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  • synthesis
  • Cyclin A has a second function in S phase, in addition to initiating DNA synthesis, Cyclin A ensures that DNA is replicated once per cell cycle by preventing the assembly of additional replication complexes. (wikipedia.org)
  • Cellular
  • Cellular apoptosis in mouse embryonic stem cells induced by cyclin A2 deletion was partly inhibited by S477D/T479E-Akt1, supporting a physiologic role for cyclin A2 in controlling Akt activation. (ascopost.com)
  • Cyclins may play broader cellular roles than previously appreciated. (aacrjournals.org)
  • This combination of dependence on phosphorylation and widespread biological impact results in dynamic regulation of multiple signalling pathways and allows for cellular adaptation to environmental changes. (wikipedia.org)
  • cdc2
  • At late prophase, cyclin A may no longer be necessary as cdc2/cyclinB1 becomes active (5). (cellsignal.com)
  • In agreement with this observation, cdc2 kinase, a cdc2/cyclin B complex essential for G 2 -M phase transition, phosphorylates SF2/ASF ( 11 ). (aacrjournals.org)
  • enhances
  • Phosphorylation at Thr-492 by PKB/AKT1 enhances its stimulatory activity in triggering cyclin-D1 (CCND1) expression and promoting apoptosis in neurons, which can be blocked by YWHAB. (abcam.cn)
  • expression
  • In a study reported in Nature , Liu and colleagues found that Akt activity fluctuates across the cell cycle, mirroring cyclin A expression. (ascopost.com)
  • Cell-cycle phosphorylation is temporally ordered, at least in part, through the sequential expression of different cyclins. (stanford.edu)
  • Increased expression of cyclin A2 has been observed in many types of cancer such as breast, cervical, liver, and lung among others. (wikipedia.org)
  • Ablation of acinus or SRPK2 abrogates cyclin A1 expression in leukemia cells and arrest cells at G 1 phase. (aacrjournals.org)
  • Furthermore, both SRPK2 and acinus are overexpressed in some human acute myelogenous leukemia patients and correlate with elevated cyclin A1 expression levels, fitting with the oncogenic activity of cyclin A1 in leukemia. (aacrjournals.org)
  • Clk/Sty was initially cloned as a cyclin-dependent kinase (CDK)-like kinase by PCR ( 4 , 5 ), as well as a dual specificity kinase in an expression screening ( 6 - 8 ). (aacrjournals.org)
  • Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. (abcam.cn)
  • This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. (abcam.cn)
  • Activation
  • It is known that activation of Akt results from phosphorylation at S473 and T308, but it is unclear whether other mechanisms are involved in full Akt activation. (ascopost.com)
  • This then leads to a series of phosphorylation events downstream in the MAPK cascade (Raf-MEK-ERK) ultimately resulting in the phosphorylation and activation of ERK. (wikipedia.org)
  • Without cyclin, a flexible loop called the activation loop or T-loop blocks the cleft, and the position of several key amino acid residues is not optimal for ATP-binding. (wikipedia.org)
  • In order to become active, they require (potentially multiple) phosphorylation events in their activation loops. (wikipedia.org)
  • activates
  • Once localized, to the trans-golgi CERK activates cytosolic phospholipase A2 (cPLA2) that has localized to the trans-golgi. (wikipedia.org)
  • transition
  • Cyclin A2 is involved in the G2/M transition but it cannot independently form a maturation promoting factor (MPF). (wikipedia.org)
  • Cyclin A has been shown to play a crucial role in the G2/M transition in Drosophila and Xenopus embryos. (wikipedia.org)
  • unclear
  • In vertebrates, there are five cyclin B isoforms (B1, B2, B3, B4, and B5), but specific role of each of these isoforms in regulating mitotic entry is still unclear. (wikipedia.org)