org)
  • 12. Placental lactogen in maternal serum as an index of fetal health. (nih.gov)
  • Gestational trophoblastic neoplasms (GTN) are a group of neoplasms from fetal trophoblastic cells including choriocarcinoma (CC), epithelioid trophoblastic tumors (ETT), and placental site trophoblastic tumors (PSTT) [ 1 ]. (hindawi.com)
  • Malaria parasitaemia was assessed in maternal peripheral and placental blood, fetal haemoglobin was measured in cord blood, and maternal HIV status was determined. (bmj.com)
  • Causal factors that predispose to poor fetal growth include maternal nutrition, impaired placental function, maternal diseases, infections, and environment influences. (bmj.com)
  • IGF2 is influenced by placental lactogen and may play a role in fetal development. (nih.gov)
  • In addition to its role in providing precursors for placental estrogen formation, the fetal adrenal cortex may participate in the events that lead to the initiation of labor and to maturation of the fetal lungs. (medscape.com)
  • Placental lactogen, also called chorionic somatomammotropin, is a polypeptide placental hormone, part of the somatotropin family. (wikipedia.org)
  • Human placental lactogen (hPL) and growth hormone (hGH) are thought to be derived from a common ancestral gene and have similar nucleotide and amino acid sequences. (nih.gov)
  • Late life metabolic syndrome, early growth, and common polymorphism in the growth hormone and placental lactogen gene cluster. (cdc.gov)
  • Value of the determination of placental lactogen hormone in the surveillance of pathologic pregnancies]. (bvsalud.org)
  • We conclude that proliferin is a placental hormone that is synthesized in certain mouse cell lines during active growth. (nih.gov)
  • We conclude that proliferin is a placental hormone that is also associated with the growth of a number of mouse cell lines in culture. (nih.gov)
  • Placental lactogen I may be important in stimulating mammary cell proliferation and in stimulating some of the adaptations of the maternal lipid and carbohydrate metabolism. (wikipedia.org)
  • Causes can be intrinsic (to the fetus) or extrinsic (maternal or placental problems). (wikidoc.org)
  • This Special Issue of the International Journal of Molecular Sciences aims at providing novel insights into the mechanisms of embryo implantation and placental development as well as at giving an overview of our current knowledge on the different signaling pathways regulating the early steps of implantation and placentation and on the pathological alterations which may impair the establishment of a physiological pregnancy. (mdpi.com)
  • 1. Serum placental lactogen levels in patients with molar pregnancy and trophoblastic tumors. (nih.gov)
  • 2. Serum placental lactogen activity in patients with molar pregnancy and trophoblastic tumors--a reliable index of malignancy. (nih.gov)
  • 5. [Clinical significance of pregnancy-specific beta glycoprotein, human placental lactogen and beta-human chorionic gonadotropin in the serum of patients with trophoblastic diseases]. (nih.gov)
  • In women, placental lactogen secretion begins soon after implantation and increases to 1 g or more a day in late pregnancy. (nih.gov)
  • This placental RNA is about 1 kilobase in length, increases sharply between days 8 and 10 of pregnancy, and then gradually declines through day 18. (nih.gov)
  • Using an antiserum prepared against a synthetic proliferin fusion protein, we show that proliferin is secreted as a glycoprotein by minced placental tissue and that it differs from mouse placental lactogen. (nih.gov)
  • DNA sequences involved in the transcriptional activation of a human placental lactogen gene. (nih.gov)
  • These data indicate that rat Pit 1 binds to the placental hGH-V and hCS-A genes and correlates with their promoter activity in GC cells after gene transfer. (nih.gov)
  • Gel mobility shift assays showed that the hPL enhancer interacted specifically with nuclear proteins from JEG-3 cells and placental tissue. (nih.gov)
  • Placental protein(s) binding this region may be instrumental in tissue-specific activity of the hPL enhancer. (nih.gov)
  • 9. In vitro biosynthesis of human placental lactogen (HPL) by chorionic tissue and the diagnostic value of HPL in trophoblastic disease. (nih.gov)
  • others are invasive mole (chorioadenoma destruens), choriocarcinoma, placental site trophoblastic tumor (PSTT), and epithelioid trophoblastic tumor (ETT). (medscape.com)
  • 7. Serum human placental lactogen (HPL) levels in patients with intact hydatidiform mole. (nih.gov)
  • Human placental lactogen (hPL) has the largest effect on blood glucose levels in this patient. (proprofs.com)
  • During the 2nd trimester, blood pressure (BP) usually drops (and pulse pressure widens), even though CO and renin and angiotensin levels increase, because uteroplacental circulation expands (the placental intervillous space develops) and systemic vascular resistance decreases. (msdmanuals.com)
  • Within the 138-bp enhancer, a 22-bp region overlapping a TEF-1 binding site was shown to be protected from DNase I digestion by placental and HeLa nuclear extracts. (nih.gov)
  • Minced pla- centas secreted immunologically detectable proliferin, which is shown to differ from the previously identified murine placental lactogen (mPL) (3). (nih.gov)