Physiological protein expression analysis of genes and proteins. Medical search. Frequent questions

The low dose was associated with a low grade inflammatory response measured by changes in mRNA expression. (cdc.gov)
In this study, we identified six genes with sequence homology to Nkl and characterized their patterns of mRNA expression and abundances in rainbow trout (Oncorhynchus mykiss). (usda.gov)
Patterns of tissue-specific mRNA expression were asymmetric among the six trout Nkl homologues, with nkl1, nkl3, and nkl-like a & b occurring in immune competent organs such as spleen, gill, intestine and kidney, as well as pineal gland, brain and oocytes. (usda.gov)
We provide a searchable web resource for exploring differential mRNA expression and splice form usage between excitatory, PV, SST, and VIP neurons ( http://research-pub.gene.com/NeuronSubtypeTranscriptomes ). (jneurosci.org)
We sorted excitatory neurons and key inhibitory neuron subtypes from mouse brains and assessed differential mRNA expression. (jneurosci.org)

The results showed that nine ZmCAMTA genes showed highly diversified gene structures and tissue-specific expression patterns. (frontiersin.org)
second, to provide a more detailed annotation and quantification of true human-mouse orthologous transcripts defined as transcripts of orthologous genes exhibiting the same splicing patterns. (biomedcentral.com)
Conclusion: Our exploratory findings unravel the expression patterns of TBL1XR1/NCOR1 in B-cell lymphoma variants. (iiarjournals.org)
For the first time we described the kinetics of hepatic ontogenesis at mRNA level in mule ducks and highlighted different expression patterns depending on the cellular pathway. (biomedcentral.com)
Since liver sampling was only possible from the 12th day of embryogenesis (E12), we analyzed hepatic gene expression at 7 sampling points every 4 days from this point up to 4 days post-hatch (D4) and revealed different patterns of expression depending on the cellular pathway. (biomedcentral.com)
The genome-wide identification and the gene expression patterns of all these identified OBPs and CSPs across developmental stage-related S. frugiperda have not been reported. (slu.se)
Here, we screened for genome-wide SfruOBPs and SfruCSPs, and analyzed the gene expression patterns of SfruOBPs and SfruCSPs repertoires across all developmental stages and sexes. (slu.se)
The gene expression patterns of SfruOBPs and SfruCSPs revealed strong correlations with their respective phylogenic trees, indicating a correlation between function and evolution. (slu.se)
an effect which may be explained by an increased expression of adipose tissue lipolysis-related gene expression patterns following chronic supplementation [ 12 ], an increase in protein-induced thermogenesis (reviewed in [ 15 ]), and/or a consistent reduction in food intake given its satiety-stimulatory effects as discussed above. (biomedcentral.com)
Six new antimicrobial peptides (AMPs) with sequence homology to the Nk-lysin (Nkl) family of proteins have been characterized and their patterns of gene expression in rainbow trout (Oncorhynchus mykiss) described. (usda.gov)
Hence, this study was conducted to examine the changes in PAL activity and gene expression patterns in relation to texture in the edible branchlet tissues during early postharvest handling. (scialert.net)
states'' or gene expression patterns. (lu.se)
Berry intake changes hepatic gene expression and DNA methylation patterns associated with high-fat diet. (lu.se)

