• The effect of d-cycloserine on brain processing of breathlessness over pulmonary rehabilitation: an experimental medicine study. (ox.ac.uk)
  • He followed this observation with a placebo-controlled trial that demonstrated the antidepressant effect of D-cycloserine. (nrxpharma.com)
  • University of Calgary researchers have shown that the antibiotic D-Cycloserine (DCS) increases the effectiveness of transcranial magnetic stimulation (TMS) for people with major depressive disorder (MDD). (ucalgary.ca)
  • The antibiotic D-Cycloserine (DCS) helps magnetic stimulation (TMS) for people with major depressive disorder (MDD). (dr-bob.org)
  • Our current work explores the potential of several cognitive enhancers, such as the antibiotic cycloserine or the antihypertensive drug losartan, in improving CBT for anxiety disorders by targeting its underlying mechanisms of action. (ox.ac.uk)
  • Neurocognitive processes in d-cycloserine augmented single-session exposure therapy for anxiety: A randomized placebo-controlled trial. (ox.ac.uk)
  • The study is a single-blind randomized placebo-controlled trial with a 3-month intervention paradigm of either Femicept (2nd generation combined oral contraceptive) or placebo. (inclinicaltrials.com)
  • Study design: The investigators will conduct a single-blind randomized placebo-controlled trial with a 3-month intervention paradigm of either OC or placebo. (inclinicaltrials.com)
  • The purpose of this study is to evaluate the efficacy and safety of D-cycloserine versus placebo in relieving the signs and symptoms of patients with chronic lower back pain. (clinicaltrials.gov)
  • With this study, the investigators apply longitudinal study design to determine if OC use versus placebo cause changes in 5-HT4R brain binding and if such changes map onto relevant signatures of brain functions and mental states, including sexual desire. (inclinicaltrials.com)
  • Half of those also received DCS while the other half received a placebo. (ucalgary.ca)
  • Also, half of them received DCS and the other half received a placebo. (dr-bob.org)
  • Adding low doses of D-cycloserine to antipsychotics other than clozapine can temper social withdrawal in persons with schizophrenia, several studies have suggested. (autismtoday.com)
  • D-cycloserine added to clozapine for patients with schizophrenia. (harvard.edu)
  • 7 As such, a compound known as d-cycloserine (DCS) has been demonstrated to augment extinction learning by serving as a partial NMDA agonist. (psychiatrictimes.com)
  • The partial N-methyl-d-aspartate (NMDA)-receptor agonist d-cycloserine has shown promising results in enhancing efficacy of CBT, thus we hypothesised that it would similarly augment the effects of pulmonary rehabilitation in the brain. (ox.ac.uk)
  • CONCLUSION: Although increasing evidence supports therapeutic modulation of NMDA pathways to treat symptoms, we conclude that a phase 3 clinical trial of d-cycloserine would not be worthwhile. (ox.ac.uk)
  • D-cycloserine (DCS) is a partial agonist at the N-methyl-D-aspartate (NMDA) glutamate receptor, which plays an essential role in mediating learning and memory. (nature.com)
  • At the time, however, there was no understanding of brain chemistry and NMDA receptors, much less the understanding that D-cycloserine is a potent NMDA receptor. (nrxpharma.com)
  • After the effect of NMDA inhibition was discovered, there was a resurgence of interest in D-cycloserine and other overlooked NMDA-antagonist medications, such as dextromethorphan and d-methadone. (nrxpharma.com)
  • The company's lead program NRX-101, an oral, fixed-dose combination of D-cycloserine and lurasidone, targets the brain's N-methyl-D-aspartate (NMDA) receptor and is being investigated in a Phase 2b /3 clinical trial for suicidal treatment-resistant bipolar depression, which includes patients with both acute and sub-acute suicidality, an indication for which the only approved treatment is electroshock therapy. (businessinsider.com)
