Physiological phenomena does tumour. Medical search. Frequent questions

With improved understanding of tumor biology, for instance neo-vascularization and increased vascular permeability, imaging techniques such as dynamic contrast-enhanced computed tomography (CT) provide details on contrast uptake and wash-out kinetics, which is more closely reflecting the physiological and pathological phenomena. (nih.gov)
Abstract The formation and recovery of gaps in the vascular endothelium governs a wide range of physiological and pathological phenomena, from angiogenesis to tumor cell extravasation. (nsf.gov)
Cell-free DNA (cfDNA) refers to quick fragments of acellular nucleic acids detectable in virtually all physique fluids, together with blood, and is concerned in numerous physiological and pathological phenomena comparable to immunity, coagulation, getting older, and most cancers. (genetici-technologies.com)

Finally, MCT4 inhibition mitigates the induction of angiogenesis, suggesting that MCT4 also plays a crucial role in tumor-related angiogenesis. (hindawi.com)
Adipose tissue produces cytokines, which are signaling proteins that can promote cell proliferation and angiogenesis, the formation of new blood vessels that supply tumors with nutrients. (joinsequence.com)

Monocarboxylate transporter 4 (MCT4, SLC16A3 ) is elevated under hypoxic conditions in many malignant tumors including gliomas. (hindawi.com)
Malignant gliomas are the most common primary malignant brain tumors with an increasing incidence of up to nine per 100,000 habitants over the last years [ 1 , 2 ]. (hindawi.com)
Giant cell tumor is a benign bone tumor, locally aggressive with low malignant potential. (jbstjournal.com)
It is well-known that many tumours, in particular malignant breast tumours, feature electrical conductivity, which differs significantly from the electrical conductivity of surrounding healthy tissues. (medimpedance.com)
For instance, it is a well-known fact that many tumours, in particular malignant breast tumours, feature electrical conductivity (ability to conduct electrical current), which differs considerably from the electrical conductivity of surrounding healthy tissues. (medimpedance.com)
One of the main and most well-known aspects of malignant tumours is that they are composed of cells that proliferate chronically, apparently uncontrollably. (longlonglife.org)
Tumor progression was evaluated clinically using established criteria for malignant gliomas. (ajnr.org)
With advances in adjuvant chemotherapy, patients with malignant gliomas are living longer and there is a need for more sophisticated imaging surveillance of tumor progression. (ajnr.org)

Researchers have understood for numerous years that the hypoxia found in tumors leads to more aggressive and harder to treat disease and ultimately, poor patient outcome. (mdpi.com)
It is hoped that some of the insights from yeast will aid the interpretation of sequence changes found in tumors, especially in the urgent necessity to distinguish 'driver' from 'passenger' mutations. (nih.gov)

In the metabolic symbiosis model, these cells have been proposed to overexpress MCT4 to release high amounts of lactate produced during anaerobic glycolysis into the tumor microenvironment. (hindawi.com)
Specifically, the concepts of tumour heterogeneity, oncogene addiction, non-oncogene addiction, tumour initiating cells, tumour microenvironment, non-coding sequences and DNA damage response will be reviewed. (bmj.com)
It is well established that the role of the tumor microenvironment (TME) in cancer progression and therapeutic resistance is crucial, but many of the underlying mechanisms are still being elucidated. (frontiersin.org)
The mixture of conditions in the microenvironment exemplified by hypoxia-induced ovarian cancer TNTs playing a crucial role in tumor growth, as just one example, is a potential avenue of investigation that will uncover their role in relation to other known factors, including EVs. (frontiersin.org)
The tumor microenvironment (TME) is lush with a complex array of interacting parts. (frontiersin.org)

Targeting Artificial Tumor Stromal Targets for Molecular Imaging of Tumor Vascular Hypoxia. (uams.edu)
Our data provide evidence that estrogen signaling mediates the tumor vasculogenic process required for breast cancer progression and involves a key regulator of the hypoxia signaling pathway. (biomedcentral.com)

These ideas motivated a comparison between results of molecular genetic studies of experimental evolution in yeast and the molecular genetic phenomena associated with tumorigenesis and tumor progression. (nih.gov)
In addition to its normal physiological roles, estrogen is also implicated in breast cancer initiation and progression. (biomedcentral.com)
however, because abnormal enhancement is nonspecific and cannot differentiate tumor progression from therapy-related changes. (ajnr.org)

For the first time cellular physiological properties of gliomas (astrocytomas), meningiomas, medulloblastomas and neuronal tumors are compared. (logos-verlag.de)

