• Gigantism and acromegaly are syndromes of excessive secretion of growth hormone (hypersomatotropism) that are nearly always due to a pituitary adenoma. (msdmanuals.com)
  • Left image shows a 64-year-old woman who presented with acromegaly due to a pituitary adenoma. (msdmanuals.com)
  • The ghrelin peptide and ghrelin mRNA have been detected in several regions of hypothalamus, in normal pituitary, as well as in various types of pituitary adenoma, with different levels of expression in different tumour types. (nel.edu)
  • Human pituitary somatotroph adenoma tissues were obtained at the time of transsphenoidal surgery from 3 acromegalic patients and studied for ghrelin mRNA expression. (nel.edu)
  • Because of the general acceptance of postoperative chemoradiation as a result of the reporting of SWOG 9008INT-0116, but it is questionable whether a formal extradural approach to forex practice charts sella via the cavernous sinus is warranted in pituitary adenoma because of the benign nature of the tumor. (qrforex.com)
  • The pituitary tumour transforming gene (PTTG), also known as securin, is a mitotic checkpoint protein which inhibits sister chromatid separation during mitosis. (birmingham.ac.uk)
  • We conclude that PTTG may be an important gene in the mutator phenotype development in thyroid cancer. (birmingham.ac.uk)
  • Pituitary tumor-transforming gene (PTTG) family members are well documented to be involved in cell-cycle regulation and mitosis, and contribute to cancer development by their involvement in cellular transformation in several tumor types. (tmu.edu.tw)
  • Results of our coexpression analysis demonstrated that PTTG family genes were positively correlated with thiamine triphosphate (TTP), deoxycytidine triphosphate (dCTP) metabolic, glycolysis, gluconeogenesis, and cell-cycle related pathways. (tmu.edu.tw)
  • PTTG-1 is overexpressed in pituitary tumors. (medscape.com)
  • GH-secreting tumors are largely sporadic, but genetic abnormalities in the X chromosome (X-linked acrogigantism), overexpression of the pituitary tumor transforming gene ( PTTG ), and mutations in the aryl hydrocarbon receptor-interacting protein (AIP) have been discovered. (msdmanuals.com)
  • Multiple oncogene abnormalities may be involved in pituitary tumorigenesis. (medscape.com)
  • Pierre Marie, a French neurologist (Salpetriere Hospital, Paris) was the first to describe a disease that involved the pituitary gland. (medscape.com)
  • In 1886, he studied 2 patients with clinical findings of what he termed acromegaly and postulated that the pituitary gland was involved in the pathogenesis. (medscape.com)
  • G-protein abnormalities, ras gene mutations, p53 gene deletions, mutations, and rearrangements, and the association of pituitary tumors with the syndrome of multiple endocrine neoplasia have been described and are involved in the development of adenomas in the pituitary gland. (medscape.com)
  • Pituitary gland tumors may cause neurological and hormonal symptoms. (bvsalud.org)
  • The optic chiasm lies in close proximity to the pituitary gland and can be compressed by tumors leading to visual disturbances (bitemporal hemianopsia) [6]. (bvsalud.org)
  • Asymptomatic patients with an enlarged sella turcica should have an air study to exclude an 'empty sella"syndrome, an anatomical entity in which the pituitary fossa is expanded and partially filled with cerebrospinal fluid owing to the arachnoid herniation, while the pituitary gland is compressed against the posterior rim of the fossa [3]. (bvsalud.org)
  • INHBA: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. (assaygenie.com)
  • Although the tumor was benign, the resulting surgery severely damaged Gramm's pituitary gland, leadin. (blabbermouth.net)
  • Brain tumour denotes an abnormal growth of cells in the brain or in nearby organs such as the nerves, the pituitary gland, the pineal gland, etc. (indiatimes.com)
  • Other causes include: Health conditions, such as: Tumors of the adrenal gland, pituitary gland, or testes. (dashofeast.com)
  • In humans, the CRYAA gene encodes a 173 amino acid residue protein by single copy genes located on chromosome 21. (molvis.org)
  • The present findings revealed that PTTG1 and PTTG3 are two important genes with high expressions in breast cancer relative to normal breast cells, implying their unique roles in breast cancer progression. (tmu.edu.tw)