  • The company's lead program NRX-101, an oral, fixed-dose combination of D-cycloserine and lurasidone, targets the brain's NMDA receptor and is being investigated in a Phase 3 trial under a Food and Drug Administration ("FDA") Special Protocol Agreement and Breakthrough Therapy Designation in patients with bipolar depression and acute suicidal ideation, an indication for which the only approved treatment is electroshock therapy. (relieftherapeutics.com)
  • Various factors prompted Posey and his colleagues to undertake a pilot study to determine whether D-cycloserine might increase socialization in autistic children In addition to being used to treat tuberculosis for 45 years, D-cycloserine enhances the activity of the neurotransmitter glutamate in the brain. (autismtoday.com)
  • Recently, human studies using exposure therapy to treat anxiety have demonstrated that pretreatment with D-cycloserine (DCS) enhances fear reduction in anxiety disorders. (cambridge.org)
  • Results, published in JAMA Psychiatry , show that almost 75 per cent of participants treated with DCS and TMS benefited, compared to only 30 per cent of those treated with TMS and a placebo. (ucalgary.ca)
  • Similar to augmentation studies with D-cycloserine, this proof-of-concept study could help us to provide further evidence for enhancement between combined psychotherapy and pharmacologic interventions. (opensourcepsychiatry.com)
  • When animal research protocols have determined the proper dose and time frame for medications to augment psychotherapy, I would welcome a randomized, placebo-controlled clinical trial based on those animal studies. (psychiatrist.com)
  • Primary outcome measures were differences between d-cycloserine and placebo in brain activity in the anterior insula, posterior insula, anterior cingulate cortices, amygdala and hippocampus following completion of pulmonary rehabilitation. (ox.ac.uk)
  • RESULTS: No difference between d-cycloserine and placebo groups was observed across the primary or secondary outcome measures. (ox.ac.uk)
  • Military personnel with PTSD ( n = 192) were recruited into a multisite double-blind randomized controlled trial to receive nine weeks of VRE or PE, with DCS or placebo. (nature.com)
  • This is a 26-week, double-blind, randomized, placebo-controlled two-arm parallel-group trial of d-cycloserine, a pharmacological treatment selected based on positive results from previous preclinical and clinical studies, for the treatment of chronic, refractory low back pain (CBP). (clinicaltrials.gov)
  • A Randomized, Double-Blind, Placebo- and Active-Controlled, Escalating Single-Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Profiles of Subcutaneous Eflapegrastim in Healthy Japanese and Caucasian Subjects. (sc-ctsi.org)
  • Results from a randomized, double-blind, placebo-controlled, crossover, multimodal-MRI pilot study of gabapentin for co-occurring bipolar and cannabis use disorders. (musc.edu)
  • The subjects' social withdrawal was measured with four yardsticks at the start of the study, at the end of the placebo phase, and at the end of each two-week phase. (autismtoday.com)
  • The company's prior Phase 2 STABIL-B clinical trial evaluating NRX-101 in patients with Severe Bipolar Depression with Acute Suicidal Ideation & Behavior (ASIB) demonstrated a substantial improvement over available therapy in reducing depression and suicidality compared to placebo when patients were treated with NRX-101 after a single dose of ketamine. (businessinsider.com)
  • D-cycloserine has been safely used in children at high doses to treat tuberculosis, and the low doses of D-cycloserine used in persons with schizophrenia have produced limited side effects. (autismtoday.com)
  • A placebo-controlled trial of D-cycloserine added to conventional neuroleptics in patients with schizophrenia. (harvard.edu)
  • Dose-finding trial of d-cycloserine added to neuroleptics for negative symptoms in schizophrenia. (harvard.edu)
  • Participants were randomised to 250 mg d-cycloserine or placebo, administered immediately prior to the first four sessions of pulmonary rehabilitation. (ox.ac.uk)
  • DCS and placebo were equally effective for nondepressed participants. (nature.com)
  • Study participants took a pill - either DCS, a placebo or alprazolam - about 30 minutes before beginning VRE. (delraycenter.com)
