• however, the pituitary stalk, connected to the anterior pituitary and hypothalamus, is vulnerable to the effects of TBI, especially in patients with associated facial fractures, cranial nerve injuries, and dysautonomia. (medscape.com)
  • The stalk was seen at the midline extending a long distance from the hypothalamus to the pituitary gland. (ajronline.org)
  • Because the pituitary gland did not have features suggestive of adenoma on MR imaging, we assumed that the hyperprolactinemia was caused by the traction of the pituitary stalk. (ajronline.org)
  • The gland is connected to the hypothalamus in the brain by the pituitary stalk. (mayfieldclinic.com)
  • Craniopharyngiomas typically grow from the pituitary stalk upward into the third ventricle and cause symptoms similar to pituitary adenomas. (mayfieldclinic.com)
  • This is characterized by progressive hormone dysfunction, diabetes insipidus (DI), and associated MRI evidence of pituitary stalk disruption. (surgicalneurologyint.com)
  • We identified 2 (0.1%) cases of progressive pituitary endocrine dysfunction occurring in the postoperative period associated with MRI evidence of pituitary stalk disruption within 6 weeks of discharge from the hospital. (surgicalneurologyint.com)
  • This was felt to be caused by the rapid descent of the residual normal pituitary gland down to the floor of the postoperative empty sella, causing relatively swift stalk stretching. (surgicalneurologyint.com)
  • We describe two cases of secondary ESS associated with downward displacement of the residual normal pituitary gland, with MRI evidence of pituitary stalk disruption. (surgicalneurologyint.com)
  • The finding of progressing endocrine dysfunction in the weeks following surgery, with MRI evidence of pituitary stalk disruption is rare, seen in two cases to date at our institution in review of 2000 transsphenoidal tumor resections. (surgicalneurologyint.com)
  • Of this cohort, only 2 (0.10%) demonstrated rapid short-term pituitary endocrinopathy and DI with MRI evidence of pituitary stalk disruption. (surgicalneurologyint.com)
  • Your pituitary is connected to your hypothalamus through a stalk of blood vessels and nerves called the pituitary stalk (also known as infundibulum). (tomsk.ru)
  • Autopsy studies in fatal traumatic brain injury (TBI) cases demonstrate a fairly high prevalence of hypothalamic and pituitary abnormalities, including anterior lobe necrosis, posterior lobe hemorrhage, and traumatic lesions of the hypothalamic-pituitary stalk. (medscape.com)
  • The traumatic rupture of the pituitary stalk results in anterior lobe infarction because of disruption of the portal blood supply between the hypothalamus and anterior pituitary. (medscape.com)
  • Ninety percent of the anterior lobe is nourished by the hypophyseal portal veins, which originate from and follow the pituitary stalk. (medscape.com)
  • The posterior lobe vascular supply is not affected by pituitary stalk trauma, because it is supplied by the inferior hypophyseal arteries, which arise from the internal carotid artery below the level of the diaphragma sella. (medscape.com)
  • It is connected through the pituitary stalk with the hypothalamus. (howmed.net)
  • These hypothalamic cell bodies produce hormones that undergo axonal transport through the pituitary stalk and into terminal axons within the neurohypophysis. (medscape.com)
  • Increased prolactin levels possibly indicating a lesion in the hypothalamus or pituitary stalk. (doctorlib.info)
  • Magnetic resonance imaging (MRI) usually shows a homogeneous, contrastenhancing sellar mass with pituitary stalk involvement. (pediagenosis.com)
  • The granulomatous inflammation may involve the hypothalamus, pituitary stalk, and pituitary gland and cause hypopituitarism, including DI. (pediagenosis.com)
  • Head trauma may lead to direct pituitary damage by a sella turcica fracture, pituitary stalk section, trauma-induced vasospasm, or ischemic infarction after blunt trauma. (pediagenosis.com)
  • The sella Turcica is a midline depression in the sphenoid bone which contains the pituitary gland and distal portion of the pituitary stalk. (jrmds.in)
  • It actually contains the pituitary gland, pituitary stalk, arachnoid, CSF, and sometimes the optic system and 3rd ventricle. (unboundmedicine.com)
  • As part of the endocrine system, the pituitary gland makes many different hormones that travel throughout the body. (cancer.ca)
  • These hormones control certain body functions and tell other glands to make other hormones. (cancer.ca)
