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Cardiac MyosinsMyosin Light ChainsMyosinsMyosin-Light-Chain KinaseMyocardiumMyosin-Light-Chain PhosphataseMyosin Heavy ChainsMyosin SubfragmentsImmunoglobulin Light ChainsPhosphorylationMyosin Type IILightGizzardMuscle, Smoothrho-Associated KinasesCalmodulinActinsAmino Acid SequenceMolecular Sequence DataAzepinesActomyosinRabbitsCalciumMusclesChickensMyosin Type VMuscle ContractionTurkeysKineticsNonmuscle Myosin Type IIAProtein KinasesPhosphoprotein PhosphatasesPeptide FragmentsVentricular MyosinsNonmuscle Myosin Type IIBCells, CulturedElectrophoresis, Polyacrylamide GelAdenosine TriphosphatasesCattleEnzyme ActivationProtein BindingAmidesBase SequenceMyocytes, CardiacActin CytoskeletonProtein Kinase CProtein-Serine-Threonine KinasesEnzyme InhibitorsSarcomeresMyocarditisrhoA GTP-Binding ProteinMuscle ProteinsMolecular WeightCa(2+) Mg(2+)-ATPaseImmunoglobulin kappa-ChainsCalmodulin-Binding ProteinsMyosin Type IPhosphoproteinsSmooth Muscle MyosinsBinding SitesMyofibrilsCell LineImmunoglobulin lambda-ChainsHeterocyclic Compounds with 4 or More RingsIntracellular Signaling Peptides and ProteinsHeartCytoskeletonAdenosine TriphosphateNaphthalenesMuscle, Smooth, VascularTropomyosinMutationTime FactorsSignal TransductionMyocardial ContractionSerineProtein IsoformsBlotting, WesternCarrier ProteinsGene Rearrangement, B-Lymphocyte, Light ChainMuscle, SkeletalPolymerase Chain ReactionRecombinant Proteinsrho GTP-Binding ProteinsSwineMolecular Motor ProteinsHeart VentriclesStress FibersProtein Phosphatase 1RNA, MessengerOxazolesIsoenzymesPeptide MappingPotassium ChlorideTroponinPhosphopeptidesProtein ConformationImmunoglobulin Heavy ChainsPyridinesIsometric Contraction

KinasePhosphataseKinasesIsoformsTroponinMyocytesSkeletal muscleProteinsRegulatoryMyocardialContractionProteinMuscleFunctionOutput

Kinase5

• With less calcium available to combine with calmodulin, there is less activation of myosin light chain kinase and phosphorylation of myosin light chains ( click here for details ). (cvpharmacology.com)
• In h-RA phosphorylation of ribosomal S6-kinase II (RSK2-S227) was significantly higher than in h-MA. (bvsalud.org)
• These mice were produced in a C57BL/6N background which lack MLCK3, the main regulatory light chain kinase in cardiac myocytes. (bvsalud.org)
• Key role of myosin light chain (MLC) kinase-mediated MLC2a phosphorylation in the alpha 1-adrenergic positive inotropic effect in human atrium. (nih.gov)
• small GTPase Rho A and its own downstream effector Rho kinase have already been shown to play an important role in the regulation of vascular easy muscle contraction (2 22 28 Clean muscle contraction is mediated by the phosphorylation of myosin light chains and the extent of myosin light chain phosphorylation is regulated by the opposing activities of myosin light chain kinase and phosphatase. (academicediting.org)

Phosphatase4

• Myosin phosphatase (MP) is an enzyme complex that regulates muscle contraction and plays important roles in various physiological and pathological conditions. (bvsalud.org)
• Myosin phosphatase targeting subunit (MYPT) 2, a subunit of MP, interacts with protein phosphatase 1c to regulate its phosphatase activity. (bvsalud.org)
• This was associated with higher ROK-dependent phosphorylation of the regulatory subunit of myosin light-chain-phosphatase (MLCP), MYPT1-T853. (bvsalud.org)
• The predominant MLC phosphatase found in cardiac myocytes contains Myosin Phosphatase Targeting Subunit 2 (MYPT2). (bvsalud.org)

Kinases1

• The level of MLC-2v phosphorylation is dependent on the opposing activities of MLC kinases and phosphatases. (bvsalud.org)

Isoforms1

• Differential regulation of the atrial isoforms of the myosin light chains during striated muscle development. (nih.gov)

Troponin1

• An increase in blood cardiac troponin levels thus indicates cardiac muscle tissue damage. (amboss.com)

Myocytes2

• The coordinated interaction of the myofilaments actin and myosin within the myocytes gives muscle tissue the ability to contract. (amboss.com)
• In myocardial infarction , cardiac myocytes are damaged as a result of absolute oxygen deficiency and release their intracellular content into the bloodstream. (amboss.com)

Skeletal muscle1

• Of the freely available peer-reviewed resources appropriate for revision of this topic, none beat Sweeney & Hammers (2018) , as this review covers all possible examinable topics and has sections comparing skeletal muscle to smooth and cardiac muscle. (derangedphysiology.com)

Proteins2

• Regulatory proteins prevent permanent interaction between myosin and actin . (amboss.com)
• PKC phosphorylation of these proteins also inhibits their binding to RNA in vitro. (embl.de)

Regulatory2

• Basal and α 1 adrenergic receptor stimulation-induced phosphorylation of the regulatory light chain of myosin (MLC 20 ) was higher in h-RA than in h-MA. (bvsalud.org)
• Cardiac contraction is modulated by the phosphorylation state of myosin regulatory light chain 2 (MLC-2v). (bvsalud.org)

Myocardial1

• Given the current convincing evidence that myocardial injury intensifies the severity of COVID-19, cardiac management should be a priority for physicians. (biomedcentral.com)

Contraction1

• Thin filaments form a foundation over which myosin slides during contraction. (amboss.com)

Protein1

• Myofilaments are protein fibers consisting of thick ( myosin ) and thin ( actin ) filaments and are responsible for the contractile properties of muscle cells. (amboss.com)

Muscle5

• Trying to guess the examiners' minds from the way this syllabus item is positioned (in the "musculoskeletal" section), we can infer that the detailed anatomy and physiology of cardiac muscle is probably intended for the cardiovascular section , and what they wanted from us here is more of a comparison of the ultrastructural elements that distinguish the three muscle types. (derangedphysiology.com)
• Depending on the intracellular arrangement of these myofilaments , muscle tissue is classified as either striated (skeletal and cardiac) or nonstriated (smooth) muscle. (amboss.com)
• Cardiac muscle is also under involuntary control of cardiac pacemaker cells and forms the walls of the cardiac chambers ( myocardium ). (amboss.com)
• Expression and function of non-muscle myosin-IIA in Fechtner syndrome]. (nih.gov)
• Functional divergence of human cytoplasmic myosin II: kinetic characterization of the non-muscle IIA isoform. (nih.gov)

Function1

• however, the effect of knocking out MYPT2 on cardiac function is unknown. (bvsalud.org)

Output1

• Cardiac output was measured from the thermodilution technique having a Cardiomax III Thermodilution Cardiac Ouput Computer (Columbus Devices). (academicediting.org)