Phosphorylation nerve tissue proteins. Medical search. Frequent questions

These data indicate that the effects of H(2)S on background K channels are a consequence of inhibition of oxidative phosphorylation. (ox.ac.uk)
contains the enzyme systems required for the citric acid cycle, fatty acid oxidation, electron transfer, and oxidative phosphorylation. (flashcardmachine.com)
It encompasses the conversion of nutrients into energy through various metabolic pathways, such as glycolysis, Krebs cycle, and oxidative phosphorylation. (smashessays.com)
Magnesium is a modulator of oxidative phosphorylation, during which electrons are transferred from electron donors to electron acceptors (such as oxygen in redox reactions), using magnesium as a cofactor. (hippocrates.com.au)
Magnesium is required for energy production, oxidative phosphorylation, and glycolysis. (nih.gov)
Cellular respiration (oxidative phosphorylation) occurs in the mitochondria, where a series of enzymes catalyze the transfer of electrons to molecular oxygen and the generation of energy-storing adenosine triphosphate (ATP). (msdmanuals.com)
Tissues with a high energy demand (eg, brain, nerves, retina, skeletal and cardiac muscle) are particularly vulnerable to defects in oxidative phosphorylation. (msdmanuals.com)
Increase in the lactate:pyruvate ratio distinguishes oxidative phosphorylation defects from other genetic causes of lactic acidosis. (msdmanuals.com)

Background: Members of the 14-3-3 family of proteins are highly conserved proteins, localized in neurons, and are axonally transported to the nerve terminals. (icbinhibitor.com)
In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons. (arigobio.cn)
f) Neurotransmitter: Neurotransmitters are chemical messengers that transmit signals between nerve cells (neurons). (smashessays.com)
DARPP-32 (dopamine- and cAMP-regulated phosphorprotein, Mr = 32,000 as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis) is an inhibitor of protein phosphatase-1 and is enriched in dopaminoceptive neurons possessing the D1 dopamine receptor. (cornell.edu)

Activation of these receptors sustained the undifferentiated state of GICs in culture by negatively modulating the action of bone morphogenetic proteins, which physiologically signal through the phosphorylation of the transcription factors, Smads. (nih.gov)
The cross-talk between mGlu3 receptors and BMP receptors was mediated by the activation of the mitogen-activated protein kinase pathway. (nih.gov)
The channel domains of the Ry and IP3 receptors comprise a coherent family that shows apparent structural similarities as well as sequence similarity with proteins of the VIC family (TC #1.A.1). (wikipedia.org)
Afferent nerve fibers run from the receptors via the dorsal penile nerve and pudendal nerve into the spinal cord. (urology-textbook.com)
For example, prostaglandins activate G s -protein-coupled receptors and initiate cAMP- and protein kinase A (PKA)-mediated processes. (jneurosci.org)
The diversified effects of cannabinoids are now known to be mediated through the activation of G-protein-coupled receptors that are normally bound by a family of endogenous ligands, the endocannabinoids ( 1 ). (aacrjournals.org)
Two cannabinoid receptors have been characterized and cloned from mammalian tissues: the "central" CB 1 receptor and the "peripheral" CB 2 receptor. (aacrjournals.org)
These peripheral cold receptors, both Aδ- and C-fibers, have thermal thresholds (i.e., the temperature at which nerve impulses are generated) for cold activation between 30-20°C, temperatures considered to be innocuously cool [ 4 , 6 ]. (nih.gov)
The human SA node contains a more than 3-fold greater density of beta-adrenergic and muscarinic cholinergic receptors than the adjacent atrial tissue. (medscape.com)