  • The pituitary gland makes 9 different hormones. (cancer.ca)
  • Both the anterior pituitary gland and the posterior pituitary gland make hormones. (cancer.ca)
  • Adrenocorticotrophic hormone (ACTH) tells the adrenal glands to make cortisol and other steroid hormones. (cancer.ca)
  • It is given only if the pituitary produces too much or too little hormones, depending on which hormones are affected. (msdmanuals.com)
  • It has a large anterior lobe (gland cells that produce hormones) and a smaller posterior lobe (nerve cells that release hormones). (mayfieldclinic.com)
  • Thyroid-stimulating hormone: causes the thyroid gland to make other hormones that control growth, temperature, and heart rate. (mayfieldclinic.com)
  • Functioning pituitary tumors secrete high levels of hormones and interfere with other body organs. (mayfieldclinic.com)
  • Nonfunctioning pituitary tumors do not secrete hormones. (mayfieldclinic.com)
  • The pituitary, a pea-sized gland at the base of the brain, produces a number of hormones. (merckmanuals.com)
  • Hypopituitarism Hypopituitarism is an underactive pituitary gland that results in deficiency of one or more pituitary hormones. (merckmanuals.com)
  • These diseases usually manifest as hypersecretion or hyposecretion of PITUITARY HORMONES. (edu.au)
  • It releases several important hormones and controls the function of many other endocrine system glands. (tomsk.ru)
  • Your pituitary gland also tells other endocrine system glands to release hormones. (tomsk.ru)
  • A gland is an organ that makes one or more substances, such as hormones, digestive juices, sweat or tears. (tomsk.ru)
  • Endocrine glands release hormones directly into your bloodstream. (tomsk.ru)
  • Which hormones does the pituitary gland make? (tomsk.ru)
  • You can live without your pituitary gland as long as you take medication to replace the pituitary hormones that you're missing. (tomsk.ru)
  • The pituitary gland hormones are very important for maintaining several bodily functions. (tomsk.ru)
  • An untreated lack of all the pituitary hormones is life-threatening. (tomsk.ru)
  • Anterior pituitary consists of five different cell types producing six hormones. (howmed.net)
  • It detects the level of hormones produced by glands and determines how much stimulation is needed. (webdirectoryhealth.com)
  • Often referred to as the "master gland", the pituitary gland synthesizes and releases various hormones that affect several organs throughout the body (see the images below). (medscape.com)
  • Hormones secreted by adenohypophysis (anterior pituitary). (medscape.com)
  • Hormones secreted by neurohypophysis (posterior pituitary). (medscape.com)
  • The adenohypophysis constitutes roughly 80% of the pituitary and manufactures an array of peptide hormones. (medscape.com)
  • The cause is a deficiency of the hormones secreted by the anterior pituitary gland. (doctorlib.info)
  • An absence or decrease of one or more pituitary hormones leads to a loss of function in the gland or organ that it controls. (doctorlib.info)
  • Radioimmunoassay shows decreased plasma levels of some or all of the pituitary hormones. (doctorlib.info)
  • Patients typically present with headaches and signs and symptoms of deficiency of one or more pituitary hormones. (pediagenosis.com)
  • Head trauma that results in a skull base fracture may cause hypothalamic hormone deficiencies, resulting in deficient secretion of anterior and posterior pituitary hormones. (pediagenosis.com)
  • Secreting pituitary tumors release hormones that can affect the body and cause symptoms. (valleygammaknife.com)
  • Secreting pituitary tumor symptoms will depend on which hormones are in excess. (valleygammaknife.com)
  • The pituitary gland regulates many essential hormones for our existence as well as our health and well-being. (elizabethsandelmd.com)
  • The posterior pituitary (the part closer to the back of the head) secretes two stimulating hormones: antidiuretic hormone (ADH), which acts on the kidneys to regulate salt and water content in the body, and oxytocin which stimulates the uterus to contract during labor and childbirth, and breast tissue to stimulate milk production after childbirth. (elizabethsandelmd.com)
  • The anterior pituitary (the part of the gland closer to the face) secretes stimulating hormones that act on various bodily structures to stimulate the production of other hormones. (elizabethsandelmd.com)
  • Panhypopituitarism (deficiency in all hormones produced by the pituitary) can occur after severe TBIs and is life-threatening. (elizabethsandelmd.com)
