• MCs can secrete nociceptor sensitizing and activating agents, such as serotonin, prostaglandins, histamine, and proteolytic enzymes that can also activate the pain-mediating transient receptor potential vanilloid channels. (frontiersin.org)
  • Lander and his colleagues focused on an ion channel called the transient receptor potential vanilloid-2 (TRPV2), which resides within the membranes of cells throughout the body. (neurosciencenews.com)
  • Transient receptor potential vanilloid (TRPV) cation channels are polymodal sensors involved in a variety of physiological processes. (neurosciencenews.com)
  • In addition we have recently started to explore the structure and molecular function of pain receptors from animals, i.e. transient receptor potential (TRP) ion channels, and their activation by temperature and various ligands. (lu.se)
  • Follicle-stimulating hormone receptor (FSHR) is a G protein-coupled receptor (GPCR) with pivotal roles in reproduction. (frontiersin.org)
  • In turn, receptor signaling is known to drive or regulate GPCR trafficking. (frontiersin.org)
  • The availability of synthetic THC and novel analogs has allowed researchers to begin characterizing the role of this neuronal G-protein coupled receptor (GPCR). (naturalnews.com)
  • Here, we report that the recently sequenced genome from the red flour beetle Tribolium castaneum contains a gene coding for an oxytocin/vasopressin-like peptide, identical to the locust peptide, which we named inotocin (for insect oxytocin/vasopressin-like peptide) and a gene coding for an inotocin G protein-coupled receptor (GPCR). (lu.se)
  • This GPCR is strongly activated by low concentrations of inotocin (EC 50 , 5 × 10 -9 M), demonstrating that it is the inotocin receptor. (lu.se)
  • Approximately half of the members of the human GPCR superfamily are chemosensory receptors, including odorant receptors (ORs), trace amine-associated receptors (TAARs), bitter taste receptors (TAS2Rs), sweet and umami taste receptors (TAS1Rs). (mdpi.com)
  • A xenobiotic-sensing receptor is a receptor that binds xenobiotics. (wikipedia.org)
  • Because the neurobiological substrate of cariprazine has remained elusive, we took advantage of PharmacoSTORM to provide in vivo evidence that cariprazine predominantly binds to D 3 dopamine receptors on Islands of Calleja granule cell axons but avoids dopaminergic terminals. (nature.com)
  • It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. (rcsb.org)
  • While estradiol binds both receptors equally, some xenoestrogens have been shown to bind ER beta preferentially. (umsystem.edu)
  • APOE binds to cell-surface receptors to deliver lipids and to the hydrophobic amyloid-β peptide, regulating amyloid-β aggregations and clearances in the brain. (dovepress.com)
  • Even though the CD4 co-receptor increases the sensitivity of T cell signalling manyfold, it binds to its ligand, peptide major histocompatibility complex II (pMHCII), with the lowest binding affinity known to this day. (lu.se)
  • To provide insight into the molecular mechanisms of their activity and selectivity, we determined the crystal structures of the ERalpha ligand-binding domain (LBD) and a peptide from the glucocorticoid receptor-interacting protein 1 (GRIP1) coactivator complexed with the ligands OBCP-3M, OBCP-2M, and OBCP-1M. (rcsb.org)
  • However, no similar peptide could be identified in other insects, nor could its prohormone be cloned, or its physiological actions be established. (lu.se)
  • Furthermore, we identified an oxytocin/vasopressin-like peptide and receptor in the recently sequenced genome from the water flea Daphnia pulex (Crustacea). (lu.se)
  • Receptors of this type are ubiquitous and transduce binding of a wide variety of extracellular ligands (peptide hormones, neurotransmitters and other bioactive compounds) into a physiological signal. (berkeley.edu)
  • Peptide profiling, a novel ER ligand screening assay, is a method that can potentially identify SERMS by correlating in vitro ER conformation with in vivo biological response. (umsystem.edu)
  • After screening a ligand against a library of fifteen different peptides, a unique peptide profile will figuratively illustrate the induced ER conformation. (umsystem.edu)
  • Each ligand was found to have a unique peptide profile and, implicitly, a distinct ER conformation. (umsystem.edu)
