Selective Estrogen Receptor ModulatorsGABA ModulatorsCyclic AMP Response Element ModulatorAllosteric RegulationRaloxifeneSignal TransductionDose-Response Relationship, DrugCells, CulturedEstrogen Receptor ModulatorsPregnanoloneCell LineAllosteric SiteReceptors, GABA-AProtein BindingMembrane Transport ModulatorsRats, Sprague-DawleyNorpregnadienesGene Expression RegulationMolecular Sequence DataSmall Molecule LibrariesHEK293 CellsLigandsReceptors, Metabotropic GlutamateHigh-Throughput Screening AssaysMice, Inbred C57BLStructure-Activity RelationshipAlcuroniumRNA, MessengerTamoxifenCalciumCell Line, TumorBinding SitesPiperidinesBenzodiazepinesAmino Acid SequenceP-GlycoproteinDiazepamReceptor, Metabotropic Glutamate 5ThiophenesEstrogen AntagonistsMice, KnockoutDrug Evaluation, PreclinicalDrug Resistance, MultipleNeuronsProtein Structure, TertiaryDrug DiscoveryTransfectionTranscription FactorsDrug DesignEnzyme InhibitorsKineticsApoptosisTranscription, GeneticMolecular StructurePhosphorylationMutationGABA-A Receptor AgonistsModels, BiologicalBenzothiadiazinesGABA AgonistsCricetulusEstrogen Receptor alphaCarrier ProteinsRats, WistarBlotting, WesternCricetinaeCHO CellsPhthalimidesTime FactorsBase SequenceCell ProliferationGABA-B Receptor AgonistsIsoxazolesPatch-Clamp TechniquesDNA-Binding ProteinsModels, MolecularRepressor ProteinsReverse Transcriptase Polymerase Chain Reactionalpha7 Nicotinic Acetylcholine ReceptorRecombinant ProteinsDrug InteractionsEnzyme ActivationEstradiolPropylene GlycolsDisease Models, AnimalXenopus laevisAminophenolsPromoter Regions, GeneticRNA InterferenceReceptors, Calcium-SensingMembrane ProteinsBrainPyridinesGene ExpressionTumor Cells, CulturedFlumazenilCyclosporinsRadioligand AssayReceptors, EstrogenCell Survival