Physiological effect of adenosine adenosine kinase. Medical search. Frequent questions

Kikuchi K , Otsuka S , Takada S , Nakanishi K , Setoyama K , Sakakima H , Tanaka E , Maruyama I , . 1,5-anhydro-D-fructose induces anti-aging effects on aging-associated brain diseases by increasing 5'-adenosine monophosphate-activated protein kinase activity via the peroxisome proliferator-activated receptor-γ co-activator-1α/brain-derived neurotrophic factor pathway. (aging-us.com)
Gene expression and miR levels were quantified using real-time quantitative reverse transcription polymerase chain reaction, and adenosine monophosphate-activated protein kinase (AMPK) activity was measured using an AMPK Kinase Assay kit. (pnfs.or.kr)

acetyl-CoA then efficiently produces adenosine triphosphate (ATP) through the tricarboxylic acid (TCA) cycle and oxidative phosphorylation. (molcells.org)
QN upregulated the mRNA levels of adenosine triphosphate (ATP)-binding cassette subfamily A1, ATP-binding cassette subfamily G1, and scavenger receptor class B type 1, which are related to cholesterol efflux. (pnfs.or.kr)
EGCG also targets central intracellular transduction signals altered in FXS and improves memory recognition in a FXS animal model(adenosine triphosphate (ATP)-inhibitor of phosphatidylinositol 3-kinase (PI3K)and mammalian target of rapamycin (mTOR) and extracellular signal-regulated kinase (ERK1/2). (epiphanyasd.com)
Adenosine triphosphate (ATP) at millimolar levels has recently been implicated in the solubilization of cellular proteins. (waseda.jp)

Herein, we showed that glibenclamide promoted insulin release and further activated autophagy through the adenosine 5′-monophosphate (AMP) activated protein kinase (AMPK) pathway in MIN-6 cells. (hindawi.com)
Autophagy is either positively mediated by the adenosine 5′-monophosphate (AMP) activated protein kinase (AMPK) pathway [ 12 ], or negatively mediated by the mammalian target of rapamycin (mTOR) pathway [ 13 ]. (hindawi.com)
various molecular mechanisms and physiological processes regulate AMPK activity. (aging-us.com)
AMP-activated protein kinase (AMPK) is an intracellular energy sensor, which regulates cellular metabolism to maintain the energy homeostasis. (uni-giessen.de)
Therefore, the role of AMPK in endothelial barrier function was analyzed in human umbilical vein endothelial cells under physiological and pathophysiological (hypoxiareperfusion) conditions. (uni-giessen.de)
Targeted activation of AMPK by the adenosine analog AICAR at the onset of reperfusion reduced interendothelial gap formation. (uni-giessen.de)
This protective effect of AICAR on all parameters was abolished by the AMPK inhibitor Ara-A or by AMPKalpha1/2 siRNA transfection. (uni-giessen.de)
Die AMP-aktivierte Kinase (AMPK) ist ein ntrazellulärer Sensor der den zellulären Metabolismus reguliert um die energetische Homöostase zu gewährleisten. (uni-giessen.de)
We herein demonstrated that AMP-activated protein kinase (AMPK) and adenylate kinase (ADK) cooperated to maintain cellular ATP levels regardless of glucose levels. (waseda.jp)

Their function is to degrade intracellular second messengers such as cyclic adenine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) which leads to several biological processes like effect on intracellular calcium level by the Ca2+ pathway. (wikipedia.org)
This study aimed to investigate the potential effects of quercetin nanoemulsion (QN) on regulating the microRNA (miR)-33/34a pathway involved in cholesterol efflux in the liver of mice fed with a high-cholesterol (HC) diet. (pnfs.or.kr)
Here, we demonstrated that CNP activates the cAMP/protein kinase A (PKA) pathway and that this activation contributed to the elongation of the hypertrophic zone in the growth plate. (tokushima-u.ac.jp)
In summary, we revealed that CNP-induced cGMP elevation activated the cAMP/PKA pathway, and clarified that this PKA activation contributed to the bone growth-promoting effect of CNP in hypertrophic chondrocytes. (tokushima-u.ac.jp)
Here, using different experimental approaches, especially designer receptor exclusively activated by designer drug (DREADD) chemogenetic technology, we found that sustained activation of G q -protein signaling impairs the functionality of striatal neurons and we unveil the precise molecular mechanism underlying this process: a phospholipase C/Ca 2+ /proline-rich tyrosine kinase 2/cJun N -terminal kinase pathway. (jneurosci.org)
To analyze this effect anatomically, we manipulated G q -protein-dependent signaling selectively in neurons belonging to the direct or indirect striatal pathway. (jneurosci.org)

