Pigment cell. Medical search. Frequent questions

Pigment Cell & Melanoma Research is a dermatology journal publishing up-to-date manuscripts on all aspects of pigment cells and melanoma. (wiley.com)
Graphic abstract illustrates that MitoCur-1 induces melanoma cell death and sensitization of vem-resistant melanoma cell through two ways: (1) inhibition of mitochondrial TrxR2, generation of ROS, and induction of the ROS-dependent glycolytic metabolisms (Zheng et al. (wiley.com)
The depletion of anti-oxidative enzyme aggravates the accumulation of lipid ROS and ferrous iron, and then triggers ferroptosis leading to melanoma cell death and overcoming vem resistance in melanoma. (wiley.com)
Although a pigmented eyelid lesion may appear benign, it is wise to obtain a specimen for pathological examination because of the associated risk of mortality associated with malignant melanoma. (medscape.com)
We focus on four themes: (1) clinical melanoma research, (2) basic melanoma research, (3) clinical dermatology, and (4) basic pigment cell research, with the goal of outlining current highlights, challenges, and frontiers associated with pigmentation and melanocyte biology. (uky.edu)
Pigment Cell and Melanoma Research , 31 (6), 728-735. (uky.edu)
To understand the biological underpinnings of skin and hair pigmentation and related diseases such as albinism or melanoma, scientists and doctors need quantitative, three-dimensional information about the architecture, content and location of pigment cells. (sciencedaily.com)
Spencer Katz, an MD/PhD medical scientist training program student on Cheng's team, has modified this micro-CT technique to specifically investigate melanin, a pigment scientists are studying in human skin color and melanoma research, in whole zebrafish. (sciencedaily.com)
We have studied the transgenic mouse strain, Tyrp-1-TAg, to try to gain insight into possible molecular mechanisms common to pigmented ocular neoplasms occurring spontaneously in the eyes of these mice and human choroidal melanoma. (molvis.org)
To treat pigment disorders, your dermatologist will reverse or minimize differences in your melanoma that are causing your skin discoloration. (utah.edu)
Melanoma in situ is when abnormal melanocytes (cells that make melanin, the pigment that gives skin its natural color) are found in the epidermis (outer layer of the skin). (cdc.gov)

Single-cell RNAseq of MC1R-inhibited melanocytes elucidates a set of differentially expressed genes with no previous ties to pigmentation or melanocyte biology. (wiley.com)
Melanocytes are melanin-producing cells found in the basal cell layer of the epidermis. (medscape.com)
Nevus cells are incompletely differentiated melanocytes that are found in clumps in the epidermis or the dermis. (medscape.com)
Melanocytes produce melanin and are derived from neural crest cells. (medscape.com)
Pigmented lesions of the eyelids arise from 1 of 3 types of melanocytes, as follows: (1) epidermal or dendritic melanocytes, (2) nevus cells or nevocytes, and (3) dermal or fusiform melanocytes. (medscape.com)
The increase in the number of follicle growth cycles with aging is associated with deficits in melanocyte stem cells (McSCs) , the stem cells residing in the follicle that can form hair pigment-producing melanocytes. (medicalnewstoday.com)
In the other location-called the hair germ area-McSCs can differentiate to form melanocytes that produce melanin pigment for hair. (medicalnewstoday.com)
Instead, a recent study published in Nature suggests that the McSCs can migrate back and forth between the two aforementioned locations, differentiating to produce hair pigment-producing melanocytes in the hair germ area and then translocating to the bulge and dedifferentiating to ensure the maintenance of an adequate supply of stem cells. (medicalnewstoday.com)
This results in fewer stem cells that can develop into pigment-producing melanocytes, thus leading to hair graying. (medicalnewstoday.com)
Our study suggests that melanocyte stem cells are mobile but can start the regeneration of hair melanocytes only when they are present in a specific area within the hair follicle (hair germ compartment). (medicalnewstoday.com)
The researchers were able to visualize every cell containing melanin, called melanocytes, in the fish, and map each of their positions in 3D. (sciencedaily.com)
When the sun's rays hit the skin, melanocytes come into action: they form melanin pigments that protect the cell nucleus. (clrn.org)
Mammals and birds , in contrast, have a class of cells called melanocytes for colouration. (wikipedia.org)
Special cells in your skin called melanocytes create melanin, which gives your skin its color. (utah.edu)
Melanocytes are cells in your skin that make color (pigment). (utah.edu)
If you have melasma, it's because hormones have stimulated your melanocytes to produce more pigment in certain areas of your skin. (utah.edu)
To treat vitiligo-for example-your dermatologist may stimulate your melanocytes cells to regrow. (utah.edu)
During mouse embryonic development, a subpopulation of neural crest cell-derived melanocytes migrates and incorporates into a subregion of the cochlear epithelium, forming the intermediate cell layer of the stria vascularis. (jneurosci.org)
NC cells differentiate to form a broad array of derivatives, including neurons and glia of the peripheral nervous system, smooth muscle, cartilage, craniofacial mesenchyme, and melanocytes ( Mayor and Theveneau, 2013 ). (jneurosci.org)