  • The Bone Morphogenetic Protein Receptor ( BMPR ) family includes transmembrane receptors that play vital roles in tissue development and cellular signaling. (news-medical.net)
  • However, the physiological roles remain elusive for numerous peptides and more than 100 G protein-coupled receptors (GPCRs). (ku.dk)
  • We also identify additional peptides for nine receptors with recognized ligands and pathophysiological roles. (ku.dk)
  • The present discovery of a new ligand based on genomic approaches could facilitate the understanding of the physiological roles of extra-thyroid TSH receptor systems and the structural-functional basis of receptor signaling by related glycoprotein hormones. (jci.org)
  • The significance of loss of GCC ligands early in intestinal tumorigenesis remains obscure because (patho)physiological roles of GCC signaling in intestine, beyond regulation of intestinal fluid and electrolyte homeostasis, are poorly defined. (jefferson.edu)
  • The main aim of our research is to understand the molecular details and physiological roles of the multitude of water channel-like proteins present in plants and animals. (lu.se)
  • Mutational analysis and chimeric constructs have revealed that allosteric modulators of the calcium-sensing, metabotropic glutamate and GABA B receptors bind to the seven transmembrane domain, through which they modify signal transduction after receptor activation. (aspetjournals.org)
  • In particular, the laboratory focuses on novel functions of the cell-surface transmembrane receptor family called neuropilins. (navbo.org)
  • The biological activities of the FGFs are mediated by a family of type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding. (rndsystems.com)
  • Immunolabeling and autoradiography have traditionally been applied as the methods-of-choice to visualize and collect molecular information about physiological and pathological processes. (nature.com)
  • Cannabinoid receptors are utilized endogenously by the body through the endocannabinoid system, which includes a group of lipid proteins, enzymes, and receptors that are involved in many physiological processes. (rcsb.org)
  • Since the first reports on chemokine function, much information has been generated on the implications of these molecules in numerous physiological and pathological processes, as well as on the signaling events activated through their binding to receptors. (nih.gov)
  • Since the discovery of the two main cannabinoid receptors CB1 and CB2 in the early '90, intensive research reviled a substantial influence of this system on many physiological and pathophysiological processes. (logos-verlag.de)
  • Members of this family of receptors are involved in regulation of numerous physiological and patho-physiological processes and have great potential as targets for the treatment of diseases such as cancer, diabetes, coronary heart disease and asthma. (jnu.ac.in)
  • Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. (joplink.net)
  • Fibroblast growth factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentiation, angiogenesis, wound healing and tumorgenesis. (rndsystems.com)
  • Peroxisome proliferator-activated receptor-γ (PPARγ) controls adipogenesis and glucose metabolism. (jci.org)
  • Peroxisome proliferator-activated receptor-γ (PPARγ) is one of the isotypes of peroxisome proliferator-activated receptors, which are a group of closely related nuclear receptors. (jci.org)
  • miR-128-5p targets the tissue inhibitor of metalloproteinases (TIMPs), silent information regulator 2 (SIRT2), peroxisome proliferator-activated receptor (PPAR), and p21 genes, which are linked to the behaviours of VSMCs. (hindawi.com)
  • The research contained in this thesis first sought to improve our current knowledge on the transcriptional regulation by peroxisome proliferator-activated receptors (PPAR)-α activation on human liver in vivo using a novel humanized-liver mouse model. (wur.nl)
  • Immunotoxicity of perfluorooctanoic acid and perfluorooctane sulfonate and the role of peroxisome proliferator-activated receptor alpha. (cdc.gov)
  • Activation of the peroxisome proliferator-activated receptor alpha (PPAR alpha) modulates lipid and glucose homeostasis, cell proliferation and differentiation, and inflammation. (cdc.gov)
  • This is in contrast to taste-enhancing molecules, which bind to different parts of sweet and umami receptors. (aspetjournals.org)
