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  • protein
  • In the presence of Walsh protein (a specific inhibitor of cyclic AMP-dependent protein kinases) cyclic AMP mediated phosphorylation of four polypeptides was demonstrated at pH 6.0. (le.ac.uk)
  • This protein was tentatively identified as an ATPase whose activity was modulated by its phosphorylation state. (le.ac.uk)
  • Does Protein Kinase A-Mediated Phosphorylation of the Cardiac Ryanodine Receptor Play Any Role in Adrenergic Regulation of Calcium Handling in Health and Disease? (ahajournals.org)
  • Approximately 10 years ago, the Marks laboratory 4 reported that protein kinase (PK)A-mediated (hyper)phosphorylation of RyR2 at S2809 in the failing heart caused increased RyR Ca sensitivity and abnormal channel activity. (ahajournals.org)
  • synthesis
  • The net result in phosphorylation of ADP is the formation of the high-energy molecule ATP, which the cell can use as a kind of universal energy currency to power many important cell processes, such as protein synthesis. (infoplease.com)
  • metabolism
  • Phosphorylation of glucose is a key reaction in sugar metabolism because many sugars are first converted to glucose before they are metabolized further. (wikipedia.org)
  • Hepatic cell is freely permeable to glucose, and the initial rate of phosphorylation of glucose is the rate-limiting step in glucose metabolism by the liver (ATP-D-glucose 6-phosphotransferase) and non-specific hexokinase (ATP-D-hexose 6-phosphotransferase). (wikipedia.org)
  • 2017
  • Recent evidence confirms widespread histidine phosphorylation at both the 1 and 3 N-atoms of the imidazole ring Recent work from 2017 (preprinted at BioRxiv ) suggests widespread human protein phosphorylation on multiple non-canonical amino acids, including motifs containing phosphorylated histidine, aspartate, glutamate, arginine and lysine in HeLa cell extracts. (wikipedia.org)
  • receptor
  • Supattapone S, Danoff SK, Theibert A, Joseph SK, Steiner J, Snyder SH (1988) Cyclic AMP-dependent phosphorylation of a brain inositol trisphosphate receptor decreases its release of calcium. (springer.com)
  • mechanisms
  • Protein phosphorylation is involved in many mechanisms that contribute to neuronal plasticity, i.e. in the modulation of the information processing and storage properties of nerve cells resulting, ultimately, in the ability of the nervous system to learn. (springer.com)
  • chemical
  • Due to the chemical lability of these phosphorylated residues, and in marked contrast to Ser, Thr and Tyr phosphorylation, the analysis of phosphorylated Histidine using standard biochemical and mass spectrometric approaches is much more challenging and special procedures and separation techniques are required for their preservation alongside classical Ser, Thr and Tyr phosphorylation. (wikipedia.org)
  • Due to the chemical lability of these phosphorylated residues, special procedures and separation techniques are required for their preservation alongside classical Ser, Thr and Tyr phosphorylation. (wikipedia.org)