MetabolicAlcoholPhosphatidylinositol-4-phosphate 5-kinaTransfer of a phosphate groupSignal TransductionProteinsPentoseSphingosineKinasesPhosphorylationEnzyme classGlycerolCatalyzesDiphosphatePhosphatidylinositolsGlycolysisOrganicSugarRapidlyQuantitativeCalciumReactionTermsClassKinase activityPhosphatidylinositolAlcoholHexoseSignaling moleculeEnzymesSphingosine 1-phosphaInorganic phosphatePyruvateGamma-phosphateNucleotideAmino AcidsGalactoseMetabolismResiduesDerivativesActivityPhosphataseEsterCatalysisPentavalentElectronBackboneGlycosyl groupsSystemSignificantlyCompoundsFramework
Metabolic1
- Glycerol 3-phosphate is a chemical intermediate in the glycolysis metabolic pathway. (hmdb.ca)
Alcohol3
- This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. (alchetron.com)
- Polyprenol found in animal tissues that contains about 20 isoprene residues, the one carrying the alcohol group being saturated. (lookformedical.com)
- Transferases, Transferring phosphorous-containing groups, Phosphotransferases with an alcohol group as acceptor. (uma.es)
Phosphatidylinositol-4-phosphate 5-kina1
- PEP3 was recently identified as phosphatidylinositol transfer protein (PtdInsTP), and here we report that PEP1 consists of the type I phosphatidylinositol-4-phosphate 5-kinase (PtdInsP5K). (nih.gov)
Transfer of a phosphate group2
- A group of enzymes that catalyzes the transfer of a phosphate group onto a phosphate group acceptor. (bvsalud.org)
- A group of enzymes that catalyze an intramolecular transfer of a phosphate group. (lookformedical.com)
Signal Transduction1
- Sphingosine kinase 1 (SK1) is a lipid enzyme with oncogenic properties that converts the proapoptotic lipids ceramide and sphingosine into the antiapoptotic lipid sphingosine-1-phosphate and activates the signal transduction pathways that lead to cell proliferation, migration, the activation of the inflammatory response, and the impairment of apoptosis. (uea.ac.uk)
Proteins2
- A group of enzymes that are dependent on cyclic GMP and catalyzes the phosphorylation of serine or threonine residues of proteins. (harvard.edu)
- The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. (lookformedical.com)
Pentose1
- The hypothesis that CP12 is essential to separate oxidative pentose phosphate pathway activity from Calvin-Benson cycle activity, as proposed in cyanobacteria, was tested. (essex.ac.uk)
Sphingosine1
- Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration. (uams.edu)
Kinases1
- Phosphatidylinositol can be phosphorylated by a number of different kinases that place the phosphate moiety on positions 4 and 5 of the inositol ring, although position 3 can also be phosphorylated by a specific kinase. (ymdb.ca)
Phosphorylation1
- The sucrose phosphotransferase system of Streptococcus mutans catalyzes the phosphorylation of sucrose to sucrose-6-phosphate with concomitant translocation of this disaccharide across the cytoplasmic membrane in reactions requiring intracellular phosphoenolpyruvate. (ox.ac.uk)
Enzyme class1
- The systematic name of this enzyme class is ATP:D-fructose-phosphate 6-phosphotransferase . (alchetron.com)
Glycerol3
- Glycerol 3-phosphate is produced from glycerol, the triose sugar backbone of triglycerides and glycerophospholipids, by the enzyme glycerol kinase. (hmdb.ca)
- Glycerol 3-phospate may then be converted by dehydrogenation to dihydroxyacetone phosphate (DHAP) by the enzyme glycerol-3-phosphate dehydrogenase. (hmdb.ca)
- The glycerol 3-phosphate shuttle is used to rapidly regenerate NAD+ in the brain and skeletal muscle cells of mammals (wikipedia). (hmdb.ca)
Catalyzes2
- An enzyme that catalyzes the reversible isomerization of D-mannose-6-phosphate to form D-fructose-6-phosphate, an important step in glycolysis. (lookformedical.com)
- Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. (nih.gov)
Diphosphate2
- A rather large group of enzymes comprising not only those transferring phosphate but also diphosphate, nucleotidyl residues, and others. (wakehealth.edu)
- Enzymes that catalyze the transfer of mannose from a nucleoside diphosphate mannose to an acceptor molecule which is frequently another carbohydrate. (lookformedical.com)
Phosphatidylinositols1
- Phosphatidylinositols are acidic (anionic) phospholipids that consist of a phosphatidic acid backbone, linked via the phosphate group to inositol (hexahydroxycyclohexane). (ymdb.ca)
Glycolysis1
- DHAP can then be rearranged into glyceraldehyde 3-phosphate (GA3P) by triose phosphate isomerase (TIM), and feed into glycolysis. (hmdb.ca)
Organic1
- belongs to the class of organic compounds known as monosaccharide phosphates. (ecmdb.ca)
