Phosphorylates protein kinase. Medical search. Frequent questions

c-Src phosphorylates specific tyrosine residues in other tyrosine kinases. (wikipedia.org)
Inhibition of the kinase domain is halted through binding of the Ras-binding domain, or residues 155-227 of the protein, to the Ras-GTP effector domain. (news-medical.net)
In addition to autoinhibition, CR3 is also inhibited when the protein is not post-translationally phosphorylated at certain serine and tyrosine residues in the CR2 hinge region. (news-medical.net)
MS analysis identified the peptide that was missing in the S90 and S93 mutant protein as LGPELSPSPTSPTATSTTPSR (corresponding to amino acid residues 83-103 of human TTP). (usda.gov)
Phosphorylates Tyr residues at the C-terminus of PTPN11 creating a binding site for the SH2 domain of GRB2. (abcam.com)
can phosphorylate substrate proteins on serine, threonine, tyrosines or histidine residues. (horizondiscovery.com)
In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. (bvsalud.org)

B-Raf is a protein encoded by the BRAF gene and is involved in the RAS/MAPK pathway, which regulates cellular growth and division. (news-medical.net)
The underlying mechanisms of these effects were primarily mediated by G 1 phase cell cycle arrest and inhibition of the mitogen-activated protein kinase (MAPK)/extracellular signal-regulate kinase 1/2 (Erk 1/2) and protein kinase B (Akt) signaling pathways. (spandidos-publications.com)
Further, there are signaling pathways that participate in regulation, such as Wnt channel, mitogen-activated protein kinase (MAPK) channel, bone morphogenetic protein (BMPs) channel, peroxisome proliferator activated-receptors (PPARs) channel, and Notch channel. (frontiersin.org)
Mitogen-activated protein kinases such as RAF kinases involved in the MAPK signaling pathways and cyclin dependent kinases (CDKs) involved in cell cycle regulation are prime examples of pathways implicated in cancers. (horizondiscovery.com)
Phosphorylation and enzymatic activity of AMPK are increased, whereas levels of phosphorylated mTOR and p38 MAPK are diminished upon inducible inactivation of TAK1 in skeletal muscle. (jci.org)

It phosphorylates and activates protein kinase B (PKB) protein. (sigmaaldrich.com)
The interaction of tubulin with these polypeptides involves a GTP transfer from the exchangeable GTP-binding site (E site) of tubulin to Gα, which activates the G-protein (transactivation) ( Roychowdhury and Rasenick, 1994 ). (jneurosci.org)
MTX increases intracellular accumulation of adenosine monophosphate (AMP) and 5-aminoimidazole-4-carboxamide ribonucleotide which activates AMP-activated protein kinase (AMPK). (bmj.com)
BRAF is a cytoplasmic protein kinase, which activates the MEK-ERK signalling pathway. (bath.ac.uk)
Phosphorylation turns on (activates) the kinase. (medlineplus.gov)

EXPERIMENTAL Reagents and antibodies Apigenin, emodin and anti-His6 antibody had been extracted from Sigma, anti-eIF2 as well as the catalytic subunit from the PP2A (proteins phosphatase 2A) phosphatase had been from Cell Signaling Technology, anti-CK2 and anti-eIF5 had been from Santa Cruz Biotechnology and anti-eIF2 was from Cell Signaling Technology. (bioinf.org)
The anti-eIF2 antibody grew up in rabbits immunized using the recombinant proteins, as well as the immunoglobulin small fraction was extracted from Formoterol supplier sera by Proteins ACagarose Formoterol supplier chromatography (Amersham Biosciences). (bioinf.org)
Immunoprecitation demonstrated that a TcPKAc monoclonal antibody was able to pull-down proteins recognized by trans-sialidase antibodies as well as a SA85-1.1 antibody and vice versa. (elsevierpure.com)
In addition, a phospho-(Ser/Thr) PKA substrate antibody detected bands on immunoblot analysis of trans-sialidase antibody precipitated proteins from parasite lysate and the media of L 6 E 9 myoblasts infected with trypomastigotes as well as from a SA85-1.1 antibody precipitated proteins from parasite lysate. (elsevierpure.com)
By MALDI-TOF mass spectrometry, we identified this protein to be cMyBP-C. These data were confirmed by immunostaining using the p-PKD-Ser744/748 antibody, which displayed a striated pattern similar to the one observ ed for a regular cMyBP-C antibody. (scirp.org)
To our knowl edge there are no antibodies commercially availa ble for phosphorylated cMyBP-C. Thus, the p-PKD- Ser744/748 antibody can accelerate research into th e role of cMyBP-C phosphorylation in cardiomyo cytes. (scirp.org)
This antibody does not detect the non-phosphorylated α-subunit of rat CaM kinase II nor the ~60kDa β-subunit in either phosphorylation state. (enzolifesciences.com)

