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HyperinsulinismGlucose Clamp TechniqueInsulinBlood GlucoseMuscle, SkeletalGlucoseDiabetes MellitusDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Insulin ResistanceDiabetes ComplicationsDiabetes Mellitus, ExperimentalGlucose Tolerance TestHyperglycemiaObesityHypoglycemic AgentsDiabetes, GestationalFastingHemoglobin A, GlycosylatedFatty Acids, NonesterifiedC-PeptideBody WeightIslets of LangerhansRisk FactorsGlucose IntoleranceTriglyceridesAdipose TissueGlucagonHypoglycemiaRats, ZuckerLeptinLiverInsulin-Secreting CellsBody Mass IndexPrediabetic StateReference ValuesDiabetes InsipidusHypertensionFructoseMetabolic Syndrome XMetforminLipidsBlood PressureReceptor, InsulinMice, ObeseDietary CarbohydratesDietary FatsStreptozocinPostprandial PeriodEatingTime FactorsProinsulinHomeostasisInsulin Receptor Substrate ProteinsCardiovascular DiseasesDiabetic NephropathiesPancreasAcanthosis NigricansHyperlipidemiasHypertriglyceridemiaPolycystic Ovary SyndromePrevalenceDisease Models, AnimalForearmAdiposityLipid MetabolismCohort StudiesRats, Sprague-Dawley
Hyperglycemia and hyperinsulinemiaObesityMellitusAssociated with insulin resistanceAnorexia nervosaSkeletal muscleMetabolismPathogenesisBiochemicalHepaticTypeFattyKetosisGlucose homeostasisPeripheralChronicComplications of diabeObesePrevalenceMiceExcess2022SupplOnsetStudyBloodDiabeticHormoneDurationSubjectsResponseAffectPatients
Hyperglycemia and hyperinsulinemia2
Obesity10
  • Evidence for detrimental effects on nutrient dilution, obesity, diabetes or cognition is limited. (nature.com)
  • Obesity has a strong relationship to insulin resistance and diabetes mellitus, a chronic metabolic disease that alters many physiological functions. (bvsalud.org)
  • Obesity is a major risk factor for type 2 diabetes mellitus development and is characterized by an abnormal expansion of adipose tissue and low-grade chronic inflammation that contribute to insulin resistance. (bvsalud.org)
  • Dr. Perry and her colleagues have recently identified hyperinsulinemia-induced increases in tumor glucose uptake and oxidation as a critical driver of colon cancer in two mouse models of the disease, and mitochondrial uncoupling as a potential therapeutic strategy against the disease, and went on to show that responsiveness to insulin is a metabolic signature of obesity-associated tumor types in vitro . (yale.edu)
  • 1. What is the molecular mechanism by which obesity and hyperinsulinemia promote tumor growth? (yale.edu)
  • This condition results in the development of pathological conditions such as type 2 diabetes, obesity, cardiovascular disease, hepatic steatosis and stroke. (enterosys.com)
  • Our primary interest is to investigate the role of insulin resistance as an underlying cause of chronic disease, including obesity, type 2 diabetes, non-alcoholic steatohepatitis, asthma, and chronic kidney failure. (pbrc.edu)
  • Researchers found significant familial clustering of polycystic Sex, such as those with a family history of obesity, type 2 diabetes, seborrheic alopecia, hypertension, etc., have a higher probability of developing PCOS. (articles01.com)
  • Risk factors for insulin resistance include obesity , sedentary lifestyle , family history of diabetes, various health conditions, and certain medications. (wikipedia.org)
  • The sum of inflammatory signals and deranged substrate handling induce most of the metabolic syndrome traits: insulin resistance, obesity, diabetes, liver steatosis, hyperlipidemia and their compounded combined effects. (medscape.com)
Mellitus14
Associated with insulin resistance1
Anorexia nervosa1
  • The hypothesis is therefore compatible with several etiologic factors leading to hyperinsulinemia in anorexia nervosa and major depression, and resulting in decreased food intake and weight loss. (blogspot.com)
Skeletal muscle4
  • That insulin can act in this way has been proposed based on increases in limb blood flow and skeletal muscle blood volume which occurred after hyperinsulinemia. (wikipedia.org)
  • Vascular recruitment in skeletal muscle during exercise and hyperinsulinemia assessed by contrast ultrasound. (wikipedia.org)
  • Physiologic hyperinsulinemia enhances human skeletal muscle perfusion by capillary recruitment. (wikipedia.org)