  • Correspondingly, most cancer signaling pathways seem to converge on one or more TFs, termed "master regulators" (MRs) [ 4 ], which direct tumor development, progression, and metastasis through hierarchical control of gene expression patterns. (aging-us.com)
  • Aberrant expression, overexpression or signal reprogramming of GPCRs and G proteins in tumour cells can contribute to cancer development and progression. (nature.com)
  • These alterations may arise from cancer-specific changes in gene copy number, as well as from other genetic, epigenetic and post-translational changes resulting in higher protein expression, thereby enhancing tumour progression and metastasis. (nature.com)
  • Emerging evidence indicates that Long non-coding RNAs (LncRNAs) and microRNAs (miRNAs) play crucial roles in tumor progression, including hepatocellular carcinoma (HCC). (biomedcentral.com)
  • Dysfunctions of long non-coding RNA (lncRNAs) have been associated with the initiation and progression of hepatocellular carcinoma (HCC), but the clinicopathologic significance and potential role of lncRNA PTTG3P (pituitary tumor-transforming 3, pseudogene) in HCC remains largely unknown. (biomedcentral.com)
  • Mechanistically, over-expression of PTTG3P up-regulated PTTG1, activated PI3K/AKT signaling and its downstream signals including cell cycle progression, cell apoptosis and epithelial-mesenchymal transition (EMT)-associated genes. (biomedcentral.com)
  • Of the 30,000 or so genes that are currently thought to exist in the human genome , there is a small subset that seems to be particularly important in the prevention, development, and progression of cancer. (cancerquest.org)
  • Cancer cells release exosomes with various functions into the tumour microenvironment during cancer progression. (ijbs.com)
  • As previously reported, colorectal cancer cell-derived exosomes have important roles in tumour progression including invasion, angiogenesis, immune modulation and distal metastasis through effectively delivering microRNAs, mRNAs and proteins ( 10 - 12 ). (ijbs.com)
  • Most of these tumors are benign, but certain factors involved in the genesis of the tumor may determine its rate of growth and aggressiveness. (medscape.com)
  • Thus, both tumor growth characteristics, as well as hormonal excess are the hallmarks of these invariably benign tumors. (endocrine-abstracts.org)
  • Villwock et al noted that pituitary tumors constitute 10-15% of all diagnosed intracranial tumors, 90% of which are adenomas. (medscape.com)
  • [ 4 ] Nonfunctioning adenomas are associated with hypermethylation of p16 prolactinomas, and corticotropin-secreting tumors express galectin-3 (Gal-3), a gene involved in cell growth and apoptosis. (medscape.com)
  • Pituitary adenomas, with a few exceptions, are not under the control of hypothalamic releasing factors. (medscape.com)
  • Cooper Odelia, Melmed Shlomo Subclinical hyperfunctioning pituitary adenomas: the silent tumors Best practice & research. (ucla.edu)
  • Recent cancer genome deep sequencing efforts have revealed an unanticipated high frequency of mutations in G proteins and G-protein-coupled receptors (GPCRs) in most tumour types. (nature.com)
  • A striking 4.2% of all tumour sequences deposited to date show activating mutations in GNAS (a complex locus that encodes Gα s ). (nature.com)
  • Transforming mutations in GNAS have been well documented in human thyroid and pituitary tumours, and recent sequencing efforts have shown these mutations to be present in a wide variety of additional tumour types, including colon cancer, hepatocellular carcinoma, and parathyroid, ovarian, endometrial, biliary tract and pancreatic tumours. (nature.com)
  • Deep sequencing studies show that 4.2% of tumours carry activating mutations in GNAS (encoding Gα s ), and that oncogenic activating mutations in genes encoding Gα q family members ( GNAQ or GNA11 ) are present in ∼ 66% and ∼ 6% of melanomas arising in the eye and skin, respectively. (nature.com)
  • ALL cancers have lots of additional changes, the so-called 'passenger' mutations, that may contribute to the cancer, but are not the main genes. (cancerquest.org)
  • Mutations in DNA repair genes are associated with a substantially increased lifetime cancer risk and research has shown that men with mutations and high cortisol and high mean 8-OHdG (a biomarker of oxidative DNA damage) levels have a significantly higher risk of prostate cancer. (brighton.ac.uk)
