PIWI-interacting RNAs (piRNAs) are small non-coding RNAs that partner with PIWI proteins to protect germline tissues from destabilizing transposon activity. (omicsdi.org)
The piwi interacting RNAs (piRNAs) are small non-coding RNAs that specifically bind to the PIWI proteins, a functional requirement. (omicsdi.org)
PIWI-interacting RNAs (piRNAs) are thought to silence transposon and gene expression during development. (omicsdi.org)
PIWI-interacting RNAs (piRNAs) are small noncoding RNAs that play important roles in germline development and carcinogenesis. (omicsdi.org)
PIWI Argonaute proteins and Piwi-interacting RNAs (piRNAs) are expressed in all animal species and play a critical role in cellular defense by inhibiting the activation of transposable elements in the germline. (molcells.org)
Somatic tissues2
However, the roles of piRNAs in somatic tissues are largely unknown. (omicsdi.org)
Recently, new evidence suggests that PIWI proteins and piRNAs also play important roles in various somatic tissues, including neurons. (molcells.org)
RNAs2
In Caenorhabditis elegans , RNA-dependent RNA polymerases (RdRPs) are used for the small RNA-guided production of additional small RNAs 8 that are complementary to terminally modified mRNA fragments 9 . (nature.com)
piRNA is the most diverse class of regulatory RNAs in general. (molcells.org)
Germline1
The piRNAs regulate germline development, transposons control, and gene expression. (omicsdi.org)
Transposable elements1
Given that one of the major roles of the piRNA pathway is the inactivation of transposable elements, impairment of this pathway can lead to overexpression of transposable elements, which may result in increased genome stability and thus germ cell defects and sterility. (molcells.org)
Transcriptional level1
Integrated mRNA and miRNA profiling data provided comprehensive gene expression information on the wild-type and multi-tepal mutant at the transcriptional level that could facilitate our understanding of the molecular mechanisms of floral patterning of C. goeringii . (biomedcentral.com)
MRNA3
A piRNA utilizes HILI and HIWI2 mediated pathway to down-regulate ferritin heavy chain 1 mRNA in human somatic cells. (omicsdi.org)
We discovered a human piRNA (piR-FTH1) which has a complementary sequence in the ferritin heavy chain 1 (Fth1) mRNA. (omicsdi.org)
Since the current piRNA-mediated knockdowns of target mRNA are mostly reported in germ line cells, piRNA-mediated post-transcriptional gene regulation in somatic cells is rather unique in its application and mechanistically uses an alternative pathway to siRNA and miRNA. (omicsdi.org)
Roles1
The results suggest that the roles for the two factors in DNA methylation maintenance pathways can be traced back to the last eukaryotic common ancestor and that the CDC7A-HELLS-DNMT axis shaped the evolutionary retention of DNA methylation in eukaryotes. (elifesciences.org)
Regulate1
dGLYAT was found to regulate Gadd45 -mediated JNK pathway activation and cell invasion. (sdbonline.org)
Silence1
This stable silencing requires components of the small RNA pathway and can silence homologous sequences in trans . (nature.com)
Transcriptome1
In this study, we used the deep sequencing of small RNA Transcriptome to explore the piRNA expression in six clear cell renal carcinoma (ccRCC) tissues and matched adjacent normal tissues and found that six piRNAs were upregulated and sixteen were downregulated in ccRCC tissues. (omicsdi.org)
Genes3
The majority of the gene ontology terms and Kyoto Encyclopedia of Genes and Genomes pathway enrichment responses were for membrane-building and ploidy-related processes, consistent with the excessive floral organs and altered cell size observed in the mutant. (biomedcentral.com)
Genes controlling floral organ identity have been identified through the genetic analysis of homeotic mutants, leading to the ABCDE model, in which five classes of regulatory genes (A, B, C, D and E) work in a combinatorial manner to confer the organ identities of the four whorls [ 10 ]. (biomedcentral.com)
Enriched pathways analysis of these positively correlated genes featured Toll-like receptor and SUMOylation pathways. (preprints.org)
Suggests1
Taken together, our study reveals reduced expression in GBM of piR-8041 and other piRNAs with tumor suppressive properties, and suggests that restoration of such piRNAs may be a potential strategy for GBM therapy. (omicsdi.org)
Proteins4
