Memory phenotypeHigh physiological stressBehavioralMutationsMiceGenotypeSummarizeCognitivePlasticityExpressed genesGeneticMetabolicAirwayPathologicalRenalDifferentiationNeuronalResponsesDiseaseDisruptionMolecularProteinsBiomarkersFindings showExhibitApparentDifferencesPlantMechanismsDataInsightsBrainEffectsIndividualsSummaryModelsControlFunctionHumanFunctionsFactorReview
Memory phenotype2
- These CD3/CD46-stimulated IL-10-producing CD4 + cells proliferate strongly, suppress activation of bystander T cells and acquire a memory phenotype. (nature.com)
- Furthermore, A. fumigatus particles exhibited greater persistence in the lungs of recipient mice when compared to non-viable A. fumigatus or A. versicolor , and this correlated with increased maintenance of airway memory-phenotype CD8 + T cells. (cdc.gov)
High physiological stress4
- Additionally, concomitant high physiological stress experienced during the war may have contributed to the initiation of the GWI phenotype. (cdc.gov)
- To investigate the relationship between ACh and neuroinflammation in discrete brain regions, we used our previously established mouse model of GWI, which combines an exposure to a high physiological stress mimic, corticosterone (CORT), with GW-relevant AChEIs. (cdc.gov)
- For example, previously we found that several GWI-relevant organophosphate acetylcholinesterase inhibitors produce heightened neuroinflammatory responses following subchronic exposure to stress hormone as a mimic of high physiological stress. (cdc.gov)
- MAIN METHODS: Adult male C57BL/6J mice received a subchronic exposure to corticosterone (CORT) at levels mimicking high physiological stress followed by exposure to the sarin surrogate, diisopropyl fluorophosphate (DFP). (cdc.gov)
Behavioral4
- The progeny are assessed for behavioral, physiological or dysmorphological changes. (wikipedia.org)
- The SF control systems are validated against the behavioral and physiological data. (europa.eu)
- The decline could be due to physiological alterations toward a non-optimal state, which leads to the failure of proper behavioral execution. (elifesciences.org)
- The Jackson Laboratory KOMP Phenotyping Center provides a powerful and efficient phenotyping pipeline to assess the physiological, behavioral and morphological effects of eliminating a single gene. (jax.org)
Mutations5
- It is known to induce point mutations, which implies that by mapping for the desired phenotype, the researcher can identify a single candidate gene responsible for the phenotype. (wikipedia.org)
- Eighteen isofemale strains were used in our tests and, after the first generation, all the individuals produced in each strain were maintained at 29°C. Different phenotype alterations were observed in subsequent generations, similar to mutations already well characterized in D. melanogaster (white, sepia, blistered and curly). (scielo.br)
- Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
- Finally, it seems appropriate to consider the "sodium channel syndrome" (mutations in the gene of the α subunit of the sodium channel, SCN5A gene) as a single clinical entity that may manifest in a wide range of phenotypes, to thus have a better insight on these cardiac syndromes and potential outcomes for their clinical treatment. (bvsalud.org)
- For a more thorough review of the role of phosphatidylinositol and the cellular and physiological functions of OCRL1 please refer to the following 2 reviews: (1) McCrea HJ, De Camilli P. Mutations in phosphoinositide metabolizing enzymes and human disease. (medscape.com)
Mice7
- Identification of the candidate gene is then achieved by positional cloning of the mutant mice with the phenotype of interest. (wikipedia.org)
- We used loss- and gain-of-function approaches including genetic manipulation of the lipolytic enzyme Pnpla2 , change in environmental temperature, and lifestyle interventions to comprehensively test the premise that a thermogenic-like BAT phenotype is coupled with enhanced glucose tolerance in female mice. (diabetesjournals.org)
- Mice homozygous for a null allele are viable and fertile with no apparent tissue abnormalities under physiological conditions. (jax.org)
- Kitlg mutant mice have defects in spatial learning, a phenotype proposed to be due to the Kitlg expression domain in the adult hippocampus. (discovermagazine.com)
- A complementary approach uses mice with targeted gene disruption to elucidate the physiological roles of ion exchangers and associated proteins under in vivo conditions. (yale.edu)
