Phosphorylation regulates focal adhesions. Medical search. Frequent questions

The best characterized FAK phosporylation event is the auto-phosphorylation at the tyrosine397 (Tyr397) which creates a motif that is recognized by various SH2 domain-containing proteins, such as src which phosphorylates FAK on Tyr576. (aacrjournals.org)
We prepared Titanium (Ti) and Ce-TZP/Al 2 O 3 disks with different surface roughness, namely, mirrored and machined surfaces, on which HGF-1 were cultured, and then the biological parameters of the cultured cells, including cell morphology and gene expression of focal adhesion proteins were assessed. (alliedacademies.org)
FAK's ability to bind numerous structural and signaling proteins via a variety of interactions is important for FAK activation level, and for FAK interaction with a variety of substrates localized to sites of cell adhesion. (fishersci.com)
Important NF-B target genes in endothelial cells are Complement Component 7 Proteins web adhesion molecules like intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin that mediate adherence of inflammatory cells which includes monocytes,neutrophils, lymphocytes, and macrophages for the vascular wall triggering extravasation into tissues (30407). (adenosine-kinase.com)
PDLIM2 (also called Mystique or SLIM) is certainly Mouse monoclonal to ALDH1A1 a cytoskeletal and nuclear PDZ-LIM area protein that regulates the balance of many transcription elements including NFκB and sign transducer and activator of transcription proteins (STATs) in hemopoietic and epithelial cells [7-9]. (healthweeks.com)
These results suggest that elevated tyrosine phosphorylation of proteins such as beta-catenin and p120 Cas contribute to the altered adherens junctions of ras-transformed epithelia. (rupress.org)
In the present study we identify the focal adhesion-associated proteins p130Cas, Pyk2, and paxillin as novel members of the tyrosine kinase signaling pathway downstream of CD36 and show that assembly of this complex is essential for microglial migration. (neuroprobe.com)
In the mammalian epithelial cell sheet, TJs regulate molecular transport within the intercellular space and independent compartments of proteins and lipids localized to apical and basolateral membranes [4,5]. (synanet2020.com)
As cells are capable of sensing and responding to the stiffness of their surrounding matrix via mechanisms that include changes in the phosphorylation of focal adhesion proteins, like FAK and Src, we hypothesized that there is a relationship between abnormal tumor vasculature characteristics and tumor stiffening. (cornell.edu)
Epithelial cells adjacent to the area of the defect flatten, lose their hemidesmosome attachments, and migrate on transient focal contact zones that are formed between cytoplasmic actin filaments and extracellular matrix proteins. (medscape.com)

A lager expansion of the cell area accompanied by a greater development of actin cytoskeleton and talin1, a greater adhesion strength of CTEs to each disk, and higher gene expression level of focal adhesion protein were observed with the mirror-polished surface than the mechanically polished surface both Ti and Ce-TZP/Al 2 O 3 disks. (alliedacademies.org)
Mirror-polished Ce-TZP/Al 2 O 3 might contribute to the success of implant therapy by its strong adhesion strength to gingival connective tissues with the developed focal contact-cytoskeleton complex. (alliedacademies.org)
Although previous studies have identified different chemotropic and adhesion molecules that influence axonal development, the molecular mechanism by which these signals control the cytoskeleton remains poorly understood. (biologists.com)
The dynamic actin cytoskeleton spatially and temporally regulates protrusion, adhesions, contraction, and retraction from the cell front to the rear. (renest.best)
Together, these data are the first to identify the signaling cascade that directly links CD36 to the actin cytoskeleton and, thus, implicates it in diverse processes such as cellular migration, adhesion, and phagocytosis. (neuroprobe.com)
Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. (nih.gov)
Similarly, depletion of either Rasip1 or Arhgap29 in cultured ECs blocks in vitro lumen formation, fundamentally alters the cytoskeleton, and reduces integrin-dependent adhesion to ECM . (xenbase.org)
Migration and invasion require coordinated reorganisation of the actin cytoskeleton and regulation of cell-adhesion dynamics. (silverchair.com)
In this review, we discussed the current knowledge on the mechanisms of platelet shape change and also pathological implications and therapeutic opportunities for regulating the related cytoskeleton dynamics. (koreascience.kr)

