In order to work, cyclophosphamide first is converted by the liver into two chemicals, acrolein and phosphoramide. (hdkino.org)
Acrolein and phosphoramide are the active compounds, and they slow the growth of cancer cells by interfering with the actions of deoxyribonucleic acid (DNA) within the cancerous cells. (hdkino.org)
Its active substance cyclophosphamide is converted in the liver by cytochrome P450 into two active substances acrolein and phosphoramide. (canadianfpharmacy.com)
Mustards1
Synthesis and structure-activity relationships of nitrobenzyl phosphoramide mustards as nitroreductase-activated prodrugs. (nih.gov)
Synthesis1
Synthesis of Oligonucleotides Carrying Inter-nucleotide N‑(Benzoazole)-phosphoramide Moieties. (ebsco.com)
Cyclophosphamide2
Using a model ovotoxic alkylating drug, cyclophosphamide (CPA), and its active metabolite, phosphoramide mustard (PM), we previously showed that PM (≥3μM) caused significant follicle loss in postnatal day 4 (PND4) mouse ovaries in vitro. (hal.science)
Brain and plasma pharmacokinetics and anticancer activities of cyclophosphamide and phosphoramide mustard in the rat. (uclahealth.org)
Phosphate1
Phenyl phosphorodiamidate, a phosphoramide but also a phosphate ester, is used in agriculture to enhance the effectiveness of urea-based fertilizers. (wikipedia.org)
Phosphorus1
Phosphoramides are a class of phosphorus compounds with the formula O=P(NR2)3-n(OH)n. (wikipedia.org)
Derivatives2
In practise the term is commonly confined to the phosphoric triamides (P(=O)(NR2)3), essentially phosphoramide and derivatives thereof. (wikipedia.org)
A group of nitrogen mustard compounds which are substituted with a phosphoramide group or its derivatives. (nih.gov)
Organic1
acephate : 1300 Orthene TR: Micro Total Release : Micro Total Release : acephate : Acephate 97 UP: 0.48 tsp : 2 oz : acephate : Orthene TT&O 97: 0.67 tsp : 2 oz : acephate : Orthene TT&O WSP - - It is a mixed diacylamine, a phosphoramide, an organic thiophosphate and an organothiophosphate insecticide.It derives from a member of methamidophos. (wedl.ws)
Crystal structure1
The crystal structure of diphenyl (benzylcarbamothioyl)phosphoramide, (C6H5O)2P(O)(NHC(S) NHCH2C6H5), is reported. (ac.ir)
Studies2
164] Solid State and Solution Structural Studies of Chiral Phosphoramide-Tin Complexes Relevant to Lewis Base Catalyzed Aldol Addition Reactions (with X. Su) Tetrahedron 1999 , 55 , 8727-8738. (illinois.edu)
The researchers applied the approach and after a significant amount of SAR investigation and PK/PD studies around the chemical composition of the phosphoramide substituents, they concluded that the structure of compound shown above was the optimal structure to deliver the methyluridine-monophosphate to the liver. (michaelchimenti.com)
Mustard and acrolein3
Biotransformed by cytochrome P-450 system to hydroxylated intermediates that break down to active phosphoramide mustard and acrolein. (medscape.com)
5. Conversion of 4-hydroperoxycyclophosphamide and 4-hydroxycyclophosphamide to phosphoramide mustard and acrolein mediated by bifunctional catalysis. (nih.gov)
16. Effects of phosphoramide mustard and acrolein, cytotoxic metabolites of cyclophosphamide, on mouse limb development in vitro. (nih.gov)
Acrolein2
However, the medical use of CPO has been inadequate because of its capability to harm normal tissues, which usually results in toxicity in several organs (heart, testes and urinary bladder) [ 2 ] Hepatotoxicity is the foremost side effect of CPO because it is metabolized primarily within the hepatocytes by hepatic microsomal cytochrome p450 varied function oxidase system to construct its two-active metabolites phosphoramide mustard (PM) and acrolein. (biomedcentral.com)
Phosphoramide is linked to the immunosuppressive and antineoplastic outcomes of CPO, while acrolein is associated with the toxic effects of CPO. (biomedcentral.com)
Mustards1
BG significantly enhances the cytotoxicity and decreases the mutagenicity of nitrogen mustards [i.e., phosphoramide mustard (PM), melphalan, and chlorambucil], a group of alkylating agents not known to produce O6-adducts in DNA. (nih.gov)
Adducts2
4. Identification of phosphoramide mustard/DNA adducts using tandem mass spectrometry. (nih.gov)
15. Analysis and excision of ring-opened phosphoramide mustard-deoxyguanine adducts in DNA. (nih.gov)
Cytotoxic1
Interaction of phosphoramide mustard with DNA considered cytotoxic. (medscape.com)
Phosphoric1
In practise the term is commonly confined to the phosphoric triamides (P(=O)(NR2)3), essentially phosphoramide and derivatives thereof. (wikipedia.org)
Conjugation1
Conjugation of d4T to chitosan was attained through a phosphoramide linkage between glucosamine as well as the nucleosides monophosphate. (insulin-receptor.info)
Drug2
Bonding of Phosphoramides onto B-C59 Nanostructure as Drug Delivery Systems', Physical Chemistry Research , 6(1), pp. 15-29. (physchemres.org)
Specifically, the drug phosphoramide mustard (PM), a chemotherapy metabolite, was researched in this study. (iastate.edu)
Class1
belongs to the class of organic compounds known as organic phosphoramides. (ecmdb.ca)
General1
Our company deals with Triethylene Phosphoramide in the pharmaceutical industry in general. (chemicalbull.com)