Phosphorylase kinase, a Ca2+ sensitive enzyme, is shown to specifically catalyse the phosphorylation of this 40,000 dalton protein. (ox.ac.uk)
PKG: protein kinase G. (frontiersin.org)
Immunohistochemical and biochemical investigations of Ca2+/calmodulin-dependent protein kinase II(CaM kinase II) and protein phosphatase (calcineurin) after transient forebrain ischemia demonstrated that the activity of CaM kinase II was decreased in the CA1 region of the hippocampus early (6-12 hours) after ischemia. (nih.gov)
Evidence indicates 14-3-3 is required for Raf-1 kinase activity and phosphorylation amoung many other functions. (icbinhibitor.com)
Cdk1 (cyclin-dependent kinase 1), also known as p34Cdc2 (cell division control protein kinase 2) depends on cyclin A and B and is triggered by a positive feedback loop at the end of G2 phase, which is the key event that initiates mitotic entry. (arigobio.cn)
The translocation and the current potentiation were abolished in the presence of an A-kinase anchoring protein (AKAP) inhibitor. (jneurosci.org)
Activator of protein kinase A (cyclic AMP agonist). (biolog.de)
Phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by casein kinase II. (cornell.edu)
Purified bovine DARPP-32 was phosphorylated in vitro by casein kinase II to a stoichiometry greater than 2 mol of phosphate/mol of protein whereas two structurally and functionally related proteins, protein phosphatase inhibitor-1 and G-substrate, were poor substrates for this enzyme. (cornell.edu)
The phosphorylated residues are located NH2-terminal to acidic amino acid residues, a characteristic of casein kinase II phosphorylation sites. (cornell.edu)
In vitro, DARPP-32 phosphorylated by casein kinase II was dephosphorylated by protein phosphatases-1 and -2A. (cornell.edu)
Phosphorylation by casein kinase II did not affect the potency of DARPP-32 as an inhibitor of protein phosphatase-1, which depended only on phosphorylation of Thr34 by cAMP-dependent protein kinase. (cornell.edu)
However, phosphorylation of DARPP-32 by casein kinase II facilitated phosphorylation of Thr34 by cAMP-dependent protein kinase with a 2.2-fold increase in the Vmax and a 1.4-fold increase in the apparent Km. (cornell.edu)
Phosphorylation of DARPP-32 by casein kinase II in intact cells may therefore modulate its phosphorylation in response to increased levels of cAMP. (cornell.edu)
A multifunctional calcium-calmodulin-dependent protein kinase subtype that occurs as an oligomeric protein comprised of twelve subunits. (curehunter.com)
It differs from other enzyme subtypes in that it lacks a phosphorylatable activation domain that can respond to CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE KINASE. (curehunter.com)
In 2001, mutations were discovered in the IKB kinase-complex-associated protein ( IKBKAP ) gene, with a major haplotype mutation located in the donor splice site of intron 20. (medscape.com)

Trifluoperazine inhibits hippocampal long-term potentiation and the phosphorylation of a 40,000 dalton protein. (ox.ac.uk)
Brief high frequency stimulation induces long-term potentiation (LTP) and changes in the endogenous phosphorylation of a 40,000 dalton protein in the hippocampus in a calcium-dependent manner. (ox.ac.uk)
In addition, calmodulin stimulates and TFP inhibits the phosphorylation of the 40,000 dalton protein (as well as that of several other proteins) in a dose-dependent fashion. (ox.ac.uk)
The data are discussed in terms of a working model in which the Ca2+ dependent phosphorylation of the 40,000 dalton protein produced by high frequency stimulation is a biochemical intermediate in the production of LTP. (ox.ac.uk)

The complexes include signaling proteins such as 4 FKBP12 molecules, protein kinases, phosphatases, etc. (wikipedia.org)
Because 14-3-3 proteins bind to specific phosphoserine-containing sequences they are likely to have an important role in signaling pathways mediated by serine/threonine protein kinases. (icbinhibitor.com)

Data from biochemical analyses of LTP indicate that a 40,000 dalton synaptic membrane protein shows a highly reliable change in its endogenous phosphorylation following high frequency hippocampal stimulation. (ox.ac.uk)

Multivariable regression analyses were used to examine the associations among protein modules, AD diagnoses, cerebrospinal fluid (CSF) phosphorylated tau (p-tau), and brain glucose metabolism, stratified by APOE genotype. (bvsalud.org)
Liver mitochondrial cristae organizing protein MIC19 promotes energy expenditure and pedestrian locomotion by altering nucleotide metabolism. (harvard.edu)
Metabolism also involves the synthesis and breakdown of biomolecules, including proteins, carbohydrates, and lipids. (smashessays.com)

