• Retinal pigment epithelial (RPE) tear is an infrequent complication of pigment epithelial detachment in the elderly, and occurs either spontaneously or after laser photocoagulation. (ijo.in)
  • A significant association with best-corrected visual acuity change was demonstrated in the greatest linear dimension, presence or absence of pigment epithelial detachment, and HTRA1 -rs11200638 genotype statistically ( P =3.67×10 -4 , 1.95×10 -2 , 1.24×10 -3 , respectively). (dovepress.com)
  • Among the baseline characteristics, serous pigment epithelial detachment (B = - 2.580, P = 0.032) and thick-choroid (B = 1.980, P = 0.019) were significantly associated with recurrence. (plos.org)
  • Thinner choroid and serous pigment epithelial detachment appear protective for recurrences. (plos.org)
  • Although a pigmented eyelid lesion may appear benign, it is wise to obtain a specimen for pathological examination because of the associated risk of mortality associated with malignant melanoma. (medscape.com)
  • Long-term results of primary transpupillary thermal therapy for the treatment of choroidal malignant melanoma. (helsedirektoratet.no)
  • Accuracy of diagnosis of choroidal melanomas in the Collaborative Ocular Melanoma Study. (helsedirektoratet.no)
  • Assessment of metastatic disease status at death in 435 patients with large choroidal melanoma in the Collaborative Ocular Melanoma Study (COMS): COMS report no. 15. (helsedirektoratet.no)
  • The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma: V. Twelve-year mortality rates and prognostic factors: COMS report No. 28. (helsedirektoratet.no)
  • The typical choroidal melanoma is a brown, elevated, dome-shaped subretinal mass. (cigna.com)
  • As the tumor enlarges, it may cause distortion of the pupil (iris melanoma), blurred vision (ciliary body melanoma), or markedly decreased visual acuity caused by secondary retinal detachment (choroidal melanoma). (cigna.com)
  • Choroidal melanoma is the most common primary malignant ocular tumor in human adults. (molvis.org)
  • We have studied the transgenic mouse strain, Tyrp-1-TAg, to try to gain insight into possible molecular mechanisms common to pigmented ocular neoplasms occurring spontaneously in the eyes of these mice and human choroidal melanoma. (molvis.org)
  • In the rare instance of retinal adenocarcinoma, most patients have been enucleated with a presumed diagnosis of choroidal melanoma. (eyecancer.com)
  • However, the presence of nevus cells contiguous with a choroidal melanoma on histologic examination provides evidence that melanomas may arise from choroidal nevi. (aao.org)
  • Malignant melanoma of the conjunctiva presents as a raised pigmented or non-pigmented lesion. (medscape.com)
  • Go to Ciliary Body Melanoma , Choroidal Melanoma , and Iris Melanoma for complete information on these topics. (medscape.com)
  • 2 pigmented left iris lesions are seen, suspicious for melanoma with possible ciliary body involvement. (efsumb.org)
  • A 37-year-old patient was referred to our Imaging Department following an ophthalmic exam, which revealed 2 pigmented left iris lesions, suspicious for melanoma with possible ciliary body involvement (Fig. 1) but required an ultrasound for further evaluation. (efsumb.org)
  • In the facility population, one patient with a suspected choroidal melanoma had evidence of size and color change since 1978. (cdc.gov)
  • Choroidal melanoma is a cancer that originates from the pigment-producing cells (melanocytes) of the choroid. (msdmanuals.com)
  • Choroidal melanoma is the most common cancer originating in the eye. (msdmanuals.com)
  • Early diagnosis of choroidal melanoma is important because smaller tumors are easier to cure. (msdmanuals.com)
  • In the latter case, the rapid contraction of the choroidal vascular membrane underneath a serous RPE detachment is believed to be the underlying cause. (ijo.in)
  • Central serous chorioretinopathy (CSC) is characterized by serous neurosensory retinal detachment at the posterior pole due to leakage from the retinal pigment epithelium (RPE) [ 1 - 5 ]. (plos.org)
  • Especially cases of occult CNV with pigment epithelium detachment (PED) are not likely to respond positively to standard photodynamic therapy, often ending up in PED enlargement or tearing of the RPE. (tum.de)
  • In a retinal detachment, this space fills with fluid and detaches the neurosensory retina from the underlying retinal pigment epithelium. (medscape.com)
  • In weeks to a month times the lesions begin to clear and disappear (with prednisone) leaving behind areas of retinal pigment epithelial atrophy and diffuse fine pigmentation (scarring). (wikipedia.org)
  • Therefore, it is important to recognize benign and malignant lesions of the eyelid, especially when pigmented. (medscape.com)
  • Suspicious eyelid lesions, particularly when they are pigmented, need to be removed for purposes of a biopsy. (medscape.com)
  • Pigmented lesions in infants and small children may pose a significant risk of sight loss. (medscape.com)
  • Pigmented lesions in infants and children also may be associated with pathology in contiguous structures or associated with systemic disease. (medscape.com)