c-Src can be activated by many transmembrane proteins that include: adhesion receptors, receptor tyrosine kinases, G-protein coupled receptors and cytokine receptors. (wikipedia.org)
Most studies have looked at the receptor tyrosine kinases and examples of these are platelet derived growth factor receptor (PDGFR) pathway and epidermal growth factor receptor (EGFR). (wikipedia.org)
AKT/PI3K forms a key component of many signalling pathways that involve the binding of membrane-bound ligands such as receptor tyrosine kinases, G-protein coupled receptors, and integrin-linked kinase. (senescence.info)
The ALK gene provides instructions for making a protein called ALK receptor tyrosine kinase, which is part of a family of proteins called receptor tyrosine kinases (RTKs). (medlineplus.gov)
Receptor tyrosine kinases transmit signals from the cell surface into the cell through a process called signal transduction. (medlineplus.gov)

Family with sequence similarity 20, member C also known as FAM20C or DMP4 is a protein which in humans is encoded by the FAM20C gene. (wikipedia.org)
pronounced "sarc", as it is short for sarcoma), is a non-receptor tyrosine kinase protein that in humans is encoded by the SRC gene. (wikipedia.org)
It belongs to a family of Src family kinases and is similar to the v-Src (viral Src) gene of Rous sarcoma virus. (wikipedia.org)
Two transcript variants encoding the same protein have been found for this gene. (wikipedia.org)
The duality of this product lies in it's dual specificity to the gene, pH or protein. (reageno.com)
This gene encodes one of the three members of the human AKT serine-threonine protein kinase family which are often referred to as protein kinase B alpha, beta, and gamma. (senescence.info)
Subsequent phosphorylation of both threonine residue 308 and serine residue 473 is required for full activation of the AKT1 protein encoded by this gene. (senescence.info)
Mutations in the ALK gene change single protein building blocks (amino acids) in ALK receptor tyrosine kinase. (medlineplus.gov)
This phenomenon, known as gene amplification, results in overexpression of ALK receptor tyrosine kinase. (medlineplus.gov)
This translocation fuses the ALK gene to the NPM gene and results in a fusion protein called NPM-ALK. (medlineplus.gov)

An early event in the signal transduction pathway induced by these cell-cell interactions is the rapid inactivation of a flagellar protein kinase that phosphorylates a 48 kDa flagellar protein. (elsevierpure.com)
RAF genes encode serine and threonine kinase proteins downstream of Ras in the pathway. (news-medical.net)
AKT proteins also participate in the mammalian target of rapamycin (mTOR) signalling pathway which controls the assembly of the eukaryotic translation initiation factor 4F (eIF4E) complex and this pathway, in addition to responding to extracellular signals from growth factors and cytokines, is disregulated in many cancers. (senescence.info)
The association," he said, "is partly through upregulation of the phosphatidylinositol-3-kinase (PI3K)/protein kinase B pathway that results in downregulation of glycogen synthase kinase-3-beta, which is implicated in the formation of neurofibrillary tangles, a hallmark of Alzheimer's disease pathology. (medscape.com)
Tyrosine kinase of the non-receptor type, involved in the interleukin-2 and interleukin-4 signaling pathway. (lu.se)
The activation continues through a series of proteins in a signaling pathway. (medlineplus.gov)
As a result, the kinase and the downstream signaling pathway are constantly turned on (constitutively activated). (medlineplus.gov)
Rather, we found that phosphorylated activation loop Y842 serves as a binding site of SHP2, which is required for FLT3-induced activation of RAS/ERK pathway. (lu.se)