  • This study was undertaken to examine the effect of physiological hyperinsulinemia on the phosphorylation of the insulin receptor (IR-beta), insulin receptor substrate (IRS), Akt kinase and GSK-3 in isolated skeletal muscle, in people with type 2 diabetes (n=9) and control subjects (n=11). (e-enm.org)
Metabolism3
  • outer environment (such as environmental endocrine disruptors) Some people have found that hyperinsulinemia and hyperglycemia can affect the fetus in utero, resulting in abnormal growth and metabolism after birth. (articles01.com)
  • internal environment (such as intrauterine androgen exposure levels and androgen metabolism levels in different physiological cycles, etc. (articles01.com)
  • Centre for Diabetes, Endocrinology, and Metabolism (OCDEM), The University of Oxford, Oxford, England Exogenous ketosis achieved through ingestion of the ketone monoester (KME) alters metabolic responses to exercise, but ergogenic effects on performance are equivocal. (humankinetics.com)
Pathogenesis4
  • Prospective studies are needed to further investigate the importance of GV in the pathogenesis of long-term complications of diabetes. (hindawi.com)
  • Insulin resistance indicates a deregulated set of biochemical pathways and physiological functions involved in the pathogenesis of a number of diseases, including type 2 diabetes and cancer. (researcher-app.com)
  • We also discuss the possibility that dysfunction of this brain-centric system contributes to the pathogenesis of type 2 diabetes by raising the defended level of glycemia. (silverchair.com)
  • Whether the brain participates in the physiological control of circulating glucose levels therefore remains a matter of controversy, and the possibility that a dysfunctional central control system contributes to the pathogenesis of diabetes is only beginning to be explored. (silverchair.com)
Biochemical1
Hepatic1
Type23
  • This study was designed to investigate the relationship between serum adiponectin and testosterone in patients with type 2 diabetes. (biochemia-medica.com)
  • Serum level of adiponectin and testosterone were prospectively measured in 65 patients with type 2 diabetes and in 20 healthy subjects. (biochemia-medica.com)
  • We conclude that patients with type 2 diabetes have lower serum adiponectin concentration than healthy individuals, and that there is a weak inverse correlation between adiponectin and testosterone serum concentrations in male diabetics. (biochemia-medica.com)
  • The circulating concentrations of adiponectin are inversely proportional to adiposity, and low adiponectin concentrations predict the development of type 2 diabetes and cardiovascular disease (2). (biochemia-medica.com)
  • In school-aged girls with type 1 diabetes, the decrease in adiponectin concentrations was correlated with increasing levels of testosterone (8). (biochemia-medica.com)
  • Therefore, we performed this prospective study to investigate the relationship between plasma testosterone and adiponectin in a group of adult patients with type 2 diabetes. (biochemia-medica.com)
  • Between January and July 2008, 65 patients with type 2 diabetes were recruited to this study. (biochemia-medica.com)
  • The Aim of the present study was to examine whether there is a relationship between autonomic nervous system function and glycemic variability (GV) in patients with type 2 diabetes (T2D). (hindawi.com)
  • The concept of glycemic variability (GV) in type 2 diabetes (T2D) has recently attracted great interest for several reasons, including association with higher levels of markers of oxidative stress [ 9 ] and increased mortality in certain circumstances, such as sepsis and critical illness [ 10 ]. (hindawi.com)
  • Promising research over the past decades has shown that some types of pentacyclic triterpenes (PTs) are associated with the prevention of type 2 diabetes (T2D), especially those found in foods. (bvsalud.org)
  • Purpose We determined the feasibility of substituting sitagliptin or mitiglinide for bolus insulin injection therapy in patients with type 2 diabetes. (bmj.com)
  • Methods 60 patients with type 2 diabetes were enrolled and randomized to switch from mealtime dosing of a rapid-acting insulin analog to either sitagliptin or mitiglinide for 16 weeks. (bmj.com)
  • While Type 1 Diabetes-an autoimmune disease-has been increasing, Type 2 Diabetes (or T2D) still causes the lion's share of cases (90 to 95% according to the Centers for Disease Control and Prevention 2 ). (hphr.org)
