• In this process, the SHP2 tyrosine phosphatase plays a crucial role in a mechanism that includes an acyl-CoA synthetase-4 (Acsl4), arachidonic acid (AA) release and StAR induction. (conicet.gov.ar)
  • In murine models, PTPN22 deficiency resulted in pronounced colitis, increased NLRP3 phosphorylation, but reduced levels of mature IL-1β. (uzh.ch)
  • Searching for proteins in platelets that can interact with the N-terminal SH3 domain of CrkL (using a combination of a pull-down assay followed by mass spectrometry), we have found that human platelets express DOCK5, a putative Rac guanine nucleotide exchanger, as a CrkL-binding protein. (nii.ac.jp)
  • By mass spectrometry, we found that the proteins, which reportedly interact with WAVE/Scars, are present in platelets. (nii.ac.jp)
  • Thus, we have effectively employed mass spectrometry to demonstrate hitherto unreported proteins in platelets and their interactions. (nii.ac.jp)
  • One of the most extensively investigated inflammasomes is nucleotide and oligomerization domain, leucine-rich repeat containing protein family, pyrin containing domain 3 (NLRP3) in innate immune cells including macrophages. (frontiersin.org)
  • NLRP3 protein) ( 3 ). (frontiersin.org)
  • Thioredoxin-interacting protein (TXNIP) is an α-arrestin family member and acts as a scaffold protein with several protein-protein interacting domains. (ahajournals.org)
  • Using specific antibodies against isoforms of WAVE (WASP [Wiskott-Aldrich syndrome protein] family Verprolin-homologous protein, also called Scar), we demonstrated that human platelets express all 3 isoforms. (nii.ac.jp)
  • We performed a mutational analysis of the PTP gene family in cutaneous metastatic melanoma and identified 23 phosphatase genes harboring somatic mutations. (sigmaaldrich.com)
  • Journal Article] Thrombopoietin upregulates nucleolin mRNA and protein in thrombopoietin-dependent megakaryocytic cell line, UT-7/TPO. (nii.ac.jp)