RATIONALE: AMP-activated protein kinase (AMPK) is an important regulator of energy balance and signaling in the heart. (ox.ac.uk)
In vitro studies showed that cTnI is a good AMPK substrate and that Ser150 is the principal residue phosphorylated. (ox.ac.uk)
Furthermore, on AMPK activation during ischemia, Ser150 is phosphorylated in whole hearts. (ox.ac.uk)
Studies of human umbilical vein endothelial cells (HUVEC) and arterial endothelial cells (HAEC) showed that therapeutically relevant concentrations of MTX phosphorylate AMPKα Thr172 , and induce cytoprotective genes including manganese superoxide dismutase (MnSOD) and haem oxygenase-1 (HO-1). (bmj.com)
Mechanistically, MTX treatment led to cyclic AMP response element-binding protein (CREB) Ser133 phosphorylation, while AMPK depletion attenuated this response and the induction of MnSOD and HO-1. (bmj.com)
Conversely, during starvation mTORC1 is inhibited and autophagy is induced by AMP-activated protein kinase (AMPK), leading to generation of intracellular nutrients and energy during degradation of non-functional or non-essential organelles or protein aggregates [ 4 , 6 ], in turn contributing to cell survival. (springer.com)

We describe here the meriolins, a new family of inhibitors of cyclin-dependent kinases (CDK). (rcsb.org)
Cyclin-dependent kinases (CDKs) are serine/threonine protein kinases that act as key regulatory elements in cell cycle progression. (proteopedia.org)
Development of Highly Potent and Selective Diaminothiazole Inhibitors of Cyclin-Dependent Kinases. (proteopedia.org)

VEGF-induced pMF was attenuated by the MEK/ERK inhibitor U0126 [1,4-diamino-2,3-dicyano-1,4-bis( o -aminophenylmercapto)butadiene] and was abolished by the phosphotidinositol 3 kinase/Akt inhibitor LY294002 [2-(4-morpholinyl)-8-phenyl-1(4 H )-benzopyran-4-one hydrochloride], demonstrating that ERK mitogen-activated protein kinases and Akt are both required for full expression of VEGF-induced pMF. (jneurosci.org)

catalytic subunit of CK2 (CK2) inhibits its activity in proteins substrates [16]. (bioinf.org)
Conserved region 3 (CR3) is a catalytic protein kinase domain. (news-medical.net)
PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit a) is one of the four subunits of the 110kDa catalytic subunit of PI3K protein, which contains a regulatory region of 85kDa. (sigmaaldrich.com)
PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit a) is one of the four catalytic subunits of PI3K protein, which plays an essential role in extracellular growth signaling. (sigmaaldrich.com)
A well-known example of a lipid kinase is phosphoinositide 3-kinase which is implicated in a number of cancers, mainly through alterations to its catalytic subunit - PIK3CA. (horizondiscovery.com)

Using a panel of kinase inhibitors, we found ALK inhibitor AZD3463 selectively inhibited the activation and downstream signaling of FLT3-ITD and did not affect the wild-type FLT3 (FLT3-WT). (lu.se)

The central/C-terminal locations also support the binding sites for CK2, whereas the phosphorylation sites because of this proteins kinase can be found in the N-terminal area. (bioinf.org)
The current presence of three lysine blocks and phosphorylation sites for proteins kinase CK2 and PKC (proteins kinase C) are quality from the N-terminal area of mammalian eIF2 [21]. (bioinf.org)
In today's work, we researched the phosphorylation of individual eIF2 as well as the relevance of the primary phosphorylation sites and of the complete N-terminal site of eIF2 in its discussion with some companions, in proteins synthesis and in cell viability. (bioinf.org)
In vitro, this kinase accounts for near half of the FRQ kinase activity, and it can phosphorylate the FRQ region that contains the three known functionally important phosphorylation sites. (elsevierpure.com)

Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase, and the stimulation of glycogen synthesis. (thermofisher.com)
Survival factors can suppress apoptosis in a transcription-independent manner by activating AKT1 which then phosphorylates and inactivates components of the apoptotic machinery. (senescence.info)
GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. (cellsignal.com)

Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin (1). (cellsignal.com)
As an example, in post-mortem brain of patients with Alzheimer's disease (AD), several studies have reported reduction of insulin, insulin-like growth factor 1 and insulin receptor and an increase in tau protein and glycogen-synthase kinase-3β compared to healthy controls suggesting an impairment of metabolism in the AD patient's brain. (lu.se)