William Kaelin, Jr. was in 1995 engaged in the study of the von Hippel-Lindau tumor suppressor gene, and after isolation of the first full-length clone of the gene showed that it could suppress tumor growth in VHL mutant tumorigenic cell lines. (nobelprize.org)

Tumor Flare Phenomenon: Transient worsening of tumor symptoms may occur during the first few weeks of treatment with ZOLADEX, which may include ureteral obstruction and spinal cord compression. (nih.gov)

Slow growing tumor cells - astrocytoma cells during serum deprivation and neuronal tumor cells of the neurocytoma and the DNT - showed the highest density of Na+-currents. (logos-verlag.de)

SUVmax analysis may become more useful as an assessment of tumor biology in future risk stratification models for cancers. (nih.gov)
Even with continual advances in drug discovery and delivery technologies that have substantially improved outcomes in systemic cancers, there has been disappointingly little impact on tumors of the brain. (nature.com)
Thus, there is an urgent need to innovate new strategies to safely manage or treat brain cancers and therein a substantial need for a better understanding of how brain tumor dissemination can be limited or controlled. (nature.com)

Combination of Gold Nanoparticle-Conjugated Tumor Necrosis Factor-a and Radiation Therapy Results in a Synergistic Antitumor Response in Murine Carcinoma Models. (uams.edu)
We have recently identified a family with a mutation close to the protease docking site of tumor necrosis factor alpha converting enzyme in the tumor necrosis factor receptor p55 molecule, leading to a periodic fever syndrome with autoimmune phenomena. (biomedcentral.com)
Cachexia is thought to be caused by bioactive molecules produced by the tumor, such as alpha-lymphotoxin (tumor necrosis factor [TNF] alpha), peptides, and nucleotides, which are able to affect metabolism. (medscape.com)
A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. (embl.de)
The release of soluble tumour-necrosis factor-alpha (TNF-alpha) from its membrane-bound precursor is one of the most intensively studied shedding events because this inflammatory cytokine is so physiologically important. (embl.de)

Tumor blood vasculature tends to be heterogeneously distributed, densely branched, tortuous, malformed, and hyperpermeable relative to that found within physiological tissues. (cornell.edu)
The electrical impedance method of diagnostics is based on the fact that electrical conductivity (ability to conduct electrical current) of biological tissues correlates considerably to their physiological status. (medimpedance.com)
The MEM makes it possible to obtain the picture of biological tissues electrical conductivity distribution in the breast in its transverse sections and locate such tumours in the obtained images. (medimpedance.com)
Tumour growth induces marked changes in the oxidative metabolism of distant tumour-free tissues and organs of the host [ 17 ]. (biomedcentral.com)

Dynamic, contrast-enhanced MR imaging is a valuable adjunct to conventional imaging in assessing tumor activity during antiangiogenic therapy, and correlates better than conventional studies with clinical status and response to therapy. (ajnr.org)
Invasive recordings (intracranial EEG, or iEEG) are taken from patients undergoing treatment for epilepsy or brain tumors to study the physiological correlates of memory function. (upenn.edu)

Persons with the most common pediatric brain malignancy, medulloblastoma, fare only slightly better than average, with a 71.9% 5-year survival, though the most common adult brain tumor, glioblastoma multiforme (GBM), incurs a mere 5.1% 5-year survival rate 2 . (nature.com)

ETHE1 had no impact on TNBC cell proliferation and xenograft tumor growth but promoted TNBC cell migration and invasion in vitro and lung metastasis in vivo. (bvsalud.org)
Phosphorylated eIF2α in turn upregulated the expression of ATF4, a transcriptional activator of genes involved in cell migration and tumor metastasis. (bvsalud.org)

We investigated the impact on tumor malignancy in F98 glioma cells using in silico analysis, in vitro cell culture assays, and ex vivo vascular organotypic glioma impact model (VOGIM) [ 35 ] by implanting F98 cells into rat brain slices. (hindawi.com)
Microbeam radiation therapy alters vascular architecture and tumor oxygenation and is enhanced by a galectin-1 targeted anti-angiogenic peptide. (uams.edu)
In particular, it plays a vital role in the physiological and pathological activities of the three important cells, Endothelial cells, macrophages and vascular smooth muscle cells. (wjgnet.com)

Dietary lariciresinol attenuates mammary tumor growth and reduces blood vessel density in human MCF-7 breast cancer xenografts and carcinogen-induced mammary tumors in rats. (uams.edu)
In this work, we used cytotoxicity and enzymatic assays and morphological analysis to examine the effects of a proteolysis-inducing factor (PIF)-like molecule purified from ascitic fluid of Walker tumour-bearing rats (WF), which has been suggested to be responsible for muscle atrophy, on cultured C 2 C 12 muscle cells. (biomedcentral.com)