While the aberrant expression of PIWI proteins has been linked with poor outcomes for many cancers, less is known about the expression or function of piRNAs in cancer. (omicsdi.org)
A piRNA-like small RNA interacts with and modulates p-ERM proteins in human somatic cells. (omicsdi.org)
piRNA-like-163 (piR-L-163), the top downregulated piRNA-L in NSCLC cells, binds directly to phosphorylated ERM proteins (p-ERM), which is dependent on the central part of UUNNUUUNNUU motif in piR-L-163 and the RRRKPDT element in ERM. (omicsdi.org)
Thus, piRNA/piRNA-L may play a regulatory role through direct interaction with proteins in physiological and pathophysiological conditions. (omicsdi.org)
Survival1
Over-expression of the most down-regulated piRNA in GBM tissue, piR-8041, was found to reduce glioma cell line proliferation, induce cell cycle arrest and apoptosis, and inhibit cell survival pathways. (omicsdi.org)
Insights1
A full understanding of neuronal PIWI-piRNA pathways will ultimately provide novel insights into small RNA biology and could potentially provide precise targets for therapeutic applications. (molcells.org)
Gene2
However, piRNA-mediated post-transcriptional gene regulation in human somatic cells is not well understood. (omicsdi.org)
We showed previously that cytoplasmic release of mtDNA activates the cGAS STING TBK1 pathway resulting in interferon-stimulated gene (ISG) expression that promotes antiviral immunity4. (regenerativemedicine.net)
Diseases3
This work begins to lay the groundwork with a broader impact on treatment of various diseases that are linked to elevated levels of specific mRNAs which have a piRNA target. (omicsdi.org)
Aberrant activation of SFKs leads to diseases such as cancer, blood disorders, and bone pathologies. (bvsalud.org)
This review also discusses the consequences of dysregulation of neuronal PIWI-piRNA pathways in certain neurological disorders, including neurodevelopmental and neurodegenerative diseases. (molcells.org)
Expression3
We performed array-based piRNA expression profiling in seven pairs of normal brain and glioblastoma multiforme (GBM) tissue specimens, and identified expression of ~350 piRNAs in both tissues and a subset with dysregulated expression in GBM. (omicsdi.org)
Distinctive piRNA/piRNA-L expression patterns are observed between HBE and NSCLC cells. (omicsdi.org)
Aberrant GLYAT expression is associated with human cancers, yet its role in cancer remains unknown. (sdbonline.org)
Cancer3
Here we report the identification of 555 piRNAs in human lung bronchial epithelial (HBE) and non-small cell lung cancer (NSCLC) cell lines, including 295 that do not exist in databases termed as piRNA-like sncRNAs or piRNA-Ls. (omicsdi.org)
Aberrant glycolytic reprogramming is involved in lung cancer progression by promoting the proliferation of non-small cell lung cancer cells. (cjphysiology.org)
[8] Nonetheless, whether paeonol participates in the regulation of A549 cell (human non-small cell lung cancer cell) proliferation through other signaling pathways remains to be elucidated. (cjphysiology.org)
Cell2
The complex cell signaling pathways of multicellular organisms such as plants and humans can make understanding the mechanisms of this inherited process very difficult. (wikipedia.org)
Firstly, loss of dGLYAT suppressed scrib depletion- or Egr overexpression-induced JNK pathway activation and invasive cell migration. (sdbonline.org)
Found1
piRNAs form a complex with the PIWI protein and can be found in both vertebrates and invertebrates. (molcells.org)
This review summarizes the neuronal functions of the PIWI-piRNA pathway in multiple animal species, including their involvement in axon regeneration, behavior, memory formation, and transgenerational epigenetic inheritance of adaptive memory. (molcells.org)
Complex1
The PIWI protein and piRNA form a complex, called piRNA-induced silencing complex (piRISC). (molcells.org)
Factors1
CVD prevalence continues to increase as human life expectancy also continues to rise, likely due to greater exposure to the traditional external risk factors and intrinsic pathways of aging [ 3 ] . (oaepublish.com)
Human1
piRNA-8041 is downregulated in human glioblastoma and suppresses tumor growth in vitro and in vivo. (omicsdi.org)
Small1
This cycle of small RNA production can act across generations, leading to effects that last for varying numbers of generations (Supplementary Table 1 ). (nature.com)