  • BMPR family of proteins is a valuable tool for studying ligand-receptor interactions, downstream signaling events, and determining therapeutic targets. (news-medical.net)
  • Efforts to identify and clone the CB1 receptor demonstrate that it is one of the most abundant proteins in the brain. (naturalnews.com)
  • Family C G-protein-coupled receptors are characterized by a large extracellular domain containing the orthosteric agonist binding site known as the "venus flytrap module" because of its bilobal structure and the dynamics of its activation mechanism. (aspetjournals.org)
  • Under physiological conditions, the energetic gain resulting from ligand-induced dimerization of extracellular domains overcomes this opposing clash, stabilizing the A-loop-transphosphorylating dimer. (nyu.edu)
  • This explains how quantitative differences in the stability of ligand-induced extracellular dimerization promotes formation of the intracellular A-loop-transphosphorylating asymmetric complex to varying extents, thereby modulating intracellular kinase activity and signaling intensity. (nyu.edu)
  • Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. (joplink.net)
  • Using three orthogonal biochemical assays, we pair 17 proposed endogenous ligands with five orphan GPCRs that are associated with diseases, including genetic, neoplastic, nervous and reproductive system disorders. (ku.dk)
  • The most commonly lost gene products in colorectal carcinogenesis include guanylin and uroguanylin, the endogenous ligands for guanylyl cyclase C (GCC, GUCY2C), the intestinal receptor for diarrheagenic bacterial enterotoxins. (jefferson.edu)
  • This novel role in restricting the proliferating compartment and organizing the crypt-villus axis suggests that dysregulation of GCC, reflecting loss of endogenous ligands, might contribute to tumorigenesis by potentiating hyperproliferation which, in turn, may amplify disruption of genomic integrity. (jefferson.edu)
  • By the end of the decade scientists had discovered two distinct cannabinoid receptors (CB1 and CB2), isolated endogenous cannabinoids (Anandamide and 2-Arachidonylglycerol), synthesized a cadre of ligands, and generated cannabinoid receptor knockout mice (i.e. (naturalnews.com)
  • Stimulation of CD95 by its physiological ligand CD95L induces its oligomerization leading in turn to the transduction of either apoptotic or non‐apoptotic signals. (researchgate.net)
  • When the ER is bound, the ligand induces a unique ER shape and in turn causes an array of tissue-specific biological responses. (umsystem.edu)
  • Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. (joplink.net)
  • Key players in the controlled induction of cell death are the Death Receptors (DR). CD95 is a prototypic DR activated by its cognate ligand CD95L triggering programmed cell death. (researchgate.net)
  • Here we report the pairing of cognate peptides and receptors. (ku.dk)
  • Nuclear Receptors (NRs), that include steroid hormone receptors, are intra-cellular transcription factors that regulate gene expression in response to their cognate ligands. (jnu.ac.in)
  • It was reported recently that PPARγ activation by its agonistic ligands modifies lymphocyte function. (jci.org)
  • In contrast to T cells, which did not exhibit a significant difference, B cells from PPARγ +/- showed an enhanced proliferative response to stimulation by either lipopolysaccharide or cross-linking of antigen receptors. (jci.org)
  • Peroxisomal proliferator activator receptor alpha (PPARα) is a ligand-activated transcription factor that plays a major role in the regulation of lipid metabolism. (wur.nl)
  • A comprehensive understanding of the physiological and molecular function of PPARα target genes is needed for the accurate development of therapeutical strategies. (wur.nl)
  • Then, we pursued to expand our understanding on the physiological and molecular function of two PPARα target genes, Hilpda and Slc25a47. (wur.nl)
  • This multiauthored review contains brief descriptions of current and recently published work exploring immunomodulation by PFOA and PFOS, as well as a short overview of other PPAR alpha ligands of therapeutic and environmental interest. (cdc.gov)
  • The present study was performed to examine that transforming growth factor beta (TGF-β) in root-surrounding tissues on deciduous teeth during the physiological root resorption regulates the differentiation induction into odontoclast. (preprints.org)