The epigenetic plasticity of amphibian retinal pigment epithelium (RPE) allows them to regenerate the entire retina, a trait known to be absent in mammals. (nih.gov)
Purpose Invasion of pigmented cells into the retina occurs in retinal degenerative diseases, such as macular telangiectasia type 2 (MacTel) and retinitis pigmentosa (RP). (bmj.com)
Interestingly, we also found clusters of KRT18-positive cells in the retina that were not pigmented. (bmj.com)
Conclusions Our findings suggest that RPE cells invading the retina dedifferentiate (losing classic RPE markers) and can be pigmented or unpigmented. (bmj.com)
Therefore, the number of RPE cells invading the retina in retinal degenerative disease may be underappreciated by funduscopy. (bmj.com)
In many forms of human retinal disease, including age-related macular degeneration (AMD), the underlying pathogenesis resides within the support cells of the retina, the retinal pigment epithelium (RPE). (ca.gov)
Age-related macular degeneration (AMD), a leading cause of blindness, is characterized by the death of the retinal pigmented epithelium (RPE), which is a monolayer posterior to the retina that supports the photoreceptors. (ca.gov)
Apical polarization of N-CAM in retinal pigment epithelium is dependent on contact with the neural retina. (rupress.org)
The retinal pigment epithelium (RPE) is unique among epithelia in that its apical surface does not face a lumen, but, instead, is specialized for interaction with the neural retina. (rupress.org)
The RPE is a monolayer of cells between the neural retina and choroidal blood supply, and is critically important for photoreceptor function. (arvojournals.org)
[3] It is a common misconception that all albino animals have characteristic pink or red eyes (resulting from the lack of pigment in the iris allowing the blood vessels of the retina to be visible), however this is not the case for some forms of albinism. (wikipedia.org)
The inverted image of the objects projected to the retina, however can be processed at high resolution only at the central fovea, where light reaches the cone receptor cells directly. (9dok.org)
Because of a blood - retina barrier ( tight junction formation), RPE cells restrict the entry of hydrophilic macromolecules (e.g., small interfering RNA ( siRNA )) through blood stream and eye drops . (bvsalud.org)

Retinal pigment epithelial cell. (nih.gov)

A pigmented spindle cell nevus is a skin condition characterized by a dark brown to black macule or papule, usually less than 6 mm. (wikipedia.org)
Nevus cells may or may not produce pigment and, therefore, can be classified as melanotic or amelanotic. (medscape.com)