The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. (lookformedical.com)
Studies employing synthetic peptides encompassing each phosphorylation site confirmed this difference between the kcat values for phosphorylation of the two sites. (cornell.edu)

In conditions with primary optic atrophy (eg, pituitary tumor, optic nerve tumor, traumatic optic neuropathy, multiple sclerosis), optic nerve fibers degenerate in an orderly manner and are replaced by columns of glial cells without alteration in the architecture of the optic nerve head. (medscape.com)
Optic nerve fibers exhibit marked degeneration, with excessive proliferation of glial tissue. (medscape.com)
In addition to these four pathways, tumors can undergo infiltration around nerve fibers and metastasis along nerves, that is, perineural invasion (PNI), which refers to the phenomenon of perineural invasion by tumor cells filling the perineurial space, wrapping around nerves in a continuous concentric sheath-like pattern, infiltration, and metastasis of extension along nerves around nerve fibers or into perineurium within the perineurium [ 7 ]. (hindawi.com)
Within this muscle and protective tissue there may be thousands of muscle fibers (also known as muscle cells) that are bundled together and wrapped in another connective tissue covering called the endomysium . (mokshayogaamazonica.com)
Above mentioned centers send nerve fibers to the inferior hypogastric plexus, which are passed on to the pelvic organs. (urology-textbook.com)
The cavernous nerves of the penis consist of autonomic nerve fibers from the inferior hypogastric plexus. (urology-textbook.com)
In the membranous portion of the urethra, the nerve fibers are located between 3 and 9 o'clock. (urology-textbook.com)
In addition, nerve fibers accompany the arteries or sensory nerves. (urology-textbook.com)
The autonomic nerve fibers innervate the helicine arteries. (urology-textbook.com)
The conducting system of the heart consists of cardiac muscle cells and conducting fibers (not nervous tissue) that are specialized for initiating impulses and conducting them rapidly through the heart (see the image below). (medscape.com)

Regulation of neurabin I interaction with protein phosphatase 1 by phosphorylation. (cornell.edu)
Here we show that neurabin I binds protein phosphatase 1 (PP1) and inhibits PP1 activity. (cornell.edu)

Glial cell line-derived neurotrophic factor family receptor alpha (GFRα) members have been widely connected to the mechanisms contributing to cell growth, differentiation, cell migration and tissue maturation. (medsci.org)
Based on whether it cooperates with the second receptor RET, GFRα has also been widely linked to the mechanisms that contribute to cell growth, differentiation and migration and tissue maturation. (medsci.org)
Similar current changes after PKA activation were obtained from human embryonic kidney 293t cells transfected with the wild-type heat transducer protein vanilloid receptor 1 (VR-1). (jneurosci.org)
Receptor dimerization and autophosphorylation attracts proteins containing Src homology 2 (SH2) or phosphotyrosine binding (PTB) domains including adaptor proteins like FRS2 and GRB2. (springer.com)

Since the protein lacks enzymatic activities, it will be difficult to develop chemical compounds capable to directly and specifically modulate Sprouty functions. (springer.com)

Inactivation of p300 acetyltransferase reversed the resveratrol-induced expression of VEGFs and motor repair in rats that had undergone sciatic nerve crush injury. (vinomis.com)

We hypothesized that an imbalance of Ca2+/calmodulin dependent protein phosphorylation-dephosphorylation may be involved in delayed neuronal death after ischemia. (nih.gov)

Publications] Sasaki,T.: 'A mammalian inhibitory GDP/GTP exchange protein(GDI)for smg p25A is active on the yeast SEC4 protein. (nii.ac.jp)
In the early to mid-twentieth century, a number of laboratories began to observe cold-induced electrical impulses when recording from mammalian sensory nerves. (nih.gov)

Any of the enzymatically catalyzed modifications of the individual AMINO ACIDS of PROTEINS, and enzymatic cleavage or crosslinking of peptide chains that occur pre-translationally (on the amino acid component of AMINO ACYL TRNA), co-translationally (during the process of GENETIC TRANSLATION), or after translation is completed (POST-TRANSLATIONAL PROTEIN PROCESSING). (lookformedical.com)

