AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
Dopamine and cAMP-Regulated Phosphoprotein 32ThreoninePhosphorylationDopaminePhosphoproteinsProtein-Serine-Threonine KinasesSerineProtein KinasesProtein Kinase CEnzyme ActivationSignal TransductionReceptors, Dopamine D2Cyclic AMP-Dependent Protein KinasesProto-Oncogene Proteins c-aktAmino Acid SequenceMolecular Sequence DataCell LineCells, CulturedCalcium-Calmodulin-Dependent Protein KinasesReceptors, Dopamine D1Mitogen-Activated Protein KinasesProtein Kinase InhibitorsDopamine AgonistsMAP Kinase Signaling SystemPhosphatidylinositol 3-KinasesPhosphoserineDopamine Antagonistsp38 Mitogen-Activated Protein KinasesReceptors, DopamineCyclic AMPMitogen-Activated Protein Kinase 1TyrosineProtein-Tyrosine KinasesReceptors, Dopamine D3PhosphothreonineProtein BindingEnzyme InhibitorsPhosphoprotein PhosphatasesMitogen-Activated Protein Kinase 3KineticsMutationsrc-Family KinasesMitogen-Activated Protein Kinase KinasesCasein Kinase IITransfectionBlotting, WesternProtein Kinase C-deltaProtein Kinase C-alphaAMP-Activated Protein KinasesIsoenzymesBinding SitesJNK Mitogen-Activated Protein KinasesCDC2 Protein KinaseTetradecanoylphorbol AcetateDopamine Plasma Membrane Transport ProteinsCalciumPhosphopeptidesRecombinant ProteinsGlycogen Synthase Kinase 3Proto-Oncogene ProteinsDopamine AgentsProtein Structure, TertiaryCalcium-Calmodulin-Dependent Protein Kinase Type 2Peptide MappingIntracellular Signaling Peptides and ProteinsSubstrate SpecificityBase SequenceRats, Sprague-DawleyProtein Processing, Post-TranslationalCyclic GMP-Dependent Protein KinasesExtracellular Signal-Regulated MAP KinasesMutagenesis, Site-DirectedCell Line, TumorProtein Kinase C-epsilonRecombinant Fusion ProteinsHeLa CellsTime FactorsProtein Kinase C betaDose-Response Relationship, DrugImmunoblottingPhosphotyrosinePrecipitin TestsCarrier ProteinsElectrophoresis, Polyacrylamide GelCasein KinasesModels, BiologicalDNA-Binding ProteinsApoptosisRNA, MessengerGene Expression RegulationCell Cycle ProteinsProtein Phosphatase 1Cell NucleusCyclin-Dependent KinasesTumor Cells, CulturedSequence Homology, Amino AcidProtein Transport3-Phosphoinositide-Dependent Protein KinasesMolecular WeightRibosomal Protein S6 Kinases
PathwayPhosphataseReceptorFunctionSpecificallyActivation
Pathway3
  • in which it acts as a modulator of the cAMP pathway. (jneurosci.org)
  • As tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO), which convert tryptophan to kynurenine, are rate-limiting enzymes of the kynurenine pathway, we screened TDO or IDO inhibitors for effects on the production of proinflammatory cytokines in a mouse macrophage cell line. (bvsalud.org)
  • In addition to the D1 receptor/PKA/DARPP-32 signaling pathway, D1 receptor stimulation is known to activate Rap1/ERK signaling. (bvsalud.org)
Phosphatase4
  • Activation of CB1 receptors, either by an agonist or by inhibition of reuptake of endogenous cannabinoids, stimulates phosphorylation at Thr34, thereby converting DARPP-32 into an inhibitor of protein phosphatase-1. (jneurosci.org)
  • The activity, localization, and substrate specificity of the protein phosphatase 2A (PP2A) heterotrimer are controlled by various regulatory B subunits. (frontiersin.org)
  • Protein phosphatase 2A (PP2A) is an enzyme that specifically removes phosphates from serine and threonine residues and is essential for various signaling pathways involved in cell development and growth ( 1 , 2 ). (frontiersin.org)
  • DARPP-32, phosphorylated at Thr34 by PKA, inhibits protein phosphatase 1 (PP1), and amplifies the phosphorylation of other PKA/PP1 substrates following D1 receptor activation. (bvsalud.org)
Receptor3
  • Here, we report that the motor depressant effect produced by the cannabinoid receptor agonist (-)-cis-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]trans-4-(3-hydroxypropyl)cyclohexanol (CP55,940) is attenuated by genetic inactivation of the dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32), which is abundantly expressed in the medium spiny neurons of the striatum. (jneurosci.org)
  • The endocannabinoid system has been shown to exert both negative and positive control on striatal dopamine D 2 receptor transmission. (jneurosci.org)
  • Dopamine regulates psychomotor function by D1 receptor/PKA-dependent phosphorylation of DARPP-32. (bvsalud.org)
Function1
  • Our results suggest that PP2A-PR72 plays an important role in regulating cardiac contractile function and Ca 2+ cycling, indicating that the upregulation of PR72 in heart failure is an attempt to compensate functionally. (frontiersin.org)
Specifically1
Activation1
  • This, in turn, prevents dephosphorylation of downstream target proteins, thereby amplifying the effects produced by activation of the cAMP/PKA cascade ( Greengard, 2001 ). (jneurosci.org)