By optimizing the amount of H 2 O 2 added and the timing of the addition, the yield of extracellular water-soluble yellow pigments significantly increased and reached a maximum of 209 AU, when 10 mM H 2 O 2 was added on the 3rd day of fermentation with M. ruber CGMCC 10910. (biomedcentral.com)
This experiment provides a potential strategy for improving the production of Monascus yellow pigments. (biomedcentral.com)
A large body of evidence indicates that Monascus yellow pigments are beneficial to human health in appropriate doses and can potentially be used as nutraceutical or therapeutic agents. (biomedcentral.com)
In submerged fermentation, Monascus yellow pigments generally consist of a large amount of intracellular alcohol-soluble pigments and a small amount of extracellular water-soluble pigments [ 10 ]. (biomedcentral.com)
Water-soluble yellow pigments have been a popular area of research due to their high stability and convenient utilization [ 11 ]. (biomedcentral.com)
Water-soluble yellow pigments can be synthesized via chemical modification of intracellular alcohol-soluble pigments [ 12 ], but this strategy is a potential risk in food applications. (biomedcentral.com)
Chen has shown that both extracellular and intracellular yellow pigments are the main pigments produced during long periods of high cell density culturing by Monascus anka [ 19 ]. (biomedcentral.com)

Hair follicles contain several different types of cells, including melanocyte stem cells that generate cells that produce the pigment melanin responsible for hair color. (medicalnewstoday.com)
A new study in mice shows that these melanocyte stem cells migrate between two sites in the hair follicle during each cycle of hair growth and shedding- from a site where they produce the pigment for hair color to another where they produce stem cells. (medicalnewstoday.com)
The study found that aging results in a greater portion of these melanocyte stem cells getting stuck at the site where they produce stem cells, which leaves a smaller portion of stem cells to generate melanin-producing cells, resulting in the graying of hair. (medicalnewstoday.com)
Melanocyte stem cells are found in two distinct locations at the base of each hair follicle. (medicalnewstoday.com)
D . , a cell biologist at New York University, said, "[Our] analysis revealed melanocyte stem cells are more dynamic/mobile than previously thought. (medicalnewstoday.com)
We revealed that as melanocyte stem cells move within the hair follicle, stem cells can reversibly alter cell state from immature to mature state, and this reversibility is critical for the proper maintenance of these stem cells. (medicalnewstoday.com)
Dr. Ito also noted, "The study is built upon previous studies showing that maintaining healthy melanocyte stem cells is the key to preserving hair color. (medicalnewstoday.com)
Our study also suggests that melanocyte stem cell localization may be altered during the course of aging. (medicalnewstoday.com)
Some dermatologists think it may be caused by an autoimmune disease that causes your immune system to attack melanocyte cells in your skin. (utah.edu)
Melanocyte cells help your skin produce a substance called melanin, which gives your skin its color. (utah.edu)
If you have melasma, your dermatologist will use a treatment that causes your melanocyte cells to produce less pigment. (utah.edu)
Its receptor tyrosine kinase, c-Met , is expressed in the cochlear epithelium and melanocyte-derived intermediate cells in the stria vascularis. (jneurosci.org)
Anti-melanocyte-specific cytotoxic T cells exert a central role in the final effector stage. (medscape.com)

Dermoscopic image of pigmented basal cell carcinoma with blue globules in the left part of the lesion. (iiarjournals.org)
Reflectance confocal microscopy image showing bright cordlike structures with clefting (arrow) and elongated vessels (arrowhead) in the border, in pigmented basal cell carcinoma. (iiarjournals.org)
Reflectance confocal microscopy image showing dark silhouettes in non-pigmented basal cell carcinoma. (iiarjournals.org)
It is estimated that of all benign and malignant lesions of the eyelid, roughly 35% are comprised of basal cell carcinoma and squamous cell carcinoma . (medscape.com)
These cells are destined to reside in the basal cell layer of the epidermis. (medscape.com)
Results: HZ increased basal protein levels of HSP-27 without altering those of HSP-70 in THP-1 cells, and promoted long-term cell survival without inducing apoptosis. (unito.it)
Given that basal cell carcinoma rarely metastasizes, laboratory and imaging studies are not commonly clinically indicated in patients presenting with localized lesions. (medscape.com)
A skin biopsy is often required to confirm the diagnosis and determine the histologic subtype of basal cell carcinoma (BCC). (medscape.com)
[ 58 ] Usually, BCCs are well differentiated and cells appear histologically similar to basal cells of the epidermis. (medscape.com)
The nuclei resemble that of the basal cells of the epidermis, although they have a larger nuclear-to-cytoplasmic ratio and lack intercellular bridges. (medscape.com)
Nodular basal cell carcinoma. (medscape.com)
Melanin is also present within the tumor and in the surrounding stroma, as seen in pigmented basal cell carcinoma. (medscape.com)