  • Previous studies have found that DIM can improve type 2 diabetes by enhancing glucose uptake through the activation of insulin signaling in 3T3-L1 cells, and by lowering the plasma glucose levels in high-fat-diet-fed obese mice [13, 14]. (researchgate.net)
  • Type 2 diabetes (T2D) is an emerging health risk in obese children and adolescents. (e-apem.org)
  • Type 2 diabetes (T2D) is a major health problem that has reached epidemic proportions around the world. (e-apem.org)
  • Type 2 diabetes is a pathological state characterized by hyperglycemia, hyperinsulinemia, glucose intolerance and insulin-resistance. (enterosys.com)
  • Kirwan JP, Sacks J, Nieuwoudt S. The essential role of exercise in the management of type 2 diabetes. (pbrc.edu)
  • Insulin resistance underlies a constellation of adverse metabolic and physiological changes (the insulin resistance syndrome) which is a strong risk factor for development of type 2 diabetes and CHD. (cambridge.org)
  • Early diagnosis and treatment along with weight loss may reduce the risk of long-term complications, such as type 2 diabetes and heart disease. (doctornadia.com)
  • That's got to be one of the reasons that the medical establishment transitioned a few years ago from the Fasting Blood Sugar to the A1c as a diagnostic tool for Pre-diabetes and Type 2 Diabetes. (thenutritiondebate.com)
  • Type 2 Diabetes, a Dietary Disease #342: Is "cheating" okay? (thenutritiondebate.com)
  • Hyperinsulinemia, a condition arising from insulin resistance, often precedes the onset of type 2 diabetes-a well-established cancer risk factor. (joinsequence.com)
Fatty2
  • Fatty acids are involved in a diverse array of physiological functions in a variety of tissues. (diabetesjournals.org)
  • Björntorp , P ( 1994 ) Fatty acids, hyperinsulinemia, and insulin resistance: which comes first? (cambridge.org)
Ketosis1
Glucose homeostasis2
Peripheral2
  • Though subcutaneous insulin delivery is the standard route of insulin administration, it is associated with injection pain, needle phobia, lipodystrophy, noncompliance and peripheral hyperinsulinemia. (ajpsonline.com)
  • It is speculated that due to peripheral polyneuropathy arising out of diabetes, diabetic urethropathy possibly contributes to deterioration of voiding function by altering the integrity of urethra vesicle coordination. (jhrr.org)
Chronic1
  • This rapid increase has raised concerns not only due to its association with chronic conditions like diabetes and cardiovascular diseases but also because of its intricate link to cancer. (joinsequence.com)
Complications of diabe3
  • The 1982 publication of The Prevention and Treatment of Five Complications of Diabetes: A Guide for Primary Care Practitioners was an initial attempt to provide straightforward and practical information that primary care practitioners could immediately apply in their practice in the diagnosis and prevention of complications of diabetes. (cdc.gov)
  • The scope of the present revised edition has been broadened to cover nine complications of diabetes, and the recommendations for the previous five. (cdc.gov)
  • The recommendations relate to the prevention, detection, and treatment of the major complications of diabetes. (cdc.gov)
Obese1
  • After hyperinsulinemia, serum and interstitial total adiponectin is reduced in both obese and lean men. (biochemia-medica.com)
Prevalence4
  • however, there are 422 million adults with diabetes worldwide, and prevalence continues to grow. (hphr.org)
  • The Centers for Disease Control and Prevention and the National Institutes of Health performed a population-based observational study of diabetes in youth also demonstrating an increasing prevalence of T2D in United States between 2001 and 2009. (e-apem.org)
  • In India, particularly the number of diabetes cases is expected to increase from 40.6 million in 2006 to 79.4 million by 2030, [1] with a prevalence of about 12.1%, and the onset of which is found to be a decade earlier than their Western counterparts. (jhrr.org)
  • [3] The prevalence of DBD increases with the duration of diabetes, and DBD can occur in the early stage of disease. (jhrr.org)
Mice2
  • However, Ffar1 +/+ and Ffar1 −/− mice had similar weight, adiposity, and hyperinsulinemia on high-fat diets, and Ffar1 −/− mice showed no improvement in glucose or insulin tolerance tests. (diabetesjournals.org)
  • In this study, we investigated whether DIM could improve insulin-dependent diabetes and nephropathy in streptozotocin (STZ)-induced diabetic mice. (researchgate.net)
