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  • Acetylation
  • Overall, our study suggests that S -glutathionylation and phosphorylation of IKKα plays an important role in histone acetylation on proinflammatory gene promoters and NF-κB-mediated abnormal and sustained lung inflammation in pathogenesis of chronic inflammatory lung diseases. (physiology.org)
  • It is well known that CS exposure causes inflammation in the lung by activation of redox-sensitive NF-κB via phosphorylation/acetylation of its subunit, RelA/p65 ( 11 , 39 , 54 ). (physiology.org)
  • nuclear
  • Protein O-GlcNAcylation occurs in all animals and plants and is implicated in modulation of a wide range of cytosolic and nuclear protein functions, including gene silencing, nutrient and stress sensing, phosphorylation signaling, and diseases such as diabetes and Alzheimer's. (pnas.org)
  • Thus, Tax-mediated increases in NF-kappaB nuclear translocation result from direct interactions of Tax and MEKK1 leading to enhanced IKKbeta phosphorylation of IkappaB alpha. (nih.gov)
  • nucleus
  • Binding of various ligands to their cognate cell surface receptors, results in phosphorylation of STAT3 molecules that further dimerizes with each other at SH2 domain and gets translocated to the nucleus. (hindawi.com)
  • molecules
  • Two motifs that are centered on Y74 and Y85 are spaced 7 residues apart to form an immunoreceptor tyrosine-based activation motif (ITAM) commonly found in Fc receptors and signal molecules of B-cell and T-cell receptors. (wikipedia.org)
  • Gene
  • Its phosphorylation and gene expression are regulated throughout development and in response to extracellular signals regulating cell proliferation, differentiation and function. (wikipedia.org)
  • regulatory
  • The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. (genecards.org)
  • Phosphorylation is the most heavily studied regulatory PTM, and proteomic approaches for global enrichment, detection, and characterization of this modification have provided the basis of our current knowledge of the complexity and redundancy in cell signaling networks ( 12 - 16 ). (pnas.org)
  • activity
  • Deletion of the C-terminal 33 residues resulted in reduced phosphatidylserine-dependent ATPase activity, phosphatidylserine flippase activity, and neurite extension in PC12 cells. (pubmedcentralcanada.ca)
  • Most interestingly, in analogy to phosphorylation, synaptic activity leads to a dynamic modulation of O-GlcNAc levels ( 10 ) and is also involved in long-term potentiation and memory ( 11 ). (pnas.org)
  • Activation of the PI3K pathway leads to AKT phosphorylation, triggering a downstream cascade of events that are likely to interact with AR transcriptional activity. (aacrjournals.org)
  • domain
  • We propose a model in which the C-terminus of ATP8A2 consists of an autoinhibitor domain upstream of the C-terminal 33 residues and an anti-autoinhibitor domain at the extreme C-terminus. (pubmedcentralcanada.ca)
  • These two iso forms of LMP2 only differ in that LMP2A contains an extra 119 residue N-terminal domain encoded in exon 1. (wikipedia.org)
  • functions
  • The limiting factor impeding rapid progress in deciphering the biological functions of protein O-GlcNAcylation has been the inability to easily identify exact residues of modification. (pnas.org)