Kv3 channel subunits encoded by Kcnc genes are distinguished by rapid activation and deactivation kinetics that support high-frequency, narrow action potential firing. (jneurosci.org)
PSD-95 is a member of the MAGUK (membrane associated guanylate kinase) family (which also includes PSD-93, SAP97 and SAP102) and functions as a scaffold protein that can cluster membrane receptors, ion channels, including NMDA receptor subunits, Kv1 potassium channels and Caspr2. (antibodiesinc.com)
Subfamily1
This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. (wikipedia.org)
Shaker1
Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). (wikipedia.org)
Localization1
Simplified cerebellar circuitry illustrating direction of information flow and Kv3 channel localization. (jneurosci.org)
Membrane3
They regulate the excitability of cells and contribute to their resting membrane potential [ 1 , 2 ]. (ersjournals.com)
My laboratory is interested in ion channels and the membrane mechanisms that regulate the activation and function of T lymphocytes. (uc.edu)
Ion channels, located on the membrane of T cells, are the effectors which link antigen recognition to T cell function and gene regulation by controlling calcium homeostasis. (uc.edu)
Protein1
Voltage-gated potassium channel subunit beta-2 is a protein that in humans is encoded by the KCNAB2 gene. (wikipedia.org)
Cell1
1. Role of ion channels in T cell response and adaptation to hypoxia. (uc.edu)
Regulatory1
Recent studies show that modulation of TASK-1 channels, either directly or indirectly by targeting their regulatory mechanisms, has the potential to control pulmonary arterial tone in humans. (ersjournals.com)
Functional2
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. (wikipedia.org)
This review summarises our current state of knowledge of the functional role of TASK-1 channels in the pulmonary circulation in health and disease, with special emphasis on current advancements in the field. (ersjournals.com)
The C-terminus SH3-binding domain of Kv1.3 is required for the actin-mediated immobilization of the channel via cortactin. (uc.edu)
Human1
Potassium (K + ) channels constitute the largest group of ion channels in the human genome. (ersjournals.com)
Cancer4
PD1 blockade enhances K+ channel activity, Ca2+ signaling, and migratory ability in cytotoxic T lymphocytes of patients with head and neck cancer. (uc.edu)
A defect in KCa3.1 channel activity limits the ability of CD8+ T cells from cancer patients to infiltrate an adenosine-rich microenvironment. (uc.edu)
Kv1.3 Channels Mark Functionally Competent CD8+ Tumor-Infiltrating Lymphocytes in Head and Neck Cancer. (uc.edu)
Potassium channels of T lymphocytes take center stage in the fight against cancer. (uc.edu)
Role1
The role of cerebellar Kv3.1 and Kv3.3 channels in motor coordination was examined with an emphasis on the deep cerebellar nuclei (DCN). (jneurosci.org)
Cells1
Previously we reported that increased lateral deviation while ambulating and slips while traversing a narrow beam of ataxic Kcnc3 -null mice were corrected by restoration of Kv3.3 channels specifically to Purkinje cells, whereas Kcnc3 -mutant mice additionally lacking one Kcnc1 allele were partially rescued. (jneurosci.org)
Voltage-gated ion channels2
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. (wikipedia.org)
Several recent reports further suggest that local protein translation in the dendrites of neurons and interactions between IA channels with other types of voltage-gated ion channels further expands the functional diversity of native neuronal IA channels. (nih.gov)
19981
HN - 2006(1998) MH - Actin-Related Protein 2-3 Complex UI - D051376 MN - D5.750.78.730.246 MN - D12.776.220.525.246 MS - A complex of seven proteins including ARP2 PROTEIN and ARP3 PROTEIN that plays an essential role in maintenance and assembly of the CYTOSKELETON. (nih.gov)
Molecular1
Here, we review the diverse molecular mechanisms that have been shown or proposed to underlie the functional diversity of native neuronal IA channels. (nih.gov)
Regulation3
While the importance of SGLT1 in glucose absorption has been systemically studied in detail, little is currently known about the regulation of SGLT1 activity by cation channels and transporters. (mdpi.com)
posttranslational regulation of Kv channels. (nih.gov)
In contrast, the presynaptic BK channels did not contribute significantly to regulation of action potentials or transmitter release under basal experimental conditions, i.e., without 4-AP, even at high stimulation frequencies. (jneurosci.org)
Interact1
In available structures, Lys-295 in the lariat loop of arrestin-3 and its homologue Lys-294 in arrestin-2 directly interact with the activator-attached phosphates. (bvsalud.org)
Subcellular1
These results indicate that the functional role of BK channels depends on their subcellular localization. (jneurosci.org)
Depends1
The maintenance of membrane potential mainly depends on the activities of cation channels and transporters. (mdpi.com)