Excess1
20221
  • Diabetes Metab J. 2022;46(1):1-2. (e-dmj.org)
Suppl1
Onset1
  • Clinical symptoms of autonomic dysfunction may not appear until long after diabetes onset, but subclinical CAN, manifested by reduced HRV (the earliest indicator of CAN), may be detected as early as within 1-2 years after diagnosis of diabetes [ 3 ]. (hindawi.com)
Study2
  • diabetic cystopathy, " " diabetic complication urinary tract, " " diabetic urethropathy, " and " diabetic bladder dysfunction " to study the current understanding on the pathophysiology of diabetes induced on the lower urinary tract dysfunction. (jhrr.org)
  • Considering its negative impact on the quality of life, particularly among the growing elderly population in India, we performed literature search through PubMed and unbound Medline database using the terms " diabetic cystopathy, " " diabetic complication urinary tract, " " diabetic urethropathy, " and " diabetic bladder dysfunction " to study the current understanding on the pathophysiology of diabetes induced on the lower urinary tract dysfunction. (jhrr.org)
Blood6
  • Cardiac autonomic neuropathy (CAN) in diabetes results from damage to the autonomic nerve fibers (parasympathetic and sympathetic) that innervate the heart and blood vessels, with resultant abnormalities in heart rate control and vascular dynamics [ 1 ], ultimately leading to diminished heart rate variability (HRV) [ 2 ]. (hindawi.com)
  • Do Diabetes Also Mean Low Blood Sugar Level? (diabetestalk.net)
  • Diabetes means a condition of high blood sugar. (diabetestalk.net)
  • In latent diabetes, a precursor to diabetes, blood sugar level may be normal. (diabetestalk.net)
  • I had to stop taking these other 2 anti-diabetes oral meds completely to avoid hypos (dangerously low blood sugars), but have continued for the last 14 years on the quarter-dose Metformin. (thenutritiondebate.com)
  • If you have diabetes, monitor your blood sugar carefully if you are taking DHEA. (medlineplus.gov)
Diabetic1
  • Diabetes itself does not cause changes in personality or psychiatric illness, but particular subgroups of the diabetic population appear to be at risk for developing psychosocial problems. (cdc.gov)
Hormone2
  • Insulin resistance ( IR ) is a pathological condition in which cells either fail to respond normally to the hormone insulin or downregulate insulin receptors in response to hyperinsulinemia . (wikipedia.org)
  • Pubertal development follows physiological chronology of events owing to modifications on some hormone secretion patterns. (bvsalud.org)
Duration1
  • A total of 50 (29 males) patients with T2D (mean age 58.4 ± 9.9 years, median diabetes duration 5.5 [IQR 2.0-9.25] years), on oral antidiabetic agents, underwent ECG recording and subcutaneous glucose monitoring, simultaneously and continuously, for 24 hours. (hindawi.com)
Subjects1
  • Direct evidence for insulin-induced capillary recruitment in skin of healthy subjects during physiological hyperinsulinemia. (wikipedia.org)
Response1
  • The term 'insulin resistance' refers to a reduced glucose uptake in response to physiological insulin levels. (e-apem.org)
Affect2
  • Under physiological circumstances, GH does not affect total glucose turnover directly. (diabetestalk.net)
  • [4] As diabetes tends to affect the older population, concurrent factors such as benign prostatic hyperplasia (BPH), neurological disorders, and aging may contribute to voiding dysfunction in these patients. (jhrr.org)
Patients5
  • In the diabetes group, the serum adiponectin level in patients with renal dysfunction (22.3 (21.5-23.1) ng/mL) was higher than in patients with no complications (12.1 (11.45-12.75) ng/mL) and than in patients with coronary artery disease (11.2 (10.25-12.15) ng/mL) (P = 0.009). (biochemia-medica.com)
  • We anticipate continued widespread use of this guide in assisting practitioners in the care of their patients with diabetes. (cdc.gov)
  • This publication is designed to help the primary care practitioner in the day-to-day management of patients with diabetes. (cdc.gov)
  • A companion publication entitled Take Charge of Your Diabetes: A Guide for Patients is available. (cdc.gov)
  • Direct psychological consequences can arise from any one of these factors, making it harder for patients to treat their diabetes and live productive, enjoyable lives. (cdc.gov)