S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. (wikipedia.org)
see RTKRas/MAP kinase signaling ), LIN-12 (see LIN-12/Notch signaling in C. elegans ), and WNT (see Wnt signaling ), as well as the functions of the SynMuv and mediator proteins (see Transcriptional regulation ). (wormbook.org)
The exon junction complex (EJC) deposited on spliced mRNAs, plays a central role in the post-transcriptional gene regulation and specific gene expression. (nature.com)
This study provides the first evidence that different EJCs can have distinct functions, illuminating EJC-dependent gene regulation. (nature.com)
Analyses of the ftnA, dps and psm genes in different regulatory mutants revealed that their (pp)pGpp-dependent regulation can occur independent of the regulators PerR, Fur, SarA or CodY. (nih.gov)
Notably, a large number of stress-related elements present in the promoter regions of some ZmCAMTA genes, indicating a genetic basis of stress expression regulation of these genes. (frontiersin.org)
CAMTAs participate in gene expression regulation by binding to the cis -elements in the promoter regions of numerous target genes. (frontiersin.org)
Chromosomal gene structure of human myeloperoxidase and regulation of its expression by granulocyte colony-stimulating factor. (rusmedserv.com)
The COPDKB has now been extended to integrate over 40 public data sources on functional interaction (e.g. signal transduction, transcriptional regulation, protein-protein interaction, gene-disease association). (biomedcentral.com)
In addition, castor bean SAP gene expression varied in response to different stresses, including salt, drought, heat, cold and ABA and MeJA, suggesting that the transcriptional regulation of castor bean SAP genes might operate independently of each other, and at least partially independent from ABA and MeJA signal pathways. (kib.ac.cn)
Furthermore, it was confirmed that Beclin 1 expression by NS5A was involved in the negative regulation of starvation‑induced liver cancer apoptosis, which was accompanied by reduced p53 and apoptosis regulator Bax expression, as well as decreased caspase‑3/-7 activation. (spandidos-publications.com)
Continued studies focused on genes showing minimal changes in the TMA-induced model but with clear up-regulation in the ovalbumin model. (cdc.gov)
Biofilm-associated cells can be differentiated from their suspended counterparts by generation of an extracellular polymeric substance (EPS) matrix, reduced growth rates, and the up- and down-regulation of specific genes. (cdc.gov)
Here we describe a different method of transgene regulation by the use of the human glial ®brillary acidic protein (GFAP) promoter. (lu.se)

S100 genes include at least 19 members which are located as a cluster on chromosome 1q21. (wikipedia.org)
Human thyroid peroxidase: complete protein sequence, chromosome mapping, and identification two alternately spliced mRNAs. (rusmedserv.com)
Chromosomal locations of these peptides show that nkl1 was located on chromosome arm 25q, whereas the other five nkl genes were clustered on chromosome arm 19q. (usda.gov)
Lowe syndrome is caused by an inherited mutation in the OCRL gene, mapped to chromosome Xq 26.1, which encodes the OCRL1 protein. (medscape.com)

Helix 3, 4, and the hinge region are the most divergent areas between individual S100 proteins, and so it is likely that the sequence of these regions is pivotal in fine-tuning calcium-dependent target binding by S100 proteins. (wikipedia.org)
Cloning and sequence analysis of the human salivary peroxidase-encoding cDNA. (rusmedserv.com)
In other words, the identification of true orthology relationships between gene products now should progress beyond primary sequence and "splicing orthology", consisting in ancestrally shared exon-intron structures, is required to define orthologous isoforms at transcript level. (biomedcentral.com)
Phylogenetic analysis revealed a conserved structure of Nkls among the teleosts and further protein sequence analyses suggests that all six nkl genes fall within the Nkl sub-family of the Saposin family of proteins. (usda.gov)
Sequence alignment and phylogenetic analysis of the two putative proteins revealed that HaTreh-1 and HaTreh-2 belong to soluble and membrane-bound trehalase groups, respectively. (arizona.edu)
Structural analysis showed that castor bean SAP gene structures and functional domain types vary greatly, differing in intron number, protein sequence, and functional domain type. (kib.ac.cn)
Sequence analysis detects mutations in 95% of males and 95% of female carriers. (medscape.com)

Thus, it is of interest to further examine how WPH versus WPC ingestion differentially affects various physiological systems. (biomedcentral.com)
Trehalase plays a significant role in various physiological processes in insects. (arizona.edu)

Moreover, functional enrichment analysis revealed that neurodevelopment, neurotransmission activity, and metabolism related biological processes were involved in nicotine addiction. (hindawi.com)
Functional and evolutionary analyses of genes are usually performed on one or few representatives of their expression products, i.e. transcripts and proteins. (biomedcentral.com)
Strict orthology of genes requires vertical descent from a common ancestor in the absence of intervening gene duplications, and it is often interpreted as indicating functional equivalence. (biomedcentral.com)
To understand the molecular-genetic basis of functional specialization and identify potential drug targets specific to each neuron subtype, we performed a genome wide assessment of both gene expression and splicing across EXC, PV, SST and VIP neurons from male and female mouse brains. (jneurosci.org)
These results reveal numerous examples where neuron subtype-specific gene expression, as well as splice-isoform usage, can explain functional differences between neuron subtypes, including in presynaptic plasticity, postsynaptic receptor function, and synaptic connectivity specification. (jneurosci.org)
This analysis reveals numerous examples of neuron subtype-specific isoform usage with functional importance, identifies potential drug targets, and provides insight into the neuron subtypes involved in psychiatric disease. (jneurosci.org)
Analysis of the hemp leaf extract and functional groups that were associated with ZnONP-HL and CuONP-HL confirmed the presence of terpenes, flavonoids, and phenolic compounds. (cdc.gov)