  • Our data suggest that this XRE concatemer site concurrently regulates the expression of both Tiparp gene and its cis anti-sense non-coding RNA following ligand or suspension induced AhR activation. (aspetjournals.org)
  • Recombinant A2/B5 heterodimeric glycoproteins, purified using cation exchange and size fractionation chromatography, activated human TSH receptors, but not LH and FSH receptors, and showed high affinity to TSH receptors in a radioligand receptor assay. (jci.org)
  • This research project is focused on the preparation of a Tc-99m labeled complex designed to retain high affinity to the sigma1 receptor subtype. (umsystem.edu)
  • In the first part of this thesis, the interaction between the rat CD2 (rCD2) adhesion protein and its ligand rat CD48T92A (rCD48T92A), a high-affinity mutant of the wild type rat CD48, was used to establish a new method of obtaining single-cell binding affinities of T cells interacting with SLBs using imidazole titrations. (lu.se)
  • Xenobiotic receptors recognize the foreign chemicals and trigger detoxification and metabolism pathways in different host tissues. (wikipedia.org)
  • The molecular underpinnings common to and connecting these disorders are not known, but may include shared genetic risk factors ( 1 , 8 ), regulation of brain cations ( 9 , 10 ), or common receptor signaling events that activate pain ( 11 ), inflammation ( 12 ), or oxidative ( 13 ) pathways. (frontiersin.org)
  • Unfolded Protein Response (UPR) and Death Receptor (DR) signalling are cellular stress pathways frequently activated towards pro-tumoral cellular outputs in cancer. (researchgate.net)
  • The resulting free energy landscapes will reveal all conformational states with physiological relevance and the preferred transition pathways, which can be analysed further using molecular dynamics simulations. (europa.eu)
  • Neuropilins are interesting receptors in that they can bind to multiple ligands with disparate signaling pathways and elicite a broad spectrum of responses. (navbo.org)
  • In contrast, the expression level of receptor activator of NF-κB ligand (RANKL) was increased in R2 and R3. (preprints.org)
  • It was extended to measure blood receptor activator of nuclear factor kappa-B ligand (RANKL) and osteoprotegerin (OPG) among participants and identify possible associated risk factors for osteopaenia or osteoporosis among them. (uwi.edu)
  • Receptor activator of nuclear factor kappa-B ligand (RANKL) and osteoprotegerin (OPG) and their ratio are critical for physiological bone remodelling, and related abnormalities may lead to several osteopathies. (uwi.edu)
  • From the screen, we identified a family of ERbeta-selective agonists whose members contain bulky oxabicyclic scaffolds in place of the planar scaffolds common to most ER ligands. (rcsb.org)
  • As a byproduct of World Community Grid computations, we happened to find the agonists of TrkB which appear to function similarly to Brain-derived neurotrophic factor (BDNF), which is a physiological ligand of TrkB. (worldcommunitygrid.org)
  • CD95 is a member of the TNF receptor superfamily that is ubiquitously expressed in healthy and pathological tissues. (researchgate.net)
  • Membrane trafficking of G protein-coupled receptors (GPCRs) tightly orchestrates the signaling from this superfamily of signaling receptors. (frontiersin.org)
  • The protein encoded by this gene is a member of the TNF-receptor superfamily. (cancerindex.org)
  • utilized a cell-free immunoprecipitation assay to analyze the neutralizing potential of the mouse monoclonal antibody 3F6 to hinder the BMPR2-ECD ligand-binding activity. (news-medical.net)
  • Antibody 3F6 reduces BMPR2-ECD ligand-binding activity in a modified immunoprecipitation assay. (news-medical.net)
  • The complexity of interactions between orthosteric and allosteric ligands is revealed by a number of adequate biochemical and electrophysiological assay systems. (aspetjournals.org)
  • Each ligand is screened using a two-hybrid fusion protein reporter gene assay. (umsystem.edu)
  • They often have no effect on their own and therefore act only in conjunction with physiological receptor activation. (aspetjournals.org)
