Other names in common use include adenylylsulfate kinase (phosphorylating), 5'-phosphoadenosine sulfate kinase, adenosine 5'-phosphosulfate kinase, adenosine phosphosulfate kinase, adenosine phosphosulfokinase, adenosine-5'-phosphosulfate-3'-phosphokinase, and APS kinase. (wikipedia.org)
PAPS8
Adenosine phosphosulfate (also known as APS) is the initial compound formed by the action of ATP sulfurylase (or PAPS synthetase) on sulfate ions after sulfate uptake. (ecmdb.ca)
PAPS synthetase 1 is a bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. (ecmdb.ca)
The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS). (ecmdb.ca)
The gene encodes for 3'-phospoadenosine 5'-phosphosulfate (PAPS) synthase 1 (PAPSS1), a dual function enzyme comprising an ATP sulfurylase and a kinase domain. (oncotarget.com)
These enzymes take a sulfuryl group from the convenient carrier molecule PAPS (3'-phosphoadenosine-5'-phosphosulfate), and transfer it to the target molecule. (rcsb.org)
ATP sulfurase (left) and APS kinase (center) from fungi, and the human form with both enzymes together in PAPS synthetase 1 (right). (rcsb.org)
First, ATP sulfurylase attaches sulfate to the adenosine nucleotide, then APS kinase adds an additional phosphoryl group to create PAPS. (rcsb.org)
In 3′-phosphoadenosine-5′-phosphosulfate (PAPS), the key feature is the mixed phosphosulfate anhydride that activates the sulfate toward transfer, in much the same way as the terminal phosphate is activated in ATP. (heresy.is)
Sulfate1
In enzymology, an adenylyl-sulfate kinase (EC 2.7.1.25) is an enzyme that catalyzes the chemical reaction ATP + adenylyl sulfate ⇌ {\displaystyle \rightleftharpoons } ADP + 3'-phosphoadenylyl sulfate Thus, the two substrates of this enzyme are ATP and adenylyl sulfate, whereas its two products are ADP and 3'-phosphoadenylyl sulfate. (wikipedia.org)
Enzyme1
Characterization of the phosphorylated enzyme intermediate formed in the adenosine 5'-phosphosulfate kinase reaction. (yale.edu)
Penicillium1
Adenosine 5'-phosphosulfate kinase from Penicillium chrysogenum. (wikipedia.org)
The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast. (academicinfluence.com)
Phosphoryl1
Transfer of P as the PO32 group opens the biological world of phosphate monoesters brought about by phosphoryl transfer enzymes and includes all the kinases for low molecular weight metabolites and for proteins in their myriads. (tutordale.com)
Adenosine3
Other names in common use include adenylylsulfate kinase (phosphorylating), 5'-phosphoadenosine sulfate kinase, adenosine 5'-phosphosulfate kinase, adenosine phosphosulfate kinase, adenosine phosphosulfokinase, adenosine-5'-phosphosulfate-3'-phosphokinase, and APS kinase. (wikipedia.org)
Adenosine 5'-phosphosulfate kinase from Penicillium chrysogenum. (wikipedia.org)
The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). (nih.gov)
GAF domain, Histidine kinase-, Domain of unknown function (DUF4118), His Kinase A (phospho-acceptor) domain, Osmosensitive K+ channel His kinase sensor domain [Interproscan]. (ntu.edu.sg)
Synthase1
In Vivo Validation of PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate synthase 1) as a Cisplatin-sensitizing Therapeutic Target. (nih.gov)
Ensembl3
protein_coding" "AAC73720","dpiB","Escherichia coli","sensory histidine kinase in two-component regulatory system with CitB [Ensembl]. (ntu.edu.sg)
protein_coding" "AAC73789","kdpD","Escherichia coli","fused sensory histidine kinase in two-component regulatory system with KdpE: signal sensing protein [Ensembl]. (ntu.edu.sg)
protein_coding" "AAC74078","torS","Escherichia coli","hybrid sensory histidine kinase in two-component regulatory system with TorR [Ensembl]. (ntu.edu.sg)
Bifunctional1
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. (nih.gov)