This brain tumor type is highly proliferative and shows an infiltrative growth pattern, accounting for the high recurrence rates in patients. (hindawi.com)
Besides, upregulated MCT4 has been linked to altered tumor metabolism as well as to increased growth and survival in breast and pancreatic cancer [ 33 , 34 ]. (hindawi.com)
However, there has only been one previous functional study investigating MCT4 in glioblastoma (GBM) neurospheres, mainly focusing on tumor growth and survival dependent on the oxygen level [ 14 ]. (hindawi.com)
We find some very striking similarities, including recurring genomic rearrangements, alterations of the regulation of specific growth-promoting genes, population-genetic features that affect the fitness trajectories of growth rate variants in evolving populations, and physiological and metabolic similarities derived from the conservation of the basic plan of growth and cell multiplication among all eukaryotes. (nih.gov)
Anginex synergizes with radiation therapy to inhibit tumor growth by radiosensitizing endothelial cells. (uams.edu)
however, many of their functional roles in mediating tumor growth remain unknown. (frontiersin.org)
The latest developments have shown that the rapid elongation of the main beam and antler branches are a controlled form of tumour growth, regulated by the tumour suppressing genes TP73 and ADAMTS18. (academic-accelerator.com)
The causes of hypertrophic osteoarthropathy remain unknown, although several hypotheses have been developed (eg, estrogen or growth hormone [GH] production by the tumor, vagal hyperactivity). (medscape.com)
By accumulating mutations on specific genes, either to activate proliferation in the event of growth factor reception[5] or to prevent it in its absence[6], the tumour can continue to grow permanently. (longlonglife.org)

Estapa recalls a moment when she went to a follow-up visit at the gynecologist's office after the removal of an ovarian tumor. (wbur.org)
HE4 is a protein currently used as a tumor marker for ovarian carcinoma with markedly higher specificity than CA125. (ginekologiaipoloznictwo.com)

Some people with Cushing's syndrome have a benign tumour in part of the brain. (nails-beauty.de)
Giant cell tumor (GCT) of bone is a benign but locally aggressive tumor with tendency for local recurrence [2]. (jbstjournal.com)

In conclusion, these data clearly provide evidence that a disturbance of physiological immunosuppressive mechanisms might contribute to the pathogenesis of autoimmune diseases. (biomedcentral.com)
However, the scope of modern Immunology now encompasses all aspects of self vs. non-self recognition phenomena including organ transplantation, tumour immunology and autoimmune diseases. (utoronto.ca)

The incidence of this tumour is fairly low, with two to three cases per 100 000 people in Europe and North America. (bmj.com)
For other human tumour virus- primate species are related to the hu- tween data in humans and in experi- es, the use of humanized severe man tumour viruses, the incidence of mental animals is not obvious. (who.int)

In other cases, paraneoplastic syndromes result from the production and release of physiologically active substances by the tumor. (medscape.com)

We studied 5 consecutive cases of GCT involving the distal radius operated by en-bloc resection of tumor followed by reconstruction with ipsilateral non-vascularized fibular graft with a minimum 1 year follow-up. (jbstjournal.com)
All 18 patients received external beam radiation at the time of their initial diagnosis after surgical resection of the original tumor. (ajnr.org)

Shedding of activating surface molecules represents another physiological way to prevent hyperactivation. (biomedcentral.com)
In addition to humoral factors, tumour-derived molecules have also been proposed as mediators of cancer cachexia. (biomedcentral.com)

In a broad sense, these syndromes are collections of symptoms that result from substances produced by the tumor, and they occur remotely from the tumor itself. (medscape.com)
How do you deal with complex clinical manifestations of conditions, such as signs (visually observable patient abnormalities), symptoms (abnormal perceptions of illness that only the patients can report, such as pain, itching, fatigue, depressive feelings), and syndromes (clusters of signs, symptoms, and other clinical phenomena that may or may not be indicative of a specific underlying disease)? (cdc.gov)