By preventing ADO phosphorylation, ADK inhibition increases intracellular ADO concentrations, altering the equilibrium of the bidirectional transport systems responsible for ADO reuptake with the net effect of increasing the local concentration of ADO in the extracellular compartment. (axonmedchem.com)
The reaction continues when cAMP activates protein kinase which catalyzes phosphorylation, activating a ribonucleic acid (RNA) polymerase. (nfpt.com)
There is a mounting evidence of the modulation properties of the major catechin in green tea, epigallocatechin-3-gallate ( EGCG ), on dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) gene overexpression in the brains of DS mouse models. (epiphanyasd.com)

By producing the second messenger cGMP, which regulates various effector systems such as phosphodiesterases, ion channels, and protein kinases, sGC plays an important role in different physiological processes, thus representing a very attractive pharmacological target. (nih.gov)
ROS may induce intracellular calcium increase and subsequent contraction of PASMCs via direct or indirect interactions with protein kinases, phospholipases, sarcoplasmic calcium channels, transient receptor potential channels, voltage-dependent potassium channels and L-type calcium channels, whose relevance may vary under different experimental conditions. (ersjournals.com)

PDEs are enzymes that hydrolyze cyclic adenosine 3,5-monophosphate (cAMP) and cyclic guanosine 3,5-monophospahate (cGMP), which are intracellular second messengers, into AMP and GMP. (wikipedia.org)
The mutated form synthesizes cyclic adenosine 3',5'-monophosphate instead of cGMP, allowing the detection of enzymatic activity by a reporter gene approach. (nih.gov)
C-type natriuretic peptide (CNP) stimulates endochondral bone formation through binding to its specific receptor, guanylyl cyclase (GC)-B. However, CNP/GC-B signaling dynamics in different stages of endochondral bone formation have not been fully clarified, especially in terms of the interaction between the cyclic guanine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP) pathways. (tokushima-u.ac.jp)

The most important physiological activator of sGC is nitric oxide, which activates the enzyme upon binding to the heme moiety. (nih.gov)

The therapeutic effects of PDE5 inhibition have been demonstrated in several cardiovascular conditions, chronic kidney disease and diabetes mellitus. (wikipedia.org)
The properties of adenosine inhibition of catecholamine-induced responses were investigated, using an isolated rat heart preparation. (umassmed.edu)

The primary cellular pathways that mediate the longevity-extending effects of natural products involve nutrient-sensing pathways. (frontiersin.org)
Among them, the sirtuin, AMP-activated protein kinase, mammalian target of rapamycin, p53, and insulin/insulin-like growth factor-1 signaling pathways are most widely studied. (frontiersin.org)

Mammalian circadian rhythms can be observed from the genetic level to the tissue level, and even to the macroscopic level, affecting behavior, biochemical and physiological processes. (frontiersin.org)
Unfortunately, the complete lack of information on the biosynthetic machinery of mammalian polyP has hampered our understanding of the physiological relevance of this polymer in mammals. (silverchair.com)

Pyruvate metabolism affects macrophage polarization, mitochondrial dynamics and MAM formation, which are critical in determining macrophage function and immune response. (molcells.org)
We have developed a novel neocortical epilepsy model based on the abnormal adenosine metabolism implicated in focal epileptogenesis. (world-sci.com)

Formation of cGMP initiates several reactions in the body including influence on cGMP ion channels, cGMP binding proteins and protein kinase G (PKG). (wikipedia.org)
These results provide insights regarding the cross-talk between cGMP and cAMP signaling in endochondral bone formation and in the physiological role of the CNP/GC-B system. (tokushima-u.ac.jp)

We provide evidence for potential influences of E3 ligase and poly adenosine diphosphate (ADP-ribose) polymerase 1 (PARP1) activity on neurodegenerative pathology. (frontiersin.org)
This initial interaction (platelet adhesion) sets the stage for other adhesive reactions that allow the platelets to interact with other agonists in the vicinity of vessel injury, such as adenosine 5'-diphosphate (ADP), subendothelial collagen, and thrombin. (medscape.com)

A previous study has shown that a sleep disorder, namely, familial advanced sleep phase syndrome, which is caused due to mutations in the gene casein kinase Iδ leads to sleep problems that trigger migraines. (arkhealthandselfreliance.com)

Activator of protein kinase A (cyclic AMP agonist). (biolog.de)