  • Although there exists research claiming deficiencies of one or more pituitary hormones in PES ( 1 ), the evidence is inconsistent, raising the question of whether or not an "ESS" truly exists. (unboundmedicine.com)
  • Pituitary tumors may either be clinically silent or secrete hormones, including prolactin, growth hormone (acromegaly), adrenocorticotrophic hormone (Cushing's disease) or, rarely, thyroid-stimulating hormone or gonadotropins. (bvsalud.org)
  • Pituitary neuroendocrine tumors (PitNETs) are considered common in the general population. (avhandlingar.se)
  • What Are Pituitary Tumors? (cancer.ca)
  • A small percentage of pituitary tumors run in families, but most cases do not have any obvious hereditary factor. (atheistsforhumanrights.org)
  • Parasellar tumors are growths near the part of the brain known as the sella turcica. (atheistsforhumanrights.org)
  • In children, ESS may be associated with early onset of puberty, growth hormone deficiency, pituitary tumors, or pituitary gland dysfunction. (nih.gov)
  • Tumors that grow from the pituitary gland can affect the whole body by interfering with normal hormone levels. (mayfieldclinic.com)
  • There are various kinds of pituitary tumors: adenomas, craniopharyngiomas, and Rathke's cleft cysts. (mayfieldclinic.com)
  • When pituitary tumors grow they can compress the above-mentioned structures and cause symptoms. (mayfieldclinic.com)
  • These tumors may compress the normal pituitary gland decrease hormone production (hypopituitarism). (mayfieldclinic.com)
  • Based on size, pituitary tumors may be classified as microadenomas (less than 10mm) or macroadenomas (larger than 10mm). (mayfieldclinic.com)
  • Treatment of PPP is focused on the originated diseases such as congenital adrenal hyperplasia, McCune-Albright syndrome, severe hypothyroidism, disorders of the adrenal gland, tumors of the ovary or testis, and rare genetic syndromes [ 4 ]. (springeropen.com)
  • Pituitary tumors are variable, and patients can experience a wide range of symptoms. (valleygammaknife.com)
  • It is vital to work with a doctor in northern NJ who understands pituitary tumors and can effectively manage your case. (valleygammaknife.com)
  • Pituitary tumors can vary in size, makeup and the symptoms they cause, so you'll want a doctor who is experienced and knowledgeable about pituitary tumor treatments. (valleygammaknife.com)
  • Your best approach is to work with a specialist in the tri-state area who has experience diagnosing and treating pituitary tumors. (valleygammaknife.com)
  • At this point, you can appreciate how different pituitary tumors can be in their presentation and the symptoms they cause. (valleygammaknife.com)
  • Pituitary gland tumors may cause neurological and hormonal symptoms. (bvsalud.org)
  • The optic chiasm lies in close proximity to the pituitary gland and can be compressed by tumors leading to visual disturbances (bitemporal hemianopsia) [6]. (bvsalud.org)
  • However, many pituitary adenomas, especially microadenomas, do not cause serious symptoms and are never found. (atheistsforhumanrights.org)
  • Closely related to pituitary adenomas are craniopharyngiomas and Rathke's cleft cysts. (mayfieldclinic.com)
  • CTLA4 expression was higher (P = 0.022) in pituitary adenomas than normal glands, with the greatest levels seen in PRL- and GH-secreting adenomas (P = 0.009 and 0.023 versus normal, respectively). (bvsalud.org)
  • 1 The pituitary is the "master gland" of the body, which controls growth, metabolism, and reproductive activity and sits in the sella turcica at the base of the brain. (pfizer.com)
  • Known as the master gland, the pituitary controls the other endocrine glands in the body. (mayfieldclinic.com)
  • Because the pituitary controls the function of most other endocrine glands, it is often called the master gland. (merckmanuals.com)
  • It is also called master gland as pituitary controls the function of most other endocrine glands. (webdirectoryhealth.com)
  • Contrast-enhanced coronal T1-weighted spin-echo MR image (TR/TE, 440/11) shows abnormal shape of sella, downward displacement of pituitary gland through defect in basisphenoid ( long arrow ), and stretching and thinning of infundibulum ( short arrow ). (ajronline.org)
  • b) The infundibulum, median eminence, pars tuberalis and posterior lobe are supplied by the internal carotid artery, whereas the pars distalis receives most of its blood supply from venous drainage from the infundibulum and the posterior lobe of the pituitary gland. (capsulehealth.one)
