Picornavirus capsid protein. Medical search. Frequent questions

Foot-and-mouth disease virus (FMDV) nonstructural protein 3A plays important roles in virus replication, virulence, and host range. (asm.org)
Replication of picornaviruses occurs associated to cell endomembranes that are recruited during viral infection ( 25 ). (asm.org)
in poliovirus (PV), the interaction between the RNA replication complex and intracellular membranes appears to be accomplished by proteins 3A and 2C, which have membrane-binding properties ( 11 , 60 ). (asm.org)
In alphaviruses, this process is thought to be mediated, at least in part, by the viral protease (nsP2) which is responsible for processing the nonstructural polyproteins (P123 and P1234) into individual proteins (nsP1-nsP4), forming the viral replication complex. (bvsalud.org)
The foot-and-mouth disease virus (FMDV) capsid is highly acid labile and tends to dissociate into pentameric subunits at acidic condition to release viral RNA for initiating virus replication. (biomedcentral.com)
Productive picornavirus infection requires the hijacking of host cell pathways to aid with the different stages of virus entry, synthesis of the viral polyprotein, and viral genome replication. (wrlfmd.org)
Picornaviruses form replication complexes in association with membranes in structures called replication organelles. (microbiologyresearch.org)
Common themes to emerge from studies of picornavirus replication are the need for cholesterol and phosphatidylinositol 4-phosphate (PI4P). (microbiologyresearch.org)
Other picornaviruses, for example the cardioviruses, are believed to initiate replication at the endoplasmic reticulum and subvert PI4KIIIα to generate PI4P. (microbiologyresearch.org)
A critical role of a cellular membrane traffic protein in poliovirus RNA replication. (microbiologyresearch.org)
Before the replication begins, early proteins are synthesized in the nucleus of the infected cells. (biologydiscussion.com)
Within 12h of infection and before start of DNA replication, there begins early protein synthesis. (biologydiscussion.com)
Late proteins are synthesized when DNA replication is over. (biologydiscussion.com)
Non-structural proteins (NSP) are produced during viral replication. (ncl.edu.tw)
12. LiuJZ, BlancaflorEB, NelsonRS (2005) The Tobacco mosaic virus 126-kilodalton protein, a constituent of the virus replication complex, alone or within the complex aligns with and traffics along microfilaments. (prelekara.sk)
The arteriviruses are highly species specific, but share many biological and molecular properties, including virion morphology, a unique set of structural proteins, genome organization and replication strategy, and the ability to establish prolonged or true persistent infection in their natural hosts. (bionity.com)
Both viral and cellular proteins are required for replication and transcription. (bionity.com)
The P2 and P3 regions encode the nonstructural proteins associated with replication. (expasy.org)
577Role of Cellular Proteins in RV Replication. (vdocuments.net)

They are viruses that represent a large family of small, positive-sense, single-stranded RNA viruses with a 30 nm icosahedral capsid. (wikipedia.org)
Picornaviruses are nonenveloped, with an icosahedral capsid. (wikipedia.org)
The icosahedral capsid is said to have a triangulation number of 3, this means that in the icosahedral structure each of the 60 triangles that make up the capsid are split into three little triangles with a subunit on the corner. (wikipedia.org)
The virus particle (25-30 nm) has an icosahedral capsid made of protein, without envelope, containing a single strand of ribonucleic acid (RNA) containing a positive encoding of its genome. (creative-biolabs.com)
One is that the RNA is packaged into the immature capsid after the arrangement of 12 copies of pentamer into a icosahedral capsid. (biomedcentral.com)
Non-enveloped, spherical, about 30 nm in diameter, pseudo T=3 icosahedral capsid surrounding the naked RNA genome. (expasy.org)