Quantitative real-time PCR was used to test the expression of ZmCAMTA genes under several abiotic stresses (drought, salt, and cold), various stress-related hormones [abscisic acid, auxin, salicylic acid (SA), and jasmonic acid] and biotic stress [rice black-streaked dwarf virus (RBSDV) infection]. (frontiersin.org)
Quantitative real-time PCR (qPCR) analyses of the spatiotemporal expression pattern of HaTreh in H. armigera revealed that HaTreh-1 was expressed mainly in the midgut, with lower expression in the integument and head, Malpighian tubules, trachea, and fat body. (arizona.edu)

New CodY independent transcriptional changes were detected including genes involved in the SOS response, iron storage (e.g. ftnA, dps), oxidative stress response (e.g., perR, katA, sodA) and the psmα1-4 and psmß1-2 operons coding for cytotoxic, phenol soluble modulins (PSMs). (nih.gov)

S100A1 has been demonstrated as a regulator of the genetic program underlying cardiac hypertrophy, in that S100A1 inhibits alpha1 adrenergic stimulation of hypertrophic genes, including MYH7, ACTA1 and S100B. (wikipedia.org)
Numerous studies aiming to identify the genetic variants or candidate genes have found a large number of promising genes and chromosomal regions involved in the etiology of nicotine addiction [ 13 ]. (hindawi.com)
The COPD Knowledge Base is the only publicly available knowledge resource dedicated to COPD and combining genetic information with molecular, physiological and clinical data as well as mathematical modelling. (biomedcentral.com)

Micro- array data from the ovalbumin and TMA model of asthma were also compared to previous data using Aspergillus as allergen to identify putative asthma `signature genes', i.e. genes up-regulated with all 3 allergens. (cdc.gov)

Kimura S, Ikeda-Saito M. Human myeloperoxidase peroxidase, two enzymes with separate and distinct physiological functions, are evolutionary related members gene family. (rusmedserv.com)
Since multiple transcript and protein variants expressed by the same gene are, by definition, structurally distinct and need not to be functionally equivalent, the concept of gene orthology should be extended to the transcript level in order to describe evolutionary relationships between structurally similar transcript variants. (biomedcentral.com)

Here, using recombinant complex reconstitution and transcriptome-wide analysis, we showed that the EJC peripheral protein complexes ASAP and PSAP form distinct complexes with the EJC core and can confer to EJCs distinct alternative splicing regulatory activities. (nature.com)
To determine how the ASAP complex interacts with the EJC core, we performed in vitro coprecipitation assays 3 with Tandem Affinity Purification (TAP)-tagged recombinant proteins corresponding to full-length human SAP18, RNPS1 and ACINUS. (nature.com)
Individual ASAP proteins were incubated with recombinant EJC core proteins either in the presence or absence of ssRNA and ADPNP. (nature.com)
Recombinant Human Neuroserpin is a 44.8 kDa non-glycosylated protein containing 395 amino-acid residues. (peprotech.com)
Increasing gene dosage greatly enhances recombinant expression of aquaporins in Pichia pastoris. (lu.se)
These vectors have a number of appealing features including the expression by using the machinery of the host cell instead of depending abilities to ef®ciently transduce cells in the central nervous system, on recombinant regulatory proteins. (lu.se)

2014. OsiSAP1 overexpression improves water-deficit stress tolerance in transgenic rice by affecting expression of endogenous stress-related genes. (kib.ac.cn)
Using toxin-induced lesions we investigated to what extent transgene expression could be regulated in accordance with the activation of the endogenous GFAP gene. (lu.se)
The vast majority of these cells did not divide, suggesting that the transgene was indeed regulated in a similar fashion as the endogenous GFAP gene. (lu.se)
An aspect of gene delivery to the brain that is currently being regulate the endogenous GFAP expression in a lesioned brain. (lu.se)

Insects' odorant-binding proteins (OBPs) and chemosensory proteins (CSPs) are essential for the chemical recognition during behavioral responses or other physiological processes. (slu.se)
High mobility group box 1 (HMGB1) participates in a variety of physiological processes of the body and has an inseparable relationship with tumors. (accscience.com)
Theoretically, the possibilities include (1) a primary T-cell mediated autoimmune response causing muscle damage, (2) a primary degenerative process involving abnormal protein processing leading to a secondary inflammatory response, and (3) separate and independent immune and degenerative processes caused by an external trigger. (medscape.com)