Adenosine (ADO) is an endogenous homeostatic inhibitory neuromodulator that reduces cellular excitability at sites of tissue injury and inflammation. (axonmedchem.com)
An abnormal increase in blood glucose may be due to a defect in insulin self-secretion caused by the immune system (type 1 diabetes mellitus, T1DM), or resistance to the cellular effects of insulin, as well as insufficient insulin secretion (type 2 diabetes mellitus, T2DM) [ 1 ]. (hindawi.com)
authors":{"en":[{"name":"Horikawa Kazuki"},{"name":"Nagai Takeharu"}],"ja":[{"name":"堀川一樹"},{"name":"Nagai Takeharu"}]},"description":{"en":"Bioluminescence imaging of cellular function is a promising strategy. (tokushima-u.ac.jp)

ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory. (axonmedchem.com)
Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor. (axonmedchem.com)
Additionally, histological analysis of the growth plate of PKAchu mice demonstrated that CNP increased the length of the growth plate, but coadministration of a PKA inhibitor, H89, inhibited the growth-promoting effect of CNP only in the hypertrophic zone. (tokushima-u.ac.jp)

Scientists reviewed the existing literature that links caffeine and headaches and summarized the possible mechanisms of caffeine's effect on migraine and other headaches. (arkhealthandselfreliance.com)
Consumption of caffeine both occasionally and regularly has a significant effect on the nervous system. (arkhealthandselfreliance.com)
Although several studies have indicated that the consumption of caffeine impacts headaches, the underlying mechanism behind this effect is not fully understood. (arkhealthandselfreliance.com)
Individuals with a history of seizures or hypotension are advised not to consume excess caffeine, as it can induce adverse effects. (arkhealthandselfreliance.com)
Long-term consumption of caffeine triggers a cascade of physiological processes in migraine patients, which leads to different outcomes including worsening of the headaches. (arkhealthandselfreliance.com)
A structural similarity between caffeine and adenosine has been established, along with the fact that adenosine significantly affects the development of migraine. (arkhealthandselfreliance.com)
Several studies have indicated the antagonization of adenosine by caffeine which could lead to the development of migraine attacks. (arkhealthandselfreliance.com)
Caffeine is an antagonist at adenosine receptors, which tells us that adenosine is important in the regulation of vigilance. (heresy.is)
Black tea contains 2% to 4% caffeine, which affects thinking and alertness. (medlineplus.gov)
Drinking large amounts might cause side effects due to the caffeine content. (medlineplus.gov)
Consuming more than this during pregnancy is possibly unsafe and has been linked to an increased risk of miscarriage, increased risk of sudden infant death syndrome (SIDS), and other negative effects, including symptoms of caffeine withdrawal in newborns and lower birth weight. (medlineplus.gov)

Adenosine induces vasodilation and modulates endogenous calcitonin gene-related peptide (CGRP) release. (arkhealthandselfreliance.com)

In the presence of 15 mM Mg++ adenosine reduced by approximately 56% the 2-fold increase in myocardial membrane adenylate cyclase activity produced by 1 microM isoproterenol without affecting basal or fluoride-stimulated activity. (umassmed.edu)
The results suggest that physiological concentrations of adenosine attenuate the catecholamine-induced increase in cAMP content, cAMP-dependent protein kinase activation, phosphorylase a formation, and contractile parameters in the working heart, via reducing the beta-adrenergic activation of adenylate cyclase. (umassmed.edu)

While endogenous biosynthesis of l-carnitine from the amino acids lysine and methionine is sufficient for essential processes - along with dietary sources of carnitine from protein-rich red meat, for example - dietary supplementation of carnitine may pose benefits in certain physiological conditions. (priceplow.com)
Under normal physiological conditions, synaptic transmission between the basolateral amygdala (BLA) and the neighboring main island (Im) of GABAergic intercalated cells (ITCs) is strongly inhibited by endogenous opioids. (jneurosci.org)

and, diet and exercise that affect these same hormones and intracellular chemicals. (nfpt.com)
Adenosine also reduced the isoproterenol-induced increase in enzyme activity assayed at 1-2 mM Mg++, a level that more closely approximates the intracellular activity of the ion. (umassmed.edu)

The effect on PKG reduces levels of calcium leading to relaxation of smooth muscles (see figure 2). (wikipedia.org)
The NREM sleep deprivation reduces the normal release of specific neurotransmitters, which can affect the ability of the receptors to refresh and restore sensitivity. (org.sa)
Using patch-clamp electrophysiology in brain slices prepared from male rats, we reveal that opioid withdrawal abruptly reduces the ability of these peptides to inhibit neurotransmission, a direct consequence of a protein kinase A (PKA)-driven increase in the synaptic activity of peptidases. (jneurosci.org)
Adenosine 5'monophosphate-activated protein kinase activation reduces the risks of psoriasis and its comorbidities: a mendelian randomisation study in the UK Biobank. (cdc.gov)