- For example, work with mice lacking anion exchanger Slc26a6, which can function as an oxalate transporter, revealed a phenotype of calcium oxalate kidney stones. (yale.edu)
- Combinations of biocompatible light guides and electrodes are developed to allow identification of phenotype (by using optogenetic methods) of the neurons recorded from in mice. (lu.se)
Genotype3
- Finally, different ways of bridging the gap between genotype and phenotype are discussed. (hindawi.com)
- Effective high-throughput mouse phenotyping is therefore critically important to establish baseline genotype/phenotype understanding for functional analysis of the KOMP resource. (jax.org)
- We use computational tools to ask big multi-disciplinary questions concerning identity, genotype-phenotype relationships, and evolution. (lu.se)
Summarize1
- Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes. (mousephenotype.org)
Cognitive2
- In light of recent research indicating hyperexcitability could be a predictive marker of cognitive dysfunction, we further argue that the hyperexcitability phenotype could be leveraged to improve the diagnosis and treatment of AD, and present potential targets for future AD treatment development. (nature.com)
- Recent studies have indeed evidenced different cognitive and neuropsychiatric phenotypes when comparing patients based on motor symptom asymmetry and physiological markers. (unige.ch)
Plasticity1
- How plasticity interacts with physiological syndromes through lifetime in long-lived species is currently unknown. (wiley.com)
Expressed genes1
- In this study, we used comparative transcriptomics to identify differentially expressed genes underlying cln5 -deficiency phenotypes during growth and the early stages of multicellular development. (frontiersin.org)
Genetic4
- it has been used in forward (phenotype based) genetic screens with which one can identify and study a phenotype of interest. (wikipedia.org)
- Depending on the region being assessed, forward genetic screens can be classified as illustrated in Figure 2 as: Region Specific screens: Studies are designed specifically to obtain a gradient of phenotypes by generating an allelic series which are helpful in studying the region of interest. (wikipedia.org)
- Genetic, physiological and biochemical characterization of Bacillussp. (biomedcentral.com)
- Genetic, physiological and biochemical characterization of Bacillus sp. (biomedcentral.com)
Metabolic2
- The hyperuricaemic phenotype, a common factor in metabolic disease, may have evolved in Pacific ancestors as a protection against malaria," Professor Merriman explains. (otago.ac.nz)
- In contrast to humans, where a sugar rich diet is a major risk factor for metabolic diseases, these bats have metabolic and physiological adaptations to such highly-specialized diets. (hum-molgen.org)
Airway1
- Numerous phenotypes of asthma have inflammation, airway hyperresponsiveness and mucus produc- been described, and a better understanding of the pathophysio- tion. (cdc.gov)
Pathological2
- One of the greatest scientific challenges is to understand how the brain functions in physiological and pathological conditions. (lu.se)
- This review summarizes the physiological and pathological roles of alpha-synuclein and its implication in Parkinson's disease pathogenesis. (medscape.com)
Renal1
- When more patients were described, the phenotype was expanded to include the renal tubular defects that comprise Fanconi syndrome , and an X-linked inheritance pattern was noted. (medscape.com)
Differentiation2
- however, the physiological conditions underlying Tr1 differentiation are unknown. (nature.com)
- By manipulating ROCK pathway, we demonstrate that stretch-induced Yap/Taz activation promotes alveolar differentiation toward AT1 phenotype via ROCK activity. (lu.se)
Neuronal2
- Neuronal hyperexcitability in Alzheimer's disease: what are the drivers behind this aberrant phenotype? (nature.com)
- SCN1A-deficient excitatory neuronal networks display mutation-specific phenotypes. (medscape.com)
Responses3
- Thus, plastic responses were combined with a physiological syndrome linking SMR and TEWL. (wiley.com)
- These pro- has been implicated as contributing apoptosis, inflammation, and several liferating cel s replace dead cel s to the cancer phenotype, through pleiotropic responses. (who.int)
- We use a combination of field-based research, including individual tracking, and laboratory experiments where we can control the availability of cues and study physiological and behavioural responses in individuals. (lu.se)
Disease2