Members of this family are large proteins, some exceeding 5000 amino acyl residues in length. (wikipedia.org)
Polyprenol found in animal tissues that contains about 20 isoprene residues, the one carrying the alcohol group being saturated. (lookformedical.com)
We have found that the C-terminal systeine residues of smg p21B, rhoA p21, and smg p25A are geranylgeranylated, and that these prenylation are essential for each small G protein to bind to membranes. (nii.ac.jp)
A glutathione S-transferase (GST)-neurabin I fusion protein (residues 318-661) containing the putative PP1 binding domain (residues 456-460) inhibited PP1 activity (K(i) = 2.7 +/- 1.2 nM). (cornell.edu)
Phosphorylation of GST-neurabin I (residues 318-661) by PKA significantly reduced its binding to PP1 by overlay and by glutathione-Sepharose coprecipitation assays. (cornell.edu)

These approaches have achieved bioengineered skeletal muscle tissue fabrication with cellular alignment in vitro, and some showed a degree of therapeutic potential in vivo. (nature.com)
Also, a vascularization strategy using co-culture with endothelial cells (ECs) and fibroblasts improved the survival of the bioengineered skeletal muscle tissues 20 , 21 . (nature.com)
While host nerve integration and formation of NMJs were evident within the implanted skeletal muscle constructs, we observed that the constructs did not support the full restoration of defected muscles at 8-week post-implantation, which is likely due to the delayed integration of host nerve. (nature.com)
Each skeletal muscle is enveloped by a protective tissue sheath called the epimysium . (mokshayogaamazonica.com)

Developmental biologist Rita Levi-Montalcini , who in the beginning of 1950's moved from her homeland Italy, to Viktor Hamburger's laboratory in St. Louis, USA, showed in 1952 that when tumours from mice were transplanted to chick embryos they induced potent growth of the chick embryo nervous system, specifically sensory and sympathetic nerves. (nobelprize.org)
Subsequently, we used a model of neuroinvasion in nude mice to assess the effect of NGF in vivo on tumor nerve invasion as well as on nociceptive transmission. (hindawi.com)
Here, we report that mechanical pain hypersensitivity in sciatic nerve-injured mice shows pronounced diurnal alterations, which critically depend on diurnal variations in glucocorticoids from the adrenal glands. (nature.com)
To determine the pathological relevance of the diurnal secretion of adrenal glucocorticoids in neuropathic hypersensitivity, we investigated the influence of adrenalectomy on the threshold of mechanical allodynia in nerve-injured mice. (nature.com)

Proteins encoded by the mitochondrial genome or proteins encoded by the nuclear genome that are imported to and resident in the MITOCHONDRIA. (harvard.edu)
These redox reactions, called electron transport chains, form a series of protein complexes within the cell's mitochondria that release energy or ATP. (hippocrates.com.au)

In the affected ventral spinal cord, resveratrol enhanced the expression of several vascular endothelial growth factor family proteins (VEGFs) and increased the phosphorylation of p300 through Akt signaling, indicating activation of p300 acetyltransferase. (vinomis.com)
Resveratrol activated p300 acetyltransferase-mediated VEGF signaling in the affected ventral spinal cord, which may have thus contributed to the acceleration of nerve regeneration and motor repair. (vinomis.com)
SGK-1 protein levels in spinal astrocytes are increased in response to glucocorticoid stimuli and enhanced ATP release by opening the pannexin-1 hemichannels. (nature.com)
Data indicated that nestin regulated NF-kappa B (NF-kappaB) activity in foetal spinal cord tissues. (cusabio.com)

It has been reported that signaling from the nerve growth factor (NGF) pathway associated with peripheral nerves is able to contribute to perineural invasion (PNI) of pancreatic cancer (PC). (hindawi.com)
2010). Although axons in peripheral nerves have the capacity to regenerate after injury, a number of clinical reports and studies in recent years have indicated that functional recovery, especially motor function, is far from satisfactory even with advances in surgical procedures (Ruijs et al. (vinomis.com)

Dihydropyridine-sensitive channels are present in the T-tubular systems of muscle tissues. (wikipedia.org)