The progression of AMD may be prevented through anti-inflammation and antioxidation in retinal pigment epithelium (RPE) cells. (nih.gov)
These intraretinal pigmented cells may be derived from the retinal pigment epithelium (RPE), but differences and similarities between intraretinal pigmented cells and RPE have so far not been well characterised. (bmj.com)
Protective effects of human iPS-derived retinal pigment epithelium cell transplantation in the retinal dystrophic rat. (ca.gov)
The retinal pigment epithelium (RPE) is the primary target of AMD ( 2 , 3 ). (spandidos-publications.com)
Expression of RPE-specific markers was assessed by flow cytometry, quantitative polymerase chain reaction, and immunocytochemistry, and RPE function was determined by phagocytosis of rod outer segments and secretion of pigment epithelium-derived factor. (ca.gov)
To identify key genes differentially expressed in the human retinal pigment epithelium (hRPE) following low-level West Nile virus (WNV) infection. (molvis.org)
Primary hRPE and retinal pigment epithelium cell line (ARPE-19) cells were infected with WNV (multiplicity of infection 1). (molvis.org)
The study, conducted at the University of Eastern Finland , aimed to improve model design for the retinal pigment epithelium (RPE), located in the lack of the eye, forming the outer blood-retinal barrier which plays a key role in diseases such as age-related macular degeneration. (drugtargetreview.com)
Lately, there are growing concerns in terms of safety to retinal tissues, especially to the retinal pigment epithelium (RPE). (uni-tuebingen.de)
Primary cultures of retinal pigment epithelium (RPE) from human adult donors (haRPE) and induced pluripotent stem cell derived-RPE (iPSC-RPE) are valuable model systems for gaining mechanistic insight and for testing potential therapies for age-related macular degeneration (AMD). (umn.edu)
receptor cells nourished by pigment epithelium II. (9dok.org)
Functional Peptide-Modified Liposomes for siRNA Delivery to Rat Retinal Pigment Epithelium Cells: Effect of Peptide Sequences. (bvsalud.org)

Suspicious eyelid lesions, particularly when they are pigmented, need to be removed for purposes of a biopsy. (medscape.com)
Through established protocols 2 , fibroblasts from a skin biopsy can be returned to a pluripotent state and serve as a renewable, autologous source of replacement cells that avoids the ethical complications of hESCs. (nature.com)

QBAM images of iPSC-RPE were used to train DNNs that predicted iPSC-RPE monolayer transepithelial resistance, predicted polarized vascular endothelial growth factor (VEGF) secretion, and matched iPSC-RPE monolayers to the stem cell donors. (jci.org)

Here we report the differentiation of human iPS cells into RPE. (ca.gov)
In this study, we investigated the maintenance of hESCs and their differentiation into RPE using Synthemax II-SC, which is a novel, synthetic animal-derived component-free, RGD peptide-containing copolymer compliant with good manufacturing practices designed for xeno-free stem cell culture. (ca.gov)
The CSF-1 receptor triggers signaling pathways that control many important cellular processes, such as cell growth and division (proliferation) and maturation of the cell to take on specific functions (differentiation). (medlineplus.gov)
This differentiation of stem cells to a cell type that performs a specific function is thought to be irreversible. (medicalnewstoday.com)
In plants, albinism is characterised by partial or complete loss of chlorophyll pigments and incomplete differentiation of chloroplast membranes. (wikipedia.org)