- The pipeline also includes additional disease-relevant phenotypes based on proven protocols and expertise from additional internal and external investigators that comprise our panel of JAX KOMP2 Domain Experts. (jax.org)
- Murine models have shown that the ability of A. fumigatus to germinate at physiological temperature may be an important factor that facilitates invasive disease. (cdc.gov)
Disruption1
- Our aim is to investigate how aging alters synapses and how synaptic disruption contributes to the development of neurodegeneration-like phenotypes upon aging. (uni-ulm.de)
Molecular1
- Program in Molecular and Integrative Physiological Sciences Department of Environmental Health. (bvsalud.org)
Proteins1
- As bioactive compounds tend to interact with multiple proteins with various physiological effect, we aimed to identify other potential shared targets to understand the extent in which these chemicals could lead to GWI. (cdc.gov)
Biomarkers1
- We hypothesized the existence of distinct phenotype-based groups within the very heterogeneous population of patients of heart failure with preserved ejection fraction (HFpEF) and using an unsupervised hierarchical clustering applied to plasma concentration of various biomarkers. (karger.com)
Findings show1
- Our findings show that SLO is vital to in vivo phenotype and illness final result. (holliseden.com)
Exhibit1
- Thus with any progeny carrying a mutation induced by radiation at one of the 7 loci, would exhibit the mutant phenotype in the first generation itself. (wikipedia.org)
Apparent1
Differences3
- We show that graded differences in these and other physiological properties across the MSO neuron population enable the MSO to duplex the encoding of ITD information in both fast, submillisecond time-varying signals as well as in slower envelopes. (jneurosci.org)
- SIGNIFICANCE STATEMENT Neurons in the medial superior olive (MSO) encode sound localization cues by detecting microsecond differences in the arrival times of inputs from the left and right ears, and it has been assumed that this computation is made possible by highly stereotyped structural and physiological specializations. (jneurosci.org)
- We sought to characterize them as "biomarker phenotypes" and to conclude differences in their overall characteristics. (karger.com)
Plant1
- I am an university lecturer in physiological plant ecology and principal investigator at the Department of Biosciences of the University of Helsinki. (helsinki.fi)
Mechanisms1
- While in the field we collect physiological samples from free-living animals, and experimentally manipulate phenotypes (through hormone implants) to tease out mechanisms of control. (washington.edu)
Data1
- To this end, detailed and high-quality data on the information processing in multiple neurons identified with respect to their phenotypes and connections in the brain is needed. (lu.se)
Insights1
- however, animal and cell models have provided insights into some of the factors involved in this phenotype. (nature.com)
Brain1
Effects1
Individuals1
- In these individuals, germline pathogenic variants give rise to phenotypes that can shed light on the physiological function of the proto-oncoprotein. (cam.ac.uk)
Summary1
- Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. (mousephenotype.org)
Models1
- Two key knowledge gaps currently limit the development of more predictive and general models of pathogen transmission: (1) the physiological basis of heterogeneity in host contribution to pathogen transmission (reservoir potential) remains poorly understood, and (2) a general means of integrating the ecological dynamics of host communities has yet to emerge. (usgs.gov)
Control1
Function1
- From a physiological and pathophysiological point of view, the conformational states of the sodium channel during heart function constitute a significant aspect for the diagnosis and treatment of heart diseases. (bvsalud.org)
Human1
- Here we show that co-engagement of CD3 and the complement regulator CD46 in the presence of IL-2 induces a Tr1-specific cytokine phenotype in human CD4 + T cells. (nature.com)
Functions1
- [ 2 ] and (2) Mehta ZB, Pietka G, Lowe M. The cellular and physiological functions of the Lowe syndrome protein OCRL1. (medscape.com)
Factor1
- The primary success factor is the physiological relevancy of the model developed. (genoway.com)
Review1
- Perform quantitative and qualitative assessment of phenotypes for each mutant line using automated calling procedures and technical, statistical and scientific review. (jax.org)