In this research project, we have investigated the C-terminal structures of small G proteins, purified the regulatory proteins for small G proteins, and made monoclonal antibodies against small G proteins and their regulatory proteins. (nii.ac.jp)
Among these regulatory proteins, we have cloned the cDNAs of smg p21 GDS, smg p25A GDI, and rho GDI, and made monoclonal antibodies against them. (nii.ac.jp)
We have also found that smg p25A is mainly detected inneural tissues by use of its specific monoclonal antibody, and that the levels of smg p25A mRNA increase in PC12 cells after their differentiation into neuron-like cells. (nii.ac.jp)

Our findings reveal an unappreciated circadian machinery affecting pain hypersensitivity caused by peripheral nerve injury, thus opening up novel approaches to the management of chronic pain. (nature.com)

Additionally, very similar protein control mechanisms are at work to mature important cells in other tissues such as pancreatic islets, the cell type that fails to function effectively in type 2 diabetes. (science20.com)
Western blotting was employed to determine NGF level in PC and paracarcinoma tissues and in PC cell lines as well as pancreatic ductal epithelial cells. (hindawi.com)
NGF level was preeminently higher in PC tissues and cell lines than in paracarcinoma tissues and normal pancreatic epithelial cell lines. (hindawi.com)
Review: Evaluation of pancreatic cancer stem cells-related markers CD133, CD44, Oct4, and Nestin proteins in PANC-1 and SW1990 cells by western blotting. (cusabio.com)

The nerve cells generated by this new method show the same functional characteristics as the mature cells found in the body, making them much better models for the study of age-related diseases such as Parkinson's and Alzheimer's, and for the testing of new drugs. (science20.com)
In addition, for age-related diseases such as Parkinson's and Alzheimer's, both of which affect millions worldwide, mature nerve cells which show the same characteristics as those found in the body are crucial in order to enhance understanding of the disease and ultimately determine the best way to treat it. (science20.com)
However, by engineering proteins which cannot be modified by phosphate and adding them to human cells, the researchers found they could produce nerve cells that were significantly more mature, and therefore more useful as models for disease such as Alzheimer's. (science20.com)
METHODS: Plasma protein modules/cascades were analyzed using weighted gene co-expression network analysis (WGCNA) in the Alzheimer's Disease Neuroimaging Initiative study. (bvsalud.org)
Increased VDAC1 has also been reported in the affected nerves in Alzheimer's disease. (lu.se)

We have purified and characterized several GDP/GTP exchange proteins (GDP dissociation stimulator (GDS) and GDP dissociation inhibitor (GDI)) and GTPase activating Proteins (GAP) for small G proteins. (nii.ac.jp)
The potentiation was prevented in the presence of the selective PKA inhibitor PKI 14-22 , suggesting PKA-mediated phosphorylation of the heat transducer protein. (jneurosci.org)

When cells are dividing, transcription factors are modified by the addition of phosphate molecules, a process known as phosphorylation, but this can limit how well cells can convert to mature nerves. (science20.com)
Thick muscle filaments are made of myosin protein molecules layered in a cylindrical shape. (mokshayogaamazonica.com)

Mitochondrial Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
This graph shows the total number of publications written about "Mitochondrial Proteins" by people in Harvard Catalyst Profiles by year, and whether "Mitochondrial Proteins" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Mitochondrial Proteins" by people in Profiles. (harvard.edu)
The unfolded protein response of the endoplasmic reticulum supports mitochondrial biogenesis by buffering nonimported proteins. (harvard.edu)
A defect in mitochondrial protein translation influences mitonuclear communication in the heart. (harvard.edu)
The long-term goal is to develop a new class of drugs, which targets the mitochondrial protein VDAC1. (lu.se)

Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair. (arigobio.cn)

Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. (abcam.com)
The most commonly used and readily available method for assessing magnesium status is measurement of serum magnesium concentration, even though serum levels have little correlation with total body magnesium levels or concentrations in specific tissues [ 6 ]. (nih.gov)

The cholinergic nerve endings stimulate the NO-synthase and, therefore, release NO (nitric oxide). (urology-textbook.com)
The SA node is densely innervated with postganglionic adrenergic and cholinergic nerve terminals. (medscape.com)