  • Working with Caroline Garett, Greg Scutt, Andrew Overall as well as students studying towards their PhDs in biomedicine [link with programme area], the research examined the impact of hormones associated with stress in tumour tissue from women with mutations in cancer genes, focusing on women who are at high risk of cancer of the breast. (brighton.ac.uk)
  • Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant familial cancer syndrome characterized primarily by endocrine tumors of the parathyroids, anterior pituitary, and enteropancreatic endocrine tissues. (johnshopkins.edu)
  • Since strong consensus regarding commonly altered MRs in hepatocellular carcinoma (HCC) is lacking, we generated a compendium of HCC datasets from 21 studies and identified a comprehensive signature consisting of 483 genes commonly deregulated in HCC. (aging-us.com)
  • We downloaded Trp metabolism-related genes' expression data from different public databases, including TCGA, Gene Expression Omnibus (GEO) and Hepatocellular Carcinoma Database (HCCDB). (biomedcentral.com)
  • We identified two metabolic phenotypes based on genes of the Trp metabolism pathway, and we established a risk model that could be used for predicting prognosis and guiding immunotherapy in patients with hepatocellular carcinoma. (biomedcentral.com)
  • Decreased expression and frequent allelic inactivation of the RUNX3 gene at 1p36 in human hepatocellular carcinoma. (medicalnote.jp)
  • Ghrelin is one of the peptides involved into GH-release, binding to specific GHS receptors on hypothalamus and pituitary. (nel.edu)
  • Ovarian insufficiency is considered primary if the ovary fails to function normally in response to appropriate gonadotropin stimulation provided by the hypothalamus and pituitary. (medscape.com)
  • Ovarian insufficiency is considered secondary if the hypothalamus and pituitary fail to provide appropriate gonadotropin stimulation. (medscape.com)
  • Recently, efforts have revealed that HPV virus oncogenes inactivate the tumour suppressor proteins p53 and pRB, leading to increased genomic instability, and among other cancer hallmarks, and in some cases, integration of HPV into the host genome [6, 7]. (fortuneonline.org)
  • The normal versions of genes in the first group are called proto-oncogenes. (cancerquest.org)
  • The mutated or otherwise damaged versions of these genes are called oncogenes. (cancerquest.org)
  • A useful analogy to consider when thinking about tumor suppressors and oncogenes is an automobile. (cancerquest.org)
  • We have two copies of each gene and for oncogenes, a single defective copy is enough to cause a cell to divide. (cancerquest.org)
  • Numerous genes have been identified as proto-oncogenes. (cancerquest.org)
  • As stated in the introduction to this section, the defective versions of these genes, known as oncogenes, can cause a cell to divide in an unregulated manner. (cancerquest.org)
  • Pituitary tumors are common neoplasms, and recognition of their presentation is critical since a favorable therapeutic outcome is dependent on early identification of the lesion. (medscape.com)
  • Pituiatry tumors account for about 15% of all intracranial neoplasms. (endocrine-abstracts.org)
  • The most frequently mutated GPCRs include thyroid-stimulating hormone receptor (TSHR), Smoothened (SMO), glutamate metabotropic receptors (GRMs), members of the adhesion family of GPCRs and receptors for bioactive lipid mediators such as lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) that accumulate in the tumour microenvironment. (nature.com)
  • A hypoxic tumour microenvironment, which is defined as a condition in which the oxygen pressure in the tumour tissue is less than 5 to 10 mm Hg, is extremely important for cancer metastasis ( 5 , 6 ). (ijbs.com)
  • Artificial modulation of PTTG3P (down- and over-expression) was performed to explore the role of PTTG3P in tumor growth and metastasis in vitro and in vivo. (biomedcentral.com)
  • Our findings suggest that PTTG3P, a valuable marker of HCC prognosis, promotes tumor growth and metastasis via up-regulating PTTG1 and activating PI3K/AKT signaling in HCC and might represent a potential target for gene-based therapy. (biomedcentral.com)
  • Mounting evidence has linked mutation and dysregulation of lncRNAs to cancer initiation, growth and metastasis and they may act as oncogenic factors or tumor suppressors [ 8 , 9 ]. (biomedcentral.com)
  • Hair follicles were cultured in Williams E medium and treated with or without 650-nm red light.Real-time RT-PCR and immunofluorescence staining were used to detect the expression level of genes and proteins in hair follicles, respectively. (bvsalud.org)