  • Activation of the pheromone receptor-coupled G protein initiates a four-tiered cascade of protein kinases, ultimately resulting in stimulation of a messenger-activated protein kinase or MAPK (Fus3) that translocates into the nucleus. (berkeley.edu)
  • A long-standing mystery shrouds the mechanism by which catalytically repressed receptor tyrosine kinase domains accomplish transphosphorylation of activation loop (A-loop) tyrosines. (nyu.edu)
  • Next, I showed that the expression of P2X4R was sufficient to enhance the cytosolic Ca2+ response to the activation of endogenous histamine H1 receptors and to promote lysosome fusion. (cam.ac.uk)
  • In addition, switching cells from adherent to suspension culture also activates the AhR, representing a non-xenobiotic, physiological activation of AhR signaling. (aspetjournals.org)
  • Here, we show that the AhR is recruited to target gene enhancers in both ligand (YH439) treated and suspension cells, suggesting a common mechanism of target gene induction between these two routes of AhR activation. (aspetjournals.org)
  • This work lends novel insights into how AhR signaling drives different transcriptional programs via the ligand versus suspension modes of activation. (aspetjournals.org)
  • This previously unrecognized role of GCC as a tumor suppressor by restricting proliferation and maintaining genomic integrity suggests that receptor dysregulation reflecting ligand insufficiency is a key event during early colorectal tumorigenesis. (jefferson.edu)
  • Low molecular weight (LMW) allosteric FSHR ligands were developed for use in assisted reproductive technology yet could also provide novel pharmacological tools to study FSHR. (frontiersin.org)
  • To our knowledge, this is the first report on the molecular cloning of an oxytocin/vasopressin-like receptor and its ligand from arthropods. (lu.se)
  • NYU Chemistry Professor Nate Traaseth and colleagues published a study in Nature Chemical Biology called ' Molecular basis for receptor tyrosine kinase A-loop tyrosine transphosphorylation . (nyu.edu)
  • In the second part of this thesis, we characterized the physiological and molecular function of HILDPA in ATM in the context of obesity-induced inflammation and in hepatocytes during NASH. (wur.nl)
  • These differences have stimulated the search for subtype-selective ligands. (rcsb.org)
  • The weak uterotrophic activity of these ligands in immature rats and their ability to stimulate expression of an ERbeta regulated gene in human U2OS osteosarcoma cells provides more physiological evidence of their ERbeta-selective nature. (rcsb.org)
  • On the other hand, due to the scarcity of sigma2 selective ligands, less is understood about this subtype. (umsystem.edu)
  • This dual ligand quality characterizes what is now known as a selective estrogen receptor modulator (SERM). (umsystem.edu)
  • Such receptors exhibit unique ligand-binding specificities and mediate distinct signaling cascades, even though they could cross-interact with other TGF-β family ligands. (news-medical.net)
  • Estrogen receptors alpha (ERalpha) and beta (ERbeta) have distinct functions and differential expression in certain tissues. (rcsb.org)
  • Allosteric ligands modulate receptor function by binding to a site distinct from the recognition site for the endogenous agonist. (aspetjournals.org)
  • Four distinct genes encoding closely related FGF receptors, FGF R1 - 4, are known. (rndsystems.com)
  • The amino acid changes could alter the protein charge and stability, inducing distinct physiological functions. (dovepress.com)
  • G protein-coupled receptors (GPCRs) belong to the largest class of drug targets. (mdpi.com)
  • The technology has been shown to be applicable to all major classes of drug targets, including GPCRs, kinases, enzymes, ion channels, and protein-protein and protein-ligand interactions, enabling broader research applicability. (drugdiscoverynews.com)
  • From a pharmacological perspective, Cannabis' (and CBD's) diverse receptor profile explains its potential application for such a wide variety of medical conditions. (rcsb.org)
  • The phenylpiperazine and phenylpiperidine chemical classes of ligands have been identified to bind at sigma1 receptor sites and a pharmacological model has been proposed. (umsystem.edu)
  • In a combinatorial synthetic approach, several new libraries of new ligands were synthesised and subsequently pharmacological tested. (logos-verlag.de)