Furthermore, the expression pattern of ZmCAMTA genes under RBSDV infection was analyzed to investigate their potential roles in responses of different maize cultivated varieties to RBSDV. (frontiersin.org)
The early environment can have short- and long-term impacts on the physiology of many animal species and can be used to influence physiological responses that is called programming. (biomedcentral.com)
Indeed embryogenesis is a period of development with high plasticity which can be disturbed by environmental stimuli leading to a modification of certain physiological responses in adulthood [ 1 , 2 ]. (biomedcentral.com)
and b) liberate bioactive peptides that are able to exhibit physiological responses that otherwise would be diminished from consuming intact protein sources. (biomedcentral.com)
This study provides a comprehensive profile of castor bean SAP genes that advances our understanding of their potential physiological and molecular functions in regulating growth and development and their responses to different abiotic stresses. (kib.ac.cn)

S100A1 is a member of the S100 family of proteins expressed in cardiac muscle, skeletal muscle and brain, with highest density at Z-lines and sarcoplasmic reticulum. (wikipedia.org)
These biophysical properties seem to be well conserved across the S100 family of proteins. (wikipedia.org)

Further, emerging evidence suggests that nicotine can also regulate the expression of genes/proteins involved in various functions such as ERK1/2, CREB, and c-FOS [ 20 - 22 ], as well as the expression state of multiple biochemical pathways, for example, mitogen-activated protein kinase (MAPK), phosphatidylinositol phosphatase signaling, growth factor signaling, and ubiquitin-proteasome pathways [ 23 - 25 ]. (hindawi.com)
We further identified changes in module eigenproteins indicative of dysregulation in protein translation and trafficking pathways. (stanford.edu)
Thus, protein products with different properties, or transcripts subject to different post-transcriptional regulatory pathways can be generated in different proportions in different tissues, developmental stages or physiological conditions. (biomedcentral.com)
TBL1XR1 over-expression has been linked to poor prognosis in several solid organ cancers, impacting various oncogenic signaling pathways ( 6 ). (iiarjournals.org)
The expression levels of 50 mRNAs were quantified for these 7 sampling points and classified into 4 major cellular pathways. (biomedcentral.com)
Therefore, the aim of the present study was to analyze a wide range of genes involved in liver development, cell stress, lipid and carbohydrate metabolisms throughout embryogenesis in mule ducks to better understand the ontogeny of pathways related to liver fattening. (biomedcentral.com)
We established a general human molecular knowledge network of over 3.6 million connections (e.g. gene-disease associations, protein-protein interactions) with disease-specific signal transduction (54 pathways) and metabolite (122) information manually curated from the literature. (biomedcentral.com)
Two of these genes, arginase 1 and eotaxin 1 are the focus of continuing investigations in mouse models of asthma regarding differences in mechanistic pathways depending on the allergen. (cdc.gov)
Array studies provide candidate genes to identify common mechanistic pathways in the effector phase, as well as mechanistic pathways unique to individual allergens. (cdc.gov)

Antimicrobial peptides (AMPs) are short peptides/proteins that form key components as the first-line defense of the innate immune system in many species including mammals, lower vertebrates, fish, insects and plants. (usda.gov)

Our data suggest that current gene and transcript data may still be rather incomplete - with several splicing variants still unknown. (biomedcentral.com)

Protein S100-A1, also known as S100 calcium-binding protein A1 is a protein which in humans is encoded by the S100A1 gene. (wikipedia.org)
In humans, defects in neuroserpin, caused by point mutations in the neuroserpin gene, underlie a hereditary disorder called the familial encephalopathy with neuroserpin inclusion bodies (FENIB). (peprotech.com)