Magnesium guard the ion channels that allow calcium to enter and leave the cell, orchestrating the exact amount of calcium that's required to cause a muscle or nerve cell to contract and then flushing that extra calcium out to prevent excessive contraction. (hippocrates.com.au)
Magnesium is intimately involved in efficient nerve conduction. (hippocrates.com.au)
Magnesium is a cofactor in more than 300 enzyme systems that regulate diverse biochemical reactions in the body, including protein synthesis, muscle and nerve function, blood glucose control, and blood pressure regulation [ 1-3 ]. (nih.gov)
Magnesium also plays a role in the active transport of calcium and potassium ions across cell membranes, a process that is important to nerve impulse conduction, muscle contraction, and normal heart rhythm [ 3 ]. (nih.gov)
An adult body contains approximately 25 g magnesium, with 50% to 60% present in the bones and most of the rest in soft tissues [ 4 ]. (nih.gov)

By studying how nerves form in developing tadpoles, researchers from the University of Cambridge were able to identify ways to speed up the cellular processes by which human nerve cells mature. (science20.com)
The pattern of cellular growth has long been known, but it is the Italian developmental biologist Rita Levi-Montalcini and the American biochemist Stanley Cohen with their discovery of nerve growth factor (NGF) and epidermal growth factor (EGF), respectively, who could show how the growth and differentiation of a cell is regulated. (nobelprize.org)
Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. (cusabio.com)

Raf family members will activate MEK1/2 followed by phosphorylation of ERK1/2 which acts on a large variety of targets. (springer.com)
Discussion of insecticide mode of action will focus on interactions with protein targets and the resulting expression of toxicity in the insect. (umn.edu)
As bioactive compounds tend to interact with multiple proteins with various physiological effect, we aimed to identify other potential shared targets to understand the extent in which these chemicals could lead to GWI. (cdc.gov)
We followed a reverse screening approach where each chemical is computationally docked to a library of protein targets. (cdc.gov)

Thin muscle filaments are made of actin protein and have a twisting shape. (mokshayogaamazonica.com)

AChE inhibition induces an acetylcholine build-up, disrupting signals between nerves and muscles, which in high doses leads to asphyxiation. (cdc.gov)

Retrograde degeneration - Degeneration starts from the proximal portion of the axon and proceeds toward the optic disc (eg, optic nerve compression by intracranial tumor). (medscape.com)
After the primary infection, the virus spreads from the infected epithelial cells to nearby sensory nerve endings and is transported along the nerve axon to the cell body located in the trigeminal ganglion. (medscape.com)
Recurrent ocular HSV infection has traditionally been thought of as reactivation of the virus in the trigeminal ganglion, which migrates down the nerve axon to produce a lytic infection in ocular tissue. (medscape.com)

The optic nerve head sits at a major transition between an area of high pressure to an area of low pressure (intracranial pressure) and is composed of 4 types of cells: ganglion cell axons, astrocytes, capillary-associated cells, and fibroblasts. (medscape.com)
On the contrary, knockdown of Sprouty proteins increases proliferation of activated astrocytes and, consequently, reduces secondary brain damage in neuronal lesion models such as kainic acid-induced epilepsy or endothelin-induced ischemia. (springer.com)

Spry1, Spry2, and Spry4 but not Spry3 are induced transcriptionally and limit the duration and intensity mainly of ERK phosphorylation in response to growth factor (GF) stimulation (with the exception of EGF signaling). (springer.com)
The piezoelectric Cs/Gel/PHA/PBT hydrogels developed here with favorable immunomodulation, angiogenesis, and osteogenesis functions may be used as a substitute in periosteum injuries, thereby offering the novel strategy of applying piezoelectric stimulation in bone tissue engineering for the enhancement of combat effectiveness in grassroots troops. (biomedcentral.com)

In the same way that nerve cells can be "excited to death," muscle cells stimulated by too much calcium can go into uncontrollable spasm, resulting in tissue damage such as occurs in a heart attack. (hippocrates.com.au)
Primary HSV-1 infection occurs most commonly in the mucocutaneous distribution of the trigeminal nerve. (medscape.com)