Picornaviruses are a group of related nonenveloped RNA viruses which infect vertebrates including fish, mammals, and birds. (wikipedia.org)
citation needed] Picornaviruses are classed under Baltimore's viral classification system as group IV viruses, as they contain a single-stranded, positive-sense RNA genome. (wikipedia.org)
Arthropod-infecting viruses, including Cricket paralysis virus, Drosophila C virus, and Tussock moth virus, are additional unclassified picornaviruses. (medscape.com)
Antirhinoviral compounds, the so-called human rhinovirus (HRV) coat protein inhibitors, have been developed to bind into a hydrophobic pocket in the viral capsid, stabilizing the capsid and interfering with cell attachment and/or uncoating of the viruses. (inteligand.com)
Acute poliomyelitis is caused by small ribonucleic acid (RNA) viruses of the enterovirus group of the picornavirus family. (medscape.com)
Non-enveloped viruses protect their genomes by packaging them into an outer shell or capsid of virus-encoded proteins. (wrlfmd.org)
Packaging and capsid assembly in RNA viruses can involve interactions between capsid proteins and secondary structures in the viral genome as exemplified by the RNA bacteriophage MS2 and as proposed for other RNA viruses of plants, animals and human. (wrlfmd.org)
In the picornavirus family of non-enveloped RNA viruses, the requirements for genome packaging remain poorly understood. (wrlfmd.org)
Despite their apparent complexity, the structure of most viruses is formed of the simple repetition of only a few proteins, sometimes also lipids. (suncana.co)
Using Cinema 4D, I created 3d models of two small RNA viruses from crystallographic data structures from the Protein Data Bank: 4RHV - rhinovirus that causes the common cold, and 1FPV, a picorna virus. (suncana.co)
BACKGROUND: Picornaviruses are responsible for a wide range of mammalian diseases and, in common with other RNA viruses, show considerable antigenic variation. (ox.ac.uk)
Foot-and-mouth disease viruses (FMDVs) constitute one genus of the picornavirus family and are classified into seven serotypes, each of which shows considerable intratypic variation. (ox.ac.uk)
Enveloped viruses have, in their lipid bilayer, an impermeable barrier between their genomes and the outside environment, reducing the need for continuity of any protein layer. (basicmedicalkey.com)
Picornaviruses are non-enveloped plus-strand ssRNA animal viruses with icosahedral capsids. (rcsb.org)
Viruses have specific proteins on their surface to attach to a host cellular surface molecule. (goalfinder.com)
The attachment proteins and their positioning vary for different type of viruses. (goalfinder.com)
Some of the non-enveloped viruses like picornaviruses and phages are capable of directly injecting their genome into the host cell. (goalfinder.com)
B) Viruses are enclosed in protein capsids rather than plasma membranes. (easynotecards.com)

The rest of the genome encodes structural proteins at the 5' end and nonstructural proteins at the 3' end in a single polyprotein. (wikipedia.org)
This study is targeted on generating libraries of possible new HRV coat protein inhibitors built in an analogous structural manner as the WIN compounds. (inteligand.com)
The viral genome encodes four structural capsid proteins (VP1 to VP4) and seven nonstructural (NS) proteins, the leader Lb/ab protease, and proteins encoded in the P2 (2B and 2C) and P3 (3A, 3B, 3C, and 3D) regions ( 9 ). (asm.org)
The uncoating of FMDV depends on irreversible structural rearrangements triggered by the interaction between the pH-sensitive amino acid residues with other residues in the capsid. (biomedcentral.com)
We confirmed the close relationship of their structural proteins but showed apparent additional recombination events in the 2A gene and 3′UTR of the HRV-Ca strain. (plos.org)
The inactivated vaccines consist of purified viral particle without or with only minor contaminants of NSP and thus induce antibody mainly against structural proteins of virus. (ncl.edu.tw)
The polyprotein is initially processed by the viral protease into various precursor and mature proteins to yield the structural proteins, replicase, VPg, and a number of proteins that modify the host cell, ultimately leading to cell lysis . (expasy.org)
There are four structural viral proteins, of which VP1 has been shown to elicit protective immunity in cattle ( Bachrach 1977 ). (wikisource.org)

