The most common piperidines and piperazine are phencyclidine (PCP), ketamine, benzylpiperazine (BZP), and 3-trifluoromethylphenylpiperazine (TFMPP). (medscape.com)
However, we kept in mind that within the previous series, a pair of closely related compounds, and , differing only in the piperazine/piperidine moiety in the structural core showed a significantly different affinity at sigma-1 receptors (σRs). (iasp-pain.org)
Therefore, we first focused on an in-depth analysis of the protonation states of piperazine and piperidine derivatives in the studied compounds. (iasp-pain.org)
Cinnarizine is a drug derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker, it is also known to promote cerebral blood flow, and so is used to treat cerebral apoplexy, post-trauma cerebral symptoms, and cerebral arteriosclerosis.However, it is more commonly prescribed for nausea and vomiting due to motion sickness or other sources such as chemotherapy,vertigoor Ménière's disease. (imexoverseas.in)
Compounds6
These transformations tolerated a broad range of the nucleophilic reagents thus allowing the synthesis of a wide variety of hetero- and carbocyclic compounds including the derivatives of pyridine, pyrimidine, pyrazole, pyran, dioxane, and isoxazole as well as their heterofused derivatives. (researchgate.net)
Piperidine is a widely used building block and chemical reagent in the synthesis of organic compounds, including pharmaceuticals such as vasodilators and antipsychotic medications (PMID: 25255204). (foodb.ca)
Piperidines are compounds containing a piperidine ring, which is a saturated aliphatic six-member ring with one nitrogen atom and five carbon atoms. (foodb.ca)
The Piperidines and its analogues represent one of the most prominent compound classes which are widely distributed in biologically active compounds, pharmaceuticals and natural products [1]. (lupinepublishers.com)
Several compounds possessing Piperidines scaffold have been reported to exhibit a wide range of valuable bioactive properties including antihypertensive, neuro-protective, antiinflammatory, antibacterial, anti malarial and anticonvulsant activities [2]. (lupinepublishers.com)
Phenylethylamine derivatives are the broadest1
The phenylethylamine derivatives are the broadest hallucinogen group and incorporate many substances. (medscape.com)
Pyridine2
Pyridine and its derivatives are very important in industrial field as well as in bio chemistry. (chemicalland21.com)
Other tropane derivatives, found in the same plants in small quantities, as well as liquid and volatile pyridine derivatives, often associated with tropane alkaloids, are of no practical importance. (medprep.info)
Synthesis6
In this study, we explored the catalyst‐free one‐pot multi‐component synthesis of 1,4‐dihydropyridine derivatives by following green chemistry protocol. (researchgate.net)
Synthesis of 8-hydroxy and 8-mercapto derivatives of acyclic adenine nucleoside and nucleotide analogs. (cas.cz)
A simple and efficient protocol has been developed for the synthesis of highly substituted Piperidines derivatives. (lupinepublishers.com)
So far, to the best of our knowledge, there is no report available on the use of camphor sulfonic acid as an organ catalyst for the synthesis of highly substituted Piperidines. (lupinepublishers.com)
The pot atom step economic (PASE) synthesis of highly substituted Piperidines from relatively simple starting materials has been reported in the literature. (lupinepublishers.com)
Synthesis of highly substituted Piperidines involves three component reactions of two equivalents of aldehydes, two equivalents of anilines and one equivalent Β-ketoesters. (lupinepublishers.com)
Alkaloid3
The hallucinogenic drugs can be categorised into 4 basic groups: indole alkaloid derivatives, piperidine derivatives, phenylethylamines and the cannabinols. (erowid.org)
Methanolic extracts of green fruits isolated a new piperidine alkaloid, (+)-3- O -feruloylcassine ( 1 ), in addition to the known (−)-spectaline ( 2 ) and (−)-3- O -acetylspectaline ( 3 ). (stuartxchange.org)
Phytochemical studies isolated a new piperidine alkaloid (3-O-feruloylcassine and known spectaline and 3-O-acetylspectaline which showed moderate antioxidant activities and marginal COX-2 inhibition. (stuartxchange.org)
Pyrimidine1
Pyrimidine and its derivatives are biologically important components of nucleic acids (DNA, RNA) and coenzymes. (chemicalland21.com)
Hypersensitivity1
History or evidence of allergy or hypersensitivity to Fexofenadine, Loratadine, Levocetirizine, Cetirizine, Hydroxyzine or any piperidine derivative drugs or any of the excipients of this product. (who.int)
Inhibition2
These piperidine sulfonamides were subjected to in vitro AChE enzyme inhibition studies and in vivo antiamnesic study to reverse scopolamine induced memory loss in rats. (uni-mysore.ac.in)
Two derivatives (3a and f) in this class of piperidines (3a-i) showed considerable inhibition against different sources of ACNE in vitro and reduced average number of mistakes done by wistar rats as compared to scopolamine treated group in vivo (rodent memory evaluation). (uni-mysore.ac.in)