Sugar1
- When blood sugar is high, however, the secretion of insulin produces the opposite effect by removing the phosphate group from phosphofructokinase 2, which leads to activation, and formation of fructose 2,6-bisphosphate. (alchetron.com)
Rapidly1
- The 20-kDa light chain is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors. (ouhsc.edu)
Quantitative1
- Seven different isomers are known, but the most important in both quantitative and biological terms are phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate. (ymdb.ca)
Calcium1
- An enzyme that phosphorylates myosin light chains in the presence of ATP to yield myosin-light chain phosphate and ADP, and requires calcium and CALMODULIN. (ouhsc.edu)
Reaction1
- This reaction is a phosphoryl group transfer from ATP to fructose 6-phosphate, yielding fructose 1,6-biphosphate. (alchetron.com)
Terms1
- No significant difference was observed between the control and hypothyroid groups in terms of the BMD Z-scores. (bvsalud.org)
Class1
- L-fuculose 1-phosphate is a member of the chemical class known as Hexoses. (ecmdb.ca)
Kinase activity1
- Although binding of VAMP3 to PI4K2A did not require kinase activity, acute depletion of phosphatidylinositol 4-phosphate (PtdIns4P) on endosomes significantly delayed VAMP3 trafficking. (nih.gov)
Phosphatidylinositol1
- Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. (wakehealth.edu)
Alcohol1
- phosphotransferases with an alcohol group as acceptor) inhibitor that interferes with the action of hexokinase, EC 2.7.1.1, an enzyme that phosphorylates hexoses forming hexose phosphate. (ebi.ac.uk)
Hexose5
- belongs to the class of organic compounds known as hexose phosphates. (ecmdb.ca)
- These are carbohydrate derivatives containing a hexose substituted by one or more phosphate groups. (ecmdb.ca)
- Catalysis of the reaction: hexose + phosphoramidate = hexose 1-phosphate + NH3. (planteome.org)
- Link to all annotated objects annotated to phosphoramidate-hexose phosphotransferase activity. (planteome.org)
- Link to all direct and indirect annotations to phosphoramidate-hexose phosphotransferase activity. (planteome.org)
Signaling molecule1
- This establishes that sphingosine kinase, in addition to producing sphingosine-1-phosphate as a signaling molecule, also consumes dihydrosphingosine to regulate ceramide synthesis. (nih.gov)
Enzymes7
- A group of enzymes that catalyzes the transfer of a phosphate group onto a phosphate group acceptor. (bvsalud.org)
- A rather large group of enzymes comprising not only those transferring phosphate but also diphosphate, nucleotidyl residues, and others. (nih.gov)
- A group of enzymes that transfers two phosphate groups from a donor such as ATP to two different acceptors. (ucdenver.edu)
- Structure and literature database searches on phosphotransferases suggest that such a hybrid TS is consistent with many structures and physical organic studies and likely holds for most enzymes catalyzing phosphoryl transfer. (riken.jp)
- Enzymes that catalyze the transfer of glycosyl groups to an acceptor. (childrensmercy.org)
- Some of the enzymes in this group also catalyze hydrolysis, which can be regarded as transfer of a glycosyl group from the donor to water. (childrensmercy.org)
- The International Union of Pure and Applied Chemistry and the International Union of Biochemistry (IUPAC/IUB) commission on the classification and nomenclature of enzymes placed the enzymes that transfer high energy phosphate bonds from nucleotides into two divisions: the transferases (kinases) and the ligases (synthetases) [ 1 ]. (biomedcentral.com)
Sphingosine 1-phospha2
- Evidence Suggests Sphingosine 1-Phosphate Might Be Actively Generated, Degraded, and Transported to Extracellular Spaces With Increased S1P 2 and S1P 3 Expression in Colon Cancer. (medscape.com)
- BACKGROUND: A pivotal role of sphingosine 1-phosphate (S1P) in cancer has been suggested based on the ceramide-S1P rheostat theory that the intracellular balance between prosurvival S1P and proapoptotic ceramide determines cell fate. (medscape.com)
Inorganic phosphate2
- Homeostasis of cellular fluxes of inorganic phosphate (Pi) supervises its structural roles in bones and teeth, its pervasive regulation of cellular metabolism, and its functionalization of numerous organic compounds. (nih.gov)
- Most often another carbohydrate molecule acts as an acceptor, but inorganic phosphate can also act as an acceptor, such as in the case of PHOSPHORYLASES. (childrensmercy.org)
Pyruvate1
- Catalysis of the reaction: glycerone + phosphoenolpyruvate = glycerone phosphate + pyruvate. (tamu.edu)