In vivo tumorigenesis experiments, Tanezumab markedly alleviated nerve invasion of PC cells as well as relieved nociceptive conduction in animal models. (hindawi.com)

Food is made up of proteins, carbohydrates, and fats. (medlineplus.gov)

A genetically heterogeneous group of heritable disorders resulting from defects in protein N-glycosylation. (lookformedical.com)

Both types of muscles are controlled by the brain, which sends electric signals to the muscles through nerves telling them to either contract or relax. (mokshayogaamazonica.com)
Afferent signals pass via the pudendal nerve to the sacral erection center, and efferent signals reach via the inferior hypogastric plexus the erectile tissue. (urology-textbook.com)

Three proteins from this module, C-reactive protein (CRP), complement C3, and complement factor H (CFH), had dose-dependent associations with CSF p-tau and cognitive impairment only in APOE Îµ4 homozygotes. (bvsalud.org)
The syndrome is characterized by abnormal adhesion-dependent functions, especially defective tissue emigration of neutrophils, leading to recurrent infection. (lookformedical.com)
We have recently shown that it is possible to restore the normal function of beta-cells by blocking the protein VDAC1 (Voltage-Dependent Anion Channel 1), which is dramatically increased in beta cells of people with T2D. (lu.se)

These results suggest that smg p21 and smg p25A can be used as potential tumor markers for tumors derived from hematopoietic and neural tissues, respectively. (nii.ac.jp)

Several years ago, researchers determined that a group of proteins known as transcription factors, which are found in many tissues throughout the body, regulate both mechanisms. (science20.com)
These are mature nerve cells generated from human cells using enhanced transcription factors. (science20.com)

Immunogen: Recombinant full length protein (Human 14-3-3 gamma). (icbinhibitor.com)

The forskolin-induced current potentiation was greatly reduced in cells transfected with VR-1 mutants carrying point mutations at the predicted PKA phosphorylation sites. (jneurosci.org)

An inorganic ion or a non-protein molecule e.g. coenzyme required for enzyme activity. (flashcardmachine.com)
Indeed, the researchers hypothesized that menthol exerted its actions on "an enzyme" that was involved in the activation of these nerves [ 13 ]. (nih.gov)

Citation: Ding Z, Cao J, Shen Y, Zou Y, Yang X, Zhou W, Guo Q and Huang C (2018) Resveratrol Promotes Nerve Regeneration via Activation of p300 Acetyltransferase-Mediated VEGF Signaling in a Rat Model of Sciatic Nerve Crush Injury. (vinomis.com)
This study showed that the motor deficits caused by sciatic nerve crush injury were alleviated by daily systematic resveratrol treatment within 10 days. (vinomis.com)

At the level of the primary afferent nerve, the site at which thermal stimuli are converted into neuronal activity, temperature-sensitive members of the TRP channel family are found. (nih.gov)

A new method of generating mature nerve cells from skin cells could greatly enhance understanding of neurodegenerative diseases, and could accelerate the development of new drugs and stem cell-based regenerative medicine. (science20.com)

Anatomy57

Organisms11

Diseases11

Chemicals and Drugs106

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Phenomena and Processes43

Disciplines and Occupations2

Technology, Industry, Agriculture2

Information Science3

Oxidative Phosphorylation8

Neurons4

Receptors9

Kinase17

40,000 dalton protein4

Kinases2

Endogenous1

Metabolism3

Peptides2

Fibers10

Phosphatase2

Receptor4

Modulate1

Rats1

Calmodulin1

Mammalian2

Amino Acids1

Residues5

Skeletal muscle4

Mice4

Mitochondria2

Spinal4

Peripheral nerves2

Muscle tissues1

Monoclonal3

Caused by peripheral nerve injury1

Pancreatic4

Alzheimer's5

Inhibitor2

Molecules2

Mitochondrial6

Upon DNA damage1

Concentrations2

Cholinergic nerve2

Magnesium5

Cellular3

Targets4

Actin protein1

Inhibition1

Axon3

Astrocytes2

Stimulation2

Occurs2

Conduction1

Carbohydrates1

Defects1

Signals2

Dependent3

Tumor1

Transcription factors2

Immunogen1

Mutations1

Enzyme2

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