In summary, our data highlight MCT4 /SLC16A3 as a key gene for distinct hallmarks of tumor malignancy in glioma cells. (hindawi.com)
This process enables tumor cells, including those within the core of the heterogeneous tumor mass to survive, despite being at a distance from blood vessels that supply their metabolic needs [ 16 , 17 ]. (hindawi.com)
As cells are capable of sensing and responding to the stiffness of their surrounding matrix via mechanisms that include changes in the phosphorylation of focal adhesion proteins, like FAK and Src, we hypothesized that there is a relationship between abnormal tumor vasculature characteristics and tumor stiffening. (cornell.edu)
C, where tumor cells die (mostly, due to protein denaturation). (misis.ru)
Iron oxide Fe3O4 in physiological conditions may cause the appearance of active forms of oxygen, deleterious to tumor cells. (misis.ru)
On top of all of that, this technology can also be used for the targeted transport of medication to tumor cells. (misis.ru)
The present work contains an analysis of voltage-dependent Na+-, Ca2+- and K+-channels in brain tumor cells of different origin. (logos-verlag.de)
Furthermore, the modulatory effect of NGF on Na+-channel properties seems to be a general phenomenon in neural tumor cells. (logos-verlag.de)
Voltage-gated Na+-channels were also found in cells of a neurocytoma, a dysembryoblastic neuroepithelial tumor (DNT) and a medulloblastoma. (logos-verlag.de)
The specific inhibitor tetrodotoxin blocked the Na+- currents by at least 85% in all tumor cells. (logos-verlag.de)
Given the lack of access, and the dispersed nature of brain tumor cells, we explore the possibility of electric fields inducing directed tumor cell migration. (nature.com)
In this study we investigate the properties of populations of brain cancer undergoing electrotaxis, a phenomenon whereby cells are directed to migrate under control of an electrical field. (nature.com)
To further understand electrotactic migration of tumor cells, we performed RNA-sequencing for pathway discovery to identify signaling that is differentially affected by the exposure of direct-current electrical fields. (nature.com)
When a tumor arises, the body may produce antibodies to fight it by binding to and destroying tumor cells. (medscape.com)
[ 9 ] For example, antibodies or T cells directed against the tumor may mistakenly attack normal nerve cells. (medscape.com)
Initial works revealed that activation of the EMT program in epithelial cells induces the acquisition of stem cell properties, which in the context of cancer may contribute to the appearance of tumor initiating cells (TIC). (mdpi.com)
An immune system is a collection of mechanisms within an organism that protects against disease by identifying and killing pathogens and tumor cells. (wikidoc.org)
We will see that the cancerous tumour is a much more complex element than the simple cluster of aberrant cells responsible for the dysfunction of our body. (longlonglife.org)

it also allowed the development of complex physiological responses. (nobelprize.org)
In essence, Immunology is the study of the physiological responses that result when foreign (i.e., non-self) materials are introduced into a vertebrate organism such as humans. (utoronto.ca)

In line with this observation, elevated extracellular lactate concentrations up to 40 mM and corresponding low extracellular pH (pH e ) have been found in solid tumors under hypoxic conditions [ 18 - 22 ]. (hindawi.com)

Upon successful completion of preclinical trials, starting in 2020 we are planning to begin clinical trials of the first domestic method of imaging and therapy for breast tumors. (misis.ru)
Giant cell tumors (GCT) of the bone are aggressive and are recognised for variable clinical behaviour, which is not always related to radiographic or histological appearance [1]. (jbstjournal.com)
Tumor response to treatment, based on clinical findings, did not correlate well with conventional imaging findings. (ajnr.org)

This causes functional tumors to form on a dog's adrenal or pituitary glands. (nails-beauty.de)

Hypogonadism that arises after puberty is exemplified by hypothalamic-pituitary disease (e.g. tumour, infiltration, trauma, radiation). (medscape.com)

It also increases physiological stress, things like cortisol levels, which can contribute to weight gain. (wbur.org)

The study included 59 women in individual trimesters of physiological pregnancy and 20 nonpregnant healthy controls. (ginekologiaipoloznictwo.com)
The mean age of pregnant women in physiological pregnancy was similar to the age of controls. (ginekologiaipoloznictwo.com)
An increase in HE4 values in pregnant women should be taken into consideration while diagnosing adnexal tumors during pregnancy. (ginekologiaipoloznictwo.com)

In addition to its importance as a biological phenomenon, defective apoptotic processes have been implicated in an extensive variety of diseases. (biomedcentral.com)

Conditions like gallstones or non-alcoholic fatty liver disease (NAFLD) induce oxidative stress, a phenomenon that triggers DNA damage . (joinsequence.com)

Rapid breast tumor development relies on formation of new vasculature to supply the growing malignancy with oxygenated blood. (biomedcentral.com)

Circulating tumor DNA and liquid biopsy: opportunities, challenges, and recent advances in detection technologies. (genetici-technologies.com)

Goals of treatment are to achieve satisfactory removal of the tumor, lessen the chance of local recurrence and to preserve as much wrist function as possible. (jbstjournal.com)

Furthermore, tumors are known to stiffen as they progress, a phenomenon that has largely been attributed to heightened extracellular matrix protein cross-linking. (cornell.edu)

