PyrophosphataseTransferasePRPPSubunitDiphosphataseSynthetasePurineProteinRiboseEnzymeAdenosine monophosphatePhosphateMoleculesComplexEnergyPyrophosphate synthetaseHisGSynthaseCatalyzesAdenosine MonophosphatePyrophosphorylaseBiosynthesisMycobacteriumReactsProteinAmineEnzymaticGlucoseReactionExtractsFormProcess
Pyrophosphatase2
- Other names in common use include phosphoribosyl-ATP pyrophosphatase, and phosphoribosyladenosine triphosphate pyrophosphatase. (wikipedia.org)
- Comment: Genetic evidence suggests that DVU1186 ( Q72CU7_DESVH ) is phosphoribosyl-ATP pyrophosphatase ( PMC5764234 ). (lbl.gov)
Transferase4
- 17770) Quinolinate phosphoribosyl transferase CP001857 CDS Arcpr_0019 complement(17767. (go.jp)
- Activation of the hetero-octameric ATP phosphoribosyl transferase through subunit interface rearrangement by a tRNA synthetase paralog. (hashem-lab.fr)
- Two major genetic mutations lead to gout, urolithiasis, and related problems: Mutations in the gene that encodes hypoxanthine-guanine phosphoribosyl transferase are associated with a spectrum of diseases in children, which ranges from the Lesch-Nyhan syndrome at the severe end of the spectrum to simple hyperuricemia at the mild end. (sagepub.com)
- Phosphoribosyl transferase domain [Interproscan]. (ntu.edu.sg)
PRPP7
- The PRPS1 gene provides instructions for making an enzyme called phosphoribosyl pyrophosphate synthetase 1, or PRPP synthetase 1. (medlineplus.gov)
- This enzyme helps produce a molecule called phosphoribosyl pyrophosphate (PRPP). (medlineplus.gov)
- Ribose 5-phosphate reacts with ATP to produce 5-Phosphoribosyl-1-pyrophosphate (PRPP). (biologyonline.com)
- Ribose-phosphate diphosphokinases or PRPP synthetases (EC 2.7.6.1, also called ribose-phosphate pyrophosphokinases) are a family of enzymes that catalyze the synthesis of PRPP from ATP and ribose-5-phosphate (R5P), yielding AMP as an additional product. (biomedcentral.com)
- Phosphoribosyl Pyrophosphate is synthesized by PRPP synthase, by combining ribose 5-phosphate with ATP to form PRPP and AMP as a by-product. (picmonic.com)
- Mutations in the 5'-phosphoribosyl-1-pyrophosphate (PRPP) synthetase genes can result in overactivity of the pathway, leading ultimately to increased urate production. (sagepub.com)
- Additionally, a decrease in inositol monophosphate and guanosyl monophosphate leads to an increase in conversion of 5-phosphoribosyl-1-pyrophosphate (PRPP) to 5-phosphoribosylamine, which further exacerbates uric acid overproduction. (msdmanuals.com)
Subunit2
- ATP synthase, alpha subunit, C-terminal [Interproscan]. (ntu.edu.sg)
- Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'- dephosphocoenzyme-A) of the gamma subunit of citrate lyase. (string-db.org)
Diphosphatase1
- In enzymology, a phosphoribosyl-ATP diphosphatase (EC 3.6.1.31) is an enzyme that catalyzes the chemical reaction 1-(5-phosphoribosyl)-ATP + H2O ⇌ {\displaystyle \rightleftharpoons } 1-(5-phosphoribosyl)-AMP + diphosphate Thus, the two substrates of this enzyme are 1-(5-phosphoribosyl)-ATP and H2O, whereas its two products are 1-(5-phosphoribosyl)-AMP and diphosphate. (wikipedia.org)
Synthetase2
- Orthologous to human PRPS1 (phosphoribosyl pyrophosphate synthetase 1). (nih.gov)
- The conversion of the Oxygen moiety(of Xanthosine Monophosphate) to Nitrogen moiety of (GMP) requires a high-energy reaction carried out by GMP synthetase with ATP and Glutamine as substrates. (picmonic.com)
Purine2
- PRRP though becomes committed particularly to purine biosynthesis when PRRP is converted into 5-phosphoribosyl amine by having the pyrophosphate of PRRP replaced by the amide group of glutamine. (biologyonline.com)
- ATP.E. Disorders of Purine and Pyrimidine Metabolism Rebecca S. Wappner PURINE AND PYRIMIDINE METABOLISM Purine and pyrimidine nucleotides are important constituents of RNA, DNA, nucleotide sugars, and other high-energy compounds and of cofactors such as adenosine triphosphate and nicotinamide-adenine dinucleotide. (euroasfalti.net)
Protein1
- Catalyzes the formation of 2-(5''-triphosphoribosyl)-3'- dephosphocoenzyme-A, the precursor of the prosthetic group of the holo- acyl carrier protein (gamma chain) of citrate lyase, from ATP and dephospho-CoA. (string-db.org)
Ribose1
