• In pupillary constriction induced by pilocarpine, not only is the sphincter nerve supply activated but that of the dilator is inhibited. (wikipedia.org)
  • Clark 2002) Although miosis (pupillary constriction) can be absent or can reflect other conditions, its presence still should raise a high level of suspicion. (cdc.gov)
  • Unexpected pupillary constriction during surgery increases the risk of complication. (bvsalud.org)
  • These signs occur because of impaired innervation of the extraocular muscles by CN III, IV, and VI, as well as disrupted pupillary constriction controlled by the parasympathetic efferent pathway of CN III. (e-jvc.org)
  • It is also worth noting that the reductions in pupil size observed over time in the pilocarpine [hydrochloride] 1.25% [twice daily] group mirrored visual acuity improvements from Hour 0 to Hour 9, suggesting a mechanism of action primarily based on pupil constriction. (optometryadvisor.com)
  • Pilocarpine, the active ingredient in Vuity, has been around for decades with applications most often linked to glaucoma. (easydrugcard.com)
  • Vuity (pilocarpine HCL ophthalmic solution) is the first and only eye drop on the market for a condition that affects nearly every adult over the age of 40, presbyopia. (easydrugcard.com)
  • citation needed] If the drug pilocarpine is administered, the pupils will constrict and accommodation is increased due to the parasympathetic action on the circular muscle fibers, conversely, atropine will cause paralysis of accommodation (cycloplegia) and dilation of the pupil. (wikipedia.org)
  • Certain drugs cause constriction of the pupils, such as opioids. (wikipedia.org)
  • Side effects are possible dim or blurred vision, headache, constriction of the pupils, and eye ache. (optimalvision.co.uk)
  • Enlarged pupils will be the result of dilation, while pinpoint pupils are the result of constriction. (idairco.com)
  • Given the use of pilocarpine as an antidote to atropine poisoning, Miss Marple ascertains that the husband's elderly father had actually committed the murder by emptying his bottle of eye drops (containing atropine sulfate) into his son's water glass. (christiesmysteries.com)
  • Study limitations include failure to evaluate treatment efficacy after administration of the second daily pilocarpine hydrochloride 1.25% dose beyond 3 hours and failure to compare vision improvements vs a control group using spectacles or contact lenses. (optometryadvisor.com)
  • Researchers conducted a randomized, controlled, multicenter, phase 3 study to evaluate the safety, efficacy, and pharmacokinetics of pilocarpine hydrochloride 1.25% compared with vehicle when administered twice daily during a 2-week study duration. (optometryadvisor.com)
  • At most, the ophthalmologist may prescribe reading glasses or pilocarpine eyedrops for vision impairment caused due to Left Adie's Tonic Pupil. (epainassist.com)
  • The constriction of the pupil and near vision are closely tied. (wikipedia.org)
  • Pilocarpine hydrochloride 1.25% treatment can improve distance corrected near vision without significantly compromising corrected distance visual acuity. (optometryadvisor.com)
  • 57.4% women) with objective and subjective evidence of presbyopia impacting daily activities and randomly assigned them to treatment with pilocarpine hydrochloride 1.25% (n=114) or vehicle treatment (n=116). (optometryadvisor.com)
  • The research team performed a pilocarpine plasma level assessment among a subgroup of 10% of study participants and evaluated treatment-related adverse events among the entire cohort. (optometryadvisor.com)
  • Overall, a significantly greater proportion of participants achieved the primary and secondary outcome measures with pilocarpine hydrochloride 1.25% compared with vehicle - between-treatment differences were 27.3% (95% CI, 17.3%-37.4%) and 26.4% (95% CI, 16.8%-36.0%), respectively. (optometryadvisor.com)
  • Headache , which was reported in 8.8% (n=10) of individuals treated with pilocarpine hydrochloride 1.25% and 3.4% (n=4) of vehicle group participants, was the most common treatment-related adverse event. (optometryadvisor.com)
  • The values decreased from 0.540 ± 0.185, 0.445 ± 0.172, and 0.388 ± 0.149 mm to 0.464 ± 0.199, 0.378 ± 0.156, and 0.324 ± 0.137 mm after pilocarpine administration, respectively. (bvsalud.org)
  • Pilocarpine accumulation index was 1.11 or less at the study conclusion among the subgroup participants who underwent pilocarpine plasma level assessment. (optometryadvisor.com)
  • For temporary pupillary constriction to relieve symptoms of optical aberrations. (medscape.com)
  • However, if the pupil does not constrict after pilocarpine 1% instillation, one can avoid costly investigations and reassure the patient that the pupillary dilation was due to a chemical exposure. (medscape.com)