This is controlled during the cell adhesion procedure through molecules and signalling pathways following a biological cascade, including proliferation and Extracellular Matrix (ECM) production [ 9 ]. (alliedacademies.org)
β1 integrin is the major β integrin subunit in pancreatic beta-cells and forms heterodimers with 12 α integrin subunits, which interact with components of the extracellular matrix (ECM) to control intracellular signaling via the focal adhesion kinase (FAK) and extracellular signal related kinase 1 and 2 (ERK1/2) pathways [ 4 ]. (oncotarget.com)
The binding of extracellular matrix ligands to integrins triggers autophosphorylation at Tyr-397, and activation of FAK through phosphorylation of Tyr residues (Tyr-576 and Tyr577) in the kinase domain activation loop. (fishersci.com)
Our results demonstrate that cytoglobin expression is correlated with a more quiescent phenotype of stellate cells in culture and that cytoglobin is regulated by the extracellular matrix through integrin signalling dependent on activation of focal adhesion kinase. (biomedcentral.com)
Rasipl null angioblasts fail to properly localize the polarity determinant Par3 and display defective cell polarity, resulting in mislocalized junctional complexes and loss of adhesion to extracellular matrix ( ECM ). (xenbase.org)

Current studies indicate that focal adhesion kinase regulates NF-B phosphorylation and transcriptional activity in response to flow (313). (adenosine-kinase.com)

At the front edge of cells, PAK1 promotes focal adhesion formation by phosphorylating PIX, while at the back edge, it directs focal adhesion disassembly. (rndsystems.com)
In particular, vimentin intermediate filaments undergo phosphorylation and reorientation in smooth muscle cells, which may regulate cell contraction and focal adhesion assembly/disassembly. (renest.best)
The four panels represent roughly the different steps in the formation and disassembly of focal adhesions. (mechanobio.info)
Most rights set aside.Cellular migration is often a dynamic method that necessitates synchronised formation along with disassembly of major adhesions (FAs). (sb415286inhibitor.com)
Paxillin has been shown to hole the C-terminal website involving FAK in FAs, as well as an increasing variety of research has related paxillin association with GIT1 throughout key adhesion disassembly. (sb415286inhibitor.com)

Significant reductions in the phosphorylation of signaling molecules focal adhesion kinase, extracellular signal-regulated kinases 1 and 2, and v-Akt murine thymoma viral oncogene were observed in male MIPβ1KO islets when compared to controls. (oncotarget.com)
In addition, phosphorylation of other Tyr residues (Tyr-925, and Tyr-861) creates binding sites for SH2 domains of intracellular signaling molecules such as Src, PI3 kinase, and Grb2. (fishersci.com)
It has been shown that expression of a constitutively active type of IKK, the central activator of NF-B, in endothelial cells drives full expression of these adhesion molecules in the absence of any cytokine stimulation, indicating that the IKK/IB/NF-B axis is essential and sufficient for the pro-inflammatory activation with the endothelium (308). (adenosine-kinase.com)
Furthermore, the p130Cas-interacting kinase Pyk2 and the cytoskeletal adapter protein paxillin also demonstrate CD36-dependent phosphorylation, identifying these focal adhesion molecules as additional members of this β-amyloid signaling cascade. (neuroprobe.com)

Inhibiting Focal Adhesion Kinase (FAK), Protein Kinase B (PKB) and Extracellular Regulated Rotein Kinases (ERK) affects cell motility and survival. (aging-us.com)
Interaction with ECM is a major driver of HSC morphology [ 11 ], and signal transduction from integrin activation occurs at least partly through aggregation and subsequent activation of focal adhesion kinases (FAKs) by autophosphorylation of tyrosine 397 (Y397). (biomedcentral.com)
The absence of either FAK or Src-family kinases prevents PKL phosphorylation and suppresses localization of PKL Panobinostat but not GIT1 to focal adhesions after Rac activation. (healthyguide.info)
Manifestation of Panobinostat an triggered FAK mutant in the absence of Src-family kinases partially restores PKL localization suggesting that Src activation of FAK is required for PKL phosphorylation and localization. (healthyguide.info)
Inhibitors of tyrosine kinases decrease the level of tyrosine phosphorylation and restore a normal epithelial morphology to the ras-transformed cells. (rupress.org)
Western blot analysis was conducted, which indicated that SKLB1002 inhibited VEGF-induced phosphorylation of VEGFR2 kinase and the downstream protein kinases including extracellular signal-regulated kinase, focal adhesion kinase, and Src. (medkoo.com)
Tyrosine kinases Fyn and FAK interact with NCAM and undergo phosphorylation and this transiently activates the MAPK, ERK 1 and 2, cAMP response element binding protein (CREB) and transcription factors ELK and NFkB. (uni-freiburg.de)