The first is through its anti‐androgenic effect, thus influencing expression of the genes possibly involved in this condition and the second might be through lowering the insulin resistance that is usually present in some patients with HS. (cassiopaea.org)

2001. Effects of daily dermal application of DEET and permethrin, alone and in combination, on sensorimotor performance, blood-brain barrier, and blood- tests barrier in rats. (cdc.gov)

Under physiological circumstances, the resistance of the endothelial cell lining to interactions with platelets and coagulation factors prevents thrombosis. (medscape.com)

Diabetes is a metabolic disease, partly due to hypoinsulinism, which affects ∼8% of the world's adult population. (hindawi.com)
No. D 009 & B 007 ), no metabolic side effects. (biolog.de)

Cognition and behavior are affected by aging-related changes at multiple levels, from single molecules to whole organs. (aging-us.com)
This review focused on the biological explanation as well as the research investigating the numerous effects that SD can have on cognition. (org.sa)

As detailed above, cortisol possesses a multitude of potentially degradative physiological effects, including: inhibiting glucose uptake, causing a constriction of the vasculature (vasoconstriction), the breakdown of glycogen, and inarguably the result most would desire to avoid, proteolysis (the breakdown of muscle tissue). (sportsnutritionauthority.net)
Simultaneously the effects on glycemic control revealed that soy protein and/or isoflavones are not significantly effective in reducing circulating glucose levels. (encyclopedia.pub)

This suggests that regulation of CBF by adenosine and ADK may play an important role in neocortical epilepogenesis. (world-sci.com)

In the present study, we experimentally evaluated the effects of 1,5-AF on aging-associated brain diseases in vivo using an animal model of acute ischemic stroke (AIS), stroke-prone spontaneously hypertensive rats (SHRSPs), and the spontaneous senescence-accelerated mouse-prone 8 (SAMP8) model. (aging-us.com)
The oxygen sensing and signal transduction machinery is located in the pulmonary arterial smooth muscle cells (PASMCs) of the pre-capillary vessels, albeit the physiological response may be modulated in vivo by the endothelium. (ersjournals.com)
Our study investigated the effect of capsaicin in vitro and in a mouse model in vivo . (techscience.com)
mesenteric arteries (MA) and veins (MV) were mounted on glass cannulas, intravascularly filled with fluorescent dextran and incrementally pressurized above their in vivo physiological values. (bvsalud.org)

Autophagy as a self-protective mechanism of cells has been widely studied and has particular physiological effects in different tissues or cells. (hindawi.com)
The major PDE5 inhibitors (a subset of the phosphodiesterase inhibitors) are sildenafil, tadalafil, vardenafil, and avanafil, and although all share the same mechanism of action each has unique pharmacokinetic and pharmacodynamic properties which dictate their suitability in various conditions and their side effect profile. (wikipedia.org)

despite its beneficial physiological activity, it exhibits considerably low bioavailability. (pnfs.or.kr)

They occasionally exhibit toxic, mutagenic or carcinogenic effects, or they modulate immune responses. (cdc.gov)

Several studies have reviewed the effects of individual natural compounds on aging and aging-related diseases along with the underlying mechanisms. (frontiersin.org)
To garner a more comprehensive understanding of the effects of circadian rhythms on health and neurodegeneration, the underlying fundamental molecular mechanisms and interrelated processes must be explored ( Cox and Takahashi, 2019 ). (frontiersin.org)
The effects of ginseng oligosaccharides (GSOs) on neuronal oxidative injury induced by glutamate (GLU) and the molecular mechanisms involved were investigated. (sdbonline.org)
However, the significance of this high ATP level under physiological conditions and the mechanisms that maintain ATP remain unclear. (waseda.jp)

PS's ubiquity coincides with its necessity for crucial physiological functions, as the phospholipid is implicated in several components of cell communication, as well as the mediation of catecholamine synthesis and transmission in the brain (along with other neuroendocrine functions). (sportsnutritionauthority.net)

No genetic data is available confirming DdPPK2 polyP kinase activity. (silverchair.com)

Perfusion of hearts with 0.1 microM isoproterenol increased myocardial cAMP content 2.8-fold, activation of cAMP-dependent protein kinase 4.4-fold, phosphorylase a formation 3.4-fold, left ventricular pressure 1.8-fold, rate of ventricular pressure development 2.1-fold, and rate of ventricular relaxation 2.2-fold within 1 minute. (umassmed.edu)

GSOs also mitigated the deleterious effects of GLU on the mitochondrial membrane potential and Cyt C release, thus alleviating mitochondrial dysfunction, and increased GSH levels and CAT activity in both cells and Drosophila brain tissue. (sdbonline.org)