Gamma-phosphate2
- EC 2.7.1.20) is an enzyme that catalyzes the transfer of gamma-phosphate from Adenosine triphosphate ( ATP ) to adenosine (Ado) leading to formation of Adenosine monophosphate ( AMP ). (wikipedia.org)
- Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. (rcsb.org)
Nucleotide1
- On the basis of these conserved mechanisms, the role of the nucleotide C8-H in initiating the formation of a pentavalent intermediate between the γ-phosphate of the ATP and the substrate nucleophile is defined. (biomedcentral.com)
Amino Acids2
- We also found that membrane and water-soluble proteins utilize essentially an identical set of amino acids for interacting with lipid head and tail groups. (riken.jp)
- In contrast, interactions between lipid head groups and amino acids showed a more variable pattern, apparently constrained by each protein's specific molecular function. (riken.jp)
Galactose1
- An enzyme that catalyzes reversibly the formation of galactose 1-phosphate and ADP from ATP and D-galactose. (nih.gov)
Metabolism1
- Engineering starch accumulation by manipulation of phosphate metabolism of starch. (ucdenver.edu)
Residues3
- Protein kinases that catalyze the PHOSPHORYLATION of TYROSINE residues in proteins with ATP or other nucleotides as phosphate donors. (lookformedical.com)
- We showed that the lipophilicity of amino acid residues determines the amino acid preferences for lipid tail groups in both membrane and water-soluble proteins, suggesting that tightly-bound lipid molecules and lipids in the annular shell interact with membrane proteins in a similar manner. (riken.jp)
- To this end, the putative mechanistic role of the C8 proton in the catalysis of the 22 families within the 10-fold groups was also investigated in the context of the conserved catalytic residues of each group of kinases. (biomedcentral.com)
Derivatives1
- Four phosphoenolpyruvate (PEP) derivatives, carrying reactive or activable chemical functions in each of the three chemical regions of PEP, were assayed as alternative substrates of enzyme I (EI) of the Escherichia coli PEP:glucose phosphotransferase system. (ox.ac.uk)
Activity1
- [25] [26] The enzymatic activity of AdK from different sources show a marked dependence on phosphate (Pi) and/or pentavalent ions and it is a conserved property of the PfkB family of proteins. (wikipedia.org)
Phosphatase1
- We perform QM/MM simulations for the reversible phosphorylation of phosphoserine phosphatase (PSP), which belongs to one of the largest phosphotransferase families characterized to data. (riken.jp)
Ester1
- The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety. (lookformedical.com)
Catalysis1
- The critical question that needed to be answered was to what extent the functionality required for the catalysis of phosphoryl transfer is conserved within the 25 families or 12 fold-groups. (biomedcentral.com)
Pentavalent1
- Associated with the "push" mechanism and "pull" mechanisms are a series of proton transfer cascades, initiated from C8-H, via the tri-phosphate backbone, culminating in the formation of the pentavalent transition state between the γ-phosphate of the ATP and the substrate nucleophile. (biomedcentral.com)
Electron1
- The resultant structures of the active site at TS in both reactions have compact geometries but a less electron density of the phosphoryl group. (riken.jp)
Backbone1
- As a consequence of this phenomenon, 15N line shapes of NH3 signals in a conventional 1H-15N heteronuclear single quantum coherence (HSQC) correlation experiment are much broader than those of backbone amide groups. (nih.gov)
Glycosyl groups1
- and those transferring other glycosyl groups. (childrensmercy.org)
System1
- Mechanism-based inhibition of enzyme I of the Escherichia coli phosphotransferase system. (ox.ac.uk)
Significantly2
- The BMD Z-scores were significantly higher in patients with hyperthyroidism than those in the control group and in patients with hypothyroidism. (bvsalud.org)
- RESULTS: Mean BMD Z score in the obese and normal weight group was within the normal limits and significantly higher in the obese group. (bvsalud.org)
Compounds1
- Compounds 3 and 4, obtained by modification of the carboxylic and phosphate groups of PEP, were neither substrates nor inhibitors of EI, highlighting the importance of these functionalities for recognition by EI. (ox.ac.uk)
Framework1
- These simulations show that an N -glycan modification like the bisecting GlcNAc selects a certain 'key' (or group of 'keys') within the framework of the 'bunch of keys' mechanism. (riken.jp)