  • The definition of a receptor in both pharmacological and physiological terms requires that it has particular intuitive with ligands that have a place to a given pharmacological course [ 3 ]. (alliedacademies.org)
  • Our findings suggest that TGF-β is closely related to the regulation of OPG induction and RANKL-mediated odontoclast differentiation depending on the timing of RANKL and OPG mRNA expression in the root-surrounding tissues of deciduous teeth during physiological root resorption. (preprints.org)
  • They include the following nuclear receptors: Constitutive androstane receptor (CAR) Pregnane X receptor (PXR) CAR and PXR are xenobiotic receptors and they both are members of NR1I nuclear receptor family. (wikipedia.org)
  • The Nuclear Receptor family is a large group of ligand-activated transcription factors with 48 members presently identified in the human genome. (jnu.ac.in)
  • Type I receptors consist of BMPR1B (ALK6) and BMPR1A (also called ALK3), while type II receptors comprise BMPR2 and ActRII (Activin receptor type II) subtypes. (news-medical.net)
  • As reagents, they can be utilized to probe the physiological functions of the ER subtypes to provide information complementary to that obtained from knock-out animals. (rcsb.org)
  • Cannabis contains more than 400 different chemical compounds, of which 61 are considered cannabinoids, a class of compounds that act upon endogenous cannabinoid receptors of the body [A32584]. (rcsb.org)
  • Tetrahydrocannabinol (THC) and cannabidiol (CBD) are two types of cannabinoids found naturally in the resin of the marijuana plant, both of which interact with the cannabinoid receptors that are found throughout the body. (rcsb.org)
  • All compounds exhibited a similar requirement for receptor internalization to increase cAMP and proportion of FSHR endosomes with active Gαs, suggesting regulation of cAMP signaling induced by T1 may be altered. (frontiersin.org)
  • Physiological effects of using cannabis make sense in the context of its receptor activity as the hippocampus and amygdala are primarily involved with regulation of memory, fear, and emotion. (rcsb.org)
  • It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. (cancerindex.org)
  • The receptors are ligand inducible transcription factors that exhibit unique biological actions. (umsystem.edu)
  • A comparison of these structures with existing ER structures suggests that the ERbeta selectivity of OBCP ligands can be attributed to a combination of their interactions with Met-336 in ERbeta and Met-421 in ERalpha. (rcsb.org)
  • We will apply our pipeline to ionotropic glutamate receptors, which are tetrameric ligand-gated ion channels with large, dynamic, multi-domain architectures that are critical to synaptic transmission and plasticity in the mammalian central nervous system. (europa.eu)
  • Allosteric receptor modulation is an attractive concept in drug targeting because it offers important potential advantages over conventional orthosteric agonism or antagonism. (aspetjournals.org)
  • Constitutive Activated Receptor(CAR) identified was depicted to bind DR-4 motifs. (wikipedia.org)
  • But what makes the sigma receptors so great is the fact that they bind a variety of ligands. (umsystem.edu)
  • Both estradiol and xenoestrogens can bind two estrogen receptors (ERs), ER alpha and ER beta, to elicit biological responses. (umsystem.edu)
  • Members of the RYK/Derailed family have recently been shown to regulate axon guidance in both Drosophila and mammals by acting as Wnt receptors. (biologists.com)
  • Classic xenobiotic metabolizing AhR targets such as Cyp1a1 , Cyp1b1 , and Nqo1 were regulated by both ligand and suspension conditions. (aspetjournals.org)
  • An elective implies of recognizing unused medicate targets is forward pharmacology based on phenotypic screening to recognize 'vagrant' ligands whose targets are along these lines recognized through target deconvolution. (alliedacademies.org)
  • Receptors, which find on both the cell surface and inside the cell, are sedate targets where pharmaceutical deliver their advantageous impacts in different illness states. (alliedacademies.org)
  • Research carried out on macrolide antibiotics, and glucocorticoids induction of CYP3A were perceived to utilize glucocorticoid receptor. (wikipedia.org)
  • analyzed the impact of RN1 (a natural product extracted from Panax notoginseng ) on bone morphogenetic protein receptors (BMPR1A and BMPR2). (news-medical.net)