  • In pupillary constriction induced by pilocarpine, not only is the sphincter nerve supply activated but that of the dilator is inhibited. (wikipedia.org)
  • Clark 2002) Although miosis (pupillary constriction) can be absent or can reflect other conditions, its presence still should raise a high level of suspicion. (cdc.gov)
  • The affected pupil will respond more briskly to accommodation than to light (light-near dissociation) and is supersensitive to dilute pilocarpine eye drops, which induce pupillary constriction. (bvsalud.org)
  • Unexpected pupillary constriction during surgery increases the risk of complication. (bvsalud.org)
  • PILOPINE HS ® (pilocarpine hydrochloride ophthalmic gel) 4% is a direct acting cholinergic parasympathomimetic agent which acts through direct stimulation of muscarinic neuroreceptors and smooth muscle such as the iris and secretory glands. (nih.gov)
  • Pilocarpine HCl ophthalmic solution is a sterile solution for ophthalmic administration having the following composition: a direct-acting cholinergic parasympathomimetic agent, which acts through direct stimulation of muscarinic neuroreceptors and smooth muscle such as the iris and secretory glands. (medscape.com)
  • Betoptic ® Pilo Ophthalmic Suspension contains betaxolol hydrochloride, a cardiovascular (beta 1 ) adrenoceptor antagonist and pilocarpine hydrochloride, a cholinergic parasympathomimetic agent. (nih.gov)
  • The two most commonly used drugs which increase the production of saliva, Evoxac (civemeline), and Salagen (pilocarpine), are considered cholinergic agonists , which means that the drugs enhance the effects of acetylcholine. (reasonablywell.net)
  • PILOPINE HS ® (pilocarpine hydrochloride ophthalmic gel) 4% is a sterile topical ophthalmic aqueous gel which contains more than 90% water and employs carbopol 940, a synthetic high molecular weight cross-linked polymer of acrylic acid, to impart a high viscosity. (nih.gov)
  • pilocarpine hydrochloride 4% (40 mg). (nih.gov)
  • PILOPINE HS ® (pilocarpine hydrochloride ophthalmic gel) 4% is a miotic (parasympathomimetic) used to control intraocular pressure. (nih.gov)
  • There have been no long-term studies done using pilocarpine hydrochloride in animals to evaluate carcinogenic potential. (nih.gov)
  • Pregnancy Category C. Animal reproduction studies have not been conducted with pilocarpine hydrochloride. (nih.gov)
  • It is also not known whether pilocarpine hydrochloride can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. (nih.gov)
  • PILOPINE HS ® (pilocarpine hydrochloride ophthalmic gel) 4% should be given to a pregnant woman only if clearly needed. (nih.gov)
  • Because many drugs are excreted in human milk, caution should be exercised when pilocarpine hydrochloride is administered to a nursing woman. (nih.gov)
  • Pilocarpine hydrochloride sometimes can be used as a trial medication to evaluate symptoms related to edge glare and optical aberrations secondary to IOL decentration. (medscape.com)
  • Pilocarpine hydrochloride is a white powder. (nih.gov)
  • Betoptic ® Pilo Ophthalmic Suspension is prepared by affixing a one-inch, blunt, 27 gauge cannula (supplied) to the syringe containing the pilocarpine hydrochloride solution and adding the entire contents of the syringe through the opening in the dropper tip to the DROP-TAINER ® containing the betaxolol suspension and mixing well. (nih.gov)
  • citation needed] If the drug pilocarpine is administered, the pupils will constrict and accommodation is increased due to the parasympathetic action on the circular muscle fibers, conversely, atropine will cause paralysis of accommodation (cycloplegia) and dilation of the pupil. (wikipedia.org)
  • The neuropathic pain model was established by ligature of the left sciatic nerve to induce chronic constriction injury (CCI). (biomedcentral.com)
  • Differentiation between paralytic mydriasis and pharmacologic mydriasis can be made by using a pilocarpine 1% eye drop test. (medscape.com)
  • A dilated pupil from paralytic mydriasis will constrict with pilocarpine 1%, whereas a dilated pupil from pharmacologic mydriasis will not constrict. (medscape.com)
  • A traumatic pupil would stay dilated in response to pilocarpine 1%, making it difficult to differentiate from pharmacologic mydriasis. (medscape.com)
  • [ 3 ] Not everyone agrees that the pilocarpine 1% test is reliable when mydriasis occurs secondary to plant exposure because the concentration of alkaloids in the plant is unpredictable. (medscape.com)
  • Pilocarpine lowers IOP predominantly by increasing the outflow of aqueous humor from the eye. (nih.gov)
  • A topical ocular overdose of an ophthalmic product containing pilocarpine may be flushed from the eye(s) with warm tap water. (nih.gov)
  • When the pharmacologic effect is secondary to plant or chemical toxicity, the 1% pilocarpine test can be useful. (medscape.com)