  • There is an opening in the center of the diaphragm sellae through which passes the infundibulum, connecting the pituitary gland with the base of the brain. (mhmedical.com)
  • Plain film and tomographic assessment of the pituitary fossa in 140 acromegalic patients. (thejcdp.com)
  • Small pituitary fossa in Cushing's syndrome due to adrenal neoplasm. (thejcdp.com)
  • Roentgen standards size of the pituitary fossa from infancy through adolescence. (thejcdp.com)
  • An empty sella , also known as an empty pituitary fossa , refers to the appearance of the sella turcica when the pituitary gland appears shrunken or invisible and CSF fills the space instead. (radiopaedia.org)
  • Most strictly, some authors reserve the term empty sella for when there is essentially no visible pituitary tissue and the fossa is at least a little enlarged (grade V). (radiopaedia.org)
  • An empty sella is believed to result from herniation of the arachnoid space into the pituitary fossa through a deficient diaphragma sellae , found in 20% of the population 4,5 . (radiopaedia.org)
  • An empty sella (ES), also known as an empty sella turcica (empty pituitary fossa) is defined as an intrasellar herniation of subarachnoid space within the sella which leads to flattening of the pituitary gland towards the posteroinferior wall. (romj.org)
  • Methods - We carried out a systematic search in both Russian and English databases (E-library, PubMed, GoogleScholar, OxfordPress, ClinicalKeys) using keywords "empty sella", "empty sella turcica", "empty pituitary fossa", "prevalence" and their combinations. (romj.org)
  • During the research, specialists also examine the sella turcica - a specific fossa in the sphenoid bone of the skull, where the hypophysis is located. (medicina.ru)
  • Diaphragma sellae -This small shelf of the meningeal dura mater covers the hypophysial fossa in the sella turcica of the sphenoid bone. (mhmedical.com)
  • Adrenocorticotropic hormone: causes the adrenal glands to make cortisol. (mayfieldclinic.com)
  • It stimulates your adrenal glands to produce cortisol (the "stress hormone"), which has many functions, including regulating metabolism, maintaining blood pressure, regulating blood glucose (blood sugar) levels and reducing inflammation, among others. (tomsk.ru)
  • Less commonly, the condition occurs after pituitary surgery, radiation therapy, or infarction (death) of a pituitary tumor. (msdmanuals.com)
  • Anterior hypothalamic trauma often is observed on postmortem studies and may be associated with pituitary hemorrhage or infarction related to TBI. (medscape.com)
  • The pituitary gland is highly vascular and therefore extremely vulnerable to ischemia and infarction. (doctorlib.info)
  • Lymphocytic hypophysitis is an autoimmune disorder characterized by lymphocytic infiltration and enlargement of the pituitary gland followed by selective destruction of pituitary cells. (pediagenosis.com)
  • Although many patients with so-called primary empty sella are entirely asymptomatic and endocrinologically normal, increasingly recognized are variable hypopituitarism (e.g. growth hormone deficiency 8 ) and hyperprolactinemia 7 . (radiopaedia.org)
  • In a primary empty sella, a defect in the sellar diaphragm allows cerebrospinal fluid to enter and enlarge the sella (50% of patients with a primary empty sella have benign increased intracranial pressure). (pediagenosis.com)
  • With a primary empty sella, pituitary function is usually intact. (pediagenosis.com)
  • Overproduction of prolactin by the pituitary gland can cause galactorrhea (excessive or abnormal lactation) and amenorrhea (absence of menstruation). (rnpedia.com)
  • Because the proteins encoded by HEXS1 , LHX3 , and LHX4 act early in pituicyte differentiation, mutations in these genes cause combined pituitary hormone deficiency, which refers to deficiencies of growth hormone (GH), prolactin, thyrotropin (thyroid-stimulating hormone [TSH]), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) (see Plate 1-13). (pediagenosis.com)
  • The superior aspect of the pituitary is covered by the diaphragma sellae, which is a fold of dura mater that separates the cerebrospinal fluid-filled subarachnoid space from the pituitary. (medscape.com)
  • Herniations of suprasellar structures into the empty sella may occur, especially when the empty sella is secondary in origin, and most of these cases present with visual disturbances due to herniation of the optic chiasm 12 . (radiopaedia.org)