Analogs2
ecstasy, Molly) is likely the most common of the phenylethylamine derivatives, some others include such newer novel synthetics as cathinones ("bath salts"), the 2C family of drugs, as well as their N-o-methoxybenzyl analogs (NBOMe). (medscape.com)
More than 60 designer analogs more toxic than PCP, but able to escape clinical detection, were common before the sale of piperidine and its derivatives became illegal in the United States in 1978. (erowid.org)
Ligands2
Dual Piperidine-Based Histamine H and Sigma-1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain. (iasp-pain.org)
In a series of 16 new ligands, mainly based on the piperidine core, we selected three lead structures (, , and ) for further biological evaluation. (iasp-pain.org)
Esters1
en)Disclosed are novel (meth)acrylic esters of unsaturated amino alcohols, a process for their preparation and their use for preparing crosslinked swellable hydrogel-forming polymers and crosslinked swellable hydrogel-forming polymers. (vtex.vn)
Enzyme2
Also, some of Piperidines analogues possess enzyme inhibitory activity against farnesyl transferees and dihydroorotate dehydrogenase [3]. (lupinepublishers.com)
In the present study, we have docked cis-2,6-dimethyl piperidine sulfonamides (3a-i) on ACNE enzyme and synthesized by nucleophilic substitution reaction between cis-2,6-dimethyl piperidine and alkyl/aryl sulfonyl chlorides in the presence of triethylamine. (uni-mysore.ac.in)
Acrolein3
1978). Methods that utilized derivatives (DNP and 7-hydroxyquinoline) combined with colorimetric or fluorimetric detection were not specific for acrolein and consistently did not correlate with those obtained from bioassays. (cdc.gov)
However, more recent studies have made better utilization of gas chromatography (GC) and HPLC techniques to improve the resolution of acrolein and acrolein derivatives from other interfering species (Al-Rawithi et al. (cdc.gov)
While a nitrogen detector can be used for the sensitive screening detection of oxazolidine derivatives used for the current NIOSH and OSHA methods, PFBHA is more reactive than 2(hydroxymethyl)piperidine and shows better recoveries for conjugated aldehydes like acrolein and crotonaldehyde, and much better recoveries for ketones. (cdc.gov)
Widely2
Piperidine is a widely used secondary amine and used to convert ketones to enamines. (foodb.ca)
Donazepil is a widely prescribed ACNE inhibitor which displays a piperidine ring in its structure. (uni-mysore.ac.in)
Centers2
This amino acid natural product features a rigid 3-azabicyclo[3.3.1]nonane ring system containing four stereogenic centers within the piperidine ring. (beilstein-journals.org)
This compound also features four stereogenic centers (three of which are located within the piperidine ring) and a tertiary alcohol. (beilstein-journals.org)
Aldehydes1
Boehm in 1943 reported the first multi component reaction between an amine, aldehydes and 1,3-dicarbonyl to synthesize functionalized piperidines [14]. (lupinepublishers.com)
Organic1
The same is true for certain derivatives: N-formylpiperidine is a polar aprotic solvent with better hydrocarbon solubility than other amide solvents, and 2,2,6,6-tetramethylpiperidine is highly sterically hindered base, useful because of its low nucleophilicity and high solubility in organic solvents. (foodb.ca)
RESPIRATORY1
In addition, bromhexine has antioxidant properties.Bromhexine is intended to support the body's mechanisms for clearing mucus from the respiratory tract.Bromhexine is a synthetic derivative of the herbal active ingredient vasicine. (imexoverseas.in)
Class1
Especially, highly substituted Piperidines have been recognized as an important class of therapeutic agents in the treatment of cancer metastasis, influenza, Parkinson's disease, viral infections including AIDS and diabetes [4]. (lupinepublishers.com)
Hydrophilic high-swell hydrogels are in particular polymers of (co)polymerized hydrophilic monomers, graft (co)polymers of one or more hydrophilic monomers on a suitable grafting base, crosslinked cellulose or starch ethers, crosslinked carboxymethylcellulose, partially crosslinked polyalkylene oxide or natural products which swell in aqueous fluids, for example guar derivatives. (vtex.vn)
Chemical1
Two sets of additive parameters used previously for the calculation of C-13 chemical shifts of mono and poly six-membered cycloalkanes were applied for the prediction of N-15 chemical shifts of some methyl piperidine derivatives. (tubitak.gov.tr)
Present1
The present invention relates to N-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-4-quinazolinamine and N-(2,3-dihydro-1H-indol-5-yl)-4-quinazolinamine derivatives of Formula (I) wherein R1, R2, R3, R4, R5, R6 and A have the meaning defined in the claims. (justia.com)
Group1
Structurally, (+)- 2 is a pipecolic acid derivative containing a cyclohexenyl ring as a substituent group. (beilstein-journals.org)
Plants1
Piperidine was obtained from the plants Psilocaulon absimile (Aizoaceae) and in Petrosimonia monandra ( https://en.wikipedia.org/wiki/Piperidine#cite_note-17). (foodb.ca)