In this work, FMDV 3A homodimerization was evidenced by an in situ protein fluorescent ligation assay. (asm.org)
A molecular model of the FMDV 3A protein, derived from the nuclear magnetic resonance (NMR) structure of the poliovirus 3A protein, predicted a hydrophobic interface spanning residues 25 to 44 as the main determinant for 3A dimerization. (asm.org)
The conflict between the acid lability in vivo and acid stability in vitro of FMDV capsid promotes the selection of a series of amino acid substitutions which can confer resistance to acid-induced FMDV inactivation. (biomedcentral.com)
We also listed all substitutions obtained by different research methods and showed them in the partial capsid of FMDV. (biomedcentral.com)
As the uncoating event of FMDV is dependent on the pH-sensitive amino acid residues in the capsid, this most pH-sensitive position indicates a potential candidate location for RNA delivery triggered by the acid-induced coat disassociation. (biomedcentral.com)
The generation of an infectious FMDV particle is a complex feat of engineering mainly involved in the process of capsid assembly, RNA encapsidation, and the viral maturation which are regulated by complicated events in infected cells. (biomedcentral.com)
The current model of dissociation of FMDV supports the assumption that the acidification system in endosome triggers the direct dissociation of FMDV into pentameric subunits, protein VP4, and RNA without intermediate. (biomedcentral.com)
Many picornaviruses, including foot-and-mouth disease virus (FMDV), assemble capsids via the multimerization of several copies of a single capsid precursor protein into a pentameric subunit which further encapsidates the RNA. (wrlfmd.org)
CONCLUSION: In FMDV type C, amino acid substitutions seen in mutants that are resistant to neutralization by monoclonal antibodies (MAbs) map to predominantly surface-oriented residues with solvent-accessible side-chains not involved in interactions with other amino acids, whereas residues which are accessible but not substituted are found to be more frequently involved in protein-protein interactions. (ox.ac.uk)
Viral RNA polymerase, a nonstructural protein, has been termed "virus infection associated antigen" (VIAA) for diagnostic purposes but is more accurately termed "FMDV nonstructural protein 3D. (wikisource.org)

The viral particle is composed of a protein capsid that contains a positive-sense RNA molecule of about 8,500 nucleotides that is infectious and encodes a single polyprotein, which is processed in infected cells by cis - and trans -acting viral proteases ( 55 ) to yield different polypeptide precursors and the mature viral proteins ( 9 , 62 ). (asm.org)
The dsDNA encodes the early proteins and capsid proteins. (biologydiscussion.com)

The virion consists of single-stranded positive-sense RNA genome of approximately 8500 nucleotides in length and icosahedron capsid protein [ 5 , 6 ]. (biomedcentral.com)
The single-stranded RNA core is surrounded by a protein capsid without a lipid envelope, which makes poliovirus resistant to lipid solvents and stable at low pH. (medscape.com)
Intro Picornaviruses are nonenveloped infections with a positive-sense single-stranded RNA genome. (palomid529.com)

Unlike those of most picornaviruses, parechovirus capsids are composed of only three subunits: VP0, VP1, and VP3. (omicsdi.org)
Capsid is made up of 72 capsomers which are built by 420 subunits. (biologydiscussion.com)
The shell of a nonenveloped virus with even a very small genome must therefore contain a large number of identical protein subunits-at least 60, if the coat-protein gene is to use up less than 25% of the coding capacity in the enclosed nucleic acid. (basicmedicalkey.com)
Acidic PH dissociates the capsid into pentameric subunits. (expasy.org)

Phosphatidylinositol-4 kinase III beta and oxysterol-binding protein accumulate unesterified cholesterol on poliovirus-induced membrane structure. (microbiologyresearch.org)

We found that interactions among pentamers in the HPeV-1 capsid are mediated by the N termini of VP0s, which correspond to the capsid protein VP4 and the N-terminal part of the capsid protein VP2 of other picornaviruses. (omicsdi.org)
Therefore, putative small molecules that could disrupt HPeV RNA-capsid protein interactions could be developed into antiviral inhibitors.Human parechoviruses (HPeVs) are pathogens that cause diseases ranging from respiratory and gastrointestinal disorders to encephalitis. (omicsdi.org)
Furthermore, we found that the interactions of the HPeV-1 genome with the capsid resulted in a partial icosahedral ordering of the genome. (omicsdi.org)
Capsid protein interactions with the ESCRT-associated Bro1 domain proteins, ALG-2-interacting protein X (ALIX) and His domain-containing protein tyrosine phosphatase (HD-PTP), which are both recruited to the pX domain of 1D (VP1pX), are critical for this process. (bvsalud.org)
The leader (L) protein is thought to exert important functions in virus-host interactions. (expasy.org)

Cell macromolecular synthesis may be controlled after CoV infection by locating some virus proteins in the host cell nucleus. (bionity.com)

Molecular, anatomic, and immunologic evidence suggests that TVH is caused by a novel picornavirus, tentatively named turkey hepatitis virus. (cdc.gov)

Aphthoviruses are more acid-labile than other picornaviruses. (medscape.com)

In order to facilitate delivery of the virus genome into the cytoplasm, the N termini of VP0s have to be released from contacts between pentamers and exposed at the particle surface, resulting in capsid disruption. (omicsdi.org)