  • Note that by convention gene names are italicized and the proteins they make are not. (cancerquest.org)
  • Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. (chemeurope.com)
  • a b Entrez Gene: ACVR2A activin A receptor, type IIA. (chemeurope.com)
  • In addition, tamoxifen induces the re-expression of the tumor suppressor gene maspin in breast cancer tissue. (medilabcompounding.com)
  • The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. (assaygenie.com)
  • Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. (assaygenie.com)
  • Tamoxifen decreases insulin-like growth factor type 1, a factor that stimulates cancer cell growth and development and induces the secretion of transforming growth factor beta (TGF-beta) which is associated with inhibiting the activity of breast cancer cells. (medilabcompounding.com)
  • However, whether there is a crosstalk between LncRNA pituitary tumor-transforming 3 (PTTG3P) and miR-383 in HCC remains unknown. (biomedcentral.com)
  • qPCR and Western blot were used to analyze LncRNA PTTG3P, miR-383 and other target genes' expression. (biomedcentral.com)
  • In this study, we identified a novel lncRNA PTTG3P, termed pituitary tumor-transforming 3, pseudogene (NCBI Accession NO.NR_002734) via microarray analysis. (biomedcentral.com)
  • Pituitary tumor-transforming 3, pseudogene is a protein that in humans is encoded by the PTTG3P gene. (wikipedia.org)
  • Pseudogene, a subclass of long non-coding RNAs (lncRNAs), are considered as genomic loci that resemble real gene, but lost some functionality because they are lack of protein-coding ability because of disabling mutation, lack of transcription, or their inability to encode RNA [ 3 ]. (biomedcentral.com)
  • This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. (cancerindex.org)
  • HER2/neu (also called ERB B2 ) is the gene that encodes the human epidermal growth factor receptor type 2. (cancerquest.org)
  • This gene encodes activin A type II receptor. (chemeurope.com)
  • We found that PTTG3P was frequently up-regulated in HCC and its level was positively correlated to tumor size, TNM stage and poor survival of patients with HCC. (biomedcentral.com)
  • IDO1 is the most studied and regulates immune cell function through the KYN pathway, and treatment combining immune checkpoint inhibitors (ICIs) with IDO1 blockade tends to inhibit tumour growth. (biomedcentral.com)
  • miR-455 has been reported to act as a tumor suppressor to inhibit cap-dependent translation and the proliferation in prostate cancer [ 11 ]. (hindawi.com)
  • Using computational predictions, we revealed that HPV-positive cervical cancers are regulated by transcription factors including, SOX2, E2F, NANOG, OCT4, and MYC, which control various processes such as the renewal of cancer stem cells, and the proliferation and differentiation of tumour cells. (fortuneonline.org)
  • knockdown in the fibroblasts significantly inhibited the cell proliferation, obviously lowered the expressions of fibrosis-related genes, and reduced the protein expression of collagen. (bvsalud.org)
  • Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. (assaygenie.com)
  • We previously found that exosomes released from hypoxic CRC cells enhanced tumour growth and angiogenesis by enhancing the proliferation and migration of endothelial cells ( 13 ). (ijbs.com)
  • Additionally, we screened 739 differentially expressed genes (DEGs) between the C1 and C2. (biomedcentral.com)
  • RNA-seq analysis and gene clustering for the differentially expressed genes suggests that leukocyte transendothelial migration, metabolism, adherens junction and other biological process maybe involved in stimulation of hair follicles by 650-nm red light treatment. (bvsalud.org)
  • Despite the differences in their normal roles, these genes all contribute to unregulated cell division if they are present in a mutant (oncogenic) form. (cancerquest.org)
  • Numbers shown below represent number of publications held in OncomiRDB database for Oncogenic and Tumor-Suppressive MicroRNAs. (cancerindex.org)
  • Harenza JL, Muldoon PP, De Biasi M, Damaj MI, Miles MF (2014) Genetic variation within the Chrna7 gene modulates nicotine reward-like phenotypes in mice. (genenetwork.org)
  • Transcription factors (TFs) drive gene expression programs that shape specific phenotypes [ 3 ], and are frequently dysregulated in cancer [ 4 ]. (aging-us.com)