PDPK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. (thermofisher.com)
Synthetic peptide corresponding to aa 281-294 (M 281 HRQET(PSO 3 )VDCLKKFN 294 ) of the α-subunit of mouse and rat CaM kinase II (Ca 2+ /Calmodulin-dependent Protein Kinase II) thiophosphorylated at (Thr 286 ). (enzolifesciences.com)

eIF2 can be a substrate for DNA-PK (DNA proteins kinase) [24], even though the phosphorylation site(s) because of this kinase never have been identified however. (bioinf.org)
The substrate specificity of FAM20C indicates, however, that it is not likely to account for the tyrosine phosphorylation of the secreted protein. (wikipedia.org)
Molecular cloning and characterization indicated that the 48 kDa substrate, termed SksC, itself is a novel protein kinase. (elsevierpure.com)
TTP is highly phosphorylated in vivo and is a substrate for several protein kinases. (usda.gov)
Dependent on the substrate they act upon they can be broadly classified into 3 categories: protein kinases, carbohydrate kinases and lipid kinases. (horizondiscovery.com)

subunit as well as for determining that it's necessary for the discussion with eIF2 [35], which gives an answer towards the discrepancy in the outcomes obtained in prior research using endogenous phosphorylated eIF2B [35C37]. (bioinf.org)
Recognizes the phosphorylated α-subunit of CaM kinase II. (enzolifesciences.com)
The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis. (bvsalud.org)

PI3K proteins form a family of lipid kinases. (sigmaaldrich.com)
These proteins are phosphorylated by phosphoinositide 3-kinase (PI3K). (senescence.info)
AKT proteins are recruited to the cell membrane by phosphatidylinositol 3,4,5-trisphosphate (PIP3) after phosphorylation of phosphatidylinositol 4,5-bisphosphate (PIP2) by PI3K. (senescence.info)

NEMO consists of 10 exons, and most mutations cause deletions of exons 4-10, resulting in a truncated protein. (medscape.com)
Hypomorphic mutations may impair but not abolish NEMO protein function. (medscape.com)

abstract = "Protein kinase A (PKA) has been suggested as a regulator of stage differentiation in Trypanosoma cruzi. (elsevierpure.com)

Raw data for results from screening kinase activity towards T279 of PI3KC2-β are provided in Supplementary Table 2 . (nature.com)

The B-Raf protein has 766 amino acids in three conserved domains. (news-medical.net)
It stimulates the growth and development of these tissues by promoting the production of proteins and increasing the uptake of amino acids. (proprofs.com)

Phosphorylation of circadian clock proteins represents a major regulatory step that controls circadian clocks. (elsevierpure.com)
These highly similar AKT proteins all have an N-terminal pleckstrin homology domain, a serine/threonine-specific kinase domain and a C-terminal regulatory domain. (senescence.info)
Dysregulation of CDK8 (Cyclin-Dependent Kinase 8) and its regulatory partner CycC (Cyclin C) , two subunits of the conserved Mediator (MED) complex, have been linked to diverse human diseases such as cancer. (sdbonline.org)

These effects were associated with inhibition of the mitogen‑activated protein kinase/extracellular signal‑regulated kinase 1/2 and protein kinase B signaling pathways. (spandidos-publications.com)

Some pharmaceutical companies are developing inhibitors of B-Raf protein as anticancer therapies. (news-medical.net)
The structures of pCDK2/cyclin A/variolin B and pCDK2/cyclin A/meriolin 3 complexes reveal that the two inhibitors bind within the ATP binding site of the kinase, but in different orientations. (rcsb.org)
The two antibodies function as a capture-target-detection sandwich (#46835 and #79774, respectively) to detect endogenous protein expression in positive and negative controls (with or without phosphatase inhibitors). (cellsignal.com)

We are primarily using cytomegaloviruses to examine how the pathogens alter signaling pathways directed by G-protein coupled receptors (GPCRs) to facilitate robust replication in tissues important for host-host dissemination. (uc.edu)
TGF-β-activated kinase 1 (TAK1) is an important signaling protein, which regulates context-dependent activation of multiple intracellular pathways. (jci.org)
Specifically, proteins involved in metabolic pathways and in mitochondrial functions are mainly downregulated in mice fed with obesogenic diets compared to SD. (lu.se)
Nearly 60% of genetic alterations have been found in AML patients involve in signaling pathways including signaling of tyrosine kinase receptor FLT3. (lu.se)

