• (konfirmi) Picrotoxin , ankaŭ konata kiel kockulin , estas venena kristala plantkunmetaĵo, unue izolita fare de la franca apotekisto kaj apotekisto Pierre François Guillaume Boullay (1777-1869) en 1812. (wikitrans.net)
  • Through the use of mice that are deficient in GalR1 receptors, a picrotoxin-kindled model was utilized to show that galanin plays a role in modulating and preventing hilar cell loss as well as decreasing the duration of induced seizures. (wikipedia.org)
  • Fifty-three per cent of all globus pallidus neurons examined had increased spontaneous firing frequencies following the iontophoretic administration of picrotoxin alone. (google.com)
  • As such, picrotoxin can be used to counter barbiturate poisoning, that can occur during general anesthesia or during a large intake outside of the hospital. (ipfs.io)
  • Reported effective treatment for early zygacine poisoning in animals consists of injection of 2 mg atropine sulfate and 8 mg picrotoxin per 45 kg bodyweight. (wikipedia.org)
  • The maximal response to unilateral injections of picrotoxin (greater than or equal to 200 ng) was characterized by the following sequence of behavioural events. (muscimol.xyz)
  • Under kinetically controlled conditions, this process generally results in exo cyclization and forms bridged ring systems like those found in picrotoxin. (wikipedia.org)
  • Finally, it was found that blindfolding the animals did not change the response to unilaterally injected picrotoxin. (muscimol.xyz)
  • In functional expression studies, TAS2R14 responds to (−)-α-thujone, the primary neurotoxic agent in absinthe, and picrotoxin, a poison found in fishberries. (wikipedia.org)
  • Sesquiterpenes such as picrotoxin and diterpenes such as clerodane diterpene are also present, while the triterpenes are scarce and where present are similar to oleanane. (wikipedia.org)
  • La ĉi-suba teksto estas aŭtomata traduko de la artikolo Picrotoxin article en la angla Vikipedio , farita per la sistemo GramTrans on 2016-06-06 08:42:10. (wikitrans.net)
  • However, over time, the narrow therapeutic window associated with picrotoxin administration-which can also induce seizures-resulted in its disuse. (wikipedia.org)
  • Picrotoxin occurs naturally in the fruit of the Anamirta cocculus, a climbing plant from India and other parts of Southeast Asia. (wikipedia.org)
  • The behavioural response to picrotoxin (25-500 ng) injected into the colliculus superior (CS) of freely moving cats was investigated. (muscimol.xyz)
  • Their data indicated that it was unlikely that picrotoxin acted simply as a voltage-gated channel blocker, although it did reduce the frequency of channel openings. (wikipedia.org)
  • Finally, it is suggested that picrotoxin resulted in a fixed code at the level of the CS, forcing the animal to execute characteristic motor patterns. (muscimol.xyz)
  • Picrotoxin is classified as an illegal performance-enhancing "Class 1 substance" by the American Quarter Horse Association . (ipfs.io)