- Ribose-phosphate pyrophosphokinase (EC 2.7.6.1) is an enzyme that catalyzes the ATP-dependent conversion of ribose-5-phosphate to phosphoribosyl pyrophosphate. (biomedcentral.com)
Enzyme1
- The systematic name of this enzyme class is 1-(5-phosphoribosyl)-ATP diphosphohydrolase. (wikipedia.org)
Adenosine monophosphate1
- Ethanol or fructose consumption increases uric acid production by net adenosine triphosphate (ATP) degradation to adenosine monophosphate (AMP). (sagepub.com)
Phosphate2
- First , carbamoyl phosphate is produced from biochemical reaction involving bicarbonate , glutamine , ATP (for phosphorylation), and water molecule. (biologyonline.com)
- In 3′-phosphoadenosine-5′-phosphosulfate (PAPS), the key feature is the mixed phosphosulfate anhydride that activates the sulfate toward transfer, in much the same way as the terminal phosphate is activated in ATP. (heresy.is)
Molecules2
- These nucleotides are building blocks of DNA, its chemical cousin RNA, and molecules such as ATP and GTP that serve as energy sources in the cell. (medlineplus.gov)
- It is noteworthy to know that 4 molecules of ATP are required to form IMP from 5-Phosphoribosylamine. (picmonic.com)
Complex1
- In contrast, a cosubstrate such as ATP or NADH inhabits a much more complex world, containing a very large number of interacting enzymes. (heresy.is)
Energy1
- This is a high-energy bond and requires ATP for energy. (picmonic.com)
Pyrophosphate synthetase1
- This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. (nih.gov)
HisG1
- Through the oligomerization and functional re-assignment of protein domains associated with aminoacylation and phosphate binding, the HisZ-HisG octameric ATP-PRT acquired the ability to initiate the synthesis of a key metabolic intermediate in an allosterically regulated fashion. (rcsb.org)
Synthase2
- ATP synthase F1 subunit delta [So. (gsea-msigdb.org)
- ATP synthase membrane subunit c l. (gsea-msigdb.org)
Catalyzes2
- The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. (nih.gov)
- Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. (biossusa.com)
Adenosine Monophosphate1
- Ethanol or fructose consumption increases uric acid production by net adenosine triphosphate (ATP) degradation to adenosine monophosphate (AMP). (sagepub.com)
Pyrophosphorylase2
- C'-A5P was prepared from adenine-8-C*# (Isotopes Specialties Company, Inc.) and 5-phosphoribosyl pyrophosphate with yeast A5P pyrophosphorylase (7). (nih.gov)
- Labeled U5P was prepared from uracil-2-C (Isotopes Specialties Company) and 5-phosphoribosyl pyrophosphate with U5P pyrophosphorylase obtained from L. bifidus. (nih.gov)
Biosynthesis1
- PRRP though becomes committed particularly to purine biosynthesis when PRRP is converted into 5-phosphoribosyl amine by having the pyrophosphate of PRRP replaced by the amide group of glutamine. (biologyonline.com)
Mycobacterium1
- Crystal structure of ATP phosphoribosyltransferase from Mycobacterium tuberculosis. (tamu.edu)
Reacts1
- ATP reacts reversibly with 5-phosphoribosyl-1-pyrophosphate to yield N-1-(5'-phosphoribosyl)- ATP and pyrophosphate. (nih.gov)
Protein3
- protein_coding" "AHY40135","CJ8421_04560","Campylobacter jejuni","amino acid ABC transporter ATP-binding protein [Ensembl]. (ntu.edu.sg)
- 11353) putative ABC transport system ATP-binding protein BBZA01000001 CDS ARMA_0011 complement(11350. (go.jp)
- 14787 ABC-2 type transport system ATP-binding protein BBZA01000002 CDS ARMA_0027 14784. (go.jp)
Amine1
- Pathway engineering in vitro from HMP pathway form 5-phosphoribosyl-1-amine ( PRA ) is condensed with it. (tripoeste.com.br)
Enzymatic1
- The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. (biossusa.com)
Glucose2
- CADP was prepared from C¥-ATP and glucose by the action of purified yeast hexokinase and isolated by chromatography on a Dowex 1 column (9). (nih.gov)
- Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). (easyomics.org)
Reaction1
- Are 3 major steps are involved in this reaction ATP is consumed essential. (tripoeste.com.br)
Extracts1
- We were able to show that extracts of Escherichia coli convert C'-adenine-labeled ATP! (nih.gov)
Form1
- This form enables the transfer of phosphoribosyl groups (such as R5P). (marquardtadvogados.com.br)
Process1
- Vesicle budding from the tER is an ATP-dependent process. (nih.gov)