  • We tested the efficacy of virtual reality exposure (VRE) or prolonged imaginal exposure (PE), augmented with D-cycloserine (DCS) for combat-related PTSD. (nature.com)
  • Of the 156 combat vets with PTSD recruited for the study, 53 were given DCS, 50 received alprazolam (or Xanax) and 53 received a placebo prior to undergoing five sessions of VRE. (delraycenter.com)
  • He said of the experiment, "D-cycloserine, combined with only five sessions of the virtual reality exposure therapy, was associated with significant improvements in objective measures of startle and cortisol and overall PTSD symptoms for those who showed emotional learning in sessions. (delraycenter.com)
  • Augmenting extinction learning with D-cycloserine reduces return of fear: A randomized, placebo-controlled fMRI study. (mpg.de)
  • D-cycloserine may help patients with anxiety disorders, or it might make their anxiety worse. (psychiatrictimes.com)
  • This discovery provided context for the 1959 discovery by Professor George Crane that D-cycloserine, a newly-developed treatment for tuberculosis was a potent antidepressant. (nrxpharma.com)
  • Anti-depressant research with D-cycloserine did not continue because another tuberculosis drug - Isoniazid - was shown to have antidepressant effects with no psychedelic effects and was developed into the first class of antidepressant drugs based on Iproniazid. (nrxpharma.com)
  • We propose to test this hypothesis by randomizing 40 subjects with major depressive disorder (MDD) and residual depressive symptoms on SSRI monotherapy to 8 weeks of treatment with either WBT in combination with a stimulant or WBT with pill placebo. (opensourcepsychiatry.com)
  • They found that VRE greatly improved the veterans' symptoms, especially when administered in conjunction with d-Cycloserine (DCS), a drug that has been used to treat anxiety and stress disorders, including phobias. (delraycenter.com)
  • The Breakthrough Therapy Designation and Special Protocol Agreement were awarded by the FDA based on the Company's prior STABIL-B trial that demonstrated substantial improvement over available therapy in reducing depression and suicidality compared to placebo when patients were treated with NRX-101 after a single dose of ketamine. (relieftherapeutics.com)
  • Adding D-Cycloserine to the TMS treatment appears to enhance TMS's ability to drive synaptic plasticity and treat depression. (ucalgary.ca)
  • However, these medications' putative ability to increase socialization in autistic youngsters has yet to be demonstrated in placebo-controlled trials. (autismtoday.com)
  • In the pilot study by Posey and his coworkers, 10 individuals who met a DSM-IV diagnosis of autism and who were on average 10 years old received a placebo for two weeks, then three different, ascending doses of D-cycloserine during each of three two-week periods. (autismtoday.com)
  • For example, subjects performed significantly better on the Clinical Global Impression Scale after they had received the medium and high doses of D-cycloserine than they had at the start of the study. (autismtoday.com)
  • Subjects performed significantly better on the social withdrawal subscale of the Aberrant Behavior Checklist after they had gotten the highest dose of D-cycloserine than they had at the start of the study (see chart). (autismtoday.com)
  • Greg's participation in the D-cycloserine study. (autismtoday.com)
  • After a 2-week screening period, individuals will be randomized to receive either 12 weeks of d-cycloserine or placebo and then followed for an additional 12 weeks to evaluate persistence of benefit at study endpoint, 24 weeks after randomization. (clinicaltrials.gov)
  • Nonetheless, she noted marked improvement in his attention, spontaneous use of language, and initiation of social interaction while he was on D-cycloserine. (autismtoday.com)
  • d-cycloserine was shown instead to interact with changes in breathlessness anxiety to dampen reactivity to breathlessness cues. (ox.ac.uk)
  • Fourteen healthy males (30.0±8.7 years of age) randomly received DCS 500 mg or placebo prior to 3.0 Tesla functional magnetic resonance imaging acquisition. (cambridge.org)