These observations strongly suggest the implication of EJC in fine-tuning of specific gene expression in different cellular contexts. (nature.com)
4 , to model the proteome-related limitations of the cell, as enzymes have to compete for the constrained total amount of cellular proteins. (nature.com)
Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) modulates cellular apoptosis, which is involved in the occurrence and development of liver cancer. (spandidos-publications.com)
By regulating the expression of several genes in host liver cells, NS5A also induces cellular proliferation, and influences the curative effect of interferon ( 7 ). (spandidos-publications.com)
For a more thorough review of the role of phosphatidylinositol and the cellular and physiological functions of OCRL1 please refer to the following 2 reviews: (1) McCrea HJ, De Camilli P. Mutations in phosphoinositide metabolizing enzymes and human disease. (medscape.com)
[ 2 ] and (2) Mehta ZB, Pietka G, Lowe M. The cellular and physiological functions of the Lowe syndrome protein OCRL1. (medscape.com)

bp that encodes a protein of 572 amino acids. (arizona.edu)

Sakamaki K, Tomonaga M, Tsukui K, Nagata S. Molecular cloning and characterization of a chromosomal gene for human eosinophil peroxidase. (rusmedserv.com)

Different statistical methods with varying selection criteria resulted in identification of similar candidate genes. (cdc.gov)
Array data are intended to provide candidate genes for hypothesis generation and further experimentation. (cdc.gov)

Thus the proteome analysis seems to be most useful for profiling gene expression in industrial samples. (avf.org)

pp)pGpp induction resulted in the downregulation of many genes involved in protein and RNA/DNA metabolism. (nih.gov)
Systems biology has long been interested in models capturing both metabolism and expression in a cell. (nature.com)
We propose here an implementation of the metabolism and expression model formalism (ME-models), which we call ETFL, for Expression and Thermodynamics Flux models. (nature.com)
Metabolic modeling, which helps making sense of the metabolism in a biological network, is an important tool for engineering biocatalysts, with applications in biofuels, drug design, microbial community analysis, and personalized medicine. (nature.com)
GEMs are particularly amenable to flux balance analysis (FBA), which models metabolism at the fluxome level using linear optimization techniques. (nature.com)
Interestingly, most mRNAs involved in lipid metabolism are overexpressed after hatching (FASN, SCD1, ACOX1), whereas genes implicated in carbohydrate metabolism (HK1, GAPDH, GLUT1) and development (HGF, IGF, FGFR2) are predominantly overexpressed from E12 to E20. (biomedcentral.com)

However, the microarray data provided a wealth of information on which proteins to examine in the proteome gels and has given new insights into the physiological activities of the cells under stressful conditions leading to arrest of fermentation. (avf.org)
Temperature gradient gel electrophoresis (TGGE) works well to differentiate yeast genera using the primers that we developed and can be used to assess the microbial purity of industrial samples to be used in the proteome analyses. (avf.org)
FBA also fails to capture growth-dependent and protein-level effects, such as enzyme saturation or proteome-related limitations. (nature.com)

2012. Expression of the Aeluropus littoralis AlSAP gene in rice confers broad tolerance to abiotic stresses through maintenance of photosynthesis. (kib.ac.cn)
2018. A stress-associated protein, AtSAP13, from Arabidopsis thaliana provides tolerance to multiple abiotic stresses. (kib.ac.cn)

The results, compiled in the Blood Proteoform Atlas (BPA), indicate that proteoforms better describe protein-level biology and are more specific indicators of differentiation than their corresponding proteins, which are more broadly expressed across cell types. (stanford.edu)
Na(+) influx via Orai1 inhibits intracellular ATP-induced mTORC2 signaling to disrupt CD4 T cell gene expression and differentiation. (nih.gov)
A vesicle trafficking protein αSNAP regulates Paneth cell differentiation in vivo. (nih.gov)

Most genome-wide analyses have been performed under stress conditions, which often mask the immediate effects of (pp)pGpp-mediated regulatory circuits. (nih.gov)
In this study, we first identified all the CAMTA homologous genes in the whole genome of maize. (frontiersin.org)
In this study, The Cancer Genome Atlas, Gene Expression Omnibus database, Human Protein Atlas, and bioinformatic tools were used to conduct pan-cancer analysis of HMGB1 in various cancers so as to elucidate its role in human tumorigenesis. (accscience.com)
In this study, we used the castor bean genome to identify and characterize nine castor bean SAP genes ( RcSAP ). (kib.ac.cn)
We used a genome-wide analysis which not only examined differential gene expression levels but could also detect differences in splice isoform usage. (jneurosci.org)
explosion further, consider that a fictitious small genome with 2002) More recently and more dramatically, the potential for 260 genes would host the same number of combinations as cell state conversions is exemplified by the reprogramming of the number of atoms in the visible universe! (lu.se)