We also found that chitin elicitor receptor kinase OsCERK1 and a mitogen-activated protein kinase cascade, the OsMKK4-OsMPK6 cascade, play essential roles in the elicitor-induced production of diterpenoid phytoalexins. (go.jp)

Contact allergen-induced innate immunity contrast to irritant contact dermatitis (ICD), which evolves emollients may help reduce irritancy and stabilize the barrier as a consequence of direct toxic effects of physical or chemi- function of the skin avoiding the penetration of contact aller- cal agents resulting in keratinocyte damage and local inflam- gens. (cdc.gov)

Since these two types are practically difficult to distinguish, aging can be referred to as a biological-psychological process during the final stages of individual growth and development, which is the inevitable result of a combination of many pathological, physiological, and psychological processes. (frontiersin.org)
The effect of ADK over-expression on cerebral blood flow (CBF) was measured using a three-dimensional high resolution imaging technique based on the optical property of biological tissues. (world-sci.com)
EGCG has numerous biological effects and in the three trials they are not claiming the same mode of action. (epiphanyasd.com)
Serious' effects are those that evoke failure in a biological system and can lead to morbidity or mortality (e.g., acute respiratory distress or death). (cdc.gov)

This reaction then produces cAMP, which actually brings the effect of the hormone in the cell. (nfpt.com)

It is important to clarify the effects of starch fine structure and protein components on the eating quality of indica rice. (bvsalud.org)
an important role in other physiological functions. (uni-giessen.de)
This study demonstrated that the Receptor for Activated C-Kinase 1 (RACK1) is important in SC function. (sdbonline.org)
The distinction between 'less serious' effects and 'serious' effects is considered to be important because it helps the users of the profiles to identify levels of exposure at which major health effects start to appear. (cdc.gov)

Very importantly no significant adverse effects were recorded and blood tests regularly taken during the trial period have remained within the normal range for all patients. (cassiopaea.org)
Public health officials and others concerned with appropriate actions to take at hazardous waste sites may want information on levels of exposure associated with more subtle effects in humans or animals (LOAELs) or exposure levels below which no adverse effects (NOAELs) have been observed. (cdc.gov)

Physiological aging refers to the physiological degeneration occurring after maturity, while pathological aging involves age-related changes caused by various external factors such as various diseases. (frontiersin.org)

A reduction in sleep does not occur independently of the effects on memory, attention, alertness, judgment, decision-making, and overall cognitive abilities in the brain, resulting in decreased function and impaired cognitive performance. (org.sa)

When perfused with the isoproterenol, 10 microM adenosine reduced the catecholamine-produced increase in cAMP, cAMP-dependent protein kinase, and phosphorylase by 30-40%, and the elevation in left ventricular pressure and rate of ventricular pressure development by 40-70% within 40 seconds. (umassmed.edu)
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In recent years, a large number of publications have reported on the diverse effects of exogenously added synthetic polyP to cultured cells. (silverchair.com)

Two processes that affect the amount of sleep obtained are the circadian and homeostatic processes. (org.sa)

Capsaicin is a phytochemical extracted from chili peppers and exerts many pharmacological actions, such as anti-tumor and anti-inflammatory effects. (techscience.com)

Doses of black tea this high might cause death or other severe side effects. (medlineplus.gov)
The points in the figures showing no-observed-adverse-effect levels (NOAELs) or lowest- observed-adverse-effect levels (LOAELs) reflect the actual doses (levels of exposure) used in the studies. (cdc.gov)

Recent evidence indicates that abnormal expression of adenosine kinase (ADK) is implicated in epileptogenesis. (world-sci.com)

Anatomy7

Organisms4

Chemicals and Drugs91

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes13

Information Science3

Monophosphate-activated protein kinase2

Triphosphate4

AMPK9

Pathway6

Phosphorylation3

Protein kinases2

Cyclic adenosine3

Activates1

Inhibition2

Pathways2

Mammalian2

Metabolism2

CGMP2

Diphosphate2

Casein1

Activator1

Cellular3

Inhibitor3

Caffeine11

Induces1

Adenylate2

Endogenous2

Intracellular2

Reduces4

Insulin1

20011

Endothelial1

Metabolic2

Cognition2

Glucose2

Regulation1

Vivo4

Mechanism2

Considerably1

Carcinogenic effects1

Mechanisms4

Crucial1

Genetic1

Activation1

Activity1

Cascade1

Consequence1

Biological4

Produces1

Important4

Adverse effects2

Refers1

Alertness1

CAMP2

Cells1

Circadian1

Pharmacological1

Doses2

Expression1