Based on CVA10 replicon RNA, SRIPs with either the enterovirus A71 (EVA71) capsid or the CVA10 capsid were generated. (virosin.org)
Chen P et al (2012) Molecular determinants of enterovirus 71 viral entry: cleft around GLN-172 on VP1 protein interacts with variable region on scavenge receptor B2. (virosin.org)

To establish the HPeV immunofluorescence assay, an antibody against HPeV capsid protein VP0 was generated by using antigenic epitope prediction data. (omicsdi.org)

It is a picornavirus, the prototypical member of the genus Aphthovirus. (creative-biolabs.com)

The Structure of Human Parechovirus 1 Reveals an Association of the RNA Genome with the Capsid. (omicsdi.org)

However, the acid stability of virus capsid is greatly required for the maintenance of intact virion during the process of virus culture and vaccine production. (biomedcentral.com)
virion consists of dsDNA and protein. (biologydiscussion.com)
The cellular molecules that allow the virus to attach on the cell surface are called virus receptors and the virion proteins that mediate the attachment are called as attachment proteins. (goalfinder.com)

The capsid-coat protein serves multiple functions, including (1) protecting the viral RNA from degradation by environmental RNase, (2) determining host and tissue tropism by recognition of cell-specific cell-membrane receptors, (3) penetrating target cells and delivering the viral RNA into the cell cytoplasm, and (4) selecting and packaging viral RNA. (medscape.com)
C) the proteins in the host's cytoplasm. (easynotecards.com)
Upon endosomal acidification, the capsid releases VP4 that opens a pore in the host endosomal membrane and the viral genomic RNA penetrates into the host cell cytoplasm. (expasy.org)

The individual protein subunit of the virus capsid and formed in repetitive sequence. (innvista.com)

In the absence of an inhibitor the hydrophobic binding pocket, which is situated underneath a depression on the virus capsid surface, can be either empty or occupied by a cellular pocket factor, a lipid or fatty acid. (inteligand.com)
Replacements L38E and L41E, involving charge acquisition at residues predicted to contribute to the hydrophobic interface, reduced the dimerization signal in the protein ligation assay and prevented the detection of dimer/multimer species in both transiently expressed 3A proteins and in synthetic peptides reproducing the N terminus of 3A. (asm.org)
A hydrophobic pocket, which can be targeted by capsid-binding antiviral compounds in many other picornaviruses, is not present in HPeV-1. (omicsdi.org)

The structure of the calicivirus capsid exemplified by a cryo- family. (cdc.gov)

Picornaviruses constitute the family Picornaviridae, order Picornavirales, and realm Riboviria. (wikipedia.org)
The Picornaviridae family (picornaviruses) causes a wider range of illnesses than most other, if not all, virus families. (medscape.com)

Processing of the viral polyprotein is achieved cotranslationally by viral encoded proteases , giving rise to the different mature viral proteins. (bionity.com)

Analysis of liver by in situ hybridization with viral probes and immunohistochemical testing of serum demonstrated viral nucleic acid and protein in livers of diseased poults. (cdc.gov)
To protect it with a gap-free protein shell, 30 Å thick, would require roughly 25,000 amino acid residues-far more than the viral nucleic acid can encode. (basicmedicalkey.com)

RNA dependent RNA polymerase was discovered in Mengovirus, a genus of picornaviruses. (wikipedia.org)
The obtained partial sequences from the major capsid protein (MCP) gene (222nt) from each of these were 100% identical to each other and 98% identical to IIV-6, the type species of the genus Iridovirus. (laboklin.com)

These proteins assemble into structures with a geometric symmetry, forming shapes such as icosahedrons (platonic solids formed of 20 triangular faces). (suncana.co)
8 'Picornaviruses of Two Different Genera Have Similar Structures' J.Mol.Biol. (rcsb.org)

Modulation of lipid synthesis and trafficking pathways by picornaviruses. (microbiologyresearch.org)

High-throughput pyrosequencing of RNA from livers of poults with turkey viral hepatitis (TVH) revealed picornavirus sequences. (cdc.gov)

ThV is the only cardiovirus to produce two additional proteins from an ORF overlapping the L protein, in another frame. (expasy.org)