Emma Lundberg's group has a wealth of experience in using microscopy to yield biological images that paint a picture of this cell-to-cell heterogeneity of protein expression information, and joining her lab has deepened my expertise in integrating datasets to perform innovative analyses of single-cell protein expression. (stanford.edu)
This resource, combining a unique new dataset and novel application of analysis methods to multiple relevant datasets, identifies numerous potential drug targets for manipulating circuit function, reveals neuron subtype-specific roles for disease-linked genes, and is useful for understanding gene expression changes observed in human patient brains. (jneurosci.org)
We also apply our analysis to two other relevant datasets for comparison, and provide a searchable website for convenient access to the resource. (jneurosci.org)

The ability to regulate transgene expression will be crucial for development of gene therapy to the brain. (lu.se)
We, developed is the ability to regulate transgene expression. (lu.se)
Materials and methods approach to regulate transgenic expression. (lu.se)

We examined the acute effects of different dietary protein sources (0.19 g, dissolved in 1 ml of water) on skeletal muscle, adipose tissue and hypothalamic satiety-related markers in fasted, male Wistar rats (~250 g). (biomedcentral.com)
Higher amounts of whey versus egg protein stimulate the greatest post-treatment anabolic skeletal muscle response, though test proteins with higher amounts of WPH more favorably affected post-treatment markers related to adipose tissue lipolysis. (biomedcentral.com)

The observation that alternative splicing produces large numbers of alternative transcripts and proteins, some of them conserved across species and others truly species-specific, suggests that, still maintaining the conventional definition of gene orthology, a new concept of "splicing orthology" can be defined at transcript level. (biomedcentral.com)
Although the physiological target of neuroserpin is still unclear, cumulative evidence suggests that it plays an important role in controlling proteolytic degradation of extracellular matrix (ECM) during synaptogenesis, and the subsequent development of neuronal plasticity. (peprotech.com)

The expression of central genes of the oxidative stress response protects the bacteria from anticipated ROS stress derived from PSMs or exogenous sources. (nih.gov)
We then surveyed the distribution of stress-related cis -regulatory elements in the −1.5 kb promoter regions of ZmCAMTA genes. (frontiersin.org)
Stress-associated proteins (SAPs) are known as response factors to multiple abiotic and biotic stresses in plants. (kib.ac.cn)
Genomic characterization and expression profiles of stress-associated proteins (SAPs) in castor bean ( Ricinus communis )[J]. Plant Diversity, 2021, 43(02): 152-162. (kib.ac.cn)

Further, clustering of these genes resulted in six clusters with themes in synaptic transmission, signal transduction, metabolic process, and apoptosis, which provided an intuitional view on the major molecular functions of the genes. (hindawi.com)

The TBL1XR1-DDR genes connection offers insights into potential DNA repair roles, paving avenues for innovative therapies in B-cell lymphomas. (iiarjournals.org)
In conclusion, our pan-cancer analysis offers a comprehensive description of the carcinogenic roles of HMGB1 in a variety of human cancers. (accscience.com)
The main aim of our research is to understand the molecular details and physiological roles of the multitude of water channel-like proteins present in plants and animals. (lu.se)

Both genetics and environmental factors influence the expression of asthma, and not all asthma is the result of a specific immune response to allergen. (cdc.gov)

The article "Differential expression of the glucose transporter gene glcH in response to glucose and light in marine picocyanobacterial" by Moreno-Cabezuelo et al. (peerj.com)

S100A1 overexpression via adenoviral gene transfer in adult rabbit cardiomyocytes or a cardiac-restricted S100A1 murine transgenic enhanced cardiac contractile performance by increasing sarcoplasmic reticular calcium transients and uptake, altering the calcium sensitivity and cooperativity of myofibrils, enhancing SERCA2A activity and enhancing calcium-induced calcium release. (wikipedia.org)
Analysis of phenylpropanoid metabolites in transgenic tobacco showed that lignin content was affected when PAL activity is reduced to 20-25% of wild type levels (Bate et al . (scialert.net)
2018. The LmSAP gene isolated from the halotolerant Lobularia maritima improves salt and ionic tolerance in transgenic tobacco lines. (kib.ac.cn)
The neuroprotective role of neuroserpin has been demonstrated in transgenic mice lacking neuroserpin expression. (peprotech.com)
There are a number of hypothesized that regulating the transgene with a GFAP promoter in a different vectors that transduce cells in the brain in a slightly different viral vector would give rise to a high transgenic expression in the manner (for a review see, e.g. (lu.se)
2003). The therapeutic effects of different genes delivered by ment of the hGFAP promoter used here has been extensively studied and lentiviral vectors have been documented in a number of animal found to be up-regulated after several different stimuli both in vitro and models, both in rodents and primates, and examples include delivery in vivo in transgenic mice (Brenner et al. (lu.se)