We previously showed that Musashi-2 (MSI2) RNA-binding protein is associated with NSCLC progression by regulating several signaling pathways relevant to NSCLC. (researchgate.net)
These studies have served to highlight the role of AND-34/BCAR3 and p130Cas in cell adhesion and migration signaling pathways. (molvis.org)
Fyn, a Src kinase known to interact with CD36, co-precipitates with p130Cas and is an essential upstream intermediate in the signaling pathways leading to phosphorylation of the p130Cas substrate domain. (neuroprobe.com)
GSEA analysis found STARD12 and STARD14 were associated with glycolysis, oxidative phosphorylation and tumor related signaling pathways. (medsci.org)
We are also interested in the signaling pathways that regulate limited proteolysis catalyzed by the ADAM (a disintegrin and metalloprotease) family of proteases. (bu.edu)

Disruption of this p130Cas complex by small interfering RNA silencing inhibits p44/42 mitogen-activated protein kinase phosphorylation and microglial migration, illustrating the importance of this pathway in microglial activation and recruitment. (neuroprobe.com)
SLK promotes apoptosis through apoptosis signal-regulating kinase 1 (ASK1) and the mitogen-activated protein kinase (MAPK) p38. (umbc.edu)

Inflammatory cytokines and growth factors via RSK AKT and Protein Kinase A (PKA) induce phosphorylation of EphA2 Ser897. (aging-us.com)
Numerous cytokines and growth factors that are up-regulated in corneal cells further contribute to tissue inflammation. (medscape.com)

Apr 8, 2017 · c-Abl tyrosine kinase plays a critical role in regulating actin dynamics and migration of airway smooth muscle cells and nonmuscle cells. (renest.best)

Inhibition of cell/substrate adhesion with specific anti-integrin antibodies demonstrated that P-FAKSer732 activation is not induced by integrin clustering. (aacrjournals.org)
The fibrogenic responses, including cell proliferation, reactive oxygen species production, and collagen I expression, of NHLFs to MWCNTs were observed to be regulated by substrate stiffness in a time-dependent manner. (cdc.gov)
Focal adhesions act as molecular clutches that provide grip to the substrate for the lamellipodium to protrude forward during motility. (mechanobio.info)

In MCF10A/HER2 cells, TGF-beta enhanced cell motility, FAK phosphorylation, F-actin assembly, and focal adhesion formation and inhibited RhoA activity. (nih.gov)
Thus, FAK activity is regulated by a complex set of phosphorylation sites, and thisphospho-regulation could be important for cell motility, cell growth, cytoskeletal organization, and adhesion-dependent cell survival. (fishersci.com)
It is responsible for regulating focal adhesions during motility. (rndsystems.com)
Expression of AND-34 regulates epithelial cell growth pattern, motility, and growth factor dependence. (molvis.org)
The ArfGAP paxillin kinase linker (PKL)/G protein-coupled receptor kinase-interacting protein (GIT)2 continues to be implicated in regulating cell spreading and motility through its transient recruitment of the p21-activated kinase (PAK) to focal adhesions. (healthyguide.info)
Overexpression of the nonphosphorylated GFP-PKL Triple YF mutant stimulates cell distributing and protrusiveness much like overexpression of a paxillin mutant that does not bind PKL suggesting that failure to recruit PKL to focal adhesions interferes with normal cell distributing and motility. (healthyguide.info)

FAK plays a prominent role in tumor progression and metastasis regulating cellular processes including migration, invasion, epithelial to mesenchymal transition, and angiogenesis. (aacrjournals.org)
Recent studies suggest that intermediate filaments undergo reorganization during migration, which coordinates focal adhesion dynamics, cell contraction, and nucleus rigidity. (renest.best)
Motile cells are characterized by a front-rear polarization of the microtubule framework, which regulates all essential processes leading to cell migration through its role in cell mechanics, intracellular trafficking, and signaling. (renest.best)
PDLIM2 is a cytoskeletal and nuclear PDZ-LIM area protein that regulates the balance of Nuclear Aspect kappa-B (NFκB) and other transcription elements and is necessary for polarized cell migration. (healthweeks.com)
Our results show that we can tune cell stiffness and migration by regulating Notch activity and matrix stiffness. (5dok.org)
Eph/ephrin signaling is a cell-to-cell communication pathway, which regulates cell migration and proliferation. (5dok.org)
It is part of a microtubule-associated complex that is targeted at adhesion sites, and is required in focal adhesion turnover and in regulating cell migration. (umbc.edu)