Here, we look to electrical fields and their influence on cellular behavior as a means to control tumor dispersion, using the regime of low field-strength direct current, wherein electrotaxis occurs. (nature.com)

They have been imaged in vitro and also in vivo and ex vivo in tumors from human patients as well as animal models, thus not only proving their existence in the TME, but opening further speculation about their exact role in the dynamic niche of tumor ecosystems. (frontiersin.org)
Moreover, The use of animals as surrogate rine host, can provide a platform for animal models for tumour viruses in hosts for the study of human tu- in vivo infection. (who.int)

Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)

Active Matter Seminar Speaker: Max Lavrentovich, Worcester State University Title: Strongly driven mixtures and membranes: Out of equilibrium surprises Abstract: The more prosaic cousin of active matter, driven inactive matter, is still full of unexpected phenomena. (harvard.edu)

Notably, inhibition of eIF2α phosphorylation through ISRIB or ATF4 knockdown partially abolished the tumor-promoting effect of ETHE1 overexpression. (bvsalud.org)
The inhibition of TNF-alpha release (and many other shedding phenomena) by hydroxamic acid-based inhibitors indicates that one or more metalloproteinases is involved. (embl.de)

Glioblastoma is the most common form of primary brain tumour. (bmj.com)
Chemotherapy is also hindered in the brain, as transport is restricted by physiological barriers to the blood stream 7 . (nature.com)
The concept of a non-contact force being able to direct a cell's motility is potentially interesting for brain cancer therapy when you consider that controlling tumor dispersion-or possibly undoing it-could be a major boon to the management of brain tumors. (nature.com)
Dynamic, contrast-enhanced MR imaging has allowed quantitative assessment of cerebral blood volume (CBV) in brain tumors. (ajnr.org)

These two proteins are among the most frequently mutated in cancer, allowing associated tumours to grow at any cost[2]. (longlonglife.org)

More rarely, the tumor may interfere with normal metabolic pathways or steroid metabolism. (medscape.com)

They are indeed made much less sensitive to the phenomenon of classical cell death: apoptosis[10]. (longlonglife.org)

Fever may also be related to necrotic-inflammatory phenomena of the tumor and/or to alterations in liver function and consequent disorders of steroidogenesis. (medscape.com)

THAD is thought to be a physiological phenomenon resulting from regional variation in the blood supply by the portal vein and/or the hepatic artery. (wikipedia.org)

THAD may in some cases be associated with liver tumors such as a hepatocellular carcinoma. (wikipedia.org)

The field of investigation of TNT-mediated tumor-stromal, and tumor-tumor, cell-cell communication is gaining momentum. (frontiersin.org)
Another aspect of therapy with iron oxide nanoparticles is based on the phenomenon of ferroptosis - cell death from an excessive level of iron. (misis.ru)
Non-Vascularised Ipsilateral Fibular strut - A Modality to Treat Giant cell tumor of lower end radius using Anterior Approach. (jbstjournal.com)
Juxta-articular giant cell tumors of the lower end radius are common and present a special problem of reconstruction after tumor excision. (jbstjournal.com)
Campanacci's staging system for giant cell tumour of the bone [5] was used for cortical breach. (jbstjournal.com)
One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)

The laboratory study of human memory began more than a century ago, and although many behavioral phenomena have been discovered and well characterized, the development of predictive quantitative theories is still in its infancy. (upenn.edu)

These in vitro, and their expression in these human tumour virus. (who.int)

Anatomy10

Organisms9

Diseases84

Chemicals and Drugs37

Analytical, Diagnostic and Therapeutic Techniques and Equipment44

Phenomena and Processes77

Disciplines and Occupations1

Information Science4

Health Care9

Pathological phenomena3

Angiogenesis2

Malignant8

Found in tumors2

Microenvironment5

Hypoxia2

Progression3

Gliomas1

Suppressor1

Flare Phenomenon1

Growing tumor cells1

Cancers3

Necrosis factor5

Tissues4

Correlates2

Glioblastoma multiforme1

Metastasis2

Vascular3

Rats2

Growth9

Ovarian2

Benign2

Autoimmune diseases2

Incidence2

Paraneoplastic syndromes1

Resection2

Molecules2

Symptoms2

Cells18

Responses2

Hypoxic1

Clinical3

Functional1

Pituitary1

Cortisol1

Pregnancy3

Processes1

Oxidative1

Vasculature1

Biopsy1

Recurrence1

Protein1

Cellular1

VIVO2

Adult1

Abstract1

Inhibition2

Brain4

Proteins1

Metabolic1

Apoptosis1

Alterations1

Blood1

Liver1

Cell6

Study1

Vitro1