This figure increases to 87% using less stringent criteria for gene structure similarity, thus implying that for about 13% of the human RefSeq annotated genes (and about 25% of the corresponding transcripts) we could not identify any mouse transcript showing sufficient similarity to be confidently assigned as a splicing ortholog. (biomedcentral.com)

Interestingly, carbohydrate-related genes appear to be highly expressed at the start of kinetics, while most lipid-related genes are overexpress after hatching, revealing greater sensitivity to the food transition that occurs at this stage. (biomedcentral.com)
The majority of the SfruOBP genes were most highly expressed in the adult male or female stages, while more SfruCSP genes were highly expressed in the larval or egg stages, indicating their function complementation. (slu.se)

In mice with ablation of the S100A1 gene (S100A1-/-), cardiac reserve upon beta adrenergic stimulation was impaired, showing reduced contraction rate and relaxation rate, as well as reduced calcium sensitivity. (wikipedia.org)
Aquaporin-9 Protein Is the Primary Route of Hepatocyte Glycerol Uptake for Glycerol Gluconeogenesis in Mice. (lu.se)

To this end, a kinetic study was designed to determine the level of expression of selected genes involved in steatosis-related liver functions throughout embryogenesis. (biomedcentral.com)
Its integrated analysis functions provide overviews about clinical trends and connections while its semantically mapped content enables complex analysis approaches. (biomedcentral.com)
However, the potential physiological and molecular functions of SAPs remain largely unclear. (kib.ac.cn)

It has been reported that major physiological, biochemical and molecular changes have occurred in broccoli heads within hours after severed from the mother plant. (scialert.net)

It also accounts for growth-dependent parameters, such as relative protein or mRNA content. (nature.com)
In addition we integrated COPD-specific expression and co-morbidity networks connecting over 6 000 genes/proteins with physiological parameters and disease states. (biomedcentral.com)

Roitsch T, Lehle L. Structural requirement for protein glycosylation. (rusmedserv.com)

We demonstrate MetaNetwork's utility by employing it to identify groups of proteins associated with prostate cancer from a proteomic analysis of tumor and adjacent normal tissue samples. (stanford.edu)
Purification and Proteomic Analysis of Plant Plasma Membranes. (lu.se)
[ 3 ] Proteomic analysis of urine from patients with Lowe syndrome typically show low levels of megalin and cubilin denoting a decrease in the number of these multiligand receptors in the PTC. (medscape.com)

Taken together, post-endurance exercise protein intake may provide means to facilitate aerobic training adaptations. (biomedcentral.com)
Spodoptera frugiperda is a worldwide generalist pest with remarkable adaptations to environments and stresses, including developmental stage-related behavioral and physiological adaptations, such as diverse feeding preferences, mate seeking, and pesticide resistance. (slu.se)

In this study, we found that ROR2 expression was significantly decreased in aged pulp tissues and DPSCs. (bvsalud.org)
The expression levels of HaTreh-2 were detected in all 6 tissues, and HaTreh-2 was mainly expressed in the midgut and head. (arizona.edu)
High throughput RNA-seq data showed that castor bean SAP gene profiles varied among different tissues. (kib.ac.cn)
Using cDNA microarray screens and northern blot analysis, a previous study showed that Beclin 1 is upregulated in liver cancer tissues ( 11 ). (spandidos-publications.com)

However, WGCNA is not widespread in proteomic analyses due to challenges in implementing workflows. (stanford.edu)

The transcriptional coactivator Yes-associated protein (YAP) has been demonstrated to interact with and to enhance p73-dependent apoptosis in response to DNA damage. (ox.ac.uk)
Flow cytometric analysis and western blotting were used to detect apoptosis. (spandidos-publications.com)
In addition, Beclin 1 gene deletion results in tumor cell apoptosis, specifically in hypoxic regions ( 12 ). (spandidos-publications.com)
Liu et al ( 13 ) reported that Beclin 1 gene deletion by either RNA interference or the autophagy inhibitor 3-methyladenine (MA) significantly enhances melatonin-induced apoptosis in mouse hepatoma H22 cells. (spandidos-publications.com)

