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  • stabilization
  • At least 80% of clear cell renal carcinomas exhibit inactivation of the VHL gene, which leads to HIF-α protein stabilization and constitutive HIF activation. (frontiersin.org)
  • The mechanism of p53 stabilization after ribosome biogenesis inhibition is a multistep process, depending on specific factors that can be altered in tumor cells, which can affect the antitumor efficacy of ribosome biogenesis inhibitors (RiBi). (biomedcentral.com)
  • Since p53 stabilization and activation is a multistep and tightly regulated process, in principle, the prerequisite for the antitumor efficacy of drugs inhibiting ribosome biogenesis should be the presence in the tumor cells, other than a normally functioning p53, also of those factors necessary for the activation of p53 and the induction of a p53-mediated cell cycle arrest and/or the apoptosis. (biomedcentral.com)
  • vitro
  • Herein we used shRNA depletion and a novel lactate dehydrogenase (LDHA) inhibitor, GNE-140, to probe the role of LDHA in tumor growth in vitro and in vivo. (stanford.edu)
  • inhibitors
  • However, due to the high degree of structural homology within the CDK protein family, putative small-molecule CDK inhibitors may exert their effects through combinatorial inhibition of multiple CDKs and other closely related serine/threonine kinases. (aacrjournals.org)
  • Thus, combining an LDHA inhibitor with compounds targeting the mitochondrial or AMPK-S6K signaling axis may not only broaden the clinical utility of LDHA inhibitors beyond glycolytically dependent tumors but also reduce the emergence of resistance to LDHA inhibition. (stanford.edu)
  • mitochondrial
  • Expression of CHCHD4, a key component of the disulphide relay system (DRS) involved in mitochondrial protein import within the intermembrane space (IMS) was elevated by pVHL re-expression alongside enhanced expression of respiratory chain subunits of complex I (NDUFB10) and complex IV (mtCO-2 and COX IV). (frontiersin.org)
  • Expression of pVHL mutant proteins (R200W, N78S, D126N, and S183L) that constitutively stabilize HIF-α but differentially promote glycolytic metabolism, were also found to differentially promote the pVHL-mediated mitochondrial phenotype. (frontiersin.org)
  • novel
  • Using a yeast two-hybrid screen and coimmunoprecipitation assays, we identified a novel KS-Bcl-2-interacting protein, referred to as protein interacting with carboxyl terminus 1 (PICT-1), encoded by a candidate tumor suppressor gene, GLTSCR2. (pubmedcentralcanada.ca)
  • In the present study, we have established novel tumor models for analysis of cell growth and signal transduction after long-term treatment with antiandrogens. (aacrjournals.org)
  • Here, we establish a novel role for PKD3, the least studied member of the PKD family, in the regulation of prostate cancer cell growth and motility through modulation of secreted tumor-promoting factors. (aacrjournals.org)
  • ubiquitin
  • BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases. (semanticscholar.org)
  • A ubiquitin-activating enzyme (E1) activates ubiquitin in an ATP-dependent manner, and the ubiquitin is then transferred to a ubiquitin-conjugating protein (E2), which works in concert with a ubiquitin-protein ligase (E3) to conjugate the target protein at lysine residues. (aacrjournals.org)
  • Ubiquitylation of target proteins is mediated by the sequential action of 3 enzymes: a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin ligase (E3). (pubmedcentralcanada.ca)
  • sequence
  • KSHV open reading frame 16 (orf16) encodes the KS-Bcl-2 protein, which shares sequence and functional homology with the Bcl-2 family ( 9 , 31 ). (pubmedcentralcanada.ca)
  • Recombinant funsion protein containing a sequence corresponding to amino acids 1-289 of human CCND2 (NP_001750.1). (genetex.com)
  • genes
  • This phosphorylation releases Rb-mediated inhibition of E2F transcription activity, which is necessary for the transcription of genes essential for entry into S phase. (aacrjournals.org)
  • Sequential activation of the cyclin D1-dependent kinases followed by the cyclin E-dependent kinases seems to be necessary for the orchestrated phosphorylation of Rb and derepression of E2F-dependent genes. (aacrjournals.org)
  • Expression profiling was carried out on samples of 7 benign, 7 LMP and 28 invasive (moderate and poorly differentiated) serous tumors and four whole normal ovaries using oligonucleotide microarrays representing over 21,000 genes. (biomedcentral.com)
  • Five genes that were differentially expressed between invasive and either benign or normal tissues were validated by real time PCR in an independent panel of 46 serous tumors (4 benign, 7 LMP, 35 invasive). (biomedcentral.com)
  • mice
  • First, we showed that SC myelination was arrested in Rac1-CKO mice and that Rac1 knock-out abrogated phosphorylation of PAK and decreased NF2/merlin phosphorylation. (jneurosci.org)
  • Here, we show that mice deleted for the tumour suppressor LKB1 (also called STK11 ) in the spinal cord, some parts of the brain and in the endocrine pancreas (βLKB1KO mice) develop hind-limb dysfunction and axon degeneration at about 7 weeks. (biologists.org)
  • CCND2
  • The researchers identified several mutations that may contribute as cooperating mutations, including changes in CCND2 , a gene that makes a protein involved in the cell cycle. (thefreedictionary.com)
  • therapeutic
  • Metabolic reprogramming in tumors represents a potential therapeutic target. (stanford.edu)
  • However, despite early interventions and chemopreventive measures, therapeutic options are limited once prostate tumors have metastasized ( 2 ). (aacrjournals.org)
  • cells
  • Energy metabolism of tumor cells. (springer.com)
  • Scientists report in a new study that by imitating a natural process of cells, they prevented the formation of protein clumps associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. (medicalxpress.com)
  • Regulation
  • All cell strains with an AT-like and one quarter with an ATH-like RDS were found to be defective in the radioinduction of both p 53 and p 21 proteins, which are concerned with cell cycle regulation. (ahajournals.org)