Results showed that in cultured human-derived retinal pigment epithelial ARPE-19 cells , the extract of Chlorella zofingiensis and its nutritional ingredient astaxanthin exhibited significant inhibitory effects on the formation of endogenous N ε -carboxymethyllysine (CML), a key AGE representative, through the suppression of intracellular oxidative stress. (rsc.org)
A cytoplasm -responsive stearylated (STR) peptide , STR-CH2R4H2C (CH2R4) enables stable siRNA complexation, cell permeation, and intracellular dynamics control. (bvsalud.org)

Our results demonstrate that iPS cells can be differentiated into functional iPS-RPE and that transplantation of these cells can facilitate the short-term maintenance of photoreceptors through phagocytosis of photoreceptor outer segments. (ca.gov)
Induced pluripotent stem cells (iPSCs) generated from patient fibroblasts could potentially be used as a source of autologous cells for transplantation in retinal disease. (nature.com)
Stem cell-derived cell transplantation in the eye is one therapy being explored for inherited retinal degenerations such as retinitis pigmentosa (RP). (nature.com)
Using a patient's own cells for transplantation would avoid these pitfalls and is possible with induced pluripotent stem cells (iPSCs). (nature.com)
Pigment cell transplantation offers an alternative for the treatment of segmental vitiligo or stable non-segmental lesions. (medscape.com)

These cells might be a potential source for therapies to treat age-related macular degeneration. (ca.gov)
Oxidative stress has been implicated in the pathogenesis of age-related macular degeneration (AMD), the leading cause of blindness in the elderly, with retinal pigment epithelial (RPE) cells playing a key role. (princeton.edu)

As a monolayer of cells critical to photoreceptor function and survival, the RPE is an ideally accessible target for cellular therapy. (ca.gov)

This research was conducted to detail the mechanisms of these effects of lycopene-treated RPE cells. (nih.gov)
Although the precise underlying mechanisms of AMD are not fully understood, numerous lines of evidence have indicated that endoplasmic reticulum (ER) stress contributes to the etiology of RPE cell damage and neovascularization formation ( 5 - 7 ). (spandidos-publications.com)
Little is known about the mechanisms underlying macular degenerations, mainly for the scarcity of adequate experimental models to investigate cone cell death. (nature.com)
Animals can appear coloured due to two mechanisms, pigments and structural colours . (wikipedia.org)
To better understand the cytotoxic mechanisms underlying oxidative stress, we used cell culture and mouse models of iron overload, as iron can catalyze reactive oxygen species formation in the RPE. (princeton.edu)

Fruit and vegetables contain carotenoid pigments, which accumulate in human skin, contributing to its yellowness. (mdpi.com)

As the RPE is characterised by strong pigmentation, many drugs bind to cellular pigment and can accumulate in RPE cells. (drugtargetreview.com)