This conformational change exposes a large hydrophobic pocket between helix 3, 4, and the hinge region of S100A1 that is involved in virtually all calcium-dependent target protein interactions. (wikipedia.org)

This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. (wikipedia.org)

Beclin l, the mammalian counterpart of the yeast Atg6 gene, is an essential protein in autophagy ( 10 ). (spandidos-publications.com)
With roughly 30,000 genes in mammalian genomes, fection with a vector encoding MyoD (Tapscott et al. (lu.se)

Purification and characterization of two protein kinases acting on the aquaporin SoPIP2;1. (lu.se)

We observed an identical exon/intron structure for 32% of human and mouse orthologous genes. (biomedcentral.com)

In addition, NS5A significantly increases the expression of inducible nitric oxide synthase, cyclin D1 and nuclear factor-κB, but decreases p53 protein expression in HepG2 cells ( 6 ). (spandidos-publications.com)

A 300% increase in the expression of soybean pathogenesis related GmPR genes encoding antifungal and defense proteins confirmed that the biosynthesized NPs enhanced disease resistance against the fungal phytopathogen. (cdc.gov)

In this study, we cloned and characterized a soluble trehalase gene (HaTreh-1) and a membrane-bound trehalase gene (HaTreh-2) from Helicoverpa armigera, a serious polyphagous pest of crops. (arizona.edu)

The protein transducin β-like 1 X-linked receptor 1 (TBL1XR1) regulates gene expression as part of the nuclear receptor corepressor (NCoR)/silencing mediator for retinoid and thyroid receptors (SMRT) corepressor complex ( 4 ). (iiarjournals.org)

The role of post-exercise protein ingestion in enhancing the effects of running-based endurance exercise training relative to energy-matched carbohydrate intervention remains to be established. (biomedcentral.com)
Additionally, the influence of immediate versus overnight protein ingestion in mediating these training effects is currently unknown. (biomedcentral.com)
Phase I). In Phase II, identical protein supplements will be provided (0.4 + 0.4 g · kg −1 · h −1 of whey protein hydrolysate and sucrose, respectively), with the timing of ingestion manipulated to compare immediate versus overnight recovery feedings. (biomedcentral.com)
Nonetheless, the time course effects of prolonged post-exercise protein co-ingestion in enhancing the adaptive response to running-based endurance exercise training in adults remains to be established. (biomedcentral.com)

In the United States, new technologies, such as gene-insertion, stem-cell infusion, and new pharmaceuticals are within the purview of regulatory agencies, such as the Food and Drug Administration, rather than scientific funding agencies. (nae.edu)

In addition graph based navigation allowed single step network expansions to e.g. navigate from a group of patients to the diseases they are diagnosed with and from there to the genes associated with these diseases. (biomedcentral.com)

There is increasing evidence that nutrient intake can affect the adaptive response to a single exercise bout, and that protein feeding is important to facilitate this process. (biomedcentral.com)

Anatomy26

Organisms13

Diseases14

Chemicals and Drugs66

Analytical, Diagnostic and Therapeutic Techniques and Equipment51

Phenomena and Processes78

Disciplines and Occupations5

Technology, Industry, Agriculture2

Information Science9

Health Care5

MRNA expression5

Patterns13

Regulation14

Chromosome4

Sequence7

Various physiological2

Functional7

Quantitative real-tim2

Including genes involved1

Genetic3

Putative1

Evolutionary2

Recombinant6

Endogenous4

Processes3

Responses5

Family of proteins2

Pathways9

Peptides1

Variants1

Humans2

Cellular6

Encodes1

Chromosomal1

Candidate genes2

Useful for profiling gene1

Metabolism6

Proteome3

Abiotic stresses2

Differentiation3

Genome6

Datasets3

Regulate3

Skeletal muscle2

Suggests2

Stress4

Signal transduction1

Roles3

Genetics1

Differential1

Transgenic6

RefSeq1

Highly expressed2

Mice2

Functions3

Biochemical1

Parameters2

Structural1

Proteomic analysis3

Adaptations2

Tissues4

Widespread1

Apoptosis4

Calcium-dependent1

Kinase1

Mammalian2

Characterization1

Intron1

Inducible1

Defense1

Soluble1

Mediator1

Ingestion4

Regulatory1

Diseases1

Evidence1