  • Thus, MRs comprise typically a small number of TF-encoding genes (and their products) that control a disproportionate level of gene expression, giving rise to distinct molecular phenotypes associated with a particular disease. (aging-us.com)
  • Since the expression of genes defining discrete phenotypes is highly coordinated, application of reverse engineering algorithms to transcriptome datasets allows interpreting transcriptional networks by defining MRs and their associated regulons and gene circuits. (aging-us.com)
  • In this study, we used genes of the Trp metabolism pathway to identify stable metabolic phenotypes by consensus clustering. (biomedcentral.com)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • Although many altered pathways and aberrantly expressed genes involved in hepatocarcinogenesis were identified, the precise molecular mechanisms for HCC are not entirely clear [ 2 , 5 ]. (biomedcentral.com)
  • Our HCC signature covered well-established liver cancer hallmarks, and network analyses revealed coordinated interaction between several MRs. One novel MR, SEC14L2 , exerted an anti-proliferative effect in HCC cells and strongly suppressed tumor growth in a mouse model. (aging-us.com)
  • CIBERSORT and Tracking of Indels by DEcomposition (TIDE) analyses were adopted to assess the infiltration abundance of immune cells and tumour immune escape. (biomedcentral.com)
  • In order to elucidate the relationship between secretory pathway and processing for precursor molecule of peptide hormones, we performed immunoelectron microscopic studies to localize POMC-derived peptides in mouse cultured L cells (fibroblasts without secretory granules) and in mouse AtT20 cells (ACTH secreting pituitary tumor cells with secretory granules) which had been transformed with human POMC gene. (fujita-hu.ac.jp)
  • Genes whose protein products stimulate or enhance the division and viability of cells. (cancerquest.org)
  • Taken together, the results of our study indicate that hypoxia may stimulate tumour cells to release Wnt4-rich exosomes that are delivered to normoxic cells to enhance prometastatic behaviours, which might provide new targets for CRC treatment. (ijbs.com)
  • 1996). "Inhibitory effects of activin on the growth and morpholgenesis of primary and transformed mammary epithelial cells. (chemeurope.com)
  • Metallothionein stroma reaction in tumor adjacent healthy tissue in head and neck squamous cell carcinoma and breast adenocarcinoma. (nel.edu)
  • From Newman C. In Atlas of Clinical Endocrinology: Neuroendocrinology and Pituitary Disease . (msdmanuals.com)
  • He has received many honours and awards in recognition of his clinical and scientific leadership in the field of pituitary disease, including the Clinical Endocrinology Trust Medal of the Royal Society of Medicine (1994), the Neuro-endocrinology Award of McGill University (1995), and the Pituitary Society's Award for Contributions to Understanding Pituitary Disease (1997). (ucla.edu)
  • The skull of the index patient was actually examined by Harvey Cushing and Sir Arthur Keith in 1909 and found to have an enlarged pituitary fossa. (medscape.com)
  • A pediatric Foley catheter was placed into the pituitary fossa and gradually inflated to simulate the effect of a pituitary mass. (medscape.com)
  • They arise from pituitary cell types due to both cell cycle trophic dysruptions leading to adenomatous growth, as well as a coupling of specific hormone gene over-expression. (endocrine-abstracts.org)
  • An in vivo xenograft study was performed to detect tumor growth. (biomedcentral.com)
  • Specifically, transcripts for fibulin 2 (Fbln2), periostin (Postn), and versican [chondroitin sulfate proteoglycan (Cspg2)], genes critical for the developing heart and known to be induced by transforming growth factor-β (TGF-β), were decreased in their expression in menin-null MEFs. (johnshopkins.edu)
  • This first category also includes genes that contribute to tumor growth by inhibiting cell death. (cancerquest.org)
  • Topical steroids of moderate potency may be helpful, but reports have described complications such as aminoaciduria and pituitary adrenal axis suppression, especially in patients with widespread erythroderma, and thus should be used with caution. (medscape.com)
  • It is also known that alcohol, at least in part, exerts its anti-inflammatory response via activation of the hypothalamic-pituitary-adrenal axis pathway resulting in increases of glucocorticoids [ 10 ]. (cdc.gov)