The present study investigated the effects of GSK2606414 on proliferation, apoptosis, and the expression of activating transcription factor 4 (ATF4), CCAAT/enhancer‑binding protein homologous protein (CHOP) and vascular endothelial growth factor (VEGF) in human retinal pigment epithelial (RPE) cells under endoplasmic reticulum (ER) stress. (spandidos-publications.com)
ARPE‑19 human RPE cells were treated with 0.01‑50 µM GSK2606414, and ER stress was induced by thapsigargin (TG) treatment. (spandidos-publications.com)
Disruption of PERK activity has been demonstrated to reduce hydroquinone-induced apoptosis and hypoxia-induced VEGF expression in human RPE cells in vitro ( 5 , 21 ). (spandidos-publications.com)
Defined culture of human embryonic stem cells and xeno-free derivation of retinal pigmented epithelial cells on a novel, synthetic substrate. (ca.gov)
Human embryonic stem cells (hESCs) can generate an unlimited source of RPE for cellular therapies, and clinical trials have been initiated. (ca.gov)
Monascus pigments are widely used in the food and pharmaceutical industries due to their safety to human health. (biomedcentral.com)
Katz and Cheng said that human melanomas can be stained with silver and imaged in the same way to more completely characterize the tumor cells and their arrangements in tumors. (sciencedaily.com)
LEPI cells model the real-life retinal pigment epithelial layer of the eye by forming a tight epithelial layer and having hexagonal cell morphology like in the human eye (Confocal microscope image: cell nucleus is shown as blue and cell membrane as red) (credit: Mika Reinisalo). (drugtargetreview.com)
The aim of this experimental study was to examine potentially cytotoxic effects of ICG and TB on cultured human RPE cells. (uni-tuebingen.de)
In a subset of samples, haRPE and iPSC-RPE were generated from the same human donor to make a side-by-side comparison of the two cell models' response to treatment. (umn.edu)
Analysis of haRPE and iPSC-RPE generated from the same human donor showed a similar response for donors without AMD, but there were significant differences in treatment response between cell models generated from AMD donors. (umn.edu)
During lab experiments, skin cells treated with selenomelanin were able to shrug off doses of X-ray radiation that would be lethal to a human being. (space.com)
Recent clinical trials evaluating allogeneic retinal grafts derived from human embryonic stem cells (hESCs) show the procedure to be safe and potentially effective 1 . (nature.com)
A commonly used genetic typing test that uses antibodies to detect variations on the surface of human red blood cells. (ojp.gov)
Objective: To investigate the effect of malarial pigment (hemozoin, HZ) on expression of heat shock proteins (HSPs) and cell viability in human monocytes by using a stable cell line (THP-1 cells). (unito.it)
This photomicrograph of a thin film human blood smear, extracted from a patient with a malarial infection, revealed the presence of a growing, ring-staged, Plasmodium malariae trophozoite, inside an oval red blood cell (RBC), surrounded by lightly staining cytoplasm. (cdc.gov)

Cell viability was assayed with Alamar Blue. (nih.gov)
Cell proliferation was assessed using the Cell Counting kit‑8 cell viability assay. (spandidos-publications.com)
Cell viability and morphology were examined after the follow-up times of 6, 24 and 72 hours. (uni-tuebingen.de)
Results: ICG reduced cell viability at concentrations of 2.5 mg/ml and higher, when incubated for more than 5 minutes. (uni-tuebingen.de)
Alternatively, HZ-fed cells were cultured up to 72 h and cell viability parameters (survival, apoptosis and necrosis rates) were measured by flow cytometric analysis. (unito.it)
In vitro exposure of macrophages to ultrafine or fine TiO2 in the range of 0.5-200 g/ml did not significantly alter cell viability. (cdc.gov)

Conclusions: Present data show that HZ prevents cell apoptosis and enhances the expression of anti-apoptotic HSP-27 in THP-1 cells, confirming the previous evidences obtained from HZ-fed immunopurified monocytes. (unito.it)

Oxidative conditions induced by H 2 O 2 increased water-soluble yellow pigment accumulation via up-regulation of the expression levels of relative genes and by increasing the precursors of pigment biosynthesis through redirection of metabolic flux. (biomedcentral.com)
In contrast, reductive conditions induced by dithiothreitol inhibited yellow pigment accumulation. (biomedcentral.com)
The new cell model makes it possible to study this accumulation in greater detail than before. (drugtargetreview.com)
Alzheimer Disease Alzheimer disease is a progressive loss of mental function, characterized by degeneration of brain tissue, including loss of nerve cells, the accumulation of an abnormal protein called beta-amyloid. (msdmanuals.com)

The frequency of pigmented lesions of the eyelid varies according to the lesion type and patient characteristics. (medscape.com)

In 2019, a team led by Dr. Keith Cheng, distinguished professor of pathology, pharmacology and biochemistry and molecular biology, developed "X-ray histotomography" -- a cellular form of CT imaging, as a method for investigating the 3D architecture of cells and tissues in biological samples at unprecedented resolution and clarity. (sciencedaily.com)