PKL is definitely phosphorylated on tyrosine residues 286/392/592 by Src and/or FAK and these sites are required for PKL localization to focal adhesions and for paxillin binding. (healthyguide.info)
The tyrosine residues susceptible to phosphorylation are represented in red circles and their positions are numbered. (uni-freiburg.de)
Together, these data indicate that matrix stiffening promotes the phosphorylation of Src, and that Src interacts with activated FAK to phosphorylate tyrosine residues on the cytoplasmic tail of VE-cadherin, which regulate endothelial barrier junction integrity via the mediation of catenin attachment. (cornell.edu)

Intro The mammalian epithelial cell sheet consists of at least six types of cellular junctions: limited junctions (TJs), adherens junctions, desmosomes, hemidesmosomes, focal adhesions, and space junctions [1C3]. (synanet2020.com)

A) Normal MEF cells were transfected and plated on 5 μg/ml fibronectin for 180 min followed by acquisition of time-lapse images every … DISCUSSION We have recognized Src/FAK- and Rac-dependent phosphorylation of the ArfGAP PKL and identified that phosphorylation is required for PKL focal adhesion localization paxillin binding and normal cell adhesion dynamics. (healthyguide.info)

Cryopyrin (also called NALP3, PYPAF1, or NACHT, leucine-rich repeat [LRR], and PYD domains-containing protein 3) is a member of the APAF-1/NOD1-like protein family, which regulates apoptosis and inflammation. (medscape.com)

Also, in response to IONIZING RADIATION it can undergo PHOSPHORYLATION by ataxia telangiectasia mutated protein. (bvsalud.org)

Therefore abrogation of appropriate temporal-spatial rules of PKL profoundly impairs normal cell adhesion dynamics consistent with a critical part for this protein Panobinostat and its binding partners. (healthyguide.info)

Here we have identified changes in the adhesions and cytoskeletal interactions of transformed epithelial cells that contribute to their altered morphology. (rupress.org)
In particular, decreased tyrosine phosphorylation of beta-catenin is accompanied by increased interaction with both E-cadherin and the detergent insoluble cytoskeletal fraction. (rupress.org)

Focal Adhesion Kinase (FAK) and cofilin phosphorylation and RhoA Guanosine Triphosphatase (GTPase) activity Desmethyldoxepin HCl had been all improved in these spheroids in comparison to control acini. (healthweeks.com)
We conclude that PDLIM2 appearance is vital for feedback legislation from the β1-integrin-RhoA signalling axis and integration of mobile microenvironment indicators with gene appearance to regulate the polarity of breasts epithelial acini buildings. (healthweeks.com)
This was associated with dysregulation of cues from the ECM which is indicated by increased cell-cell and cell-ECM signaling through β1-integrin focal adhesion kinase (FAK) and RhoA. (healthweeks.com)

As a new modulator, lncRNAs have been shown to regulate tumor progression [ 6 ]. (oncotarget.com)

Endogenous RPTPkappa associated with EGF receptor and HER2, resulting in suppression of basal and ErbB ligand-induced proliferation and receptor phosphorylation. (nih.gov)

This cellular localization is directed by a 125 amino acid sequence at the C-terminus called the "Focal Adhesion Targeting" sequence (FAT). (fishersci.com)
Additionally, Pyk2-dependent LSR phosphorylation at Tyr-237 was required for LSR and tricellulin localization to tTJs and decreased epithelial barrier function. (synanet2020.com)

HER2 overexpression down-regulated its expression. (nih.gov)
Mechanistic studies showed that MWCNTs induced fibrogenesis of NHLFs through promoting expression and phosphorylation of focal adhesion kinase (FAK), while attenuating intracellular tension in the cells on stiff gels could increase MWCNTs uptake and thus elevate the induced fibrogenic responses. (cdc.gov)
Expression of phosphorylation-defective PLIN5 S155A in Plin5 null cells resulted in decreased rates of lipolysis and triglyceride-derived fatty acid oxidation. (uci.edu)
We now report that DU145 human prostate cancer cells with reduced levels of PAK4 expression are unable to successfully migrate in response to HGF, have prominent actin stress fibres, and an increase in the size and number of focal adhesions. (silverchair.com)
Fragile X mental retardation protein (FMRP) is one such RNA binding protein, regulating its target expression by translational control. (koreascience.kr)

Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)

Panel 4 shows sliding of adhesion and hence slight retraction of the respective section of the cell edge compared to panel 3. (mechanobio.info)

Our findings indicated a novel mechanism by which Pyk2 regulates tTJ assembly and epithelial barrier function in the mammalian epithelial cell sheet. (synanet2020.com)

Using western blotting techniques, we show that Src Y418 and VE-cadherin Y685 phosphorylation significantly increase with increasing matrix stiffness, and that FAK inhibition prevents the latter from occurring. (cornell.edu)

Due to their permeability to Ca 2+ and other cations, Piezo channel activity generates chemical as well as electrical signals in response to mechanical stimuli, allowing them to regulate a wide variety of cellular processes. (nature.com)
They are involved in multiple cellular processes in different tissues, where they regulate cell shape and position. (123dok.org)
The neural cell adhesion molecule, NCAM, is a member of the immunoglobulin (Ig) superfamily and is involved in a variety of cellular processes of importance for the formation and maintenance of the nervous system. (uni-freiburg.de)

Focal Adhesion Kinase (FAK) is a cytoplasmic tyrosine kinase that colocalizes with integrins in focal adhesions. (fishersci.com)

AND-34/BCAR3 (Breast Cancer Anti-Estrogen Resistance 3) associates with the focal adhesion adaptor protein, p130CAS/BCAR1. (molvis.org)
Basal levels of p130Cas phosphorylation were higher in AND-34 +/+ than in AND-34 −/− lens epithelium. (molvis.org)

The T cells maturation occurs in the thymus and it is regulated by a threshold that defines the limit between the positive and the negative selection of thymocytes. (wikipedia.org)
The protrusions of the cell edge are shown as green arrows corresponding to points of adhesion maturation (panels 3 and 4). (mechanobio.info)

Moreover, these cells have a concomitant reduction in cell-adhesion turnover rates. (silverchair.com)

For example, cell adhesion to a fibronectin substratum involves concurrent activation of Src and phosphorylation of the FAK activation loop. (fishersci.com)

Integrin-FAK signaling has been shown to activate a number of biological mechanisms through phosphorylation and protein-protein interactions promoting tumorigenesis. (aacrjournals.org)

In this study, we performed Reverse Protein Phase Array (RPPA) analysis of murine lung cancer, which suggests that VEGFR2 protein is strongly positively regulated by MSI2. (researchgate.net)

FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)

Upon exposure to physical or biochemical stimuli, remarkable platelet shape changes precede aggregation or adhesion. (koreascience.kr)
Platelets shape changes facilitate the formation and adhesion of platelet aggregates, but are readily reversible in contrast to the irrevocable characteristics of aggregation and adhesion. (koreascience.kr)

Furthermore, we demonstrated that membrane type-one matrix metalloproteinase activity inhibition can nullify the effect that matrix stiffening has on vascularization ex ovo, and that inhibiting the phosphorylation of FAK tyrosine residue 397 (Y397) can alleviate stiffness-induced hyperpermeability in vitro and ex ovo. (cornell.edu)

The mechanical force that activates Piezo1 arises from Myosin II phosphorylation by Myosin Light Chain Kinase. (nature.com)

Throughout cell-material interaction, adhesion is influenced by the features of a biomaterial surface, comprising topography and physicochemical properties. (alliedacademies.org)

The corneal wound repair process is intricately linked to a complex inflammatory response that must be precisely regulated to ensure proper healing. (medscape.com)

Previous studies in neural and endothelial cells (EC) have shown a new role for FAK in the regulation of centrosome functions during mitosis dependent on Ser732 phosphorylation. (aacrjournals.org)
Also, there seems to be a synergistic effect of TNF and thrombin in regulating endothelial permeability (303). (adenosine-kinase.com)