  • Dorsomorphin dihydrochloride also inhibits bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6), promotes cardiomyogenesis in mouse embryonic stem cells (ESCs) in vitro and promotes neural differentiation of hPSCs as part of a chemical cocktail. (tocris.com)
  • These effects are largely mediated through two members of the G-protein coupled receptor family, cannabinoid receptors 1 and 2 (CB1 and CB2)[A32585,A32824]. (rcsb.org)
  • This article reviews the current status of allosteric modulation at family C G-protein coupled receptors in the light of their specific structural features on the one hand and current concepts in receptor theory on the other hand. (aspetjournals.org)
  • The pheromone receptors have seven hydrophobic segments and are coupled to a heterotrimeric G protein. (berkeley.edu)
  • We have previously found that both the ALK receptor and its adaptor protein ShcC are markers for aggressiveness in neuroblastoma. (worldcommunitygrid.org)
  • The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. (cancerindex.org)
  • Here, we show that the non-receptor Src family tyrosine kinases, SRC64B and SRC42A, are involved in WNT5-mediated signaling through Derailed in the Drosophila embryonic central nervous system. (biologists.com)
  • The expression of thyrostimulin in the anterior pituitary known to express TSH receptors suggested a paracrine mechanism. (jci.org)
  • Guanylyl cyclase C (GCC), the intestinal receptor for the paracrine hormones guanylin and uroguanylin whose early loss characterizes transformation, has emerged as a component of developmental programs organizing spatiotemporal patterning along the crypt-surface axis whose loss promotes tumorigenesis through hyperproliferation and genetic instability. (jefferson.edu)
  • As cAMP signaling drives gonadotrophin hormone receptor recycling, rapid exocytic events were evaluated at single event resolution. (frontiersin.org)
  • Together with the uniform over-expression of GCC in human tumors, and the standard of care in which hormone deficiencies are treated by replacement therapy, the role of GCC as a tumor suppressor underscores the potential of oral administration of GCC ligands for targeted prevention and therapy of colorectal cancer. (jefferson.edu)
  • Vitamin D insufficiency has been defined as a serum 25(OH)D level of 21-29 ng/mL (52-72 nmol/L). This is based on the observed physiological changes in calcium absorption and parathyroid hormone levels that occur with changes in vitamin D levels. (medscape.com)
  • The positive allosteric calcium sensing receptor modulator cinacalcet is the first drug of this type to enter the market and therefore provides proof of principle in humans. (aspetjournals.org)
  • For example, the ligand tamoxifen, a commonly used breast cancer pharmaceutical, exhibits an ER antagonist response in the breast and an ER agonist response in the bone. (umsystem.edu)
  • Receptors can be characterized in terms of their selectivity, the saturability and reversibility of ligand authoritative, and usefulness. (alliedacademies.org)
  • Given the BMPR family's considerable involvement in several diseases, targeting these receptors presents a hopeful avenue for therapeutic interventions. (news-medical.net)
  • Toll-like diseases and causes severe and long-lasting health problems in the case of chronifi- receptor. (cdc.gov)
  • The sigma receptors have been known to affect several physiological functions such as psychosis, depression and uncontrolled cell proliferation. (umsystem.edu)
  • The complex physiological mechanisms involving cannabinoid receptors and their ligands in mammals is referred to as the endocannabinoid system (ECS) (4). (naturalnews.com)
  • In contrast, CB2 receptors are mainly found peripherally in immune cells, lymphoid tissue, and peripheral nerve terminals [A32676]. (rcsb.org)
  • Por and Cldnd1 were regulated predominately by ligand treatments, while in contrast, ApoER2 and Ganc were regulated predominately by the suspension condition. (aspetjournals.org)
  • Non-invasive imaging of the sigma receptor in vivo would lead to a better understanding of the role that sigma receptors play in health and disease. (umsystem.edu)
  • Fractalkine (CX3CL1) and its receptor CX3CR1 provide a physiologically-relevant neuron-microglia communication mechanism. (utsa.edu)