We show here that the neural cell adhesion molecule (N-CAM) is found both on the apical surface of RPE in situ and on the outer segments of photoreceptors, fulfilling an important requisite for an adhesion role between both structures. (rupress.org)
This gene provides instructions for making a protein called colony stimulating factor 1 receptor (CSF-1 receptor), which is found in the outer membrane of certain types of cells, including glial cells. (medlineplus.gov)
While exposure of wt mice resulted in massive pyknosis in a focal region of the outer nuclear layer (ONL), the exposure of R91W;Nrl −/− mice led to additional cell death detected within the inner nuclear layer. (nature.com)
6 , 7 High photon flux, oxygen tension and the high levels of polyunsaturated fatty acids present in rod outer segment membranes make rod photoreceptor cells especially vulnerable to photochemical damage. (nature.com)
In the sorghum caryopsis, the epidermis is composed of thick, elongated, rectangular cells which have a coating of cutin on the outer surface. (fao.org)
This indicates that the impairment caused by the noise is not limited to the outer hair cells. (cdc.gov)
Interestingly, this process seems mainly to occur in the outer hair cells, since the enhancement of the CAP-change was similar to that of the CM-change, though the noise -induced CM-change was much smaller. (cdc.gov)

Two new cell models have been developed by researchers with the possibility to explore avenues for ocular drug discovery. (drugtargetreview.com)

In normal control adult mouse eyes, ETS-1 was mostly present in the nuclei of all neuroretinal layers whereas ETS-2 was mostly localized in the cytosol of the cell bodies of these layers with a smaller amount present in the nuclei. (molvis.org)
The selenomelanin was absorbed into the cells and formed what Gianneschi called "microparasols," or tiny shields around the cells' nuclei, where DNA is stored. (space.com)
P. malariae schizonts have 6 to 12 merozoites with large nuclei, clustered around a mass of coarse, dark-brown pigment. (cdc.gov)
Tumor cells of nodular BCC, sometimes called basalioma cells, typically have large, hyperchromatic, oval nuclei and little cytoplasm. (medscape.com)

Most retinal diseases involve the degeneration of choroidal retinal pigment epithelial (RPE) cells . (bvsalud.org)

Researchmoz added Most up-to-date research on "Global Chrome Pigments Sales Market Report 2018" to its huge collection of research reports. (openpr.com)
The global Chrome Pigments market is valued at million US$ in 2017 and will reach million US$ by the end of 2025, growing at a CAGR of during 2018-2025. (openpr.com)

In the present study, for the first time, protective effects of three microalgal strains, including their extracts and active compounds, against both endogenous and exogenous AGEs in cell -based models were investigated. (rsc.org)
Some organic solvents, resin monomers and related compounds, pigments and occupational exposures in paint manufacture and painting / this publication represents the views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans which met in Lyon, 18-25 October 1988. (who.int)

PCC 6803 cells using hyperspectral confocal fluorescence microscopy and multivariate image analysis. (osti.gov)

[ 1 ] Antigen-presenting cells or histiocyte-like cells containing Birbeck granules have been identified within inflamed synovial tissues. (medscape.com)

Transformation of somatic cells with a set of embryonic transcription factors produces cells with the pluripotent properties of embryonic stem cells (ESCs). (ca.gov)
The neural crest (NC) is comprised of specialized cells that arise from the lateral border of the neural plate and migrate into specific locations during vertebrate embryonic development. (jneurosci.org)
NC cells contribute to several inner ear structures during embryonic development. (jneurosci.org)

This work laid a foundation for further research on melanin-containing cancers, or melanomas, which are typically graded by the depth of tumor cell invasion. (sciencedaily.com)
They predict that scientists will be able to, for example, count the number of tumor cells of different characteristics and more definitively study invasion, a central characteristic of cancer, helping doctors with prognostic and treatment decisions. (sciencedaily.com)
Nodular tumor aggregates may be of varying sizes, but tumor cells tend to align more densely in a palisade pattern at the periphery of these nests (see the image below). (medscape.com)

GSK2606414 treatment inhibited RPE cell proliferation in a dose‑dependent manner, however it did not induce apoptosis. (spandidos-publications.com)
We report an unusual case of Langerhans cell granulomatosis (LCG) manifested as a villous synovial proliferation in a 38-year-old female jogger. (medscape.com)
In the following report, LCG was manifested as a villous synovial proliferation mimicking pigmented villonodular synovitis (PVNS). (medscape.com)
It emphasizes the importance of immunocytochemistry to separate this histiocyte-like cell proliferation from true histiocytic and other dendritic cell types. (medscape.com)

