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  • extracellular
  • found that inhibition of either release of calcium from the endoplasmic reticulum (with TMB-8) or uptake of calcium from the extracellular medium (with EGTA, a calcium chelator) produced a global dampening of BCR-dependent phosphorylation, including phosphorylation events that occurred within the first minute of BCR activation. (sciencemag.org)
  • During a signal transmission in cells of the muscle-tendon-bone unit, extracellular matrix, cell membrane, cytoskeleton, nuclear protein matrix, and gene expression are altered by mechanical loading in muscle cells and transmitted further to cells of the tendon-bone unit in autocrine as well as paracrine manner [ 1 ]. (hindawi.com)
  • inhibits
  • The authors suggest that low-intensity activation of the BCR produces an initial calcium signal that feeds back and regulates the amplitude of a rapidly produced ROS signal, which then transiently inhibits protein tyrosine phosphatase activity, thereby controlling the amplitude and kinetics of the BCR signal. (sciencemag.org)
  • Target of Rapamycin
  • For example, Arabidopsis p70S6Kmight be a nodal point able to integrate hormonal and developmental signals with nutritional inputs, together with the Arabidopsis Target of Rapamycin (TOR) protein. (mendeley.com)
  • induces
  • This chromosomal translocation induces the formation of the chimeric protein nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), which possesses significant oncogenic potential resulting from the constitutive activation of the tyrosine kinase ALK. (bloodjournal.org)
  • PI(3,4,5)P 3 anchors Akt/PKB to the plasma membrane and induces a conformational change, which results in the phosphorylation of Akt/PKB. (hindawi.com)
  • threonine
  • Akt located at 14q32.3 in humans and sometimes called protein kinase B ([PKB] Online Mendelian Inheritance in Man no. 164730) is a multifunctional serine-threonine protein kinase that was initially identified as a mouse retrovirus oncogene in AK R t hymomas. (jci.org)
  • The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. (genecards.org)
  • Background: Mitogen-activated protein kinases (MAPKs) are a widely conserved family of serine/threonine protein kinases involved in many cellular programs, such as cell proliferation, differentiation, motility, and death. (cellsignal.com)
  • initiation
  • Release of eukaryotic initiation factor 4E (eIF4E) from its translational repressor eIF4E-binding protein (4E-BP) is a crucial event for the first mitotic division following fertilization of sea urchin eggs. (biologists.org)
  • In mammalian cells, the function of eIF4E is to recognize the 7-methyl guanosine triphosphate (m 7 GTP) `cap' at the 5′ terminus of the mRNA, thereby allowing the latter to bind to the 43S complex composed of the ribosomal 40S subunit, eukaryotic initiation factor 3 (eIF3) and eukaryotic initiation factor 2 (eIF2). (biologists.org)
  • functionally
  • We found greatly diminished IgM- but not CD40-mediated NF-κB/Rel nuclear translocation and DNA binding in B cells from X-linked immunodeficient (xid) mice that harbor an R28C mutation in btk , a mutation that produces a functionally inactive kinase. (rupress.org)
  • activity
  • The effect requires the kinase catalytical activity since the inactive mutant K127N SGK1 failed to modulate GLUT1. (diabetesjournals.org)
  • The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15. (uniprot.org)