  • Introduction: The human Pituitary Tumor Transforming Gene (hPTTG) is a phosphorylated proto-oncogene induced in multiple tumour types. (endocrine-abstracts.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Neuroepithelial Cell Transforming Gene 1 (NET1) in Tissue homogenates and other biological fluids. (noveoninc.com)
  • Histopathologically healthy tumor adjacent tissue might be considered as a cancerization field which is typified by genetic changes required for the development of cancer. (nel.edu)
  • An explanation for the development of bitemporal visual-field defects in association with pituitary tumors has been a subject of renewed interest. (medscape.com)
  • Considering the strong evidence that TRP metabolism mediates tumour development and immune suppression, a comprehensive analysis of the TRP pathway might improve the development of survival biomarkers and provide potential strategies for the precise treatment of HCC patients. (biomedcentral.com)
  • Conclusions Spliceosome-associated RNAs and TREML4, a TLR7-associated gene product, may represent biomarkers of lupus nephritis, and PTTG1, the product of a lupus-associated gene reported to be involved in epithelial-mesenchymal transition, may be a novel therapeutic target associated with active nephritis. (bmj.com)
  • The genes in the second group are called tumor suppressors. (cancerquest.org)
  • Overexpression of pituitary tumor transforming gene 1 in HCC is associated with angiogenesis and poor prognosis. (medicalnote.jp)
  • A diagram showing the major cancer genes for some cancers. (cancerquest.org)
  • 9] evaluated 100 patients with an enlarged sella turcica and the most common cause of its expansion was a primary intrasellar pituitary tumor. (bvsalud.org)
  • this gene is known to regulate the cellular mitosis process and forced expression of this gene induces tumor formation in nude mice. (medscape.com)
  • We compared the expression profiles of lncRNAs in 3 HCC tumor tissues and adjacent non-tumor tissues by microarrays. (biomedcentral.com)
  • Identification of master regulator (MR) genes offers a relatively rapid and efficient way to characterize disease-specific molecular programs. (aging-us.com)
  • Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome. (assaygenie.com)
  • Joint mouse-human phenome-wide association to test gene function and disease risk. (genenetwork.org)
  • In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. (assaygenie.com)
  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. (cancerindex.org)
  • MicroRNAs (miRNAs) are small noncoding endogenous RNAs containing 19 to 25 nucleotides that promote posttranscriptional control in regulating the expression of target gene by binding to the 3′-UTR sequences of its mRNA [ 5 ]. (hindawi.com)
  • Currently, there are 171 genes in SZGR 2.0 (with evidence in schizophrenia) that are present at this pathway. (uth.edu)
  • Description: A sandwich ELISA kit for detection of Neuroepithelial Cell Transforming Gene 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (noveoninc.com)
  • We will characterize and assess every change in every gene in the entire human genome that is associated with and may cause each patient's cancer. (houstonmethodist.org)
  • Activin A receptor, type IIA , also known as ACVR2A , is a human gene. (chemeurope.com)
  • 1994). "Expression of the type II activin receptor gene in the human placenta. (chemeurope.com)
  • We used the beta-actin, and the GAPDH genes as a reference molecules for standard curve calculation. (nel.edu)
  • A few cases of ectopic GHRH-producing tumors, especially of the pancreas and lung, also have been described. (msdmanuals.com)
  • In a recent interview with Chicago's 97.1 FM The Drive, original FOREIGNER singer Lou Gramm reflected on being diagnosed with a type of brain tumor called a craniopharyngioma more than 25 years ago. (blabbermouth.net)
  • The new affiliation builds on a longstanding relationship between the two health systems that began in 2005 with the launch of a Newport News-based stereotactic radiosurgery center that uses precisely focused, high-energy beams of radiation to treat brain tumors, pituitary tumors and other conditions. (uvahealth.com)
  • Involvement of PTTG1 (pituitary tumor-transforming 1), PI3K/AKT signaling and its downstream signals were validated by qRT-PCR and western blot. (biomedcentral.com)
  • Affected individuals carry a germ-line loss-of-function mutation of the MEN1 gene, and tumors arise after loss of the second allele. (johnshopkins.edu)