  • The frequency of pigmented lesions of the eyelid varies according to the lesion type and patient characteristics. (medscape.com)
  • Pigmented lesions of the eyelids arise from 1 of 3 types of melanocytes, as follows: (1) epidermal or dendritic melanocytes, (2) nevus cells or nevocytes, and (3) dermal or fusiform melanocytes. (medscape.com)
  • Rarely, there are multiple pigmented lesions in the same area ( bear-track lesions ). (mrcophth.com)
  • Choroidal melanomas typically start as dome-shaped lesions and, as they grow and break through Bruch membrane, they acquire a mushroom or collar-button shape (Fig 12-20). (aao.org)
  • Malignant melanomas arising from nevi (they may arise from junctional and compound nevi) usually appear as a change (increasing nodularity, variegated pigmentation, bleeding, or inflammation) in known pigmented lesions of the conjunctiva. (medscape.com)
  • Despite the mention of 2 pigmented lesions, there was no other lesion seen on ultrasound. (efsumb.org)
  • Follow-up Examinations for Occular Neoplasms and Pigmented Ocular Lesions, at the Dupont, West Virginia Plant. (cdc.gov)
  • Active and retired workers at the duPont Belle chemicals facility in West Virginia were ophthalmologically surveyed first in 1978 and again in 1979 in a follow-up study to identify cases of ocular neoplasms and determine the prevalence of ocular pigmented lesions. (cdc.gov)
  • To evaluate expression of proangiogenic matrix metalloproteinases (MMP) 2 and 9 at distinct intervals after verteporfin photodynamic therapy (PDT) in human choroidal neovascular membranes (CNV) secondary to age-related macular degeneration (AMD). (bmj.com)
  • This study was to investigate their effects on macular choroidal thickness (ChT) in myopic children. (bmj.com)
  • While age-related macular degeneration is most common in Caucasians, polypoidal choroidal vasculoptahy is more commonly seen in those of Asian, Hispanic or African descent. (illinoisretina.com)
  • Two baseline characteristics-drusen area and pigment abnormalities-are associated with the development of advanced age-related macular degeneration. (ophthalmologytimes.com)
  • Natural history of indeterminate pigmented choroidal tumors. (helsedirektoratet.no)
  • The tumors are called melanomas because they develop in pigment cells (melanocytes) located within the uvea. (allaboutvision.com)
  • However, there was no clear evidence of CNV on fluorescein angiography or OCT. Optical coherence tomography angiography confirmed the presence of an active CNV by the visualization of the neovascular network in the region corresponding to the scrolled up retinal pigment epithelium . (bvsalud.org)
  • The reported case suggests the applicability of optical coherence tomography angiography in patients in whom retinal pigment epithelial tear is detected and associated CNV is suspected. (bvsalud.org)
  • Most choroidal nevi remain stationary over long periods of observation. (aao.org)
  • Less commonly, balloon cells similar to those seen in choroidal nevi may be present. (aao.org)
  • on a retrospective review of 3806 consecutive choroidal nevi imaging cases, multimodal imaging can capture risk factors for malignant transformation of the nevus (2). (efsumb.org)
  • One other patient with choroidal nevi was suspected of having size and color change. (cdc.gov)
  • In the comparison population, two patients had size or color change in choroidal nevi. (cdc.gov)
  • Thick-choroid CSC was defined as mean subfoveal choroidal thickness more than 300.0 μ m. (plos.org)
  • Choroidal metastases are cancers that have spread to the choroid from other parts of the body. (msdmanuals.com)
  • The investigative team also found that visual acuity decreased as the typical subject aged, decreased with increased drusen area, and decreased in the presence of pigment. (ophthalmologytimes.com)
  • Longitudinal mixed effect models (using patients from both clinical trials) were used to model visual acuity as a function of drusen area, pigment, baseline age, and follow-up time. (ophthalmologytimes.com)
  • Pavingstone (cobblestone) degeneration is a peripheral retinal degeneration characterized by multiple rounded, punched-out areas of chorioretinal atrophy with prominent underlying choroidal vessels and pigmented borders (▶ Fig. 44.1). (meltingpointathens.com)
  • Kiss CG, Simader C, Michels S, Schmidt-Erfurth U. Combination of verteporfin photodynamic therapy and ranibizumab: effects on retinal anatomy, choroidal perfusion and visual function in the protect study. (medscape.com)
  • PURPOSE: The aim of this study is to discuss the effect and outcome of a combined photodynamic therapy and intravitreal injection of bevacizumab (1.25 mg) in occult and classic choroidal neovascularisation (CNV) due to AMD. (tum.de)
  • In a study conducted at the University of Pittsburgh Ophthalmology and Visual Science Research Center, investigators found that two baseline characteristics-drusen area and pigment abnormalities-were associated with the development of advanced AMD, according to Maria Palaiou, MS, data manager and clinical coordinator at the University of Pittsburgh Medical Center ophthalmology department. (ophthalmologytimes.com)