  • 13 ] ESS can be primary, due to an inherent weakness of the diaphragma sellae and downward herniation of arachnoid into the sella, or secondary, following surgical or medical management of a pituitary macroadenoma. (surgicalneurologyint.com)
  • A condition when the SELLA TURCICA is not filled with pituitary tissue. (mcw.edu)
  • Your surgeon will use high magnification to help distinguish normal pituitary tissue from the tumor. (barrowneuro.org)
  • The surgery aims to minimize trauma to the tissue surrounding your pituitary gland while facilitating a speedy recovery with as little pain or discomfort as is possible. (barrowneuro.org)
  • Particularly W. Busch, in 1951, performed a large study of 788 human cadavers during autopsy examination of the sella turcica and observed in 40 of 788, predominantly women, a sella turcica with an incomplete diaphragma sellae, where the pituitary gland was not absent but flattened in a way that it formed a thin layer of tissue in the periphery [7-12]. (romj.org)
  • Finally, in type III a diaphragma sellae is a peripheral ring of tissue 2 mm or less with: A - hypophysis freely exposed but covered with an arachnoid membrane without depression of the tissue, B - eccentric compression of the pituitary gland, C - the pituitary gland flattened to the bottom [9]. (romj.org)
  • Any event that leads to circulatory collapse and compensatory vasospasm may result in gland ischemia, tissue necrosis, or edema. (doctorlib.info)
  • The term empty sella refers to an enlarged sella turcica that is not entirely filled with pituitary tissue. (pediagenosis.com)
  • On MRI, demonstrable pituitary tissue is usually compressed against the sellar floor. (pediagenosis.com)
  • Blood test reveals decreased serum thyroxin levels in diminished thyroid gland function due to lack of TSH. (doctorlib.info)
  • For example, thyroid-stimulating hormone (TSH) acts on the thyroid gland to stimulate thyroid hormone production. (elizabethsandelmd.com)
  • Therefore, many studies have been conducted to identify the predictive factors of CPP which has been attributed to a dysfunction of the hypothalamic-pituitary-gonadal axis. (springeropen.com)
  • Serial hormone assays may be used to determine the secretory pattern and to assess the hypothalamic regulation of pituitary function. (medscape.com)
  • Anatomy and vascularization of the pituitary gland: a) The pituitary gland is located in the sphenoid bone (sella turcica) and is composed of the anterior lobe (adenohypophysis) and the posterior lobe (neurohypophysis). (capsulehealth.one)
  • The pituitary gland is entirely ectodermal in origin but is composed of 2 functionally distinct structures that differ in embryologic development and anatomy: the adenohypophysis (anterior pituitary) and the neurohypophysis (posterior pituitary). (medscape.com)
  • Adenohypophysis or anterior pituitary (develops from Rathke's pouch) b. (howmed.net)
  • In his research, Dr Sheehan reviewed (through autopsy) the effects of pituitary necrosis on 12 cases of patient's that experienced postpartum necrosis. (capsulehealth.one)
  • Simmonds' Disease due to Post-partum Necrosis of the Anterior Pituitary ", Dr Sheehan displays post-partum necrosis as a cause of Simmonds' disease, thus establishing the relationship between the two conditions. (capsulehealth.one)
  • Both of them used this term in the 1950s (1951 and 1949, respectively) while describing pituitary necrosis in postpartum women. (romj.org)
  • People with secondary ESS may have symptoms of decreased pituitary function such as absence of menstruation, infertility, fatigue, and intolerance to stress and infection. (nih.gov)
  • Learning about the symptoms and pituitary tumor treatment options can help you understand the symptoms you are experiencing. (valleygammaknife.com)
  • Some pituitary tumor symptoms are because the tumor is pressing on adjacent structures. (valleygammaknife.com)
  • A pituitary tumor can have any of these cells, which is why the symptoms can be so variable. (valleygammaknife.com)
  • Either type of pituitary tumor may still cause symptoms and/or necessitate treatment by pressing on adjacent structures, such as blood vessels and nerves. (valleygammaknife.com)
  • Your pituitary tumor symptoms are not necessarily going to be the same as the next patient's. (valleygammaknife.com)
  • Some patients do not experience any symptoms and learn about a pituitary tumor when a doctor discovers it while ordering imaging for another condition. (valleygammaknife.com)