Active mTORC1 phosphorylates the eukaryotic initiation factor 4E-binding protein-1 (4E-BP1) and 40S ribosomal protein S6 kinase 1 (S6K1) to promote protein synthesis [ 3 , 4 ]. (springer.com)

We demonstrate that protein kinase N (PKN) facilitates mTORC1 signalling by repressing PI3KC2-β-mediated phosphatidylinositol-3,4-bisphosphate synthesis downstream of mTORC2. (nature.com)

The microtubule protein tubulin regulates adenylyl cyclase and phospholipase Cβ 1 (PLCβ 1 ) signaling via transactivation of the G-protein subunits Gαs, Gαi1, and Gαq. (jneurosci.org)
regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. (proteopedia.org)
The heterodimeric TSC complex negatively regulates mTORC1 activity via the GTPase activity of TSC2, towards the small G-protein RHEB (Ras homologue enriched in brain) [ 5 ]. (springer.com)

c-Src should not be confused with CSK (C-terminal Src kinase), an enzyme that phosphorylates c-Src at its C-terminus and provides negative regulation of Src's enzymatic activity. (wikipedia.org)
One unit of 110a/p85a kinase activity is defined as the amount of enzyme required to produce 1 pmol of Phosphoinositol-3, 4,5-Trisphosphate/min at 37°C. (sigmaaldrich.com)

It catalyzes phosphorylation of serine and threonine on target proteins, converting adenosine triphosphate (ATP) to adenosine diphosphate (ADP). (news-medical.net)

The websites phosphorylated on mammalian eIF2 have already been mapped at Ser2, Ser67 (both targeted by CK2), Ser13 (targeted by PKC) and Ser218 [targeted by PKA (proteins kinase A)] [21]. (bioinf.org)
Preliminary studies for the practical outcomes of mammalian eIF2 phosphorylation for proteins synthesis showed it Formoterol supplier did not influence the power of eIF2 to create the ternary complicated with GTP and Met-tRNAiMet [33]. (bioinf.org)

Phosphorylation at CDK1, CDK4, and CDK9 sites on, respectively, protein phosphatase 1alpha, retinoblastoma protein, and RNA polymerase II is inhibited in neuroblastoma SH-SY5Y cells exposed to meriolins. (rcsb.org)
This study adds a PPP-family protein phosphatase to the proteins involved in the control of polar growth and cell shape determination in S. coelicolor. (lu.se)

An in vitro phosphorylation assay demonstrated that PKA phosphorylated the recombinant protein of an active trans-sialidase. (elsevierpure.com)

In this study, we showed that most of the kinase activity phosphorylating FRQ in vitro was calcium/ calmodulin-dependent, and the endogenous FRQ in the Neurospora extracts was phosphorylated by a Ca/ CaM-dependent kinase-like activity. (elsevierpure.com)
In AD, the propensity of neurotoxic proteins to form template or oligomers is higher and accelerates the conversion and aggregation of endogenous proteins, which eventually convert into fibrils ( Schaffert and Carter, 2020 ). (frontiersin.org)

Because most tubulin is not membrane associated, this study investigates whether tubulin translocates to the membrane in response to an agonist so that it might regulate G-protein signaling. (jneurosci.org)
These AKT proteins therefore regulate a wide variety of cellular functions including cell proliferation, survival, metabolism, and angiogenesis in both normal and malignant cells. (senescence.info)
To date, it is well known that lncRNAs participate in chromatin modifications and transcriptional and translational regulation of protein-encoding genes or regulate protein function and activity through specific binding [ 3 - 5 ]. (jcancer.org)
Similarly, primary cilia have been implicated in regulation of mTOR signaling, in which Tuberous Sclerosis Complex proteins 1 and 2 (TSC1/2) negatively regulate protein synthesis by inactivating the mTOR complex 1 (mTORC1) at energy limiting states. (springer.com)
Although the specific function of ALK receptor tyrosine kinase is unknown, it is thought to act early in development to help regulate the proliferation of nerve cells. (medlineplus.gov)

Representative gel showing phosphorylated MKK6 protein in in vitro kinase assay (KA) in plantaris muscle. (jci.org)

BRAF encodes the B-Raf protein, which is involved in signal transduction inside cells. (news-medical.net)
Mathematical modeling of signal transduction networks has previously been used to map out thermodynamical using rate equations is increasingly attracting attention as a properties of protein-folding models (6,7). (lu.se)