Monascus pigments are mixed pigments with three main colours: yellow, orange and red [ 1 ]. (biomedcentral.com)
Animals may have both biological pigments and structural colours, for example, some butterflies with white wings. (wikipedia.org)

Biological pigments are substances produced by living organisms that have a colour resulting from selective colour absorption . (wikipedia.org)
Biological pigments include plant pigments and flower pigments . (wikipedia.org)
Comparison of the biological activity between ultrafine and fine titanium dioxide particles in RAW 264.7 cells associated with oxidative stress. (cdc.gov)

Our previous study found that glucose concentration induced extracellular oxidoreduction potential (ORP) changes could influence extracellular water-soluble yellow pigment production by Monascus ruber CGMCC 10910 in submerged fermentation. (biomedcentral.com)

The acute model of light-induced retinal degeneration uses short exposure to bright white light to study photoreceptor cell death leading to loss of vision. (nature.com)

Collectively, our data suggest that exposure of R91W;Nrl −/− mice to blue light not only induces cone cell death but also disrupts the inner blood-retinal barrier. (nature.com)

ARPE-19 and primary mouse RPE cells were cultured in the presence or absence of varying concentrations of MMF (0-5000 μM) for 0 to 24 hours. (elsevierpure.com)

Induced pluripotent stem (iPS) cells have the potential to differentiate into any cell type, making them a potential source from which to produce cells as a therapeutic platform for the treatment of a wide range of diseases. (ca.gov)

This stimulates cell renewal. (clrn.org)

A study discovered a new underlying mechanism with stem cells causing the hair to turn gray, which could lead to potential treatment. (medicalnewstoday.com)
In one of the locations-called the bulge- these McSCs undergo self-renewal to maintain a population of immature stem cells. (medicalnewstoday.com)
Among the wide variety of cells present in the hair follicle include stem cells . (medicalnewstoday.com)
Stem cells in the body are responsible for the regeneration of tissue in the body and can differentiate to form an array of specialized cells. (medicalnewstoday.com)
Specifically, the division of a stem cell can result in the formation of identical daughter stem cells and/or cells that can differentiate to assume different fates. (medicalnewstoday.com)
The stem cells in the hair follicle generate the cells to help regenerate hair follicle cells and facilitate hair growth. (medicalnewstoday.com)
[ 3 , 4 ] Langerhans cells are stellate dendritic cells that arise from CD34-positive bone marrow stem cells [ 5 ] and are not a member of the mononuclear phagocytic system. (medscape.com)

Also common in ALSP are abnormally pigmented glial cells. (medlineplus.gov)
Glial cells are specialized brain cells that protect and maintain neurons. (medlineplus.gov)

Low-level WNV infection of hRPE cells induced expression of genes that are typically associated with the host cell response to virus infection. (molvis.org)
Typically, continuously growing RPE cell lines lack melanin pigment (left). (drugtargetreview.com)

Anatomy39

Organisms25

Diseases17

Chemicals and Drugs59

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Psychiatry and Psychology4

Phenomena and Processes36

Disciplines and Occupations2

Information Science4

Health Care1

Melanoma11

Melanocytes19

Retina13

Epithelial cell1

Nevus2

Yellow pigments7

Melanocyte13

Basal12

Epithelium12

Biopsy2

Secretion1

Differentiation5

Intracellular2

Transplantation5

Macular degeneration2

Monolayer1

Mechanisms5

Carotenoid1

Accumulate1

Human16

Viability6

Conclusions1

Accumulation4

Lesion1

Molecular1

Outer7

Ocular1

Nuclei4

Choroidal1

20182

Compounds2

Confocal1

Tissues1

Embryonic3

Tumor3

Proliferation4

Colours2

Biological3

Fermentation1

Degeneration1

Induces1

Primary1

Diseases1

Stimulates1

Stem Cells7

Glial cells2

Typically2