  • However, if you do experience pituitary tumor symptoms, these can act as clues to help your doctor determine what types of cells make up your tumor. (valleygammaknife.com)
  • Many of the subtle symptoms or signs of an anterior pituitary deficiency such as fatigue or cognitive problems are not always due to a hormonal abnormality. (elizabethsandelmd.com)
  • No signs or symptoms related to pituitary dysfunction were identified. (bvsalud.org)
  • Both patients developed DI, and one patient demonstrated increased pituitary hormone dysfunction. (surgicalneurologyint.com)
  • ES can be divided into partial and complete ( Figure 1 ) on the basis of the degree to which сerebrospinal fluid (CSF) occupied the intrasellar space and flattened the superior surface of the pituitary gland. (romj.org)
  • Therefore, due to the advent of X-RAY and craniography, in 1957 G. Robertson showed intrasellar air on pneumoencephalograms, and in 1958 E. P. Engels demonstrated the presence of pituitary gland during cervical myelography with ethyl iodophenylundecylate [9]. (romj.org)
  • With pulsatile CSF flow and greater leakage into the sella, intrasellar pressure increases. (unboundmedicine.com)
  • 9] evaluated 100 patients with an enlarged sella turcica and the most common cause of its expansion was a primary intrasellar pituitary tumor. (bvsalud.org)
  • A recent research study (with a meta-analysis of other research studies) led the authors to conclude that approximately one-third of TBI patients have persistent anterior pituitary dysfunction 12 months or more following the injury. (elizabethsandelmd.com)
  • It sits in a small pocket of bone in the base of the skull called the sella turcica. (mayfieldclinic.com)
  • The pituitary gland (green) is located deep within the skull in an area called the sella. (mayfieldclinic.com)
  • Pituitary is and endocrine gland located within the sella turcica, residing inside the skull. (howmed.net)
  • lies in a small pocket of bone at the skull base called the sella turcica. (threesology.org)
  • The gland is pea-sized and sits within the sella turcica, an area of the skull near the back of the nose. (valleygammaknife.com)
  • The most of cephalometric analysis and studies of the skull depend on the sella point to make liner and angular measurements, like Downs analysis (1948) [ 3 ], where he was used the sella landmark to make Y-axis plane that extend from sella to Gonthon (S-Gn) as one of skeletal reference plane, which indicate the degree of downward, reward or forward position of chin in relation to upper face. (jrmds.in)
  • The tiny gland sits in the sella turcica, a structure within the sphenoid bone, a bone that connects the facial bones to the skull bones. (elizabethsandelmd.com)
  • Pineal gland (C) Gonadotrophin releasing hormone iv. (zigya.com)
  • Pituitary function is checked by measuring hormone levels in the blood to rule out hormone excess or deficiency. (msdmanuals.com)
  • I.V. administration of gonadotropin releasing hormone distinguishes pituitary and hypothalamic causes of gonadotropin deficiency. (doctorlib.info)
  • A quantitative study of the human hypophysis cerebri, or pituitary body. (thejcdp.com)
  • Higher grades are termed complete/total empty sella and lower grades are termed partially / partial empty sella . (radiopaedia.org)
  • Poll: Do you have a partially empty sella on your brain MRI? (phoenixrising.me)
  • It is now thought that many of these patients have idiopathic intracranial hypertension and that the empty sella is actually secondary to elevated CSF pressures. (radiopaedia.org)
  • As has been alluded to above, it is difficult to pin down the epidemiology for empty sella without contamination by patients with idiopathic intracranial hypertension . (radiopaedia.org)
  • A common underlying pathology to cases of empty sella both with and without intracranial hypertension may be hemodynamically significant transverse sinus stenosis, which results in altered CSF absorption and expansion of CSF spaces 13 . (radiopaedia.org)
  • Directly above the pituitary gland is the optic chiasm, which is responsible for vision. (mayfieldclinic.com)
  • The optic chiasma (where the optic nerves cross) is located on top of the superior part of the pituitary gland. (capsulehealth.one)
  • Craniofacial developmental anomalies may result in cleft lip and palate, basal encephalocele, hypertelorism, and optic nerve hypoplasia, with varying degrees of pituitary dysplasia and aplasia. (pediagenosis.com)