Inactivation of TAK1 inhibits protein synthesis and induces proteolysis, potentially through upregulating the activity of the ubiquitin-proteasome system and autophagy. (jci.org)
In the presence of nutrients, mTORC1 is activated and promotes cell growth, including protein synthesis and energy storage. (springer.com)

PDPK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. (thermofisher.com)

Src contains at least three flexible protein domains, which, in conjunction with myristoylation, can mediate attachment to membranes and determine subcellular localization. (wikipedia.org)

Previous reports have suggested that protein kinases play important roles in the regulation of circadian clocks ( Reischl and Kramer, 2011 ). (elifesciences.org)

Pertussis toxin B-pentamer mediates intercellular transfer of membrane proteins and lipids. (uc.edu)
Small angle neutron scattering (SANS) provides unique insight into biomacromolecular complexes by combining solvent contrast variation (H2O:D2O exchange) with either natural contrast between different classes of biomolecules (proteins, RNA/DNA, lipids/detergents) and/or by applying artificial contrast, i.e. deuteration of specific biomolecules. (lu.se)

Cortisol increases the availability of these precursors and promotes the breakdown of proteins and fats, providing the necessary substrates for gluconeogenesis. (proprofs.com)

However, in an investigation of BRAF localisation using fluorescence microscopy combined with subcellular fractionation of Green Fluorescent Protein (GFP)-tagged proteins expressed in NIH3T3 cells, surprisingly, we detected N-terminally truncated BRAF (ΔBRAF) in both nuclear and cytoplasmic compartments. (bath.ac.uk)

Tristetraprolin/zinc finger protein 36 (TTP/ZFP36) binds and destabilizes some pro-inflammatory cytokine mRNAs. (usda.gov)

Mechanistic target of rapamycin (mTOR) kinase functions in two multiprotein complexes: lysosomal mTOR complex 1 (mTORC1) and mTORC2 at the plasma membrane. (nature.com)
Immunoblots showing levels of phosphorylated and total TAK1 and mTOR protein. (jci.org)
B ) Densitometry quantification of TAK1 enzymatic activity and phosphorylated vs. total levels of TAK1 and mTOR in plantaris muscle of Tak1 fl/fl and Tak1 mKO mice. (jci.org)
G ) Representative immunoblots of phosphorylated and total Akt, mTOR, and 4E-BP1 protein levels and unrelated protein GAPDH in plantaris muscle of Tak1 fl/fl and Tak1 mKO mice. (jci.org)
H ) Densitometry quantification of the ratio of phosphorylated vs. total protein levels of Akt, mTOR, and 4E-BP1 in plantaris muscle of Tak1 fl/fl and Tak1 mKO mice 14 days after SA surgery. (jci.org)

Phosphorylates CABLES1 (By similarity). (proteopedia.org)

The IKB is phosphorylated by a multiprotein complex with two kinases subunits. (medscape.com)

Cytoskeletal proteins appear to be involved in the control of intracellular signaling. (jneurosci.org)
In my laboratory researchers are examining the roles played by axonal cytoskeletal proteins in nervous system development, and in the etiology of Alzheimer's and other related neurodegenerative diseases. (uml.edu)
The results showed in this study suggest that, together with cytoskeletal proteins, mitochondria and metabolic proteins are changing their post-translational status in brains of obese mice. (lu.se)

Recognizes human MAP2K2 when phosphorylated at Thr394. (reageno.com)
Recognizes human MAP4K1 when phosphorylated at Ser171. (reageno.com)

CR1 inhibits the activity of CR3, the kinase domain, regulating the overall signaling activity of the molecule. (news-medical.net)

Our data show that the stable knockdown of HIPK2 led to wtp53 misfolding, as detected by p53 immunoprecipitation with conformation-specific antibodies, and that p53 protein misfolding impaired p53 DNA binding and transcription of target genes. (aacrjournals.org)

In Neurospora, the circadian clock protein FREQUENCY (FRQ) is progressively phosphorylated over time, and its level decreases when it is hyperphosphorylated. (elsevierpure.com)