  • Because the nevus cells are so heavily pigmented, it is usually necessary to apply melanin bleaching techniques to sections to accurately study the cytologic features (see Chapter 15, Fig 15-12D). (aao.org)
  • There is a round, well-circumscribed pigmented lesion. (mrcophth.com)
  • Another notable contribution of ultrasound to the multimodal ocular oncology assessment is the ability to help distinguish UM from its most important differential: a choroidal nevus (benign pigmented lesion). (efsumb.org)
  • [1] , [2] Recently, RPE tears have been described after intravitreal bevacizumab injection, due to rapid contraction of the underlying choroidal neovascular membrane (CNVM). (ijo.in)
  • In the past, almost all RPE adenocarcinomas were clinically diagnosed as atypical choroidal melanomas and the eyes were enucleated. (eyecancer.com)
  • In Dr. Finger's review of the literature, RPE adenocarcinomas were found to be more common in females, more likely to cause intraocular inflammation (atypical for choroidal melanomas) and have responded poorly to radiation therapy. (eyecancer.com)
  • No choroidal melanomas were observed in the comparison populations. (cdc.gov)
  • As observed on angiography, the numbers of choroidal and retinal blood vessels were significantly increased (principally on the seventh day) after the laser impacts. (molvis.org)
  • Low oxygen induced wet AMD-like appearance, with hyperproliferation of choroidal vessels that migrated into the sub-RPE zone. (neurosciencenews.com)
  • Nevus cells may or may not produce pigment and, therefore, can be classified as melanotic or amelanotic. (medscape.com)
  • plump polyhedral nevus cells: Abundant cytoplasm is filled with pigment and has a small round to oval nucleus with bland appearance. (aao.org)
  • Figure 12-16 Spindle-cell choroidal nevus (between arrows) is composed of slender spindle-shaped cells with thin, homogeneously staining nuclei. (aao.org)
  • slender spindle nevus cells (Fig 12-16): The cytoplasm contains scant pigment and a small, dark, elongated nucleus. (aao.org)
  • rs800292, rs1061170, rs1410996) in the complement factor H ( CFH ) gene, rs 11200638-SNP in the high temperature requirement A-1 ( HTRA1 ) gene, two SNPs (rs699947, rs2010963) in the vascular endothelial growth factor ( VEGF ) gene, and four SNPs (rs12948385, rs12150053, rs9913583, rs1136287) in the pigment epithelium-derived factor ( PEDF ) gene were evaluated. (dovepress.com)
  • OCT findings in patients with occult and classic choroidal neovascularisation 1, 3 and 6 months after combination therapy showed a reduced retinal thickness compared to baseline. (tum.de)
  • Optical coherence tomography showed a retinal pigment epithelial tear with subretinal fluid . (bvsalud.org)
  • The diagnosis of choroidal metastases is sometimes made during a routine eye examination with an ophthalmoscope. (msdmanuals.com)
  • Retinal pigment epithelial (RPE) tear has been described to occur spontaneously, after laser photocoagulation and in recent times, after intravitreal injection of anti-vascular endothelial growth factor (VEGF) agents. (ijo.in)
  • The present study investigated the effects of GSK2606414 on proliferation, apoptosis, and the expression of activating transcription factor 4 (ATF4), CCAAT/enhancer‑binding protein homologous protein (CHOP) and vascular endothelial growth factor (VEGF) in human retinal pigment epithelial (RPE) cells under endoplasmic reticulum (ER) stress. (spandidos-publications.com)
  • The natural history of primary acquired melanosis begins with the development of superficial epithelial pigmentation, with a typical peppered pigment distribution. (medscape.com)
  • Figure 1: (A) Fundus photograph of the left eye showing the presence of a juxtafoveal retinal pigment epithelial (RPE) tear. (ijo.in)
  • The neuroretina is tightly attached to the underlying retinal pigment only at the margins of the optic nerve and at the ora serrata. (medscape.com)
  • Pigment-producing cells derive embryologically from the neural crest. (medscape.com)
  • Results showed that in cultured human-derived retinal pigment epithelial ARPE-19 cells , the extract of Chlorella zofingiensis and its nutritional ingredient astaxanthin exhibited significant inhibitory effects on the formation of endogenous N ε -carboxymethyllysine (CML), a key AGE representative, through the suppression of intracellular oxidative stress. (rsc.org)
  • balloon cells: Abundant, foamy cytoplasm lacks pigment and has a bland nucleus. (aao.org)
  • Human retinal pigment epithelial cells (ARPE-19) were exposed to lipopolysaccharide (LPS) with or without caffeine. (frontiersin.org)
  • The retina's RPE is a layer of pigmented cells essential to the nourishment and survival of photoreceptors. (southfloridahospitalnews.com)
  • On day nine, the scientists seeded retinal pigment epithelial cells on the flip side of the scaffold. (neurosciencenews.com)
  • During AMD progression, the RPE is damaged, accompanied by a disruption of the choroidal blood-eye barrier and degeneration of photoreceptors. (spandidos-publications.com)
  • The color of our eyes is determined by the amount of pigment in the iris. (allaboutvision.com)