Rewiring of cellular membrane homeostasis by picornaviruses. (microbiologyresearch.org)
This process occurs concomitantly with the inhibition of cellular protein synthesis, caused by the expression of viral proteases. (bionity.com)

Subsequent cloning of the ≈9-kb genome showed an organization similar to that of picornaviruses with conservation of motifs within the P1, P2, and P3 genome regions, but also unique features, including a 1.2-kb sequence of unknown function at the junction of P1 and P2 regions. (cdc.gov)
When Plk1 becomes dysregulated or mislocalized, mitotic spindle assembly, protein organization, and mitotic timing impairments may occur. (uw.edu)

Each protomer consists of four polypeptides known as VP (viral protein) 1, 2, 3 and 4. (wikipedia.org)
The viral capsid of picornaviruses consists of a densely packed icosahedral arrangement of 60 protomers. (medscape.com)
Each protomer consists of 4 polypeptides, etoposide (VP) 1, 2, 3, and 4, which all derive from the cleavage of a larger protein. (medscape.com)
Capsid consists of 72 capsomers. (biologydiscussion.com)
The capsid consists of a densely-packed icosahedral arrangement of 60 protomers, each consisting of 4 polypeptides, VP1, VP2, VP3 and VP4. (expasy.org)

The external protein coat of a virus. (innvista.com)

Oxysterol-binding protein family I is the target of minor enviroxime-like compounds. (microbiologyresearch.org)
2010) A family of plasmodesmal proteins with receptor-like properties for plant viral movement proteins. (prelekara.sk)

CoV N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. (bionity.com)

Various deformations were applied to the individual capsid proteins, creating abstract shifting forms and different orientations of the individual elements, which multiplied by the icosahedral symmetry within the program, as if seeking the most stable orientation. (suncana.co)

We found that a quadrangle region in the viral capsid was the place where a great many pH-sensitive residues were distributed. (biomedcentral.com)
The data reveal a major new discontinuous antigenic site (site D) which is located near to the three-fold axis and involves residues of VP1, VP2 and VP3 which lie adjacent to each other on the capsid. (ox.ac.uk)

Because many human being picornaviruses are thought to get into their website hosts by traversing the digestive tract epithelium, we possess been interested in the conversation between these infections and digestive tract epithelial cells. (palomid529.com)

Maybe the interaction mechanism between RNA molecule and viral capsid would help us solve this puzzle. (biomedcentral.com)

8. Guenoune-GelbartD, ElbaumM, SagiG, LevyA, EpelBL (2008) Tobacco mosaic virus (TMV) replicase and movement protein function synergistically in facilitating TMV spread by lateral diffusion in the plasmodesmal desmotubule of Nicotiana benthamiana. (prelekara.sk)

The capsid is an arrangement of 60 protomers in a tightly packed icosahedral structure. (wikipedia.org)

Initiation requires a gene product A which is a globular protein. (biologydiscussion.com)

We also constructed the vectors for CVA10 subgenomic replicon with luciferase reporter and viral capsid with EGFP reporter, respectively. (virosin.org)

PKB is an anti-apoptotic protein kinase that has elevated activity in a number of human tumors [5] . (inteligand.com)
However, traditional inhibitor drugs turn off entire protein kinase populations, inhibiting the activity of Plk1 all throughout the cell, not just at the kinetochore. (uw.edu)

This picornavirus is the etiological agent of an acute systemic vesicular disease that affects cattle worldwide. (bionity.com)

amino acid identity was 99.6%-100% for the last 3 proteins. (omicsdi.org)

Anatomy5

Organisms20

Diseases2

Chemicals and Drugs10

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes10

Information Science4

Replication19

Icosahedral capsid6

Viruses18

Structural8

FMDV10

Encodes2

Single-stranded3

Subunits4

Poliovirus1

Interactions5

Infection1

Hepatitis virus1

Acid-labile1

Pentamers1

Enterovirus2

Antibody1

Aphthovirus1

Parechovirus1

Virion3

Cytoplasm3

Subunit1

Hydrophobic3

Calicivirus1

Picornaviridae2

Mature viral proteins1

Nucleic acid2

Genus2

Structures2

Lipid1

Sequences1

Cardiovirus1

Cellular2

Organization2

Consists5

Coat1

Family2

Synthesis1

ABSTRACT1

Residues2

Infections1

Molecule1

Replicase1

Arrangement1

Gene1

Subgenomic1

Kinase2

Vesicular1

Amino acid1