It phosphorylates a specific sequence on protein targets. (news-medical.net)
These observations presented a spatial and temporal resolution of the sequence of events underlying receptor-evoked involvement of tubulin in G-protein-mediated signaling. (jneurosci.org)
Download DNA or protein sequence, view genomic context and coordinates. (yeastgenome.org)
Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information. (yeastgenome.org)
Click "Protein Details" for further information about the protein such as half-life, abundance, domains, domains shared with other proteins, protein sequence retrieval for various strains, physico-chemical properties, protein modification sites, and external identifiers for the protein. (yeastgenome.org)

Fam20C, a Golgi localized protein kinase, is a serine kinase that phosphorylates both casein and other highly acidic proteins and members of the small integrin-binding ligand, the N-linked glycoproteins (SIBLING) family at the target motif SerXGlu. (wikipedia.org)

One of the upstream kinases, which phosphorylate cMyBP-C, is protein kinase D (PKD). (scirp.org)

A selectivity study done on 32 kinases showed that, compared with variolin B, meriolins display enhanced specificity toward CDKs, with marked potency on CDK2 and CDK9. (rcsb.org)

Tristetraprolin (TTP), an anti-inflammatory protein, binds to the AREs of clinically important mRNAs such as TNF mRNA and promotes the destruction of those transcripts. (usda.gov)
Human cytomegalovirus G protein-coupled receptor US28 promotes latency by attenuating c-fos. (uc.edu)

Protein phosphatases act as negative regulators of AKT proteins by dephosphorylating AKT or PIP3. (senescence.info)

Wild-type and all mutant TTP proteins were localized in the cytosol, phosphorylated extensively in vivo and capable of binding to ARE-containing RNA probes. (usda.gov)

The profiling of compound 51 against a panel of 339 kinases revealed high selectivity for CDKs, with preference for CDK2 and CDK5 over CDK9, CDK1, CDK4, and CDK6. (proteopedia.org)

Mutant B-Raf proteins that have been implicated in tumorigenesis often have elevated kinase activity, known as a gain of function mutaion. (news-medical.net)
Because another growth/trophic factor that signals via a receptor tyrosine kinase (brain derived neurotrophic factor) elicits a long-lasting facilitation of respiratory motor activity in the phrenic nerve, we tested the hypothesis that VEGFA-165 elicits similar phrenic motor facilitation (pMF). (jneurosci.org)
Receptor that binds specifically to PDGFB and PDGFD and has a tyrosine-protein kinase activity. (abcam.com)
The phosphorylated form of 40S ribosome protein S6 is thus a marker for mTORC1 activity. (springer.com)

The characterization of FAM20C as an active serine kinase in the Golgi apparatus provides a clear precedent that ATP dependent protein phosphorylation can take place in the secretory apparatus. (wikipedia.org)
Purification and characterization of two protein kinases acting on the aquaporin SoPIP2;1. (lu.se)

Phosphorylation of cMyBP-C is essential for normal cardiac function, since dephosphorylation of this protein leads to its degradation and has been associated with cardiomyopathy. (scirp.org)

Anatomy20

Organisms9

Chemicals and Drugs167

Analytical, Diagnostic and Therapeutic Techniques and Equipment14

Phenomena and Processes41

Information Science3

Residues7

MAPK5

Activates5

Antibody7

Receptor tyrosin5

Gene10

Pathway8

AMPK6

Cyclin-depende3

Mitogen-activat1

Catalytic5

Inhibitor1

Phosphorylation sites4

Inactivates3

Glycogen2

Dependent Protein Kinase2

Substrate5

Subunit3

PI3K3

Mutations2

Abstract1

Screening kinase activity1

Amino acids2

Regulatory3

Inhibition1

Inhibitors3

Pathways4

Eukaryotic initia1

Downstream1

Regulates3

Enzyme2

Serine and threonine1

Mammalian2

Phosphatase2

Recombinant1

Endogenous2

Regulate5

Vitro1

Signal transduction2

Synthesis2

Phosphatidylinositol-3,4,5-trisphosphate1

Localization1

Regulation1

Lipids2

Substrates1

Cytoplasmic1

Binds and destabilizes1

MTOR5

Similarity1

Subunits1

Cytoskeletal proteins3

Recognizes2

Inhibits1

Genes1

Circadian clock1

Sequence5

Casein1

Upstream1

Specificity1

Promotes2

Phosphatases1

Cytosol1

CDKs1

Activity4

Characterization2

Dephosphorylation1