The threshold for positive and negative selection of developing T cells is regulated by the bound between the Lck and co-receptors. (wikipedia.org)
In cells expressing RPTPkappa RNAi, phosphorylation of Src at Tyr527 was increased and (activating) phosphorylation of Src at Tyr416 was reduced. (nih.gov)
The resistance of cells on a biomaterial to compressive, tensile, or shear forces largely depends on the cell adhesion strength [ 8 ]. (alliedacademies.org)
While Akt Ser 473 phosphorylation was readily detectable in AND-34 +/+ lens epithelial cells, it was markedly reduced in the AND-34 −/− lens epithelium. (molvis.org)
These results demonstrate the loss of AND-34 dysregulates focal adhesion complex signaling in lens epithelial cells and suggest that AND-34-mediated signaling is required for maintenance of the structural integrity of the adult ocular lens. (molvis.org)
Using MCF-10A human breast epithelial cells as a model system, we have found that transformation by an activated form of ras is characterized by less developed adherens-type junctions between cells but increased focal adhesions. (rupress.org)
We sought to identify PKA phosphorylation sites in PLIN5 and assess their functional relevance in cultured cells and the livers of mice. (uci.edu)

Platelets play an essential role in hemostasis through aggregation and adhesion to vascular injury sites but their unnecessary activation can often lead to thrombotic diseases. (koreascience.kr)

LAT acts as a scaffold able to regulate the TCR proximal signals in a phosphorylation-dependent manner. (wikipedia.org)
FACS analysis showed that the P-FAKSer732 decreased upon treatment with the MEK inhibitor UO126 in a dose-dependent manner together with the levels of P(Ser 10) -Histone H3 thus demonstrating that FAK is involved in the mitotic process regulated by MEK/ERK activation. (aacrjournals.org)
The non-classical pathway refers to EphA2 ligands and tyrosine kinase non-dependent activation and phosphorylation. (aging-us.com)
Slack, B.E. and Blusztajn, J.K. (2008) Differential regulation of mTOR-dependent S6 phosphorylation by muscarinic acetylcholine receptor subtypes. (bu.edu)

This binding leads to the Tec family kinase ITK-mediated PLC-γ1 phosphorylation and activation that consequentially produce calcium (Ca2+) ions mobilization. (wikipedia.org)
Both cell adhesion and Rac activation stimulated PKL tyrosine phosphorylation. (healthyguide.info)

This study aimed to investigate the mechanical adhesion strength of the Connective Tissue Equivalents (CTEs) to the Ceria-stabilized Tetragonal Zirconia Polycrystal/Alumina (Ce-TZP/Al 2 O 3 ) surface. (alliedacademies.org)
Furthermore, the mechanical adhesion strength of CTEs to the disk surface was measured using the nano-scratch test. (alliedacademies.org)
This study provides the first evidence for the mechanical adhesion strength of CTEs to Ce-TZP/Al 2 O 3 and Ti surfaces. (alliedacademies.org)
Connective tissue equivalents, Mechanical adhesion strength, Nano-scratch test. (alliedacademies.org)

Although Piezo1 channels diffuse readily in the plasma membrane and are widely distributed across the cell, their flicker activity is enriched near force-producing adhesions. (nature.com)

In this minireview, we chronicle the research that led to the recent discovery of forkhead box L2 (FOXL2) as an essential mediator of activin-regulated FSH beta subunit ( Fshb ) transcription in vitro and in vivo. (bioone.org)

The establishment of neural circuits depends on the ability of axonal growth cones to sense their surrounding environment en route to their target. (biologists.com)

Anatomy33

Organisms7

Diseases3

Chemicals and Drugs147

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Phenomena and Processes45

Disciplines and Occupations1

Information Science3

Proteins10

Cytoskeleton9

Extracellular Matrix5

Kinase regulates1

Disassembly5

Molecules4

Kinases7

Pathways5

Mitogen-activa2

Cytokines and growth factors2

Role in regul1

Substrate3

Motility6

Migration7

Residues3

Adherens junctions1

Paxillin1

Apoptosis1

Undergo1

Dynamics1

Cytoskeletal2

RhoA3

Tumor progression1

Proliferation1

Localization2

Expression5

Intracellular1

Retraction1

Pyk21

Matrix stiffness1

Cellular processes3

Cytoplasmic1

P130Cas2

Maturation2

Turnover1

Fibronectin1

Tumorigenesis1

VEGFR21

Protein-protein inte1

Platelet2

Stiffness1

Activates1

Interaction1

Inflammatory1

Endothelial2

Cells7

Aggregation1

Dependent4

Activation2

Mechanical4

Activity1

Mediator1

Growth1